Conserved Protein Domain Family
Dpy19

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pfam10034: Dpy19 (This model is not part of the current CDD release)
Q-cell neuroblast polarisation
Dyp-19, formerly known as DUF2211, is a transmembrane domain family that is required to orient the neuroblast cells, QR and QL accurately on the anterior-posterior axis: QL and QR are born in the same anterior-posterior position, but polarise and migrate left-right asymmetrically, QL migrating towards the posterior and QR migrating towards the anterior. It is also required, with unc-40, to express mab-5 correctly in the Q cell descendants. The Dpy-19 protein derives from the C. elegans DUMPY mutant.
Statistics
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PSSM-Id: 519156
Aligned: 43 rows
Threshold Bit Score: 502.133
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002071812   17 SGFFFLYMQHVRVIFETRTNIHQLSQLEKESLIRNEDALYYSFYKKLVDGPNFWH-GYEQLKNVTDIEYPQSVNVLQRFY 95  
A8Y3M2         39 LFVGFLNYQHIYTLFENDKHFSHLADFEREMAYRTEMGLYYSYYKTIITAPSFLE-GVQLITRDTVTEHGHQINTLNRFN 117  Caenorhabditi...
Q5CR43         47 VLSSIIFSSFLILRHRKMLLRSYE---EQKMSLFSETAFYFSFYDDIVNSSESIYnIIKKMISDDRTEYPDIINSLSRFN 123  Cryptosporidi...
EFX72333       24 LVCSCLNFYHVSTMFENDRHFSHLSTLEREMTFRSEMGFYYSYYKRIVNAPSFFL-GLHSIMNDNKTEYPSTINTLQRFN 102 
XP_002427382   26 TGFAFIHMHHVSTLFENDRHFSHLSNLEREMTFRTEMGFYYHYYKKIINAPSFES-GLKALLQDNQTEYPDVINALQRFN 104 
XP_002055776   17 SGFFFLYMHHVRVIFETRTNIRHLNQLERESMLRREDALYYTFYKKLADGPDFWH-GYEQLKNVTDIEYPHSVNVLQRFY 95  
XP_001965532   17 SGFFFLYVLHVRVIFETRTNIQQLNQLEREALLRREDALYFAFYKRLAESPNFWH-GYEQLKNVTDIEYPHSVNVLQRFY 95  
Q9VWR8         17 CGFFFLYVQHVRVIFETRTNIQQLNQLEREALLRREDALYYAFYKQLAEGPDFWH-GYEQLKNVTDIEYPHSVNVLQRFY 95   fruit fly
XP_015042229   17 SGFFFLYMQHVRVIFETRTSIQTLNQLEREALLRREDALYYTFYKKLVDGPDFWH-GYEQLKNVTDIEYPNSVNVLQRFY 95  
EFN81712       32 LSFGYLHSLHVSTLFENDRHFSHLSEIEREMSFRTEMGMYYSYYKTIAESKDFFE-GMDKLIHDNLSEYGNVIDASRKYN 110 
XP_002071812   96 VLPELVTAYVFHIVRSGYNP---------------------------------ILQPMQFYFEFVWIMGGVTLLVLYLYG 142 
A8Y3M2        118 LYPEVILAFLYRPFRALAKSanwqvetcwqvn---------rgdlrpvescegIGNPHYFYITGVFVVAGTVATSLFYLG 188  Caenorhabditi...
Q5CR43        124 IYQEVILGILYKLFLEFYFKlkfiihliysfingehllkntfgfnnlssefvfLSTPYNFYFFFVNSLLGIGMGVLCGTS 203  Cryptosporidi...
