CAK27310 37 RIYTL-TATFDQGLFLQEIWSALGGR-PFESTLASElSspvlldktalptlgYLHLGQHFTPLLLLWVPLVALLGP-WSL 113 Q82RR9 82 LHQRMlTTGYDLGIFEQAVRSYAHGH-LPVAELKGP-G--------------FPLLGDHFSPVLALLAPLYRVWPApVTL 145 Streptomyces avermi... P73520 35 RHWLFqSTALDLGFFDQAIYLISQGE-YPRVSFRGF-----------------HILGDHAAFLVYPIAIFYKIYPSvYWL 96 Synechocystis sp. P... Q7VDJ5 39 RHFLLqSNAFDLGLFDQWVWLQSVGE-PPYSSMTGL-----------------HLMADHGAWLLYIPAFLYKIQPSiHWL 100 Prochlorococcus mar... Q7V4G8 29 RHALLqSNAYDLGLFDQWIWLASQGL-PPYSSMEGV-----------------HLLADHGAWALYLAAIPYHFHASvQWL 90 Prochlorococcus mar... Q9HK92 39 KYVSLnATAYDLGIYVSILENTMHGH-VMYANPLLI-----------------NSFSEHFSPFLFVIYPIYWFFPYvKTL 100 Thermoplasma acidop... Q4J7K9 43 VLYNLnYSSYNLSMFIQELYSASQGK-PFYDTINLLfRg------------iPYGLAIHPYLILYILVPLYKAFPSwLTL 109 Sulfolobus acidocal... Q4J6X7 32 RLYDLlSGAFDLGLFMQEFYSTIYGGkIFYDAANFLsFg------------aLSGLAIHPYLILFLVIPIYYLFPSwLTL 99 Sulfolobus acidocal... Q4J7K8 16 RLYDLySGAFDLGIFLQELYSTLHGR-IFYDSPNFTyYg------------vISGLGIHPYFIMFFLLPIYYFFPSwLTL 82 Sulfolobus acidocal... Q8F2H0 76 ALDSLfLGDLDYTAQLRMILPTTDGN-FFQTQYYGShEn-------------ANFLSHHMAPGILLLTPFPILFGSeLGF 141 Leptospira interrogans Q7V4G7 40 RLESL-TATYDQALFLQELWSTARGH-FFESSLSSElSaavanqd-alpsidYLHLGQHANVLTVLAAPLVALFGR-WAL 115 Prochlorococcus mar... CAK27666 40 RLWSL-SATYDQGIFNQVLWNSGHGR-WFASSLSSQlSsavlhgg-lapdpsYQRLGQHYTPLLLLWAPLVRWLGF-AAL 115 CAK24663 38 KSWVL-LAGYDQGIFQQVAWNSLHGR-WFESSLSSQlStnvvhag-elpfvgYERLGQHFTPTLLLWAPLLGVFGA-AAL 113
CAK27310 114 PIVQIGLISAGGLVLYELARCD-Ld---------ERIACWIALSYFASGTVIGPSL-ENFHDLCAV-PVLVFSLLlGIRR 181 Q82RR9 146 LVAQAALFAVAVIPLARWAEEVrG----------RRAALVVGLGYGASWGVAQAVG-FDFHEVCFAvPLLALSLT-AVGR 213 Streptomyces avermi... P73520 97 FLIQAIALALGAWPTWQLAKQT-Gl--------gEKESLTMALVYGLYPLIFNINL-FDFHTEVIAvPALLWAVW-SARA 165 Synechocystis sp. P... Q7VDJ5 101 LATQSFSLSFTSLPLWMLCKQK-Gl--------nNRKSWLICCLWWLQPVVFNVNI-FDFHPEVWAmPLLAFSYL-SIRA 169 Prochlorococcus mar... Q7V4G8 91 LASQAAGLSLTALPLWWVGRQA-Gl--------tPKLCWLICTLWWLQPVVFNANL-FDFHPEVWVmPALAACYW-ASRA 159 Prochlorococcus mar... Q9HK92 101 LIMQSVMISFSGLVIYLLAREIfFinnfkkdillEMLALFISTSYILSPYIESP-LsFDFHLMPFLiLFVPLSFYfFMKK 179 Thermoplasma acidop... Q4J7K9 110 SLVESLVLTLASLYLYKIAREVlPq--------sKLLPVISSMIFLFNPLTVASFL-SGFQVLSFI-PLFYLASYyYYLT 