Conserved Protein Domain Family
DUF2227
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pfam09988: DUF2227 (This model is not part of the current CDD release)
Uncharacterized metal-binding protein (DUF2227)
Members of this family of hypothetical bacterial proteins possess metal binding properties; however, their exact function has not, as yet, been determined.
Links
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Statistics
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PSSM-Id: 519136
Aligned: 48 rows
Threshold Bit Score: 99.666
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EKQ67834         2 PSGQTHDRITLWSLPLVAGVTFE-----------RTQNASLTLIVSGGYLFSGLMFGPDLDIH-----SRQYRRWGVLRW 65 
WP_012676822     2 ASGRTHEIINLLFLPGAV----------------YYLNPVSFEGFISGYIIGTFFLSPDNDIYh----SKPNRRWGFLRF 61  Persephonella
WP_013449814     2 PRGPVHESVNLTALALGVIAYHRlvp-----egsAALPPGTLEGFVAGYLLGSLWITPDLDLAerkntPRPARLWGWLRL 76  Oceanithermus...
WP_015235582     2 PSGQSHTFINLAAYAVLGSVALYvhr-----qgiFFIGQEDALFFTLGFLVGTVFLSPDLDLAeghvnSK--RAWGFLGA 74  Deinococcus p...
WP_013558007     2 PSGNVHNLINTAAYAALFAATALaqh-----agyVHVTPVQGLAFTAGYAAGTFLLSPDLDLAegrvnSK--RYWGILGF 74  Deinococcus m...
jgi:Deipr_1669  12 PSGRVHNYINMAVYAALGAGAVWagr-----eglVTLTQTQTLHFSLGFLAGTFLLSPDLDLSeqgvnSK--RNWGFLGP 84 
ACO46101         5 PSGRVHNLINIAAYSVLAGAVLVasr-----qdiLSITPSQALYFTLAFAVGTFLLSPDLDLAegkvdSK--RHWGVLGV 77 
WP_013176572     2 ASGRTHEAINLGVFAALAGGYAYararsladptnLLFAPETLWAFVLSYLIGTFFITPDLDLAenrmrAR--NNWGLLGL 79  Truepera radi...
WP_276958114     2 PAGRIHEAINVGALGLLSASYVYeq-------nhLGLSEAAAFGFAVAYLIGTFLVTPDLDLAeqrvrAK--GNWGVLGW 72  Allomeiotherm...
WP_013704802     2 PSGRTHEAINLTALGLLSAGYLYgrt------qgYGPPDEWAFAFVGGYLVGTFLITPDLDLAerrvtAK--RYWGVLGW 73  Marinithermus...

EKQ67834        66 IWLPYRRSMRHRAfLSHGPIVGTVVRIVYLLGWvgacLAVIGLV------------SAIAYQLTGEFETwtqffqqywll 133
WP_012676822    62 VWYPYTKIFSHRG-ISHIPVIGTATKIVYLSLVslilIYIFIFS------------LKYAFPDLDIQILdrfr------- 121 Persephonella
WP_013449814    77 LWIPYGRLFRHRG-LSHTWVVGPITRILYLVLIlegvLYGLSLLpgmgttleplttTKWLLSPVGG-------------- 141 Oceanithermus...
WP_015235582    75 LWVPYGLLFSHRG-WSHSWLIGPLTRLIYLAVMvavvTGLLHFL------------------------------------ 117 Deinococcus p...
WP_013558007    75 LWVPYGMLFSHRG-LSHTWLIGPLTRLAYLGVIvalvVGLVAFL------------------------------------ 117 Deinococcus m...
jgi:Deipr_1669  85 LWVPYGMVFSHRG-LSHTWVIGPLTRLAYLAILvflaVGALRTF------------------------------------ 127
ACO46101        78 LWVPYGMLFSHRG-LSHTWLVGPLTRLAYLAALlaliVGLLRYV------------------------------------ 120
WP_013176572    80 LWVPYGALFSHRG-LSHTWFVGPLTRLLYLVLLalalGWAASEI------------------------------------ 122 Truepera radi...
WP_276958114    73 LWVPYGLIFSHRG-WSHTWIVGPLTRLVYMVLMgallWFGGEAL------------------------------------ 115 Allomeiotherm...
WP_013704802    74 LWVPYGLLFRHRG-WSHTWIVGPLSRLAYLVLLlyllGWVAGGA------------------------------------ 116 Marinithermus...

EKQ67834       134 atESIGR-------SLR-QHYSEWLALLIGLELGALSHSLSDWISSRYKRLS 177
WP_012676822   122 -----------dvdIYSfLSGSFVFSFIFGIFLAEMVHIFTDFVYSTLKRFk 162 Persephonella
WP_013449814   142 -------------------------AGLAGYFVAQWLHLVLDRAFEPRRRKr 168 Oceanithermus profundus
WP_015235582   118 ----LPsvd--wpvTSLaFSWSLALPLLVGYYLSQWLHLIADGVRPDHKMRW 163 Deinococcus peraridilitoris
WP_013558007   118 ----VPdlr--lpgLPSsLDWKGLLPLLAGYYLSQWMHLIADGVRPDHDLRH 163 Deinococcus maricopensis
jgi:Deipr_1669 128 ----WPgvn--lpaLPDpIEWKVLLPVTLGYFLSQWLHLIADGIRPDHGLRR 173
ACO46101       121 ----APsvt--vpaIPQpISVKVVAPLIAGYYLSQWLHLIADGVRPDHGMRR 166
WP_013176572   123 --APHFGyrvgfeaEVGeSWPQLLVGSLAGYYLSQWLHLIADGIQPDHAWRR 172 Truepera radiovictrix
WP_276958114   116 --LHYLGvqldlrgQVRlPPEQVLYSGVAGYFASQWMHLLADGIWPDAgfrr 165 Allomeiothermus silvanus
WP_013704802   117 --AEALGvrwslnaELErLSPGVLWGALVGYYVSQWMHLIADGIAPDHAFkr 166 Marinithermus hydrothermalis
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