Conserved Protein Domain Family
RskA_C
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pfam10099: RskA_C (This model is not part of the current CDD release)
Anti-sigma-K factor rskA, C-terminal
This domain, formerly known as DUF2337, is found at the C-terminal end of the anti-sigma-K factor from Mycobacterium tuberculosis (RskA), which positively regulates expression of the antigenic proteins MPB70 and MPB83.
Links
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Statistics
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PSSM-Id: 519179
Aligned: 150 rows
Threshold Bit Score: 35.8821
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q4JYD2         72 AFAAAAAVVL----LA--GVgivgttsglwgggenadlaesntsesvedgggdapevfsdsegagqGANGDELMQGAEAE 145 Corynebacteriu...
WP_015750171  118 VTWIAAAVAA----VV--IGggl-----------------------------------------vaVDQFRGQQQVAQSP 150 Nakamurella mu...
WP_052539381   95 MTAVAAVSLA----VA--IPavtvsis--------------------------------qhnrmgeSPGGPGAPDITAAY 136 Corynebacteriu...
WP_013136971   95 VAAVAATLLVgl-aaG--AG-------------------------------------------------WMLLGRSPAPP 122 Segniliparus r...
P9WGX5         92 AFASAAAIAVglgaFG--LG---------------------------------------------------VLTRPSPPP 118 Mycobacterium ...
WP_019510353   97 LTAAAAAVVVgvatFG--VG---------------------------------------------------WWLRPVPQA 123 Mycobacteriaceae
WP_005518484   93 MASVAAAVVLlvggVV--IG--------------------------------------------------RQLTETPPAT 120 Prescottella equi
jgi:Arth_2738 155 LVGVAAAAVIalggVG--VG-----------------------------------------------------AYVANQN 179
WP_012750990  317 WLKVSALVLLaalvLG--VGgwt----------------------------------------vwsQFTRPGIVHRIDQS 354 Micrococcus lu...
WP_012244702  126 LTTAAAAVIA----VAgtLG----------------------------------------------------VNGIIQAQ 149 Renibacterium ...

Q4JYD2        146 DHMHSIMAMG-DVrs--vsLKAEGSTLDVVVSAEMDSGGAMVNGAPelkdGMGAQVWSIn--KNGAARSAGVI---GQDP 217 Corynebacteriu...
WP_015750171  151 EQCVATATDRs-------eLTPANGQGVVTYAPSCGAVTVDVAGLPalpdDRTYQLWALsdqAEVAPRSLGLLpqaAAGQ 223 Nakamurella mu...
WP_052539381  137 DEVTRLLTTPgttvrsertsDGRGSLALVVSDAASDDNVVIARDLPeladDRIYQLWSLd--SEGSPTSAGIM---DEGE 211 Corynebacteriu...
WP_013136971  123 SAAARILAAPdVRav--sgAIPGGGTATVVFSPELHKAVLVMNDVApprpGTVYELWLVg-pNG--PEPAGTMdahAISP 197 Segniliparus r...
P9WGX5        119 TVAEQVLTAPdVRtv--srPLGAG-TATVVFSRDRNTGLLVMNNVAppsrGTVYQMWLLggaKG--PRSAGTMgtaAVTP 193 Mycobacterium ...
WP_019510353  124 TTAEQIFAAPdVRtv--sgDIPTGGTATVVFSRERNAGVLVMNNVSppanGTVYQMWLI---DDAGPHSAGTMnaqAIAP 198 Mycobacteriaceae
WP_005518484  121 PVTAQILAASdMHsv--taEIPGGGTATTMYSKEANAAMLVMNGVTppkpDTVYQMWLV---RGDEPVPAGTMgpdQVSP 195 Prescottella equi
jgi:Arth_2738 180 DPLNQVLQAQdVRea--tvDVSGGGTATVAISTSKDAVVVKMNGVPappaGKVYQMWLIp-kDGSAPVSQGLMd--AEAL 254
WP_012750990  355 KDLFTTSEYP----------AQDGGTVQAFLSREQNSGYLTISGMPqlpeGQSYQLWLYp-sDGTAPASLGTFd--ANGF 421 Micrococcus lu...
WP_012244702  150 DPVNQVISASdVStl--dvSVQGGGQAKVSISSSKNAAVVRMENVAapasGTTYQLWLIp-qNAAAPVSLGLMs-sSTAL 225 Renibacterium ...

Q4JYD2        218 HDNVWMPLPADTMMVRVTEEPmDGSAAp--GGTV 249 Corynebacterium jeikeium K411
WP_015750171  224 PQVVTQMTRPGEVAVAVTAEPgQGSASp--TMPI 255 Nakamurella multipartita
WP_052539381  212 DRTRFAVGVDVASAVAVTDEP-TGGSDsptTEPV 244 Corynebacterium glyciniphilum
WP_013136971  198 STTAVIDNLGDSTVVGLSVEP-PGGSRkp-tGAM 229 Segniliparus rotundus
P9WGX5        194 STTATLTDLGASTALAFTVEP-GTGSPqp-tGTI 225 Mycobacterium tuberculosis H37Rv
WP_019510353  199 STTAVLPDLGDSITLAFTVEP-GEGSAap-tSTP 230 Mycobacteriaceae
WP_005518484  196 TTTAVLEGIDGATQLGFTVEP-PGGSSyp-tGTM 227 Prescottella equi
jgi:Arth_2738 255 SKPAVVKGIHSAAALGITVEP-VGGSAsp-tLPT 286
WP_012750990  422 GEPVTFRGLDRFAAMGISVEP-SSGSEvptSEPV 454 Micrococcus luteus
WP_012244702  226 GKPALVDGIDKGQALAITVEP-SGGSKtptTTPV 258 Renibacterium salmoninarum
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