Conserved Protein Domain Family
DUF2282

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pfam10048: DUF2282 
BufA1 family periplasmic bufferin-type metallophore
Members of this family are ribosomally synthesized and post-translationally modified peptide (RiPP) precursors that are modified by multinuclear nonheme iron-dependent oxidase (MNIO) enzymes. Unusual among RiPPs, these peptides have an Sec-dependent N-terminal signal peptide, and are delivered to the periplasm. Members of this family act as metallophores, analogous to methanobactin, can be induced by stress from excess concentrations of copper or other metals, reduce metal toxicity by sequestration, and are termed bufferins. This model describes the BufA1 type of bufferin.
Statistics
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PSSM-Id: 490858
Aligned: 39 rows
Threshold Bit Score: 58.8341
Created: 15-Feb-2025
Updated: 20-May-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q168V1        31 EKCY------GISLAGANDCAAGPg-tTCAGSSTVDYQGNAWTLVDKGTCTEIELpamadgtprqGSL 91  Roseobacter denitrificans O...
Q5ZXR2        33 EKCQ------GVAKAGKNDCGTAQh--ACAGQSKTDGSTTDWIYLPKGTCEKLVN----------GTV 82  Legionella pneumophila subs...
1_pfamImport   1 VKCY------GIAKAHQNQCMSIGg--iTRGSATTNGNPDAWLAVPKGVCQKIVG----------GSL 50 
WP_015820028  35 EKCY------GIVKAGKNDCAIASqgtSCAGQAKKDSIADAWIYVPKGKCDAIVG----------GSL 86  Teredinibacter turnerae
Q5ZTQ3        28 EKCSvvkdgkGLIKENKADCKGSSh--SCAGQNKA-GDSESWILVPKGQCDKINA----------GDF 82  Legionella pneumophila subs...
Q0KAQ0        34 EKCA------GIAKAGKNDCGTSKs--SCAATAKMDRDAEAWILVPAGTCEKIAG----------GRL 83  Cupriavidus necator H16
WP_012163454  38 EKCA------GIVKAGLNDCGTSKh--DCSGKATVDNDPEEWIYVPAGTCEKIVG----------Stl 87  Acaryochloris
WP_013053486  35 EKCA------GIAKAGANDCGALDgshGCAGKSKADNLPNEWLYVPAGTCEKITG----------GEV 86  Shewanella violacea
Q121X2        51 EKCY------GISAVAKNDCAEGAh--SCAGQATQARDPKSFVMLPAGDCAKIQG----------GKL 100 Polaromonas sp. JS666
Q5ZXQ8        40 ERCY------NVVRAGKNDCATSQh--SCAAQSTADRDPEAFIMLPKGLCERIVG----------GRs 89  Legionella pneumophila subs...
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