EFX72333      103 LYPEVILGAAYRGFIHFTNTagiktkecwqvdr--------gddlpavwscegLGDPSYFYINGVWLCAGITAALIFLYG 174 
XP_002427382  105 LYPEVFIGGLYRIFDFVTKRydittkqcwevnr--------gqslppvnscegLGDPMYFYLEFVWYCAGLSKAVLFIYA 176 
XP_002055776   96 VLPELVTAYFFHIVRAGFNP---------------------------------SLQPMQFYFEFVWLMGGVTLLVLYLYG 142 
XP_001965532   96 VLPELVTAYFFHIVRTGFNP---------------------------------MVQPMQFYLEFVWLMGGVTLLVLYLYG 142 
Q9VWR8         96 VLPELVTAYFFHVVRSGFNP---------------------------------MVQPMQFYLEFVWLMGGVTLLVLYLYG 142  fruit fly
XP_015042229   96 VLPELVAAYFFHLVRSGYNP---------------------------------ILQPMQFYFEFVWLMGGVTLLVLYLYG 142 
EFN81712      111 LLPEIVIGFLYHAAKNLGIVseeqcwvverg-----------dglpnvtscegLGVPVYFYLEIVWFTAMFTATMLFYYA 179 
XP_002071812  143 IMLSENVF-GGIYGVISYLMFHSF--AAKIYERPLARENFAFPFIFLQMFYLCFCIGQViytqRHS--SRLlk------i 211 
A8Y3M2        189 VLVSDSIF-GGILSVLCFAFNHGE--ATRVQWTPPLRESFAFPFIIGHIAILTYIIKYR----KSSt-AHL--------- 251  Caenorhabditi...
Q5CR43        204 TFIADGSYiSGLTCMGFLFANFRLrlLSRIS-SLPLRENFALPFIWINNMILISIIKYTnrgnQKKk------------w 270  Cryptosporidi...
EFX72333      175 CYLSRSIF-GGIIAISAFFFNHVE--CTRVQWTPPLRESFGYPLILAQILSVSWCLRQT----TPHw-KHL--------- 237 
XP_002427382  177 VVLSNS-FgGGLLTVLGFLFNHGH--CTRVQWTPPLRESFAYPFCLSQMLAITYCLKSSknkiNTKw-NLLfq------v 246 
XP_002055776  143 TLLSENVF-GGIYGVLSYLMFHSF--AAKIYERPLARENFAFPFIFLQMFYLCICIGRVlhrqKHT--SRIfm------v 211 
XP_001965532  143 TLLSENVF-GGIYGVISYLMFHSF--VAKIYERPLARENFAFPFIFLQMFYLCICIGRIihrqRHT--SRLfm------i 211 
Q9VWR8        143 TLLSENIF-GGIYGVISYLMFHSF--VAKIYERPLARENFAFPFIFLQMFYLCICIGRIihrqRHT--SRMfm------i 211  fruit fly
XP_015042229  143 TLLSENVF-GGIYGVISYLMFHSF--VSKIYERPVARENFAFPFIFLQMFYLCICIGRVihrqKHS--SRLfm------i 211 
EFN81712      180 TYLSDSVY-GGLLAILLFFFNHNE--CTRVQWTPPLRETFAYPMLLFEMYSVTLAIKKYakhdSDKepSWLkgrtrqglf 256 
XP_002071812  212 FTMSIFIAIALLSWQFSTFIFTTQILIVMTSWNISVMPTGtanAFALdFSISHLLGNALAFIISHGNGQLLFTWQLSVSL 291 
A8Y3M2        252 LLLISAAVPALLFWQFTQFAFFTQICSIFAAFSMDLVPLD---TAKT-IIKSHLSAFFISFVMLFGNEMMIAALYFPSIW 327  Caenorhabditi...
Q5CR43        271 ILLYFTSVILLEFWQFSVFVISTQILSVYALFLFGCEHSKlilVLRK-LIFFNMIAMFTSYLLHFFNYYILLTPLPQIGV 349  Cryptosporidi...
