4WSN,5GJR


Conserved Protein Domain Family
CSN8_PSD8_EIF3K

?
pfam10075: CSN8_PSD8_EIF3K (This model is not part of the current CDD release)
CSN8/PSMD8/EIF3K family
This domain is conserved from plants to humans. It is a signature protein motif found in components of CSN (COP9 signalosome) where it functions as a structural scaffold for subunit-subunit interactions within the complex and is a key regulator of photomorphogenic development. It is found in Eukaryotic translation initiation factor 3 subunit K, a component of the eukaryotic translation initiation factor 3 (eIF-3) complex required for the initiation of protein synthesis. It is also found in 26S proteasome non-ATPase regulatory subunit 8 (PSMD8), a regulatory subunit of the 26S proteasome.
Statistics
?
PSSM-Id: 519170
Aligned: 34 rows
Threshold Bit Score: 96.5557
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
4WSN_H        35 IATPPVYGQLLALYLLHNDM-NNARYLWKRIPPAIKSA-------------------NSELGGIWSVGQRIWQRDFPGIY 94  human
A7F080        64 LTKDETITNILVKSLTVFPS-PDFSLALHLLPPHILTPissssalp----aagdaplSEAVQKLAVLNTLLSSANYSQFW 138 Sclerotinia scl...
Q7S2R9        62 RIKDEVITNILVKAMTQFPS-PQFDLALHLLSPSQSNPgpns-----------sselTEAVSKLRALNAQLEGAEYARFW 129 Neurospora cras...
Q4WXE9        64 LLQPETVTNILAKALTVFPS-PAFSLCLALLPAHTQPFptadtda------sqtsdfVESIQKLARLSTLLESAQYAQFW 136 Aspergillus fum...
XP_001539935  63 LLHTETTTNILAKALTVFPS-PAFSLALALLPAYTQPFsastsssl----pmqtsdfIESIQKLARLNTLLESAQYTLFW 137
Q5CU68        90 RTNLEIVQDILLLSIIRGPLsSDFLSCTYQIPLSVQND--------------------PNIKQIIQLNDLLTSCRYANMW 149 Cryptosporidium...
Q9W2D9        64 MLNFDITYTILLKSLTSLPH-TDFVMAKCLLLPQQMKD--------------------ENVQTIIDLADILERADFTLFW 122 fruit fly
Q1HPS4        62 KFNADITCQILLKALTNFPH-TDFTLCKCLLLESVVEN--------------------ETISQIKYLADILEQCDFAQFG 120 domestic silkworm
Q567V6        61 YFQTTVTAQILLKALTNLPH-TDFTLCKCMIDQTHQEE--------------------RPIRQILYLGNLLETCHFQSFW 119 zebrafish
Q1E6D3        63 LLNAETVTNILAKALTVFPS-PAFSLSLALLPAYTQPYatsstqattanlpmqtadfVEAVQKLTHLSTLLESAQYTAFW 141 Coccidioides im...
4WSN_H        95 TTINAhQWSETVQPIMEALRDATRRRAFALVSQAYTSIIADDFAAFVGLP--VEEAVKGILEQ-GWQAD--------STT 163 human
A7F080       139 STLDSdDLYADLIADVSGFEELIRIRIASTISQSVREIPSSELENWLGMN--GEAFEKFIKEVcGWTIE--------NGS 208 Sclerotinia scl...
Q7S2R9       130 ATLDSdDLYADLTTDIAGFEDMIRVRIAQLVGQSYREIQFPVLESWLGLNn-SEATTQFITETcGWKVE--------GDV 200 Neurospora cras...
Q4WXE9       137 STLNSdDLYADLVADVAGFEELVRIRIAIEVGKAFREINAEVLEQWLDLRs-REALEKFVTEVcSWEVDktg---pnGTV 212 Aspergillus fum...
XP_001539935 138 STLNSdDLYADLVADVAGFEELVRVRIAVEVGKAFREIGADVLAQWLDLNg-LEALEKFVVDVcGWEVDknagsdltSAV 216
Q5CU68       150 NLLKTnDQLRSKVEKIQGFYDSIRDIIIYSVNCSHSCISTAVLSELLDFPkdSTELKNIIEKN-KWILD--------SAC 220 Cryptosporidium...
Q9W2D9       123 QRAEVn---RNMFRHITGFHDSIRKFVSHVVGTTFQTIRKDLLKELLGGIe-DSTLESWIKRN-GWKNQ--------GQG 189 fruit fly
Q1HPS4       121 NRVHQm---PELCSRISGFHDSIRKFVCHVVGITFQTIDKNNLANLLGGId-DVTLKHWVKKY-GWRD---------DGS 186 domestic silkworm
Q567V6       120 ASLEEn---RDLIDGITGFEESVRKFICHVVGITYQNIEYRLLAEMLGDPl-DTQVKVWMNKY-GWTEN--------EDG 186 zebrafish
Q1E6D3       142 STLNSdDLYADLTADVAGFEELIRIRIAVEVGKAFREIGADVLMGWLDMRg-METLEKFVVDVcGWEVDkskaegenGVI 220 Coccidioides im...
4WSN_H       164 RMVLPRK 170 human
A7F080       209 VIVPLNK 215 Sclerotinia sclerotiorum 1980 UF-70
Q7S2R9       201 VQIPKNA 207 Neurospora crassa OR74A
Q4WXE9       213 VKVPTNK 219 Aspergillus fumigatus Af293
XP_001539935 217 IRVPKNK 223
Q5CU68       221 EIIRipl 227 Cryptosporidium parvum
Q9W2D9       190 LVIVAMQ 196 fruit fly
Q1HPS4       187 LIFIANQ 193 domestic silkworm
Q567V6       187 QIFIHNQ 193 zebrafish
Q1E6D3       221 VRVPRNK 227 Coccidioides immitis RS
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap