Conserved Protein Domain Family
LpxR
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pfam09982: LpxR (This model is not part of the current CDD release)
Outer membrane protein LpxR
The outer membrane protein LpxR from Salmonella typhimurium is a lipid A deacylase that catalyzes the removal of the 3'-acyloxyacyl moiety from lipid A. This protein folds into a 12-stranded antiparallel beta-barrel with the N- and C- terminal ends pointing towards the periplasm and three extracellular loops consisting of alpha-helical regions at the opposite side of the beta-barrel.
Links
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Statistics
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PSSM-Id: 519134
Aligned: 49 rows
Threshold Bit Score: 227.552
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
CAL62634      12 LQFSLATSiiifgtTA-QAQEpdvescsfkpgvralknypDVFNFYYENDM--FT--GTDHNYTSGAKFS---------W 77 
WP_015264178   8 FFFSCFLGls---vPFsHGQTetga------------irkHQFSLRVDNDAlaFSh--fDRYYTNGMFFSyr------hY 64  Echinicola viet...
WP_014680212  12 FFCAVFILmnq----fvFAQDnrq--------------yaYQVGGQTDNDSyaFTg--rDRYYSNGLFFS---------F 62  Solitalea canad...
WP_008511371   7 FVISSVILls-----taFAQTkt---------------ykNEAGFQTDNDG--ILaqGSDRYYTAGDFFF---------F 55  Mucilaginibacte...
WP_012781354   9 VILILLGTa-------aCAQTy-----------------kNEFGFRSDNDS--YLaqGSDRYYTNGLFIY---------F 53  Pedobacter hepa...
WP_013632949   8 LFILLLFSldy---ssvYSQNss---------------yrSEFGFISDNDA--YLatGQDRYYTNGLFLN---------L 58  Pseudopedobacte...
WP_013685093  12 VFVPIILFts-----qlWAQDslv--------------ykEAYTIRYENDL--FAr--rDQYYSQGIFLQydhldinlkW 68  Fluviicola taff...
WP_013870971   9 IISCTCFTf-------sNAQKidnlvsf------rdidntSYFRFNYENDY--FAn--gDENYTQGYNFE---------L 62  Lacinutrix sp. ...
WP_229682971  10 LGAGLSLVsv------cGADTf---------------------gFAWDNDL--FVg--lDKNYTNGLRIS---------W 49  Alloalcanivorax...
Q0VTD4         7 LLLGVLLPvs------vIASTf---------------------gLSWDNDL--FVg--sDGHYTNGVRIS---------W 46  Alcanivorax bor...

CAL62634      78 ISANLEDyindpclpKWVRHLNQVSekvqP-------GDFDSRN--MVVSLGQAMYTP----TDKVRSDLIT--DDRPYA 142
WP_015264178  65 LSER--------------------------------------GR--LKATVSQQIYTP----ERYTSDDVNI--YDRPYA 98  Echinicola viet...
WP_014680212  63 RKAIDSKny--------------------------atSNNIVKKi-YGFELGHEIFMPftaqKGYYSEDL----IDRPYA 111 Solitalea canad...
WP_008511371  56 HHALKINh---------------------Pd------SSKLENKv-LGFEIGQKIFTPqtafLDMPNAERy---IDRPFA 104 Mucilaginibacte...
WP_012781354  54 RHALNQEk----------------------------lNDKLEKKt-YEISAGQKMYNP------MSGYAPDParQDRPFA 98  Pedobacter hepa...
WP_013632949  59 RHAVSPAri---------------------------rSDKVFKNi-WEFNVAQQMYNPk---SGYAPTQRy---VDRPFA 104 Pseudopedobacte...
WP_013685093  69 LNKFFFKv---------------------Pdiq-----------rsLQTGVTQKVYTP----SSITSDTLLL--GDRPYA 110 Fluviicola taff...
WP_013870971  63 FLKSLKKn---------------------PinflffkPNNSTKK--YGLSLEHIGFTP----DDYVSENIQF--GDRPFA 113 Lacinutrix sp. ...
WP_229682971  50 VGDGHGKcdd---ngGVTCAVARTLd---Plp----gVSAADERhaLTVSLEQIMVTP----DDIERSTPDY--TDVPYV 113 Alloalcanivorax...
Q0VTD4        47 VGEAHDHces---nsNVTCGVADFLs---Plp----gIAFRDDQhaLTFSLEQMMITP----KDISQSAPNY--NDLPYA 110 Alcanivorax bor...

CAL62634     143 GWLYLGLAYNARDDRH--MDTVEIDIGMVGPSSLARESQNFIHKVRGIDRFNGWSNQLNNELGIQF------VKERKKRI 214
WP_015264178  99 GVLYGEVGYQHFIKKG--WLSGDFLLGKIGPGSKAEDVQVWYHTLFGFPQPKGWQYQIQDGALVNLrlegavNVFREGKV 176 Echinicola viet...
WP_014680212 112 GYIYLKGMYDFFYKKEs-ALNLSASLGLIGPSTGVDKLQSWVHDAFGYYEPQGWEHQIKNSYGIDF------TATYKKVF 184 Solitalea canad...
WP_008511371 105 GYLYFGTTLNLLYKNEs-NLKLQGQLGFIGQYSYGKQIQEFIHRTLGFYKPAGWQYQVQNDFEVNL------SAEYNRLL 177 Mucilaginibacte...
WP_012781354  99 GYLYAGGALSWFRKNEs-ILKISAEVGTTGPNSLAEDGQELLHDVVGFYALDGWQYQIKNAIALNL------SAQYTKLL 171 Pedobacter hepa...
WP_013632949 105 GYLFGSYARHWLFKNEn-SIRAEIQIGTIGQHSLADKGQEFYHHAFGFYNIDGWQYQIENEIGINT------KVSYLLKL 177 Pseudopedobacte...
WP_013685093 111 ATYGYTAKFSARSKSKnyILSWSLNTGWIGKPAFGKETQTAIHRWTNNEKPLGWEHQINTGLSINL------SFGYTKMW 184 Fluviicola taff...
WP_013870971 114 SAIMLKSMIITINTTKkiRLISSFNLGIIGPAAFGEDMQVGIHKWTGNKIPKGWKNQIKNDIVVNY------EIGLEKQI 187 Lacinutrix sp. ...
WP_229682971 114 GYSNLELGLFSWDARN--LYGYGVRVGVVGPDSGAEESQKIVHRVTGSTRPRGWDNQLGPDLIGGV------YFLHAHRF 185 Alloalcanivorax...
Q0VTD4       111 GYSNLEMGLFSWDDDS--LVGYGMRLGVVGPSSGAEQSQKLAHKVTGSDEPQGWDNQLGTDLIGGL------YFINARRF 182 Alcanivorax bor...

CAL62634     215 lqISHPGGPKIDAITHYGFSLGNVKTYANAGLEFRIGTYLPNDFGTS----PI-RP--------ASDSNAPlpanvsrrL 281
WP_015264178 177 -----------DFWLQPRVALGNYDRSLGITPSFRIGR-----FNH--------RPses--fisGSRVGMP--------- 221 Echinicola viet...
WP_014680212 185 i-KNSLENRRFDCSFIGEARLGTFFIGASAGVLLRAG-GLEKMFNSAvf---naKPssgg----------------egaL 243 Solitalea canad...
WP_008511371 178 -----ARGSSVDLTFNSNAALGTGFTNAGTGVTARFG-KFNQLFNSIstgsTVsRSgks------------------kpL 233 Mucilaginibacte...
WP_012781354 172 ---HRDSNNATDFSVEGYANAGTTFSGAGAGILFRAG-GLNQLFNSAytnaVIgHNpkt------------------kgL 229 Pedobacter hepa...
WP_013632949 178 ---TESKNKKLDLSLPFSAHLGNYFSGLDMSALFRMG-KINPLNNSVatnsSIgNEg----------------------K 231 Pseudopedobacte...
WP_013685093 185 ----FTNTKWLRIEGTSFTTFGTLTNETRALGILKLGYi----------------------------------------S 220 Fluviicola taff...
WP_013870971 188 ----VTVAPVFSLQAQSKIKAGTLFTNASFGLSATFG-IIDKPFSIKn------------------------------sA 232 Lacinutrix sp. ...
WP_229682971 186 lkREYDSGYQLELGGAWGVDVNNFDGNAQSGGFIRFGRNLPGNF----------IPdyagigtaGSLvgl-------fdN 248 Alloalcanivorax...
Q0VTD4       183 kqFQWDSALQGELGYAWGVDANNFHGTSSAGGFFRVGHNLPRNF----------IPdyagigtaGSLvgl-------fdG 245 Alcanivorax bor...

