Conserved Protein Domain Family
Med4

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pfam10018: Med4 
Vitamin-D-receptor interacting Mediator subunit 4
Members of this family function as part of the Mediator (Med) complex, which links DNA-bound transcriptional regulators and the general transcription machinery, particularly the RNA polymerase II enzyme. They play a role in basal transcription by mediating activation or repression according to the specific complement of transcriptional regulators bound to the promoter.
Statistics
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PSSM-Id: 401849
View PSSM: pfam10018
Aligned: 14 rows
Threshold Bit Score: 125.612
Threshold Setting Gi: 121784218
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q2H2I4        30 QKLAEELLAAEAELSKSLKLLETHQNNNARLQQLRQETSLHDTQLKDIMSSLWNMRRELKAVP---------T------- 93  Chaetomium glob...
Q2TY58        33 PAAAVNLLDADDALTTSISTLRHHQDNYARILRLRNEAASLEEKVKEIVKTVVNYEKEIRTVCnsdeidsdsDfdsdssg 112 Aspergillus oryzae
Q5B255        33 PKAAQELLNADDSLTSTIDTLKQHQSNYARILQLRAEAQSLEDKVKDIVRLVVRYEKDIREACgdsd--sdsDtdydsee 110 Aspergillus nid...
Q0V090        30 PQAAIDLVAADDQLSHGLDQLSRHQANHARILTLRAQVEALEEQKKSSVTALATLRHELHATP----------------- 92  Parastagonospor...
Q7SA34        30 EKLAEDLVAADRELAAGLKELERHQNNHARILQLRQETASLDQQTKDIIGGLWNMRKEVKSTP---------A------- 93  Neurospora crassa
Q54D00        69 LQLMNHLIDVDKIYQNTLKKLEKHQKIQKEITEIQKEIEEKDKLISTLALNLKDIESFLENELsqdn--vniNngnasdg 146 Dictyostelium d...
Q2M0F9        39 GDLLDLLVAKDEEFRKMLELAEEQAKVEDAMDKLRAKVEVHDREIQKLQKSLKDAELILSTAIfqar------------- 105 Drosophila pseu...
Q23523        47 TNIIKLFDSKQDSIKTLLKRVPEFQEREQLIRTLEAHVEKRDEVIQQLETNLKSCEVALTRSCfhan------------- 113 Caenorhabditis ...
XP_001638176 216 AEVLEKLTSKDKELQAAVVQAKEQQKRQQDIESLKLHIAKKDEKILALEVQLKEAEQILSQALfqak------------- 282 starlet sea ane...
EDO15552      72 VKLAHQLIDVDERLFKSLDSFVEYDKISTKLEECDKEAAELDTKTKEILGTLNECHGLLNSLPmleqv------------ 139 Vanderwaltozyma...
Q2H2I4        94 --------------TSNPPPGPKHQFTTSELLAYARRISRNTLPlpgvtngvdmtptqfsasltepedsfrlqfqptqtq 159 Chaetomium glob...
Q2TY58       113 yd---sdaemqdagGRPRKLRGIREVDYRLLLDFARRISKYNHQaaadaeagakarvqiged------------------ 171 Aspergillus oryzae
Q5B255       111 sd----hdmnaphtTQTRTSRKRNEVDYRLLLDFARRISKYNHEaaadaaagmakgnhvla------------------- 167 Aspergillus nid...
Q0V090        93 ---------------ATSFPADTRPVRFDELLQYAKNISQYTVPptyrerapeaasdkdrdkddaas------------- 144 Parastagonospor...
Q7SA34        94 --------------TQYPATGPKYQFTTHELLNYAKRISRTTLPpahllynsepsesqqaggqggqpmeidsaaptpmpg 159 Neurospora crassa
Q54D00       147 ivnevlidlkqpddAASMDNIVNREVSPEDLISYAHKISGTTSA------------------------------------ 190 Dictyostelium d...
Q2M0F9       106 ------------qklASINQANKRPVSSEELIKYAHRISSANAV------------------------------------ 137 Drosophila pseu...
Q23523       114 ------------qklKQMKEAELRPVNSEMLIKLAHQISKHNSV------------------------------------ 145 Caenorhabditis ...
XP_001638176 283 ------------kklTAIEKANKGSVSSEELIKYAHQISSSNAV------------------------------------ 314 starlet sea ane...
EDO15552     140 ------------efekDIILKQRSKINSKLLLDYATKLSKFTKI------------------------------------ 171 Vanderwaltozyma...
