6KML


Conserved Protein Domain Family
HigB_toxin
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pfam09907: HigB_toxin (This model is not part of the current CDD release)
HigB_toxin, RelE-like toxic component of a toxin-antitoxin system
HigB_toxin is a family of RelE-like prokaryotic proteins that function as mRNA interferases. HigB cleaves translated mRNA only, and cleavage depended on translation of the target RNAs. HigB belongs to the RelE super-family of RNases. The toxin-antitoxin gene-pair is induced by environmental stress factors.
Links
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Statistics
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PSSM-Id: 519116
Aligned: 111 rows
Threshold Bit Score: 54.4008
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6KML_A        33 HKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKylD--KHYVFNVGGNELRVVAMVFF-ESQKCYIREVMTHKEYD 106 Escherichia coli K-12
WP_014798297  22 lQNAVDNLIRDLENNAFQTQEELKKIRPDADAVH--Sd-GFYFFNL--SIHRTLILIEFeEDGEATIIWAGSHDKYE 93  Bernardetia litoralis
WP_011586846  22 lANAIDELLQELEVKNWKNGKQLKQDRPDADLVH--Nd-GFYFFNI--NIHRTMILIEFcDDGQATIVWCGTHDEYE 93  Cytophaga hutchins...
CBL46671      54 QARALEATYKVLRNGEFRSPNQLRNVFPSLDNFK--YkdKWWVIDIGGNTLRLIAFIEF-RDNRMYVKHIVTHAEYD 127
Q8E856        19 DKDALVQIYSTLRSGTFTNPDDLRQVFPSLDNFK--YrdKWWVIDVGGNNLRIIAFIEF-RDNRMYVKHVVSHADYS 92  Shewanella oneidensis
5_pfamImport   1 -ANVLITTYKLLKEKNFDSPLELQKLFPSLDNFK--HrnKWWVIDIGGNNLRMIAYINF-MNKRFYVKHIVTHKEYD 73 
1_pfamImport   1 -SLAIRSLYRLMRETDFSSPTEMRTLIPSLDNFK--YrnKWWVLDVGGNNLRVIAYINF-VNKRFYVKHISTHAEYD 73 
Q3J706        19 DRQSIMDTYNVLRRGSFSSPSELRIVFPSLDNFK--HkkRWWAIDIGGNNLRLIAAIQF-VHQHVYVKHIVTHAEYD 92  Nitrosococcus ocea...
Q8ZKT3        19 HELALTELLNVLEKKTFTQPEEMKRYIPSLDNFK--YrdKWWVIDVSGNSLRLISYIDF-RLHKIFVKHIVSHAEYD 92  Salmonella enteric...
WP_014680802  20 AKNALIEWYNELIKADFNNFNELKIVFGNASIVA--D--NRVIFNIMGNKYRLIVRIAF-EFRAIQIKWFGTHKEYN 91  Solitalea canadensis
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