179 Sulfolobus acidocal... Q4J6X7 100 SIIQTVVISISSIYLYRIANIVlGnn------rnLRLPLILTILYLFNPLIISGLL-FDFHAEALF-PLFYMGAFyYYLR 171 Sulfolobus acidocal... Q4J7K8 83 SLTQSLIISLSSIYVYKIGSTLfKen------gfRTLPLIFTILYLFNPLSISGYL-YDFHAEVFF-PLFYLGAYyYYLI 154 Sulfolobus acidocal... Q8F2H0 142 GIGIFFFASATIPLLYYYLRKH-Si--------sKELSLCATLLWSGSSSFY--RLnHSLHFEVLV-PFLFLCLLiGIQK 209 Leptospira interrogans Q7V4G7 116 PLIQVGLLALAGLVLWRMASAR-Ls---------RPLAIRLTASYYLSGTVIGPLV-ENFHDLCWL-PLLGFLVVdGLLK 183 Prochlorococcus mar... CAK27666 116 PLVQVSLMTAAGLVLHRLARGL-Lp---------AGLAAAVACSFYCAQAVIGPTW-CNFHDLCQL-PLLVFLLLlGLLE 183 CAK24663 114 PVVQVGLITAAGLVLHRLAAPR-Lp---------ARTANWLVIAFFAGNALIGPTL-GNFSDLCQL-PLAVFVLMlGLLE 181
CAK27310 182 SNRWLYGTAALLLPLVREDVGLLAFSLGLWMVLR-----------------Qp----------rWRL------------- 221 Q82RR9 214 GRARAAALWALPLLLVKEDLGLTVAVVGLLIART-----------------G------------ERDdr----------- 253 Streptomyces avermi... P73520 166 NKWGIFLISLVTILASKAVLSLTVFMLGIWLLIW-----------------Erk----------rlM------------- 205 Synechocystis sp. P... Q7VDJ5 170 NKNFLWIFLIFIILGTRDGLVLLTLGLGFEQILR-----------------Rnf-----------tR------------- 208 Prochlorococcus mar... Q7V4G8 160 KKAWLWFGLLLLLLGCRDGLVLVVVGLGLEQALR-----------------Kr-----------WIW------------- 198 Prochlorococcus mar... Q9HK92 180 YKILNLIVLILIISLHSLFVIMVFFIISYQFIFRirnegnlnchkiirtiaNinisdnlkktpkSKYvlqkivrsktlik 259 Thermoplasma acidop... Q4J7K9 180 KRWKLFIISTALLLLTSEASYPIVLTYMVLLIIK-----------------Nknnnkl-------------------lsk 223 Sulfolobus acidocal... Q4J6X7 172 KEWKKFTLFIVFLILTMEAAYPIVIFFMIYLIMR-----------------Nr-----------RTKeenvkegfsydla 223 Sulfolobus acidocal... Q4J7K8 155 KAWRRFSTFIIFLLLSMEAAYPIVILFMIYLIIK-----------------S------------YKKgtki--------k 197 Sulfolobus acidocal... Q8F2H0 210 QKTWILLSALCLFLEIKEDLAIYLSILSFVLIFT-----------------En----------kRRK------------- 249 Leptospira interrogans Q7V4G7 184 QGWRQVMACSFLMLLVREDAGLTLFSLGLWASLR-----------------Rp----------gARA------------- 223 Prochlorococcus mar... CAK27666 184 RRWWLLLLAALLIPLVREDTGVVLFGMALWMGLR-----------------Rk----------aPWW------------- 223 CAK24663 182 SRWALTVAGALLMPLIREDTGVILVAIGLWLLVR-----------------Sr----------eRWR------------- 221