EFX72333      238 CCIAFTTTASLVTWQFSQFVFLTQVLSLTVLWIQNSTPRS---NITV-VFLGKLIGLQNAIVLLFANEMLLTSYYSCSIV 313 
XP_002427382  247 WTITLSSTSSLLLWQFSQFVLATQVVAILIMFCLGIIHKK---TVLI-ILVSQLVGLLQAAVLMFGNEFLFQSILFSLLI 322 
XP_002055776  212 CVMSLFTACALLSWQFSNFIFTTQIMIVMTSWNVSSMPVGlanAFALdYSLSHLLGNCLAFVISHGNTQLLFTWQLSVAL 291 
XP_001965532  212 FAMAVFTACAMLSWQFSTIIFTTQIIIVMTSWNLSALPTGlanSFAFdYSLSHILAHALAFILSHGNNQLLFTWQLSVSF 291 
Q9VWR8        212 FAMSLFTACALLSWQFSTFIFTTQILIMMTSWNASALPTAlvnAFVLdYSLSHLLGHALAFVMSHGNSQLLLTWQLSISL 291  fruit fly
XP_015042229  212 FVLSMFTACALLSWQFSTIIFATQIMIVMTSWNINTMPTNvanAFALdYSLSHLLGNAIAFVLSHGNSQLLFTWQLSVSI 291 
EFN81712      257 VDIFGSTICSLCTWQFSHFVFATQITVLLILKWLRIVPYD---FYKN-FCMTHALAIAAATNITNG-TLIVSSLYMCLLI 331 
XP_002071812  292 SLFLITMV---RQVRSRRltndp--lqgdyFslKFILLALL--------FASSMQAKLLDLLVKAGMLNPQDNTCVhYCD 358 
A8Y3M2        328 ALATVIYIs--PMLAGIR------------L--RPLYLLIL--------ALIFGSITLGLKVGFSKGLGIEDDAHI-FDI 382  Caenorhabditi...
Q5CR43        350 SILLSISL---CKILFKR------------EkfSLLYSFTS--------GIISLALFLVFKLILNPF--SDHDTHV-FDM 403  Cryptosporidi...
EFX72333      314 VLLGFIVFf--PHFSSRPq----------nEwlKLRNTVIY--------GVLIGACTFFLRLCVSILIGSKDDAHI-LNL 372 
XP_002427382  323 SSIAIVLSc--------------------------DFKIHYpsfhggfiLISSLVITFSLKSKISRFFS-EHDAHI-FDL 374 
XP_002055776  292 SLFLITIV---RQLRNRRctnnv--lqgdyFsfKLILLALL--------FASSMQGKLVDLLSKSGLLNWQDNTYMhYCD 358 
XP_001965532  292 SLFLITVVrhvRQVRSRRqghhdp-lqgdyFslKFILLALL--------FASSMQGKMLELLCRAGVLSVADGPHThYSE 362 
Q9VWR8        292 FLFLITMVrqlRHVRSRRlghaqdllngdlFslKFLMLTLL--------LASSVQTTLIELFNRAGVVSVTEGDQQhFFD 363  fruit fly
XP_015042229  292 SLFLITVV---RQVRSRRhvndp--lqsdyFsfKFILLALV--------FAGSMQEKLVDVLRRTGVLNVQDNNYVhYWD 358 
EFN81712      332 SSNAASLIvklSRFQNIK-----------------YEIILE--------IVMTVIFTKWIK---SYVLYSQDDAHV-FNI 382 
XP_002071812  359 LWAHWalQMKVNFVTNLS-ACNPHYVPVAWSELWQLVKTLIVkpycmYGVVMLAMFfrkwrksnVpqraasqeqrerarn 437 
A8Y3M2        383 LRSKF--TSFANFHTRLY-TCSAEFDFIQYATIEKLSSTLLI-----PLALLSIGA--------F--------------- 431  Caenorhabditi...
Q5CR43        404 LKSAIfgQEFANFDTMIYkMGGSEFSFITKEQLEMIKNSGVLfifipGTFLILFSIiidtanirAskyfpykniessfsy 483  Cryptosporidi...
