Conserved Protein Domain Family
T6SS_Tle1-like_cat

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pfam09994: T6SS_Tle1-like_cat (This model is not part of the current CDD release)
T6SS, Phospholipase effector Tle1-like, catalytic domain
This domain is found in the type VI secretion system (T6SS) protein Phospholipase effector Tle1 from Pseudomonas aeruginosa, which hydrolyze membrane phospholipids. Tle1 is organised into two distinct parts, the phospholipase catalytic module (this entry) and the putative membrane-anchoring module (pfam22137). This domain adopts a compact conformation with a classical mixed alpha/beta-hydrolase fold that shows of seven central parallel beta-sheets and 13 alpha-helices.
Statistics
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PSSM-Id: 519139
Aligned: 283 rows
Threshold Bit Score: 134.252
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
KLU90879        65 RKLVLCFDGTGNKFRGDds-----dSNILKIFRMLDRTA-SD---------QYHYYQPGIG--TYVvsnnlsahtsmraR 127 
19_pfamImport    1 RRLIVCCDGTWQDGLATkae--eeyTNILRLTRAIRQEDrRHfpp----tpQICHYVSGVGtgW---------------- 58  
XP_006956173    87 RRLIICCDGTWQDAMQTrae--deyTNILRLSRAIKQEDrRQdpp----ipQICHYISGVGtgW---------------- 144 
18_pfamImport    1 -RLIVCIDGSWDDSTSTpn-----hSNIVHLLRSIETIDkRTqps----vmQYAQYRTA--------------------- 49  
XP_006959290     2 RRLIVCVDGAWEDSTDRvg----vdSNILHLLRSIESVDkRTrpa----tmQYAHHTTA--------------------- 52  
ESK97917        47 KRIIVCCDGTWQDGISEsrr---dyTNVLRLARTINHEDvRTkpp----tpQIVFYQSGIGseK---------------- 103 
XP_007390532    26 KRIIVCCDGTWDDGLICqer--wkyTNVLRLARIMAHTDdRYvph----vpQVVFYQAGVG------------------- 80  
EMD42110        47 KRIVVCCDGTWQDGIIVedr--wkyTNVMRLARAVNHTDdRFeip----ipQVVFYQSGIGsaP---------------- 104 
XP_007929914    41 RRFVICVDGASYKPDANsi-----pTNIYRIYTSIKNGKcVDrdtgityhqE-PLYYAGIG---GA-------------D 98  
Q0U1K9          68 KRLVVCVDGTWGCPDGTagspegniSTVYRVYASVKEGYvTDkatgkrwdqQ-RVYFNGLG------------------- 127  Parastagonos...
KLU90879       128 FKSWMTKAK---DSAIGSSFDQHVVGGYRFLMRFY-SPG-DEIYIFGFSRGAYIARFLAEMLDYVGLLSHGNEEMVAF-- 200 
19_pfamImport   59 --SLSEQLI---GGATGNTLGIKIRDAYAFLSQNY-CDG-DEIFLFGFSRGAFTARTLGALINDIGILNNKEMEHFFE-- 129 
XP_006956173   145 --SISDKII---GGATGNTLGVKLRDAYAFLSQNY-CDG-DEIFLFGFSRGAFTARTLGALINDIGILDNKEMEHFFD-- 215 
18_pfamImport   50 --HFSSSLLsqlLGVAYQSFSNCLFELYAFLCMNYsEDGkDEIFLLGYSKGAYVARILAAVINEIGILPRDQLRRFFP-- 125 
XP_006959290    53 --HFSNSLVsqiLGVAYQGFANLLFELYSFISMNY-SEG-DEIFIFGFSKGAYMARILAAILNDVGVLPRDDVRQFFV-- 126 
ESK97917       104 --NFYAEYI---EGTTGGGLVDKVEEAYAFIAHNY-LPG-DEIFLFGFSRGAYTARMVATLIGAIGILGRKDMDHFAR-- 174 
XP_007390532    81 --TFGDKIIeklDGYVGASLAEKVQEAYAFIAHNY-RPG-DEIFLFGFSRGAYTARMVALLIGAIGVLDRTEMDNFAD-- 154 
EMD42110       105 --NIYDQIV---NGVTGASLGDKVEEAYAFIAHNF-QPG-DEIFLFGFSRGAYTARMIGSLIGAIGVLDRMDMDHFAE-- 175 
XP_007929914    99 DVLSKDRLQ---AGVLGNPYQDQIRNIYEKCCELS-GPH-DEAVFFGFSRGAYVVRAVAGLLHRFGAL------------ 161 
Q0U1K9         128 --NKLNALKnlhSGAFGSGLPDEIRKVYEYCCRETdGPD-DEIYFFGFSRGAFTVRAVANLLCYMHV--PKGSQKFSKee 202  Parastagonos...
KLU90879       201 ----------AWKAFAQWQC-------RRGKLREESRKKTEely----------efLKGFRETFSRPVRRIRFLGLFD-T 252 
19_pfamImport  130 ----------IFKAYHDRNDs------GNPKKAEKARNYLEpw-----------llRNPANNRHKGRQFIIKCIGVFD-T 181 
XP_006956173   216 ----------IFQAYNDRNNk------LDKKKAEEAQKLLDpw-----------llINENNQRHKGRQFIIKCIGVFD-T 267 
18_pfamImport  126 ----------ILKAFFERKRg------GKVASEAEEVLKPWl-------------lSSPSNTRHLEQQFIIKCLALFDcT 176 
XP_006959290   127 ----------ILKAYIDRKNg------GTRVDEANNVLKPWl-------------lSSPDNTRHKDQQFIVKCLGLFDcT 177 
ESK97917       175 ----------IFLSYQKLGK-------TKDQEEREALREALapfs-------aqtcPGLVRAYADGKPFSVKCLGVFD-T 229 
XP_007390532   155 ----------IFLLYQERGK-------AQDQQEIAVLDAQLslwt-------shnsPGKQRADSGPSSFSIKCVGVFD-T 209 
EMD42110       176 ----------IFIAYQKRGK-------ATDQDEIIALDKQLapwn-------qhssPGKIRADSSPTTFSVKCVGVFD-T 230 
XP_007929914   162 --------------ISAGSPefgrnykKLLKDLGHPSLSSTsnlslahvradsvssISTITTQELRPSPNIRFLGVFD-T 226 
Q0U1K9         203 fterykelleLYPGVRASDRniwgqihSHFNR--------------------------------STRPPTIRFIGAFD-T 249  Parastagonos...
