Conserved Protein Domain Family
MPAB_Lcp_cat
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pfam09995: MPAB_Lcp_cat (This model is not part of the current CDD release)
ER-bound oxygenase mpaB/B'/Rubber oxygenase, catalytic domain
This is the catalytic domain found in the endoplasmic reticulum (ER) -bound oxygenases mpaB' (MPAB2) and mpaB (MPAB) from Penicillium roqueforti and Penicillium brevicompactum and in the rubber oxygenase (Lcp) from Streptomyces sp., which contains highly conserved arginine and histidine residues. Structural analysis from Lcp revealed that Arg164, Thr168 and His198 are crucial active site residues. The mpaB and mpaB' are part of the gene cluster that mediates the biosynthesis of mycophenolic acid (MPA). Lcp (Latex clearing proteins) is a rubber oxygenase that catalyzes the extracellular cleavage of poly (cis-1,4-isoprene). This domain is also present in uncharacterised proteins from Mycobacterium sp. and hypothetical proteins, mainly from bacteria and fungi.
Links
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Statistics
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PSSM-Id: 519140
Aligned: 221 rows
Threshold Bit Score: 41.5325
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_008097837 121 NLMGFAlQGFVGENSasggvvevlvrtggfrtsvLF---------------------RRLLETFQMLLEVTD-----SLe 174
XP_013947615  76 EFPLLYdLALKYAIFk-----------------sYAidqignllnrvsdlsrpteasKRYDDTSVLLTSYVTfapgsDT- 137
4_pfamImport   3 NFYAMFaSNLIGLILvltvp----------tildVLvftnkss--------dpytafKRYLDTIRHMLRWYRydvtnAks 64 
Q9A9R2       161 ATFMNKyAALpma------------------ltgTLsnd---------------taaRRVNETATFFTTTLLp----GSl 203 Caulobacter vib...
WP_014743608 107 FLAAFVaGSLVEAYstliakafi---tsgrlgdqAG---------------------RRFRQNNQLLSEIFL-----PGg 157 Tistrella mobilis
WP_014743607 106 LIAAFVgAVLVEGFstlisksfs---itgrlvdqGV---------------------RRLKQNNRHISEIFL-----PGg 156 Tistrella mobilis
WP_014689737 116 AGLVLAyGSLLGGYRtgaaleplv-rtgrltggeTL---------------------RRIKETSLWWRSVTA-----PGg 168 unclassified Ac...
WP_005517599 123 VGDVLAyGSLLGGYNnsgplpvlt-ssgrltgerTR---------------------RRIAETGTWWNGCVA-----DGg 175 Prescottella equi
Q6FFH2       123 NGFILRdLSLMAGYLfpgfnq-------plmltgALkkq----------------agTRLAETTKWWIDITE-----PNg 174 Acinetobacter b...
WP_013686273 121 glMVLRnYCLMGGYEssaink-------plvftgALkkg----------------aaKRLTETTEFWVSIVG-----ENa 172 Fluviicola taff...

XP_008097837 175 yvqpggrghttavrvrLLHCMVRqrIlkiv-qhkGPSyydveaygvPINTLDSLHALTT-FCCNHAfi-qlPLMGisVPQ 251
XP_013947615 138 ----------------LAHSIAR--TnfmhnpylQSG---------KIKNEDMLYVLFDnMYEPVRfmklyEWRE--LSD 188
4_pfamImport  65 ksqi------svaivhGLHCAAN-------------RvsnksglglRVTQKDMALTQFG-FMGLLLlkkke--laivGTE 122
Q9A9R2       204 erhgagf--kaaamvrLMHSMVR--Fna----lkRSNlwdvgvygiPIPQVDQM--PAG-LIPIFLmsykiVATGrtVFT 272 Caulobacter vib...
WP_014743608 158 lgefgeg-wkmalrirLMHARLRllTa-------RSAdwnhedwgtPLSAAHIAFMNAA-LSGRLLer--aRVLGveLFP 226 Tistrella mobilis
WP_014743607 157 ldrhgdg-wkmsvrirLMHARLRvlLa-------TAEewdtpawgvPLSSAHIAFATAA-FSGGLLdr--aRKLGvePTE 225 Tistrella mobilis
WP_014689737 169 lapdgag-lkatlhvrVLHALVNarLe-------NDPtwdhagrglPINQYDQASTLGV-FSTSFLlh--lRLLGvrVTR 237 unclassified Ac...
WP_005517599 176 ldrfgeg-frlsvhvrVMHAFVGyhHe-------HETdwdsgarglPVNQFDQAGTLGL-FSITFLlh--tRVLGvrYTR 244 Prescottella equi
Q6FFH2       175 lqrfnag-ftstiyvrFIHALVRhqLk-------KSEkwdaqtwgiPINQFDLAMTNVA-FSGVVLlg--iRALAvfPNQ 243 Acinetobacter b...
WP_013686273 173 itnpqig-lkeclkirLMHAYARvsIl-------DEGkwqeadwgaPLNQWDMLATNLG-FSIIFLdg--lRKLGikPTE 241 Fluviicola taff...

