Conserved Protein Domain Family
APP1_cat
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pfam09949: APP1_cat 
Phosphatidate phosphatase APP1, catalytic domain
This entry represents a conserved region found in Phosphatidate phosphatase APP1 from yeast, which contains the catalytic motif DXDX(T/V), present in other Mg+2-dependent phosphatases. This domain has a weak sequence similarity to the haloacid dehalogenase-like domain. APP1 catalyzes the dephosphorylation of phosphatidate to yield diacylglycerol and may play a role in vesicular trafficking through its phosphatidate phosphatase activity at cortical actin patches.
Links
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Statistics
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PSSM-Id: 490771
Aligned: 171 rows
Threshold Bit Score: 114.521
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_014169578 264 VISDIDDTIKRTQTSDPVGILQTTF-VDEPE--AIAGMPELYRFLAEvtapaasdggSaAMTPFF-YLSASPYNLY-PFL 338
CCA66817     272 ILSDVDDILRFTQIYVPQNGLYNSF---AVPftPWSDMPSVYAKWAQ----------QnP-NFHFhYLTTTPEPFT-RQY 336
ELU41644     326 LVADIDDILRVTRIYQPADGLRNSF---ALPyvPWMNMPDVLKSWEQ----------RvQ-GLHFhYLTTTPIKVT-QFY 390
XP_003037631 264 FLADIDDILRVTRIYAPLSGLNNSF---ANPftPWSNMPAVYAQWLE----------TiP-SAHFhYLTTTPEPAT-RMY 328
XP_007928142 240 VISDIDDILRVTKIYDPKEGLLNSF---ARPyvPWENMNEIYANWST----------SlP-NLHFhYLTTLPEQVT-RQY 304
XP_016761136 269 IISDIDDILRVTKIYDPKEGLLNSF---ARPfvPWENMPEIYANWSQ----------SlP-DAHFhYLTTLPEQVT-RNY 333
XP_007697432 287 FISDIDDILRVTKIYEPKEGLLNSF---ARPftPWMNMPDIYANWSR----------TlPNNTHFhYLTTTPEQAT-RLY 352
XP_018251050 275 IVSDIDDILRVTKIYEPKEGLLNTF---ARPftPWMNMPDIYANWSS----------SvK-DLHFhYLTTTPEQAT-RNY 339
XP_008602403 339 VVSDIDDILRVTKIYKPKEGLLNSF---ARPftAWEGMPVIYSNWSS----------SaISSLHFhYLTTTPEQGT-RPY 404
Q6MP86        23 VVSDIDDTLKVSHVLS--KKGAATSfADDDSr--FVGMSEIFQMLNLqhe-----------diEFhYVSLAPKLLMnEQH 87  Bdellovibrio ba...

XP_014169578 339 RRFRQQH-YPHGALLLRDDSSMSVAGllrtltldtrDYKVQRIAK-VHGWLPQKTMLCIGDSTQSD-PEAYGEIYRSFPG 415
CCA66817     337 VDFLNKY-YPLGSFDDRPLNLTTYDQi--------fQIRKTNLER-FFHTFPNRSIVLVGDTSNGDiMRNYPQMALDFPN 406
ELU41644     391 ESFIYAN-YPLGSFDIRPLNLTTVDQi--------fQVRKVNLHR-IFETFPQRKFVLLADTSNGDiMKQYPAMVTQFPG 460
XP_003037631 329 ESFIFGN-YPLGSFDTRPYNFTTFEQt--------fRVRAVALRR-ALETFPNRRFVLIGDTSNADiMRDYPALAKEY-G 397
XP_007928142 305 EQFIYAY-YPAGSFDVRPLNFSDISAt--------lSIRQFLLTK-IFQTFPQRKFVLVADTSNSDvMRDYPKLAHDYPD 374
XP_016761136 334 EEYIYAT-YPAGSFDTRPLNFTNAKEt--------lTVREFLLVK-IFETFPQRKFVLVADTSNSDvMKDYPMMAQKYPD 403
XP_007697432 353 MDFIYKT-YPGGSFDTRPLNFSDIEAt--------lSIRQYLLTK-VFETFPERKFVLVADTSNSDvMKAYPKMAHDYPN 422
XP_018251050 340 MSFIYNT-YPLGSFDTRPLNFSDGSAt--------lSIRRFLLDK-VFQTFPDRKFILVADTSNSDvMKDYPAMYKDYPG 409
XP_008602403 405 MDFIFRT-YPAGSFDTRPLNFTNVKEt--------lQIRRYLLDR-LFQTFPNRTFVLVADTSNADvMKAYPAMYKDYPG 474
Q6MP86        88 TDFLEENgFPITKLHMNSGIKQDPEL------------KQKVIRKvLAETNPE-VVIYFGDNGQFD-AVVYDQMVKEFPH 153 Bdellovibrio ba...

XP_014169578 416 WVKLILIRK 424
CCA66817     407 TTACILIRN 415
ELU41644     461 QVQCILLRN 469
XP_003037631 398 NVQCILLRN 406
XP_007928142 375 QVQCIFLRN 383
XP_016761136 404 QVQCIFLRN 412
XP_007697432 423 QVQCIFLRN 431
XP_018251050 410 QVQCILLRN 418
XP_008602403 475 QVSCILLRN 483
Q6MP86       154 IPAVSYIRE 162 Bdellovibrio bacteriovorus
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