Conserved Protein Domain Family
12TM_1
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pfam09847: 12TM_1 
Membrane protein of 12 TMs
This family carries twelve transmembrane regions. It does not have any characteristic nucleotide-binding-domains of the GxSGSGKST type. so it may not be an ATP-binding cassette transporter. However, it may well be a transporter of some description. ABC transporters always have two nucleotide binding domains; this has two unusual conserved sequence-motifs: 'KDhKxhhR' and 'LxxLP'.
Links
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Statistics
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PSSM-Id: 490685
Aligned: 6 rows
Threshold Bit Score: 247.362
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9HM06  17 YVNISYGATSFSFIVFSLILVAPSLMEHRIY----TLSSVVLLLFVYSLFINISNSLLFFVSVninHILDPLRILPVDFP 92  Thermoplasma acidophilum
O29855  39 WIRYNALLLKIMFTFAALFSVGPAFFDDKVS----YASSLLSLFFFFLMFGTAYAHGYFQVDL---SYMHTFYSRSDISK 111 Archaeoglobus fulgidus
O29125  30 SLRVQVAKSFFIMTFLGSFLCWVAFISSGLG-----LSLIFTLSLVFSQIYPAQNIAISASS----RVFEPLRYLPVRFS 100 Archaeoglobus fulgidus
Q8U2D3  39 NIIWGVFLQSVMYLGLGVMVAVSILYSENEVqkaiFFSSYLIIPFILTLYSTSLATAYLLSS----KAVEPLKPLPLGNL 114 Pyrococcus furiosus
Q5JDA6  35 DLKKTLLFQTAMYAVFGLML-FPSLKGERDAvl-vMASTYAILPFIIAFYATVTNSSYIASL----DLFKPLLPLPIKLG 108 Thermococcus kodakare...
Q97VM1  39 NAVTIKISNIIAYTIATIVSASISLINKDAP----FSFIFLDLIILANIFTTGLNVIFFVTNY---DLKTFLLSLPLSER 111 Saccharolobus solfata...

Q9HM06  93 DHVIAVSWFIYTGSSSLFAVlpaifLAAFLLGDPYILVIGLIWSIFSVLLG-YIIGSSIFVAFGSRISGKrTRSTNILRN 171 Thermoplasma acidophilum
O29855 112 VRFYGFFRLFDWPAVIALLS-----LLVLVGMRNPAGLLPALLGFLAVIMGaLSIVILLGKRLGSVQTGR-SLRAAFFRI 185 Archaeoglobus fulgidus
O29125 101 ERMLVVF-FIDSINILAFATp---tIAVLMVKNLYFGLYSLLWIIAAILLG-YSMVFLYYALFGVKV--RsGFSKSVL-- 171 Archaeoglobus fulgidus
Q8U2D3 115 NFIVSLTLLIENLPAFVFLI-----PASLALGNSIASLLGLLWICSTILMG-HSLALFLQIKFSGIHVGKgSVVKTLVKV 188 Pyrococcus furiosus
Q5JDA6 109 GRYMSVLLLLESLPVMAFMVpg--aVRIGMVVSATSGLLVLLWSAVGLMLG-HVFGLLVYYSFGKTSSGRfADLKSLAKA 185 Thermococcus kodakare...
Q97VM1 112 DVNRAVFRGIFEFFYYGFLAsi--vIAPISTYMITSSVLQALMAELEIIFF-FSLSFALVMLLGKRI--RlGITSALFRI 186 Saccharolobus solfata...

Q9HM06 172 VGRIVFLVFVFAIFEIILYNAni---vNGIIPRLPYPYSYFIPifniqstvFFFHGIYMQATG--FIISMVYT-ALASFA 245 Thermoplasma acidophilum
O29855 186 FGLIAWLVSIYGLYLINQLAI------YLMTFKNYEAYDSLFPi-------SYGLWISQPFSAkyAALSLFYF-ALITLL 251 Archaeoglobus fulgidus
O29125 172 AGILFFAVLVFAL---------------RRFQEIPDLTPYLTP----------------------HLLLLSY--AASSAT 212 Archaeoglobus fulgidus
Q8U2D3 189 AGFLI----IAGIYFIVQALMrilednIEVIAPIFRKYFIAFP--------FAASTIYEPYKS--LVLLALYT-LPFLAL 253 Pyrococcus furiosus
Q5JDA6 186 LGVIL----IFGLFYGFSYFQdyvlqnYTSIKESLGGYEFIYP--------LSVLSVDRPSFS--APLAGIYI-AILGVA 250 Thermococcus kodakare...
Q97VM1 187 GTSLIWIVFIMLPYGL-----------TFKYVTIPTYILPIFP--------FGFLNIEG------LLISLLYTgLSVFFA 241 Saccharolobus solfata...

