Conserved Protein Domain Family
Methyltransf_33

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pfam10017: Methyltransf_33 (This model is not part of the current CDD release)
Histidine-specific methyltransferase, SAM-dependent
The mycobacterial members of this family are expressed from part of the ergothioneine biosynthetic gene cluster. EGTD is the histidine methyltransferase that transfers three methyl groups to the alpha-amino moiety of histidine, in the first stage of the production of this histidine betaine derivative that carries a thiol group attached to the C2 atom of an imidazole ring.
Statistics
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PSSM-Id: 519146
Aligned: 219 rows
Threshold Bit Score: 189.986
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EMR71335      26 LREE----IKNGLGsq----------------pP----TLPSLL-LWD----------------D-----QGQKLFDRFS 59 
XP_001276351  27 LQDE----LLDSLRggdavqsvsdgcqppiewsR----SIPTSV-LYE----------------G-----RGIDLYENIT 76 
XP_018157788  23 MSSNilenLRRVFvvak------------npvvGgelpTMPDEL-LYD----------------D-----KGLAIWADII 68 
XP_008596189  35 LKCLnidkLKDTLtai---------------aeSkdapTLPDEL-LYD----------------D-----VGLLMWNKIM 77 
XP_006669717  36 LKDLcvdrVKDTLdai---------------anSrgspTLPDEL-LYD----------------D-----EGLLLWNDII 78 
XP_013957950  21 MHQDvgerLSRVLkav---------------ygPnakpTLPDEL-LYT----------------D-----IGLPIWNEII 63 
XP_003053022  21 MYDSvaerLAETLnap---------------ysStskpVLPDEL-LYD----------------D-----VGLPIWNQII 63 
CCE29706      22 MSSDvterLLSVLqep---------------ydKnnkpSLPDEL-LYD----------------D-----GGLPIWNDII 64 
XP_007809790  20 MPTDlgerLIDTLk------------------sKdktpILPDEF-LYS----------------D-----EGLEFWKVII 59 
WP_014103159   1 MRSLsdadILHALRk------------------KeenrFLNDSIdLFSgcrtghmnpyafnepkTnddpvRGGEHWGRFV 62  Micavibrio aeru...
EMR71335      60 QT-SSYYPFHGEIEVLSQYGSDIGAsM--P-AGgALLELGCG----------AIRKTKSILSGF--------RQQqkpih 117
XP_001276351  77 RD-PAYYLYRDEFSIFQRYSQDIAT---------ALLRPVNAreakslikpeSSEDTHLILVDLvltk-----------y 135
XP_018157788  69 FT-PQFYQTRDEIALFERNSGEMAEhyip--dnaTLIDLGAG----------DMRKVNYLLEELahrg--------rkat 127
XP_008596189  78 SI-PQFYQTHDETALFDLNSAEIIRqlp---rhiTMIDLGSG----------DTNKVDHFLAEFerkk--------vqat 135
XP_006669717  79 SI-PQFYQTHDETALFKSNSSEIIRhvp---kniTMIDLGSG----------DTTKVDHFLKAFeeak--------vpat 136
XP_013957950  64 FT-PEFYQTHDEIALFDAHGSDLVArvq---pgvTLIDLGVG----------DTRKVEHLLASFekar--------leat 121
XP_003053022  64 FT-PEFYQTHDEIALFDKHGADIAKrvq---agvTVIDLGAG----------DTRKVGHLLAAFdkak--------vptk 121
CCE29706      65 SV-PEFYQTHDEISLLKKYGETITGlva---pgvTIVDIGAG----------DTRKANFLLDAFerak--------vpat 122
XP_007809790  60 SQ-DEFYQTHDEIALFKENGEAISKlfareskklFLLDIGAG----------DTGKVSHLLGKLkthaq-------vpit 121
WP_014103159  63 NTsRDYYLISEEAQLIQNFSAEIGA-IlpP-NA-LCVDLGPG------------EEKAVLTKTFpiltgmfnPSG----- 122 Micavibrio aeru...
EMR71335     118 YFALDVSRQGLTSSLAEL-QHaf--------qdS-P----FITITGLLGTYDDCvt--wLSGLKsarslgiggsgssggv 181
XP_001276351 136 rrrVDIQHEQLQRRIDQLvRQrpefsrghvdtsspmklksSISAQGICGSYYDAmg--yLASGGlvdetpelkhhggpfr 213
XP_018157788 128 YLALDISKHSLTSNLEDL---------------ApGhvggSVHMAGLWGDFQAGla--fAETITaa-------------p 177
XP_008596189 136 YLALDISKTSLDQSIASL-TA------------NhSgpdsVVNCAGLWGTFENGld--hMNKIKg--------------p 186
XP_006669717 137 YLALDISKTALDESIKSL-TA------------NhSgpnaVVKCGGLWGTFDNGlq--hVDNIKg--------------p 187
XP_013957950 122 YLALDISKASLEHSVGYL-LN------------KhPaadaKVTCAGLWGTFQDGma--yVQGIEg--------------q 172
XP_003053022 122 YLALDISKSSLVHNIRYL-VD------------KhSkansSVTCAGIWGTFQDGme--yVQKIEt--------------p 172
CCE29706     123 YLALDISAASLAHNIERL-AK------------LhPaprsYVTCTGLWGTFEDGqd-fvARHIKg--------------p 174
XP_007809790 122 YCALDISKASLEANVTKL-AK------------EhSgpgsTVNTIGLWGTFQQGqkfatEKVFDg--------------r 174
WP_014103159 123 YVAVDVNNKFIHNASTLV-QD------------Kl-----QIESSGILADFFEEtl--sIAARt---------------p 167 Micavibrio aeru...
