4C8Z,6FJW,4C9D,6NJY


Conserved Protein Domain Family
CRISPR_Cas6

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pfam10040: CRISPR_Cas6 (This model is not part of the current CDD release)
CRISPR-associated endoribonuclease Cas6
Cas6 is a member of the RAMP (repeat-associated mysterious protein) superfamily. It is among the most widely distributed Cas proteins and is found in both bacteria and archaea. Cas6 functions in the generation of CRISPR-derived guide RNAs for invader defense in prokaryotes.
Statistics
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PSSM-Id: 519160
Aligned: 162 rows
Threshold Bit Score: 29.0187
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4C8Z_A       126 FASPTFFRr------------KGVHYPvpEPRLVLES----------------------LLRRleafgplkapegvreal 171 Thermus thermop...
4_pfamImport   3 FRGPAVLRdpwrg---pgeelRTRFLP--SPSHLFSVnayslfkdky--levlwklersLVEDhsalhsagkv------- 68 
WP_014026009 160 FRSPTLPVnpwr-----pgsrWKRLLP--TPSYLLAVnahdmf-----------dpdtaLVERaliaaerilspshaal- 220 Pyrolobus fumarii
Q4J7P9       159 LITPSMFKdpfekladldrvkYRRYLP--FPAFIFSTnvfe--------------ifreTYKRniirlsyglleshnnl- 221 Sulfolobus acid...
WP_011838632 167 FRTPALLLdpyk------ktrYKRFLP--TPGNVFSYnigdllrltr---dkeyievviLVNAllnetytvletvk---- 231 Staphylothermus...
WP_014737713 167 FSSPTQLRdpfr------rgrHKSFLP--SPLNVFSTpayiyvyqrwgfkrgrflkllrVLHRvfnetytvlktvk---- 234 Thermogladius c...
WP_014126168 110 TITPVQFAvktke----rrraKLAFLP--EPLRVFKW----------------------LVITayklglvekldrnflrw 161 Thermoproteus t...
WP_245522578 139 FLSPVRFAkrstmg--rrrkvRFDFCP--SIVNILFT----------------------TVNHyssvvgvgeglrswpyl 192 Vulcanisaeta di...
WP_014127161 125 FLTPLRFAvppiy---rrrraLFDFLP--RPLSLFKS----------------------AVRHgrqlgltklgtpflkwv 177 Thermoproteus t...
Q8ZZK8       123 FLTPLRFAvkply---krkraIFDFLP--RPLSVFKS----------------------AVKHgrelgllrlgapflrwv 175 Pyrobaculum aer...
4C8Z_A       172 ler-------ttvrslegrtlpartevdtaGFVGRVVYh-------------lPRATeeealwLSALGRFAFYSGVGAKT 231 Thermus thermop...
4_pfamImport  69 --------------------wyyydrkwlpALSGSALFwv-----------reADED------VKKVIAHAALFGVGSGR 111
WP_014026009 221 --------------dtarvywylydgsrlpAMIGYVKLhvete-----gvgkgEVET------VEHLLSHAVVMGVGSGR 275 Pyrolobus fumarii
Q4J7P9       222 --------------ntvrkvwyyydgkwlpGVVGYLKFfvrkg------lrkeVMNI------FREIFIHANIMGVGTGR 275 Sulfolobus acid...
WP_011838632 232 ------------------pvkyvygnkslpGIIGYAKYmidwdl----laetkAKHL------LENILLHASIMGIGTSR 283 Staphylothermus...
WP_014737713 235 ------------------ltwfvyekrpepGLIGYAKYavndyyyeeyskrlgLREA------IEGVLATAVALGTGTGR 290 Thermogladius c...
WP_014126168 162 vyeyvdladlrchrpscvvkvkydgrrslyGFYGTAKYvvq---------ddrYMDK------LSYYVSLANFLGLGKSR 226 Thermoproteus t...
WP_245522578 193 lrwayn--yvymrdlrgrvvatrhagrpelGFIGSVEFevrs-------krqsRIQQ------LWHLLNYAELINVGTGR 257 Vulcanisaeta di...
WP_014127161 178 htyval--tdfgcrrrcvvtvelpggglarGFVGWALYrsf---------grrRLRD------LWTVIKLMEALNVGTGR 240 Thermoproteus t...
Q8ZZK8       176 htyval--tdfgcpgrciitvrlpnggiarGFVGWALYraf---------gkrRLAD------MWKTLRFAEAFNIGSGR 238 Pyrobaculum aer...
4C8Z_A       232 SLGYGR 237 Thermus thermophilus HB8
4_pfamImport 112 AAGFGD 117
WP_014026009 276 AAGFGA 281 Pyrolobus fumarii
Q4J7P9       276 AAGFGF 281 Sulfolobus acidocaldarius
WP_011838632 284 ANGFGH 289 Staphylothermus marinus
WP_014737713 291 AAGLGH 296 Thermogladius calderae
WP_014126168 227 GVGLGA 232 Thermoproteus tenax
WP_245522578 258 SMGFGV 263 Vulcanisaeta distributa
WP_014127161 241 TMGLGA 246 Thermoproteus tenax
Q8ZZK8       239 GMGLGV 244 Pyrobaculum aerophilum
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