Conserved Protein Domain Family
AbiEi_2

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pfam09952: AbiEi_2 
Transcriptional regulator, AbiEi antitoxin, Type IV TA system
AbiEi_2 is the cognate antitoxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.
Statistics
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PSSM-Id: 370761
View PSSM: pfam09952
Aligned: 8 rows
Threshold Bit Score: 147.573
Threshold Setting Gi: 116699665
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q63YV0           181 RVIaDRRRLIEEWASLFPTRLRPKLSPCRFTSwtKEsNWWSRPEILDIDA------RLGGEAGADILTHEIKPASLTIY- 253 Burkholderi...
jgi:Cpha266_0284 183 KIL-NRKKLFERWVEAYPDYLKPKLFLGRFHG--DE-FWWKNTNLDPASA------QWGGEIAASKLTGYLKPGSAALY- 251 Chlorobium ...
Q8XT49           223 RLL-DLAVLREEWTINYPLRLLPKLNMQRFAA--GDpSWWQHVELPAGLA------WWSGEVAAAKLTGQLRPGAQTLYv 293 Ralstonia s...
jgi:Sfum_3180    203 QLT-KPFELLSEWAANYDAKRNEGRNFYTFKk-----VWEFEADLAEACAesgteyALTGFSGAARLAPAVRYQRAAAYv 276 Syntrophoba...
WP_011802117     203 RLN-TTRRFLDAWALDYARRLRPKTLQAIYAT--PSfDAWEDWEIEPAQA------LWGGEAAARLLVQHLRPGVLTLY- 272 Polaromonas...
WP_003404368     200 RLV-RTDELLDLWAAAYPGGLGRANKLLVASG--DIhTWSAPDGLAV---------AVSGEQALPDEIR--NPESLMLYv 265 Mycobacterium
Q8NLZ6           202 RLM-KGDALLDSWAHAYPTGLGVSQQTFRGNG--DL---NRFKNIEPLG-------WISGEQAVPKLIS--GGNTAHIYv 266 Corynebacte...
Q6NER2           197 RLV-NAELFLSAWARAYPTGLGADLELLRGKA--QQ---LPPYNLEHLG-------VKASESAVSDHIS--DGQSASLYl 261 Corynebacte...
Q63YV0           254 ---SHRGITPRLMLNGMLRP-------DDRGN-VEVLET-----FWPAKAee-------------gwNLPHREVVHPLLI 304 Burkholderi...
jgi:Cpha266_0284 252 ---TDKKFLTDLVITNRLKK-------DPQGN-VEIFER-----FWPMDY-----------------GFGDLDTTHPIII 298 Chlorobium ...
Q8XT49           294 eptARPAVTMELAKRYRLRA-------DPAGT-LEIIDA-----FWPLNE-----------------ARTEKVTVPPLLV 343 Ralstonia s...
jgi:Sfum_3180    277 -----NVPQEELAFRLGLKE-------VSSGAnVLLMRPydagvFYGIR------------------SVGDIRIASPVQL 326 Syntrophoba...
WP_011802117     273 ----AEKMPARLLVEQRMQRvinasatLADGRvVELRKP-----FWGTLP-----------------ADGQPGIVPPALV 326 Polaromonas...
WP_003404368     266 d-tPAPGLPADLLIHNRWHR-------DPHGS-IVIRKL-----FWRNL------------------PDEQPGLAPTALI 313 Mycobacterium
Q8NLZ6           267 nddSDDKATNKIIQQGRLRRd------DTEGQ-VLVRRA-----FWRQSKkhnesyhkrnlslafptPFNMWPIAPLPVI 334 Corynebacte...
Q6NER2           262 ---GEETFSPKVIKELRLVK-------NPAGT-ITLRRA-----FW---------------------NTIDVKEIPEAIV 304 Corynebacte...
Q63YV0           305 YSDLITSGDDRNRAVAQTIY---DRYLA 329 Burkholderia pseudomallei
jgi:Cpha266_0284 299 YADLLAIGDQRTTETAKMIY---EQYLD 323 Chlorobium phaeobacteroides DSM 266
Q8XT49           344 YADLQRTREPRNVEAAVLIR---EKMEQ 368 Ralstonia solanacearum
jgi:Sfum_3180    327 YLDLMAI-KGRGEEAAQAVL---EQAIM 350 Syntrophobacter fumaroxidans MPOB
WP_011802117     327 YADLLATGDSRCLETAEMIY---DRCLA 351 Polaromonas naphthalenivorans
WP_003404368     314 YADLLASREPRQVEVAHLMRr-qDerla 340 Mycobacterium
Q8NLZ6           335 YADLLSVGDPRLSEVAYIIKtqiQEYTD 362 Corynebacterium glutamicum
Q6NER2           305 YADLLNSDDARLWDVAQIIK-----AII 327 Corynebacterium diphtheriae
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