CAK27310 222 --AGVGLCLYATAAVVLITNTV--------QPLFgtevsDRLLSA-RFGHFLsdq-ggkGSTLDLLQAMALQPQrv-vQE 288 Q82RR9 254 -rRGGALVLAGVLGSFLEMLVV--------IPAF-----NPGGTF-AYSSSVpg----aGSATPGAGELLLHYT----VG 310 Streptomyces avermi... P73520 206 ---GLITTVAGIAWFIITTKGI--------IPAFsg--eEAAAVG-RYSFLG-------DSVAEIILNLILKPQiv-lGM 263 Synechocystis sp. P... Q7VDJ5 209 ---GISVILLSSSWLLFLNNIL--------YPLLnqgkgSIMAVS-RYSYLG-------NSLEEILFKIITNPIii-fQS 268 Prochlorococcus mar... Q7V4G8 199 ---AFAAIGLALGWLAMLNHWL--------YPWLkgstgGPKAAGaLFSYLG-------DSFDEVLFNLITKPQll-iEH 259 Prochlorococcus mar... Q9HK92 260 iiITLILLVGYLYFASLMKTFIasgavalsPPSTmstgsVS------------------SSLAGLFTDLFTRPMli-eSA 320 Thermoplasma acidop... Q4J7K9 224 sfFRRNILFLSVIVATIVIALT--------LPTFlqt--------------------kyTGTSHSILQDIEQYYslnyVN 275 Sulfolobus acidocal... Q4J6X7 224 tfIRKNKLFIIIIIVTLAVGLT--------IPKYfstifSVSPP---------------TGYSSYYSSRISSLYls-gIS 279 Sulfolobus acidocal... Q4J7K8 198 ffLKNTTLFLIFIIISIIMGLT--------IPHYlnsifATSSH---------------SSTTHYLYSTITYLFlk-gIN 253 Sulfolobus acidocal... Q8F2H0 250 --EWIFIFSICIFYYFIIFPFL--------NKSAgns--------------------aeRNWKEYWG---QDPFflilQY 296 Leptospira interrogans Q7V4G7 224 --IGLMVMAMSLVYVAVMTGWI--------QPQFdsslsDRFLQE-KFGHLLqg---rtGGTFTVLWTMVTHPLrl-lAA 288 Prochlorococcus mar... CAK27666 224 --VAALIGLWGAAWCVVVTSVL--------MPAVsadvsKRFMVE-NFGQYTpda--eeLSSLEVLKGLLLQPWrl-lWE 289 CAK24663 222 --LALVLIAWGGGWVVVCTNVL--------MPLFsddnsKRFMVE-NFGQYLgadpdkgSSSLGVLKRVFSQPVll-vQQ 289
CAK27310 289 LLTPLg-PTLQL-LVALWLPLGFLPIlgLDAWLLMAVPLFLALAAQGVT-ALSINLRFMLYLVPGVFAGSVIWWRSRQal 365 Q82RR9 311 LVTPD--TKAQT-VLALLSVTGFLAV--RSPLLWAALPTLLWRFASDNQaYWGTGYHYSAVLMPVLFAAFVDALTRPG-- 383 Streptomyces avermi... P73520 264 LFTLD---NLFY-LVLLTAPVIWGIWgkAWAMFIPAIPALFVNLVTDYLpQKDLIHQYSLPILPFLLLVVMTHWYQGSsw 339 Synechocystis sp. P... Q7VDJ5 269 IDWSG---SIFY-LIILFLPFIFFLRssSLIVLSASIPLLLTNILSDSFsQRTLIHHYSLPIIMILVVASIDGMAQSNik 344 Prochlorococcus mar... Q7V4G8 260 VDWIG---GLIY-LLLISIAVAPFWRrnSLPVLMGGLPLVLVNLLSEESpQRTLIHHYSLPIAVIAVVAAIDGLAVRPkq 335 Prochlorococcus mar... Q9HK92 321 FLINFp-DKIIF-AFYAFANTGFLVFl-DPLSLLMDIPYFLYAYLSSYGpYYSLGYQYSTMIIPFIFIGALFGIRKIVqs 397 Thermoplasma acidop... Q4J7K9 276 YDILN---KLEY-WLLVFGSFGALSLf-SPLELLPALPYILLTVMSFYPnYYTPGYYYFFLVLPMLAVALVYTLKKIHdi 