CAL62634     282 SDGGVHAFVSVDGRAVAHDIFLDGNTFS--DSH----SVSKRYFIGDVAAGVAWQWVGGKITYAHYLRSKEFRGQKEAQN 355
WP_015264178 222 SKRELYFQGGVRLKRVYWNATLQGTKQSy-DVDl--aTMEPVKNVNEFFAQLVLAYPKVGFAYRFYYRTQETRLAeg-qF 297 Echinicola viet...
WP_014680212 244 RNSEWSFYALPMLSSVVYDATIQGNIFEpgpl-pneiIKEPQRLVFSQQIGFLFTERKFGLDISYNYRSKEVVNVIKASQ 322 Solitalea canad...
WP_008511371 234 NDGEFFFYLKPSISFIAYNATIQGSMFEk-QPGvneiRGTKQPVMLSQQLGGDFVKGHWIIDLSAVFQTRETKEMVQAHQ 312 Mucilaginibacte...
WP_012781354 230 VKREVFFYAKPQLNFVAYDATIQGSMFSnnDPV----TFGVKPIVFAQQIGFNYSSQRFTFDFGMIFKTKEVKSTAKAHQ 305 Pedobacter hepa...
WP_013632949 232 YKGEFYFFLKPRLNWVAYNATISGSMFNp-KSDne-iTFDSRPLVFAQEAGLAYAKERWNLGFSLTFKTKEIESSAKAHQ 309 Pseudopedobacte...
WP_013685093 221 NQKQYFIYYNPEARLVVYDGTLQGAIFVk-PSEvrvaTSQISRLISEQEFGFKIVHNHFSCSAYGHFQSKLFKNAan-hA 298 Fluviicola taff...
WP_013870971 233 KKFNFYGFLQSIGTAVVYDATLQSGMFNn-SSTytisSGEVKRLTGQYAYGFILKTRTLFFEYSRYFITKEFNSGss-aK 310 Lacinutrix sp. ...
WP_229682971 249 PGFGWELFLGSSVQYNGYSYI---------ERKggdyNIDKEDWTVTVIGGAGIRNDRFSFTVTLQHSTSPIRDSdp-iS 318 Alloalcanivorax...
Q0VTD4       246 TGFGWEVFISTFGEYIGYSYL---------ETHarqyNVETRDGVLGVTAGGGVHWDTFSFTLAIQSSTSPLRSRDESAS 316 Alcanivorax bor...

CAL62634     356 YGSITLSLEY 365
WP_015264178 298 LGSLYFYYTF 307 Echinicola vietnamensis
WP_014680212 323 FGSIKFFYFF 332 Solitalea canadensis
WP_008511371 313 WGSVSGIYRF 322 Mucilaginibacter paludis
WP_012781354 306 YGSISMFYRF 315 Pedobacter heparinus
WP_013632949 310 YGSVRVAYKF 319 Pseudopedobacter saltans
WP_013685093 299 WGGIGFSYYF 308 Fluviicola taffensis
WP_013870971 311 WGGIKIGFTF 320 Lacinutrix sp. 5H-3-7-4
WP_229682971 319 FGNMSFMWAI 328 Alloalcanivorax dieselolei
Q0VTD4       317 FGNMSFMWKI 326 Alcanivorax borkumensis SK2
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