Q2H2I4       160 tptnsfnlsfngtvstpiglsaptptttndtqpstqlppsqqPPPKTAPAddKLPAHLKpav-nplHDAAFHPW-PTEGQ 237 Chaetomium glob...
Q2TY58       172 ------------------------rdtemtgtgaigtngvedGEAEPVSSvtKDATSWLdesanmtRQVYMLPY-PMEDR 226 Aspergillus oryzae
Q5B255       168 -------------------------grdtemtgvntngnqegSPAEPVAAvtKEATSWLdesanmtRQVYMLPY-PMEDR 221 Aspergillus nid...
Q0V090       145 --------------------sgvntpahapaqpdsdapkdrdNADNKPAEvtAEEEEWLekl--qkSQIAWYPW-PSEEK 201 Parastagonospor...
Q7SA34       160 ggg-ggtataagtpaasaaptpaasgpsgpgpvttttapfsqPPPPPSANqtALPEDFKphi-nllTGYQFHPW-PTEDK 236 Neurospora crassa
Q54D00       191 ------------------------------------------------------PFGYQpn---apLASLFKPPaPQDEM 213 Dictyostelium d...
Q2M0F9       138 ----------------------------------------------------SAPLTWC-------IGDLRRPY-PTDIE 157 Drosophila pseu...
Q23523       146 ----------------------------------------------------SAPLTWQ-------MGDPSRPF-PQEHE 165 Caenorhabditis ...
XP_001638176 315 ----------------------------------------------------EAPTTWM-------AGDPRRPY-PLDIE 334 starlet sea ane...
EDO15552     172 ------------------------------------------PPTFNKGS--IGPNNFI--------------W-PAEDA 192 Vanderwaltozyma...
Q2H2I4       238 IRTGALAALQRLVDagIEPRGYDPAEQERRRVAEEKArreaee-------------rarlerEEAERKGREERERMARER 304 Chaetomium glob...
Q2TY58       227 IRLGLMGQIQLAAG--EGRPGFDPDQEVERLIREAEG-------------------------LGAADAPPVANVSDEESR 279 Aspergillus oryzae
Q5B255       222 IRMGLMGQIQLAAA--EGRPGFDPDKEVERLIREAEG-------------------------VGIADAVAPPPIGEEATR 274 Aspergillus nid...
Q0V090       202 IRIGNLSKLMYWQArgKDVDDFDIPAHEEAQRKGLAG--------------------------VVEAPPEPEPVAEPVQA 255 Parastagonospor...
Q7SA34       237 VRMGGMAAYQSLVSraVDPKGYDPEEEERRKKEEEEArkeaee-------------rairerEEEERRMREERERMARER 303 Neurospora crassa
Q54D00       214 MRSSVLFTKPPPHVlkYYGLAEIDVTTPTMAANISSPfsigg----------------nvgdVTTPTSKEQEDQQQQQQQ 277 Dictyostelium d...
Q2M0F9       158 MRNGLLGKSDQNLNggQVPHQNSGLTPDVQRGLSGP----------------------------GGAGSGGAGEVPSAFQ 209 Drosophila pseu...
Q23523       166 FRAGHLLNSKVQSTgpQLLPGKNVAQRPLITSPSASSsnggtapirtvgtplinsaptgdfsPRTGFGTDEPPPIQQQVL 245 Caenorhabditis ...
XP_001638176 335 MRSGLLGRLGEGVAmeTEIPTSTVGVAETSAVTAPVNgvvd-----------------gvanGPSASSLSWQSSLHAIGI 397 starlet sea ane...
EDO15552     193 LRRGMLAMASLHSKelTKLPNEPEEASEPDKSTEPD----------------------------KSTEPIEEEKITVDNE 244 Vanderwaltozyma...
Q2H2I4       305 EA 306 Chaetomium globosum CBS 148.51
Q2TY58       280 VG 281 Aspergillus oryzae
Q5B255       275 VN 276 Aspergillus nidulans
Q0V090       256 QA 257 Parastagonospora nodorum SN15
Q7SA34       304 ER 305 Neurospora crassa
Q54D00       278 QQ 279 Dictyostelium discoideum
Q2M0F9       210 NQ 211 Drosophila pseudoobscura
Q23523       246 RG 247 Caenorhabditis elegans
XP_001638176 398 PS 399 starlet sea anemone
EDO15552     245 GD 246 Vanderwaltozyma polyspora DSM 70294
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