350 Sulfolobus acidocal... Q4J6X7 280 LFWYD---KINF-LVILLASFGFLPIf-APTELLPGAPYILLILFSNHVpYFEIGWQYPLIGAGMFVVAMVYAISRLIkn 354 Sulfolobus acidocal... Q4J7K8 254 YAWSF---KSSF-WLMYFASFGFLPLf-SPIELLPALPYIGTSLFSIMLtYSGIGYQYVFIALGPMATASLHSLNTLLkr 328 Sulfolobus acidocal... Q8F2H0 297 IQNPEyiFQYWKgIRDLSLEWGFWNLt-GGWILFPFLGLYSVFKLSIHPwVKGLYSYYIYPLIPFLILFLKTGASWIQnh 375 Leptospira interrogans Q7V4G7 289 LVSPPg-TTLAF-LLAPALPLAFIPFvsLDVALMVAVPLFIALVSQGMS-ALSVTLRYVLALVPGLFMGAMLWWQAHSgf 365 Prochlorococcus mar... CAK27666 290 LINPPg-KTLAY-LAAQWLPLMFVPAlsLDAWLLVALPLAGLFLARGSNdPLSINIRYALLVAPGLFAGAVFWWQQRSql 367 CAK24663 290 LIDPPg-KTLRY-LLGHSLPFLFVPLisLDTWLLAGPSLLGLFLAQGTNdPLAITIRYTWLVVPGFALGALFWWERRAvp 367
CAK27310 366 feq-------rwvrrLWQSCAVASLVFALIGNPHHSLSMLIPdsl-----npWVYVSPWQQLQRGhqsRALTRNIP-KDA 432 Q82RR9 384 ---------------PVRYALAASAAVTVLLLPQFPLWQLTQ----------PATWHTDSRLASA---RRLMDRIP-DGA 434 Streptomyces avermi... P73520 340 lkk-------lrwiiLWTAIAFLALGKYTYFF--------------------GRYWHHWGQLANL---QTAVSLVQ-PGD 388 Synechocystis sp. P... Q7VDJ5 345 seis------irnryLWILLTWSLLAKPLFFI--------------------GPYLSRISLIQSA---HEAFSLIK-SDS 394 Prochlorococcus mar... Q7V4G8 336 avp--------wrllTWSTICWVALAKPWFFS--------------------GPYLERLNALTPS---HEAIANIP-SSS 383 Prochlorococcus mar... Q9HK92 398 aratdsddvrrtikkILVGVISIVIVSSLFELPLDPISPRNIfie----sgsMANFHEFAYNNGSeiaFELQKEIGeSDP 473 Thermoplasma acidop... Q4J7K9 351 -------------krVVRVALVFVLLIGVFFNPYIYTTFQSYnspkivspgyPPSFNTTLASVNQmyiNELTSLIP-PNS 416 Sulfolobus acidocal... Q4J6X7 355 -------------yrIIIVSIFVMFMLSVALNPYLYDNFQPSnssrifsggyNPKLSLSTALANYeviSIMTSLIP-HNA 420 Sulfolobus acidocal... Q4J7K8 329 -------------pgVIKVALVIVLFISFLLNPFTYNNLQAMnspryygggyVPPFNLSLANSNYeviSNMTSLIP-ENA 394 Sulfolobus acidocal... Q8F2H0 376 iyn-------skikfLYTFSKNQKLLLALIITFSVSIFRNSKete-----ypIVFEPKPDQVEEL---KTILKQIP-SND 439 Leptospira interrogans Q7V4G7 366 wsh-------lwfrrFWTGCLALGLVLTLASNPHRTFSALVPdsf-----spLVHVSPGAMLQRAataRHAVGLVP-DNA 432 Prochlorococcus mar... CAK27666 368 far-------rrlrrIWTGCVLLSLLLTLISNPNRSLSFLVPdsf-----vpWVHVSPLQQWRHGrlaRQALAVIP-PEA 434 CAK24663 368 spg-------prvrlAWGAALTLSLLLTVTSNPHRSLSMVMPdsi-----dpWLYSSPAQQWVHGlraRKALKVIP-ETD 434
