4QPK,4FMT


Conserved Protein Domain Family
HPTransfase

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pfam10090: HPTransfase (This model is not part of the current CDD release)
Histidine phosphotransferase C-terminal domain
HPTransfase is a family of essential histidine phosphotransferases. It controls the activity of the master bacterial cell-cycle regulator CtrA through phosphorylation. It behaves as a homodimer by adopting the domain architecture of the intracellular part of class I histidine kinases. Each subunit consists of two distinct domains: an N-terminal helical hairpin domain and a C-terminal [alpha]/[beta] domain. The two N-terminal domains are adjacent within the dimer, forming a four-helix bundle. The C-terminal domain adopts an atypical Bergerat ATP-binding fold.
Statistics
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PSSM-Id: 519176
Aligned: 48 rows
Threshold Bit Score: 71.5126
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4QPK_A        115 TGDAQNVATEYFRn--eKPEFT---WEG----ARVLLPKNKVKLLLNMLLIGNGAIPRGGSLAVRLE-----GSDTDPRF 180 Brucella abort...
WP_010265756   80 FDKTQSNIRQYLQ----KRGVAqllWEVeaqfADAELVEKVNRLLAHIALLSVMLMVRGEEVAVSVVd---aAEEGSVRL 152 Anaplasma
Q2GHC0         76 FNTTEHNIKNYLK----RKKIVl-eWDInaqiFDVELVEKINKLLINVTMILMFFMINGTKVKVVLSk----SNNNDFLI 146 Ehrlichia chaf...
WP_012591523   83 TGDAEKVARGLFSd--aKIKLD---WRA----PRVLLPKNKVKLILNLCLIASAAIPRGGVITVETItadakEGALEPTI 153 Methylocella s...
WP_012384019   83 TGDAERVMRGLFAe--gRSTLE---WHA----PRVLMAKDKVKLILNLCLIAMAALPRGGVVSVTIE-----GGETPSHI 148 Beijerinckia i...
WP_012169614   91 LGDAENVVRGMMEd--aRTKID---WML----PRELLPKNRVKLLLNLMLLAGMTVPRGGVIQVAAV-----GAAPDMGF 156 Azorhizobium c...
jgi:Plav_2173  86 LQDAKAVAEGLMMg--eRAALT---WNA----PAATIGKDYVKLLLNMILIGMAAIPRGGEVAVSVD-----GELAKPTL 151
WP_013418605   83 VQHIEQVARRYLEn--gKRRLH---WQA----NVPEIEKEHARLLMALLGVSINALPAGGDYYLGLSasktrAGRSRFKL 153 Rhodomicrobium...
CCB66386       84 LTTAEKISRGFVGitqgKHKLT---WRG----APGLVPKDKVKLLLNLIASAVTALPRGGEIDVSIG-----GSFEQPTF 151
WP_023788422   87 LGTAEQISRGFVGd--aKHKLV---WHV----QPGHMGKDKVKLLLNLVAVAITALPRGGEIEVRMS-----GTMEAPNF 152 Hyphomicrobium
4QPK_A        181 VIT--VKGRMLRVPPKFLELHSGAAPEE-PIDAHSVQPYYTLLLAEEAGMKISIHATAED 237 Brucella abortus 2308
WP_010265756  153 RAK--LKADEVAMHRDIERVLVYRDIDAcQLNTRNIQAYFMSLLLMRYGATFCYDAYDAI 210 Anaplasma
Q2GHC0        147 EII--AFAQKIEIHESIQSILDGDMFNQ-ELNTKNVQVNFLMMLLKSYNAKMTYEIQDTI 203 Ehrlichia chaffeensis str. Arkansas
WP_012591523  154 ALRviAQGTNAKLAPLTAAILAGAPAE--AIDAHAIQPYYAALVAQAAGMSLKAETGADF 211 Methylocella silvestris
WP_012384019  149 KID--AQGTNARLAQHVPSLLAGAPDTG-SVDAHGIQAFYTGLVAKSAGMTLDIIAEPNL 205 Beijerinckia indica
WP_012169614  157 SIA--STGVSARIPQAILPLLDGVPPEG-GLDAHAVQPFYAGLLAQDCGLVLGFSQDGET 213 Azorhizobium caulinodans
jgi:Plav_2173 152 RIR--STGQAARIPEETAKFLGGRSPDR-FLDARAAQPYFTGLVARSLGLSIDARMDGEA 208
WP_013418605  154 IIL--CRGRAARVPEGVAEVFAGDMTR--TIDGRLVIAYYATRLATEASLKLSALKEGED 209 Rhodomicrobium vannielii
CCB66386      152 LIR--CKGTGARPPQYLTDFVAGNPL---ALDAITIQAYYTWRIAPTAGMKLEILKDGAD 206
WP_023788422  153 VVR--CQGTAARPPQHLGEFISGENVP--PLDALTIQAYYTWRLARNANMTLAIVKDGAD 208 Hyphomicrobium
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