EFX72333      373 LRSKF--TSFRDFHTMLY-TCAAEFDFISLSTIYRLSSTLLL-----PIVYIAVGS------------------------ 420 
XP_002427382  375 LLAKV--TNFKNFHTMLY-TCSPEFDFLPLSTVYELTITGLI-----PTVLIVIGI--------L--------------- 423 
XP_002055776  359 LWAHWmlQAKVNFVTNLS-ACNPLYARVAWSELWQLVKTLIVkpycmYGVVMLATFfrkwrksnVitkanqeqrerarny 437 
XP_001965532  363 LWAHWalQIEVGFVTNLS-ACNPLYARVAWPELWQLVKTLIVkpycmYGVVMLAMFfrrwrksgApvsaiseeqrerarn 441 
Q9VWR8        364 ICAHWalQVNVGFVAHLS-ACNPQYARVAWSELWQLVKTMIVkpycmYGVVMLAMFfrrwrksgApvsalteeqrerark 442  fruit fly
XP_015042229  359 LWAHWafQVNVNFVTNLS-ACNPLYARVAWSELWQLVKTLIVkpycmYGVVMLAMFfrkwrksnVpttasqeqrerarny 437 
EFN81712      383 LKSKL--TDYRDFHTMLY-TCSAEFDFLQYKTYETIVKTLLL-----PTAILTGML--------A--------------- 431 
XP_002071812  438 yvledfleehrvsmsemsnkqteqqlqkCLKMLESCDHDYERykREKAkmqqeqpaerddfiAdikrlkeqinrnkereq 517 
A8Y3M2        432 ----------------------------SWDFLSKTSLLWR---TLEN--------------Ed---------------- 450  Caenorhabditi...
Q5CR43        484 qf---------edcsqindeisdsssnsSIVSTAASYSPEAAisLKQSnvhcfknnlqdeypKnlkekqssyknkk---- 550  Cryptosporidi...
EFX72333      421 ----------------------------VTLYAAGIGEMTSNsgACQKrtvaslpmkkqresRrdlkeipk--------- 463 
XP_002427382  424 ----------------------------LFKWGKHFIFKKQKhgQSQNvid----------------------------- 446 
XP_002055776  438 vledfl-eehhvsmsdmsnkqteqqlqqCFAMLESCDHDYERykREKAkmqqeqpperddfmQdikrlkaqihrnsdkqr 516 
XP_001965532  442 yvledfleehrvsmgdmsnkqtearlqqCFRLLDSCDHDYERykRTQArlrqeppaardnfmQdirrlkeqihrnsdkqr 521 
Q9VWR8        443 yvledfieehfvsmsdmssketekqlykCFRLLKSCDYDYERykRAQAslrkeqpparddfmQdikrlraqinrnsvkqr 522  fruit fly
XP_015042229  438 vledfl-eehhvsmtdmsnkqteqqlqqCFKMLESCDHDYERykLKKAklqqqqpparddfiKnikrlkaqihrnsdkqr 516 
EFN81712      432 ----------------------------LYYWYRSFKIGDYPrcIEAD-------------------------------- 451 
XP_002071812  518 genkdelqqqqaqtqdteaektfipasdpaadststtttttntinatkdkekteetlpskttdettnksssssssspnrn 597 
A8Y3M2            --------------------------------------------------------------------------------      Caenorhabditi...
Q5CR43            --------------------------------------------------------------------------------      Cryptosporidi...
EFX72333          --------------------------------------------------------------------------------     
XP_002427382      --------------------------------------------------------------------------------     
XP_002055776  517 kereqasesnlketssiesectaeadtetqaqt--------------------------------------ataketqne 558 
XP_001965532  522 keraqetkeagggdvpdpmptekeemfreddiekedla---------------------------setlpsmsrsedeqn 574 
Q9VWR8        523 keraqetkeaatdgastpteeedkdpeaeseskkknqepgsget----------------etesaadptetppsrsadne 586  fruit fly
XP_015042229  517 kerqqgataatmdtkeeepleqepdqdkdqepdhvntetvvheadevh-------hetdetqpsmsateekampapgngr 589 
EFN81712          --------------------------------------------------------------------------------     
XP_002071812  598 ghssshthnhnhshsrchrshrnsmsstssfsvvpttnaqIlNLHYMYSFLQMLVFTVIGLTVRKLFFLSFTQGCVIAPT 677 
A8Y3M2        451 ----------------------------------------SeYGEVIYNLVQLICSTTMAVLIMRLKLFMTPHLCITVAL 490  Caenorhabditi...