CAK27310 433 SVSAETQLIPMLAE--RRVLLRYPFNYRYtdeq------gqaHDVEWIVLQprfkatyaPAFRRQANTLEHGMNLTQHLL 504 Q82RR9 435 TVAASNRLVPQLTN--RARVSVFGLGGSR-------------PDAEWIIDDs-------AQPQGWPIAPDDDRRLLSEVR 492 Streptomyces avermi... P73520 389 RVLTSPHLAAHLSH--RPDLEL-AIEAEApf---------dlNRFDAVLLQ--------TNYAGWENSQGTVEALAQRVS 448 Synechocystis sp. P... Q7VDJ5 395 SILTTSYLAPHLTQ--RSQITFP-RDTKDin---------siDIYDVILLN--------PLDPGWQSDRKIQEEYLSKAR 454 Prochlorococcus mar... Q7V4G8 384 RLATTSYLAPHLSQ--RIAIDFPRRKGKSld----------lESFDVLLLN--------PKDPGWGSSQKHQQKLLSKAK 443 Prochlorococcus mar... Q9HK92 474 YLLTINNLYPVFAKdtNAYVIAFAWNSQLrnliygyhieylvNQPDSFWSN---------------QFNPSMNDLIDNNT 538 Thermoplasma acidop... Q4J7K9 417 SIVATTDLLPFVSNsmNAYVLPPYSNVNLnilknlnvlkrlaPTPNYLLID-------------------GSFLTPSFNS 477 Sulfolobus acidocal... Q4J6X7 421 VVIASSNLFPFVANdvNAY--PIYGYFNTsymi-----tylpNTPQYVLLS---------------------GQSNELTM 472 Sulfolobus acidocal... Q4J7K8 395 VVLASNNLFPFVANnlNSY--PLYGSLITssql-----kyspRFPDYIFLS---------------------EPELFLSY 446 Sulfolobus acidocal... Q8F2H0 440 SVSAGFHLSPFISL--KNPVYPIRENREW---------------KEWIIIDri-----yNS-PYLSSEKILERIDSDVQI 496 Leptospira interrogans Q7V4G7 433 SVAADTPLLPLLAE--REVALRFPKHIEYynrq------dqiESVQWVLAFpgyyrslmPLFRQETSRWRSINKALQELM 504 Prochlorococcus mar... CAK27666 435 SVAANTPLIPLLSH--RRVLVRLPAWYQWqdsd------gqrQNVDWVAIDtaqasrraKAFAPDRRRQLQLQLQLRDLQ 506 CAK24663 435 SVAANTPLVPLLAQ--RRAIVRFPYTTNYldqn------rqeQRVQWVAVDlsllerygVAFRRDWRQHKKSLAWIEDNR 506
CAK27310 505 ASGSYEIARCg--PSGILL 521 Q82RR9 493 NNGRYRTVAD---QDGYVL 508 Streptomyces avermitilis P73520 449 QDSAFTPEYQ---ENEVIL 464 Synechocystis sp. PCC 6803 Q7VDJ5 455 LE-GWDCKEW---SNGQEL 469 Prochlorococcus marinus Q7V4G8 444 QA-GWWCESW---DNGLEl 458 Prochlorococcus marinus str. MIT 9313 Q9HK92 539 FISHYGVYMEsfgQDGVIV 557 Thermoplasma acidophilum Q4J7K9 478 IEGNYGIYAE---TNGISL 493 Sulfolobus acidocaldarius Q4J6X7 473 LKGNYSIIAE---GDNLIL 488 Sulfolobus acidocaldarius Q4J7K8 447 IRGNYSMLAE---ANGLLL 462 Sulfolobus acidocaldarius Q8F2H0 497 RKLRWIQKTK---RFGLLR 512 Leptospira interrogans Q7V4G7 505 EEGRYGVVSC---ADGLVV 520 Prochlorococcus marinus str. MIT 9313 CAK27666 507 GQG-YSPVAN---ADGVVV 521 CAK24663 507 QT--YTPQAI---RDGVVV 520
Jiyao W et al.(2023). "The conserved domain database in 2023.",