KLU90879       253 VNS---------------------VPRFETAWMERAv-----SKFPYT-A-------RTSAKVIRHAVSIDERRAKFRQD 298 
19_pfamImport  182 VGA---------------------LGVPSLSSSFFPkmkseeNYMGFPdTv-----lGDKVEHCYHALSLHENRPNFVDT 235 
XP_006956173   268 VGA---------------------LGVPTLGSTLFKmhk-geNYLGFPdTv-----lGDKVEHCYHALALHENRPNFIDT 320 
18_pfamImport  177 VKPspslpgitskfnsiitrpesyFGLPda-------------------------llGQRIQHCYHAMALNENRANQREL 231 
XP_006959290   178 VQSsyklpiigsrvssiinkpeycFGLPda-------------------------llGHRIEHCYHALALNENRSNLRDL 232 
ESK97917       230 VGS---------------------LGLPEELTLQSNki---kTLFGFPdRi-----lGEHIERAYHALALNEPRKNFDCT 280 
XP_007390532   210 VGA---------------------LGLPEELT-HSEkm---kTLFGFPdRy-----lGEHIERAYQALALDEHRKDFNCT 259 
EMD42110       231 VGS---------------------TGLPEEITMNHPkv---qAIYGFNdLy-----lGEHIQRAYQALALNEMREDFNCA 281 
XP_007929914   227 IKA--------------------------------------------VdDshfdisfNSSIKHFRHALALHEDRRALQPE 262 
Q0U1K9         250 VKK-------------------------------------------FTdNglydvmpHSQIHHYRHALALNEERDEFKPE 286  Parastagonos...
KLU90879       299 LIYQSK--Hesmerkkaaaeakakehgglhqarhmihelhekyrvhhthhrlqqtpvfvdpkpevegqgqghgektngks 376 
19_pfamImport  236 RLEVKKenLak--------------------------------------------------------------------- 246 
XP_006956173   321 RFEVKKnnLer--------------------------------------------------------------------- 331 
18_pfamImport  232 RLELLRgsEdmg-------------------------------------------------------------------- 243 
XP_006959290   233 RLELSNtgRek--------------------------------------------------------------------- 243 
ESK97917       281 KLEQTDigRsk--------------------------------------------------------------------- 291 
XP_007390532   260 KFEQTEggKrk--------------------------------------------------------------------- 270 
EMD42110       282 KFEQTEggRnk--------------------------------------------------------------------- 292 
XP_007929914   263 EVHP----Pefygte----------------------------------------------------------------- 273 
Q0U1K9         287 TMMPDNdaCsp--------------------------------------------------------------------- 297  Parastagonos...
KLU90879       377 agapqpaqdrgrrqsrqaaaahppprasldhaeryrahhsrsksrathrtrdssvaaavaarrlsgaghhaghehpdrle 456 
19_pfamImport      --------------------------------------------------------------------------------     
XP_006956173       --------------------------------------------------------------------------------     
18_pfamImport      --------------------------------------------------------------------------------     
XP_006959290       --------------------------------------------------------------------------------     
ESK97917           --------------------------------------------------------------------------------     
XP_007390532       --------------------------------------------------------------------------------     
EMD42110           --------------------------------------------------------------------------------     
XP_007929914       --------------------------------------------------------------------------------     
Q0U1K9             --------------------------------------------------------------------------------      Parastagonos...
KLU90879       457 vpggdnddddedrdlahmpeasdvddgfsssdeddqDIDEVWFSGGHGDVGGGW-DIEPggksASHVPLAWMVRE 530 
19_pfamImport  247 ----------------------------------gqHCKQVWFTGCHSDIGGSYrEHE-----LSDLTLIWMCA- 281 
XP_006956173   332 ----------------------------------gqHCKQVWFTGCHSDIGGSYkEHE-----LSDLTLIWMCAc 367 
18_pfamImport  244 ----------------------------------qkC-KQVWFTGSSGDIGGSYsMKE-----LSDISRMWIASQ 278 
XP_006959290   244 ----------------------------------gqKCKQVWFTGSSGDIGGSYsVRE-----LADLTRIWMAGq 279 
ESK97917       292 ----------------------------------gqILKECWFSGSHSDIGGGYrDHD-----LADLTLTWMVAh 327 
XP_007390532   271 ----------------------------------gqILKQCWFSGSHTDIGGGFeDHD-----LSDLTLTWMAAn 306 
EMD42110       293 ----------------------------------gqVLKQCWFAGCHSDIGGGYkEHD-----LSDLTLTWMAAn 328 
XP_007929914   274 ------------------------------lrhfgrSFVQALFIGSHGDM-GGVsEKAG----LGLYPLQWMILE 313 
Q0U1K9         298 ----------------------------------grSGLQAWFIGTHRDLGGANsKDG-----LSLYPLQWVLSE 333  Parastagonospora ...
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