7THW


Conserved Protein Domain Family
DotU

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pfam09850: DotU (This model is not part of the current CDD release)
Type VI secretion system protein DotU
DotU is a family of Gram-negative bacterial proteins that form part of the membrane-joining complex of the type VI secretion system. DotU binds tightly to IcmF and together they are tethered to the inner membrane at one end and the peptidoglycan layer at the other; they interact with Lip1 which then tethers the peptidoglycan layer to the outer membrane.
Statistics
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PSSM-Id: 519102
Aligned: 110 rows
Threshold Bit Score: 89.3223
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7THW_D          3 AXLLGAWDNAYIAAAXPLL----LLVENIRSWPTRNAAE--VRPPIVRE-LQYFQQHLQKKNYPQEDINHLSy-----lL 70  Yersinia pesti...
WP_013659972   57 LKAGSELLSLTISVKRMQCp---TDMFAFRSGIKNALTD--LKYKVAKL-DYPPSVADKACFLFAVMLDEQI-------L 123 Marinomonas me...
17_pfamImport   3 VAAASPLLSLMERLCISPTl---PPIDQIRDNIEHELYA--FHGRLLGQ-DYAEELVAVAQYLLSATIDELLgknyvrlY 76 
Q5ZYB3         42 VAAAGPILSLLERLCLSPSl---PPVEDIRENIQHELRA--FHSKLDAS-KYPLDIISIAQYLLSATIDEILgksylrvY 115 Legionella pne...
Q9I1B7         37 DRDAQDVPRMVERALELST----RITRRLWRSAFASVG------------DAAGVQVKAMVYAFVALVDETL-------V 93  Pseudomonas ae...
CAN99518       31 HAFYAEVVR-QRQLVTLAHgglaPGIETVRQRLVDFLETqaVSLGRKLT-KHELRAYDDAQYVMAAMADELL-------L 101
WP_012405218   19 RTFLDELVRAQTRFSGLPDadpdLAAQSMSRHLLDLLEIqtLQSRRDST-RFEMETIADARYLKAVLADEIL-------L 90  Paraburkholder...
Q0JYH5         19 RAFLDELVKLQERFSEQPDlsgeAAAQGMNRQLLNLLEVqtLQSRRDSS-RFEMEDVADARYLKAVLADEIL-------L 90  Cupriavidus ne...
Q7VJJ2         28 LHLTLPLLLFATRLSKTGIld-dSYITNTEETFANEILS--IGSNLNALrCYEDKDLIKLRYCLCVFIDEML-------L 97  Helicobacter h...
12_pfamImport   3 VDYCLELLLLSFRLSKVTLld-tSTIESLREKIVNDILT--WSSKLSALrEYDEKDIIRLRYCLCVFIDEML-------M 72 
7THW_D         71 CTY-----IDGIFNGLQTPDSYNQSLLVEFHRDAWG-GEDCFEHLRVYXNSPKQYREVLEFydlixclGFDGKYQXIEHG 144 Yersinia pesti...
WP_013659972  124 HSSwgessGWENQTIVSELFGIKNGGEQFYVVAERA-LLQPVLLVDLLELIYIMLKMGFRGryr--anGKDQLDALMKRI 200 Marinomonas me...
17_pfamImport  77 GQP------AEFKAFTPSSHEDIGPQRRFFDIVYHI-KERATQYLDLLELAYYCLIAGFEGeqhlrpdGRHVLDNLIEEL 149
Q5ZYB3        116 NLT------TEFKSFTPLSSDGAQPQQRFFEILNYI-KERPNQFLDLIELAYFCLIAGFEGeyhlkadGRQCLDNTIEDL 188 Legionella pne...
Q9I1B7         94 FSAwpgqgAWQDKPLESHLYGSRQAGEYLPLAIKRLlDERAPASRDLANVYLQCLILGFRGrlr-gprGEALHEKWRQAL 172 Pseudomonas ae...
CAN99518      102 QAEwdgryAWAERPLEAHIFHTYVSGERIFRKLDDVlSGHDAAPSALLLVYLAALALGFQGkyr-algLRDKPERYRQDL 180
WP_012405218   91 NSPwagreHWTGYLLESTLFRTNVAGDQIFRRIEQLlSDREPSYRNIARLYLFALAMGFQGrfr-dtdATARLRSYREEL 169 Paraburkholder...
Q0JYH5         91 NADwagraAWHGHLLESTLFRTNVAGDQVFRRIEQLlLDREPSRRNLARLYLFTLGLGFQGrfr-gadAEARLRSLREEL 169 Cupriavidus ne...
Q7VJJ2         98 HNEsfinsHFAKHTLTIRLFDEMLGGDKFYGIANQW-LLTPSKHKDMLEFIYTCLILGYQGkyasdtqGKQKINHLCCNI 176 Helicobacter h...
12_pfamImport  73 KNElfinsSWANNTLTVRLFDETLGGDNFYDITHSW-LNNPAKNKDFLEFIYACLVLGYKGkysnnkdVEERILLFCNNI 151
7THW_D        145 AVLLX-------DLRSRLhTQLYGQdATQSLAIAQav-----------kGSPRRQYIKAL-KIFT 190 Yersinia pestis CO92
WP_013659972  201 EESVF---------AQGRsFSESERlPLLVSDIAeypkvikpkkpvrlwRSFASFLFLVG-ATWL 255 Marinomonas mediterranea
17_pfamImport 150 YQLIQqh----rVSKPHRlFREQTPsmpepi------------nhkpfvTGILLAAGILT-IVYL 197
Q5ZYB3        189 YQIIQky----rFNKPHRlFNENplpktik------------knykatwITTIAAVGIVI-LAFV 236 Legionella pneumophila subsp....
Q9I1B7        173 FAFAW--------QREADaADLGRRlEQPAAAPPRrlpvra---alpdgFRLGLAVLGLV-LLMS 225 Pseudomonas aeruginosa
CAN99518      181 ALHLQrvdptlaTGLTE--LCPQAHaHTLGGSSRSrlp----------slRAGVVPLAVV-AGLL 232
WP_012405218  170 YEFVYqrrpdlgGRERV--LSEPAYgNTLSHVAPRklp---------tvSRWAVILMLAA-VSLL 222 Paraburkholderia phymatum
Q0JYH5        170 YEFIYqrrpdlgGRERV--LSESAYaHTLSHIAPRklp---------tlTRWTVVFLLGL-ATLL 222 Cupriavidus necator H16
Q7VJJ2        177 ANSLApa----mGSSEGKaFELALNhqeqtrilkl----lhkkylrpfwLMAIICSIVALfFLFS 233 Helicobacter hepaticus
12_pfamImport 152 ASSLTpl----yDVSEELaFTKAYDgimkesfwqn----fqrmylkkilIALPLCIIVGV-FIYA 207
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