Q5CR43        551 ---------------------------nllldkfyninfeNqDTAISFLTFQTIFFCLLAIIISRLRVLALPYIAVVSSL 603  Cryptosporidi...
EFX72333      464 ---------------------------------sempplrKvDAAVQYNILQLIAFIIMAAIIMRLKLFMSPHLCIMASL 510 
XP_002427382  447 -------------------------------------------peVVYNFLQLGAFTIMTYFIMRLKLFWSPHLCLMASL 483 
XP_002055776  559 tetdetqpcktpsdkepangrrrpatsarrdsviptanaqIlNLHYMYSFMQMIVFTLIGLTVRKLFFLSFTQGCVIAPT 638 
XP_001965532  575 ndeqpdpdekeqpmpssnerrpkrsssarrssvvptanaqIlSLHYVYSFIQMLVFTVVGLAVRKLFFLSFTQGCVIAPT 654 
Q9VWR8        587 eeeeehsataagcgsnssghrqrkrsssrrssvvptanaqIlNMHYVYSFLQMLVFTLIGLAVRKLFFLSFTQGCVIAPT 666  fruit fly
XP_015042229  590 qkapgagagaapkpkpnanataktpsrrssssvvptantqIfNMHYMYSFLQMLVFTILGLAVRKLFFLSFTQGCVIAPT 669 
EFN81712      452 ---------------------------------------------VAYNGLQTGAFIIMAVFIMRLKLFMTPHLCIIAGA 486 
XP_002071812  678 VCSKVW---------YHRQRN--------------------------------IFWSVSLAVFLLSMFDPGMVNIREEYF 716 
A8Y3M2        491 LANSKLlggdkiaktVRSS---------------------------------------VLVGLVAMLAFRGIPNIRHQLN 531  Caenorhabditi...
Q5CR43        604 FASRKY---------LSFIFNyykpillwifrikynknkainpnkryfnnriaCFIFFATSIIFLSFSISKFPFSEIQTG 674  Cryptosporidi...
EFX72333      511 VASKKY---------MFFVKGk-------------------------------LMHLALLAALLSGMSYAGLRNLKEQRS 550 
XP_002427382  484 IMSTKYlss------------------------------------------knNLRYSILTILIAAMSYHGINNIIRQRN 521 
XP_002055776  639 VCSKIW---------YHRQRN--------------------------------IFWSVSLAVFLLSMFDPGMVNIREEYF 677 
XP_001965532  655 ICSKVW---------YHRQRN--------------------------------IFWSVSLAVFLLSMFDPGMVNIREEYF 693 
Q9VWR8        667 VCSKLW---------YHRQRN--------------------------------IFWSVSLAVFLLSMFDPGMVNIREEYF 705  fruit fly
XP_015042229  670 ICSKVW---------YHRQRN--------------------------------IFWSVSLAVFLLSMFDPGMVNIREEYF 708 
EFN81712      487 VCSKRYlekvg--------------------------------------lkseLARAAVIFLLVSGMSYHGVDRIQQEHG 528 
XP_002071812  717 PTRYTQNTDDlDSMLEWIKVNTE-RDAVFAGPVEIIGTVHLTTKRPIVNHAHLEMRQIAERTEHVYSVYSRQQSSDIYNQ 795 
A8Y3M2        532 IKGEYSNPDQ-EMLFDWIQSNTK-QDAVFAGTMPVMANVKLTTLRPIVNHPHYEHVGIRDRTLKVYSMFSKKPVAEVHQT 609  Caenorhabditi...
Q5CR43        675 LIPENNASSSkSRLVGWINSNLP-NHTPILSDMVVSATLRLATKTKIVTHPQYEHIKIRRRTQFMYSISACISLKELYET 753  Cryptosporidi...