XP_008097837 252 QEIEDYVALWRYLGHVLgt-----------------------------ptD-HFT----SAAKAKIL----MDSMs---- 289
XP_013947615 189 MEVAAFATVWRYLGDMLe-------------------------------iDfKAElgkdEWKDGIEF----FDDMviwak 233
4_pfamImport 123 EDERAILHFWRTIGYMLgiqdkynlccgsleevrgtcalilrdvyapgllNpPPR----------------FEHM----- 181
Q9A9R2       273 PEERARVELARYRCFLLglpe--------------------------dllAdTPQgvvdTMNARSATlragFD------- 319 Caulobacter vib...
WP_014743608 227 EERRAFMMIWRMAGHLTgvp---------------------------aelLpR------HEIEAQQL----FRIGr---- 265 Tistrella mobilis
WP_014743607 226 DERRSFMMIWRYSGHLMgva---------------------------pelQaV------DEAAAMRL----FRLGm---- 264 Tistrella mobilis
WP_014689737 238 ADARAVMHLWCYVGWLLgvd---------------------------eqwLpH------TERQGRRQ----LYHFl---- 276 unclassified Ac...
WP_005517599 245 READAVLHLWCYVGWLMgvd---------------------------rrwLpF------DERAGLRM----MYQIg---- 283 Prescottella equi
Q6FFH2       244 QEIESFLHFWKYIGWLMgid---------------------------ekwLvT------QESDGWRL----LYWMq---- 282 Acinetobacter b...
WP_013686273 242 EEIQGLFHFWKYVGSLLgtp---------------------------aetFpE------TESDAIRA----IYAWt---- 280 Fluviicola taff...

XP_008097837 290 ---FNER--LVTDMSLVAghnfvetvrdvppvn-------lsagfieagsrvlnGD------------------------ 333
XP_013947615 234 dfqMKHL--EPSPSITNL------------------------------------GE------------------------ 251
4_pfamImport 182 ---VEALldGMKPISPVLdtea--------------------------------------------------------fm 202
Q9A9R2       320 -----------DATCGELvratlna----------------------ylppnerPEnklfdkvergfakvfflknflngd 366 Caulobacter vib...
WP_014743608 266 ---MMEP--PPEIEGIVLanglinsapmaagvddpd-lrrrlvrqlygisrgliGG------------------------ 315 Tistrella mobilis
WP_014743607 265 ---AAEP--PPDLEAILLanglinsapvvagitdag-qrrklvrliysvsrgmiGD------------------------ 314 Tistrella mobilis
WP_014689737 277 ---SHDP--PPDANSVALaraliamtddvthgwr----rtfereralsvsswllGR------------------------ 323 unclassified Ac...
WP_005517599 284 ---ASSP--AADEHSYALaaslvdlplhthyprfqrlrrryqyerglslattllGP------------------------ 334 Prescottella equi
Q6FFH2       283 ---FAHP--QSDDSSFALgqslsqepferryrylrplqqkiayqqhlqvtqffiGR------------------------ 333 Acinetobacter b...
WP_013686273 281 ---ITQA--PADDDTIALakaltlepidgpfpsrnw-ekklvykthlgynwfflGK------------------------ 330 Fluviicola taff...

XP_008097837 334 -ALCDQLgmg---------rpGVYHyacFRG-FCWLVRT 361
XP_013947615 252 -TLRDLLls----------ayPEFMrgpMNKiLMVLVGE 279
4_pfamImport 203 aFTHELCgvpvrrplvtrysrWMYNvqvYTH-AVLLTRA 240
Q9A9R2       367 rAAARRMgveigprdfmlfglVALLvssQLA-AYRLARn 404 Caulobacter vibrioides
WP_014743608 316 -DLATALhf-----------------peTRG-MDTLTAI 335 Tistrella mobilis
WP_014743607 315 -QLADALny-----------------ppARN-FGALAAL 334 Tistrella mobilis
WP_014689737 324 -HALRDLglpy--------------rppWYA-LTRVAAN 346 unclassified Actinoplanes
WP_005517599 335 -AGVRALrvpv--------------rppWYP-LARLAVN 357 Prescottella equi
Q6FFH2       334 -KRMQKLglph-------------rsaaWFA-YYLMLRN 357 Acinetobacter baylyi
WP_013686273 331 -TSCQTMqlp---------------ktsWQI-YPHIQRF 352 Fluviicola taffensis
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