EMR71335     182 VTILWLGNSIANLdSQDQASAF------LSRFGAAcGrrarlaCRFVVSTD-----ICQRDAKVLDAYDVQRPEYRDFLL 250
XP_001276351 214 KCLMWLGSSFTNM-KPTEAARF------LRQFTRNgVlq--pgDLMLVGID-----RCRQVDKVMAAYSVSSPSWQRYVQ 279
XP_018157788 178 RVFLSLGSVLFND-PWKKAVAS------LRDWAALmRp----gDLILAGMDghdvtS----DKVWDAYHSHPALFESFFY 242
XP_008596189 187 RLFLSLGSVLCND-PWPAALGH------LKRWASElRp----eDHLLIGMDghlvaG--NRDKIWAAYHSCDDMFREFFL 253
XP_006669717 188 RLFLSLGSVLCND-AWPTALGH------LRKWAAVlRp----dDKMLIGMDghlaaD--QRDKIWAAYHSCDDKFRNFFL 254
XP_013957950 173 RLFLSLGSVLCND-PWPEALSH------LKYWAKAlRp----nDLLLVGMDahllpN--DKDKIWAAYHSRDDLYHQFFL 239
XP_003053022 173 RLFLSLGSVLCND-PWPEALSH------LKYWASAlRp----dDLLLIGMDghilpN--NREKIWDAYHSCDDLYHTFFL 239
CCE29706     175 RLFLSLGSVLCND-DWVLAVNH------LRAWKAVmRp----gDLMIAGMDahmaeE--FGDKIETAYHVRGDLYRKFFL 241
XP_007809790 175 MIYLSLGSVLCND-EWDKAVEH------LKGWKKVmRp----dDLMLVGMDghtakNKDQRKKLWDSYHKREALLEPFFE 243
WP_014103159 168 KVMVLFGGLLCNL-GRGKTPSLielsnsLKKLRKHaQt----gDYLVITQD-----INHNQTTLNAAYNHPDL--ARYIM 235 Micavibrio aeru...
EMR71335     251 NALGAANRVLGYdAFRAD----DWMPASWL-DRRERNLHFYLTARRDVLV-PLAaqetggNGnghggaqesgvVAIRKGE 324
XP_001276351 280 NGMRNAAEIL-----QEEslvgDWEYVARW-DAAEGRHVRFAKSTRPRALqSRE-------------------TAIPEGE 334
XP_018157788 243 NGFAHANALLGEpIFRPR----DWDICAEI-EEDEKRHRFFVKAKRDVVSeTQG-------------------TTLRAGL 298
XP_008596189 254 NGLKNANKLLGHkLFKEQ----DWDFNSELqEKPTTRHRFFMRARKDVRLpGGD-------------------NVISRGQ 310
XP_006669717 255 NGLTCANKLLGYkLFDEQ----DWDFIADLeDRPTTRHRCFMRANKDVSKdDG--------------------SVIFKGQ 310
XP_013957950 240 NGFDQVNKAIGEeWFQEE----DWDFMAQLeDKPTTRHRFFFRANKDVTIhKLG-------------------RTIKQGE 296
XP_003053022 240 NGFKHANQLAGEeWFREE----DWEFLAQLeHEPTTRHRFFFRANKDVKL-KMG-------------------RTIKKGE 295
CCE29706     242 NGFDNINRCLGHdIFVEA----NWQFCCQLeHTPTTRHRVYFRAKRNIECpLLN-------------------RIIQTGE 298
XP_007809790 244 NGYEVMNRSIGGrIFNNK----NFEYHAEIeDEPTTRHRNWIIARKDIWCeATN-------------------SMIKAGQ 300
WP_014103159 236 TLTHRIQRDLPTrDFNPD----HFEFYSEW-DSAEHVQILGARAK---ALstfq---iadHA-----------FAIRKGT 293 Micavibrio aeru...
EMR71335     325 RVRVVTSGKWSEEAMGQVCRQAGFHIQHSWKDETGDYCIFSLAQ 368
XP_001276351 335 HVFLAQSYKYTRADATSVFEAAGLQLLDEWVNADDDCSLFLLEN 378
XP_018157788 299 EIDWFDAHKRSERDVRKMCAEAGLEVVKSWAIDGSDMRQYLIRN 342
XP_008596189 311 EIDWFDSHKYGEQDVRLMCAKAGLTVLQSWAAPGSEFRQYLVRT 354
XP_006669717 311 EIDWFDSHKYGEDDVRLMCSKAGLTVIKSWAPKGSEFRQYLVRL 354
XP_013957950 297 ELDWFDSHKYGEESVRLMCHKAGLSVISVWQAPNSEFRQYLLKM 340
XP_003053022 296 EFDWFDSHKYGEDSVRLMCYKAGLSVLDVWQAPNSEFRQYLVRR 339
CCE29706     299 EVDWFDSHKYTENNVQIMCSKAGLSVIDVWKADGSEFRQYLIKL 342
XP_007809790 301 EYDWFDAHRYGPEKVREMCSQVELEVVKVWQAKGSHFYQYLIRP 344
WP_014103159 294 KIPLVNCYKFPAEFFLRACHSAGFKAVKTFHGTSDRIILHVLQA 337 Micavibrio aeruginosavorus
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