EFX72333      551 IVGEYSNPAL-EDLVNWIQKETPrEEAAFAGPMPIMASILLTTQRPIINHPHYEYADLRERTKVVYRAFGRGTVAELYRS 629 
XP_002427382  522 IMGEYINIPF-EEVLTWISSETL-PTDVFAGPMSIMANVLLSTGRRIVNHPHYEHHNMRERTLKVYSVFSRQNPQQVFST 599 
XP_002055776  678 PTRYTQSSDDlESMLEWIKLNTE-RDAVFAGPVEIIGTVHLTTKRPIVNHAHLEMRQMAERTEHVYSVYSRQQSSDIYNQ 756 
XP_001965532  694 PTRYSQSPDDlDSMLEWIKLNTE-RDAVFAGPVEIIGTVHLTTKRPIVNHAHLDMRQMAERTEHVYSIYSRQQSSDIYNQ 772 
Q9VWR8        706 PTRYSKSGDDlDSMLEWIKLNTE-RDAVFAGPVDIIGTVHLTTKRPIVNHAHLEMRQIAERTEHVYSVYSRQQSSDIYNQ 784  fruit fly
XP_015042229  709 PTKYEHNADDlESMLEWIKLNTE-RDAVFAGPVEIIGTVHLTTRRPIVNHAHLEMRQMADRTEHAYSVYSRQQSSDIYKQ 787 
EFN81712      529 FIGEYSNIEQ-EELFEWIKSNTP-KHAVFAGKMSLMANLMLSTRRPIVNNPYYESKEMRDRTMRVYEIFSRKDVASVYTS 606 
XP_002071812  796 C-SQLKIQYLIISLDECTNEVR--DDCDILSIWDDKQ------PTYRNYP-QFCHEL--------LHKNVPsFLKVYA-N 856 
A8Y3M2        610 M-KKMGVNYFIFQLMNCSNDERr-PECVYRGMWDEED------PKNSART-SLCDLWilaanskdNSRISP-FKIVYNpN 679  Caenorhabditi...
Q5CR43        754 MqQQYKTEYLLLSIYRCAIPRGdkNAITMIHVTNFLDninhrcNNQENIFqRTCWRIq-------LDSQSRyFDLVYR-N 825  Cryptosporidi...
EFX72333      630 L-VDLKVTYFVLQDHWCYGESR--PGCSMLNIWDIEE------PHRKDLN-PLCSILf-------EGNPSP-LQRVFS-N 690 
XP_002427382  600 L-IDMGVDYVILDETWCFYQSR--ENCSMIDLWDLVD------LENANNE-PLCPKLf-------NGNPEP-FIRAFA-N 660 
XP_002055776  757 C-TQLKIQYLIISLDECSNEVR--DDCDILSIWDDKQ------PAFRKYP-QFCHEL--------LHKNVPsFLKVYA-N 817 
XP_001965532  773 C-ARLKIQYLIISLDECKNEVR--DDCDVLAIWDEKQ------PAYRKYP-QFCHEL--------LHKNVPsFLKVYA-N 833 
Q9VWR8        785 C-AQLKIQYLIISLDECTNEVR--DDCDLLAIWDDKQ------PAYQKYP-QFCHEL--------LHKNVPsFLKVFA-N 845  fruit fly
XP_015042229  788 C-AELKIQYLIISLDECTNEVR--DDCDLLSIWDDKQ------PANRKYP-QFCHEL--------LHKQVPsFLKVYT-N 848 
EFN81712      607 L-RGLKVGYVVLEEPLCFGFANlpRGCQMIDLWDVTDng---tSRAANKP-PLCPLLf-------QGNAYP-FKRAFV-N 672 
XP_002071812  857 DNYGIIKM 864 
A8Y3M2        680 RNYIVLKI 687  Caenorhabditis briggsae
Q5CR43        826 AHYSLYKR 833  Cryptosporidium parvum
EFX72333      691 EIYVVLRV 698 
XP_002427382  661 DVFVILSL 668 
XP_002055776  818 DNYGIIKM 825 
XP_001965532  834 DHYGIIKM 841 
Q9VWR8        846 DHYGIIKM 853  fruit fly
XP_015042229  849 DNYGIIKM 856 
EFN81712      673 SNYVVLQL 680 
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