Q9HM06 246 FIYVNRKAFYRll-epTARNQSRVKtQMKAEVRSRPFSFFSKDLKISSRKSQNLVLLIMPLFFVFPtimsevlyaptska 324 Thermoplasma acidophilum
O29855 252 FFYAVRELSKEe----IAKHYGSLK-GWKIKRRGKMTAMVIKDFKQLFRNPQLFVIALLPIYGALM-------------- 312 Archaeoglobus fulgidus
O29125 213 IKLSTGRVWRSilnpeIVEVKGSSR----LSSGSPLRAMLIKDFRLILRKN-ALFPLIVPLVIVMPnvvsi--------a 279 Archaeoglobus fulgidus
Q8U2D3 254 YFYDLKRLGEVl---eGIKTYGKVAtKYKLTVANPVTAMFRKDYRIIFRKNPYLGTFLSPLLMSIYfiynlak-----eg 325 Pyrococcus furiosus
Q5JDA6 251 YYVLISRLWVRis--eGSYTSGRRRrAGGLGVYPPELALMVKDFKTALRNTPVLTGLLVPIVIPIInvagifsnpdigaf 328 Thermococcus kodakare...
Q97VM1 242 YKQSLKFLSFRl--------NSQYStKYSIKLRSPLITYLYKDIRGLLRVPQASFLLTIPVFALIFsff----------- 302 Saccharolobus solfata...

Q9HM06 325 dpiiLYNAMVAFVIVTSSFYSILFLVIEGNGI------SFIKALPLDGNSIIRWKISAPTFIFAvISISTLAAISVKAL- 397 Thermoplasma acidophilum
O29855 313 ----QLVFYIKLSEVASVLYLQIFLAITVSSFmslersSYITALPLTDLEMKFSKILEGLLIYF-VSMGIVAAVVIYKG- 386 Archaeoglobus fulgidus
O29125 280 nmpnLSIFIITTISTLSTIDLRIIGNLENVDF--------LRMLPLSKRGFVMSKACLIFVISFaASLPAGSIAFIVS-- 349 Archaeoglobus fulgidus
Q8U2D3 326 fpvmMTLFSIMGISVLGLVMLDPAFAMDREVF------PFLSSLPIKRREYLLGKMLTVSLSPLtFSAILVLLSCAFNG- 398 Pyrococcus furiosus
Q5JDA6 329 ggrlATITFVAALGWVSAVSVETLTKIEVKSF------ELLLSLPLERGRFLRGKLLTMAAIPSaVGV-LALLGLSLKGf 401 Thermococcus kodakare...
Q97VM1 303 -apvYAIFYTIFMITTSSIMLIL---LEASGM------QLLLSLPAGLRSSYISKLLIILIIYL-------IDVLIFSFf 365 Saccharolobus solfata...

Q9HM06 398 MGAAFYIIIIVDMMLYFVSSTVYNMNRlyrkipdTADTVNFYsfgGQIAFITTFAFTGLIVGSADIFSLFLQDLLRlnay 477 Thermoplasma acidophilum
O29855 387 GNLINSLSLFPTGFAVVLVAVQFSRRL-------TSEPVNVE---AVIATLISFFIVLVPAAVGGVAVLILKAPFSsy-- 454 Archaeoglobus fulgidus
O29125 350 QNPFYLFMAFAIPAIVSMLSSLIIFWQ-------KGEEIYFPe-vGFLKWIGLLLVNFGAVYAVLSPRFILSQPVA---- 417 Archaeoglobus fulgidus
Q8U2D3 399 TEALLLIPFLASPFLTSSIGILYVKHKm------GNERIELPv-lKFYDGIVMLILSMIPFIIVAIPLFLLSVPKG---- 467 Pyrococcus furiosus
Q5JDA6 402 SSPIYLPMAVLVPLATCGIALHVYYH--------GTEGLALPq-gGILKSLAVWILNAVVVGIIAG-SWYLSYPIA---- 467 Thermococcus kodakare...
Q97VM1 366 NRASLSLIMLPSTITSVELSLFISYNNv-----iKGKGMRLA---DPLSFIIREIEINSIIGIASILTFFANIYYS---- 433 Saccharolobus solfata...

Q9HM06 478 ffFLINTVIGI----IVLLFMVFR 497 Thermoplasma acidophilum
O29855 455 -aFPVSLAETLavlaVFALLNRRK 477 Archaeoglobus fulgidus
O29125 418 --DIISSVLTL----LAMTALFEK 435 Archaeoglobus fulgidus
Q8U2D3 468 --YLVSGAIIL----VGALILSKL 485 Pyrococcus furiosus
Q5JDA6 468 --LLLTAA-------IDALLLWSL 482 Thermococcus kodakarensis KOD1
Q97VM1 434 --LLFSVLSLI----MINIVVYKK 451 Saccharolobus solfataricus
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