7P14,7DCE


Conserved Protein Domain Family
XK-related

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pfam09815: XK-related (This model is not part of the current CDD release)
XK-related protein
Members of this family comprise various XK-related proteins, that are involved in sodium-dependent transport of neutral amino acids or oligopeptides. These proteins are responsible for the Kx blood group system - defects results in McLeod syndrome, an X-linked multi-system disorder characterised by late onset abnormalities in the neuromuscular and hematopoietic systems.
Statistics
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PSSM-Id: 519081
Aligned: 105 rows
Threshold Bit Score: 140.442
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7P14_A          9 MMSVLGIIIYVTDLVADIVLTVRYFYDGQYVFGVLTLSFVLCGTLIVHcFSYSWLKDDLKKAGgeneHYFLLLHCLQGGV 88  Norway rat
XP_004073149   41 VSVVLATLLYCAELVSAAVLISMYHKSGDVSWMGLTIFFMLFPAVLTQ-LTLTFVHRDVGRDR----PLVLLLHLLLLGP 115
XP_003445258   40 FSVVLATVLYCAEFVTAAVLCSMYHYTDDVIWMSFTIVFMLVPAVLIQ-LALTFIHRDLGRDR----PLVLFLHLLLLGP 114
13_pfamImport   1 FSVLLATALYCAEFVAAAVLCSLYRKTDDVIWLGFTVAFMLLPALLIQ-LALTFIHRDLGRDR----PMVLFLHLLLLGP 75 
Q5U3R0         42 FSVLWATVLYCAEFICASVLSSMYHKTEDVVWMGLTITFMLVPSVLTQ-LTLTFVHRDLGRDR----PLVLFMHLLQMGP 116 zebrafish
Q5GH21         31 FSIFTSTILFCAEIVAASVVAAGYSYSEDESWMSLTIVFMLVPSIMVQ-LTLTFIHRDLGRDR----PLILLMHLLQLGP 105 tropical clawe...
XP_005992052   35 FSILISTILFCGELIAAGVLCGCYNQSKDQVWLALTLTFMLVSSVLIQ-FALIFIHRDLTRDR----PLVLFLHLLQLGP 109
XP_002719876    5 ASVLASVFLFVAETTAALYLSSTYRSAGDRMWQALTLLFSLLPCALVQ-LTLLFVHRDLSRDR----PLVLLLHLLQLGP 79 
XP_001514150    5 WSVAASVCLLGAEAAGALGLSRAYWAAGDGAWHGLTLLFWLLPCALVQ-LTLLFVHRDLSKDR----PLLLLLHLLQLGP 79 
XP_029702972   37 fSIVLATVLYCAEFVSAAMLSNINRKTEDDIGTGFTITFMLVPAVLTQ-LALTFIHRDVGQDR----PLVLLLHLLLLGP 111 torafugu
7P14_A         89 FTRYWFVLRTGYHVVfkhShrt--------------------snfMEEQTDPhkEAIDMATDLSMLRLFETYLEGCPQLI 148 Norway rat
XP_004073149  116 IIRCFEALMLYCK-----Agkmedsyvtisk--rtflkkgqkterELHIGQVerNLATHRNAFERTSVIQAFLGSTPQLT 188
XP_003445258  115 VIRCFEALVIYFKSGkkeEpyvtisrkik-------lkkgtgtemEWEIGQTerILATHRDAFKRTAVIQAFLGSTPQLT 187
13_pfamImport  76 VIRCFEALVIFIK-----Agkienepyvtisr-qkslkkgqeglmEWEIGRSerNLATHRDAFKRTAVIQAFLGSAPQLT 149
Q5U3R0        117 IIRCIEAIVVYCQ-----AgkneepyvtisrkiklkhgrglgpafECEIGHSerKLAVHRNAFKRTAVIQAFLGSTPQLT 191 zebrafish
Q5GH21        106 IIRCVEALTVYCT-----Mgreeepyvsisrk-kklqgwgeaeeeEREVGHSlrRLATHRNAFKRTAVVQAFLGSTPQLT 179 tropical clawe...
XP_005992052  110 LVRCMESLVVYYR-----Agrkeepyvsitr--kkqlkkgcerevEQEVGHSlrKLATHRNAFKRTAVIQAFLGSTPQLT 182
XP_002719876   80 LFRCFEAFCIYCQ-----Sshneepyvsitkk-rqipknglseeiEKEVGQAegKLFTHRSAFSRASVIQAFLGSAPQLT 153
XP_001514150   80 CVRCVDVFCIYFHEGeveEpyvsitrkrq------ipkngyseeiEREVGQAegKLCTHRSAFSRASVIQAFLGSAPQLT 153
XP_029702972  112 VIRCFEALIVYFN-----Avnkeeayvtlsr--kiilkkgrkilvEWETGRSerTLAAHRNAFKRMAVIQAFLGSVPQLT 184 torafugu
7P14_A        149 LQLYAFLERGqANF--SQYMVIMVSCCAISWSTVDYQIA-LRKSLP-DKNLLrGFWPKLTYLFYKLFTLLSWMLSVVLLL 224 Norway rat
XP_004073149  189 LQLYATIQE--RYIlnGRLALMIISLLSIIYGALVCNVLaIKIRYDeYKVRL-RPVAYICMIVWRGLEIATRVTALVLFS 265
XP_003445258  188 LQLYATIQE--KYIlpTRMALMIITLISITYGALVCSVLaIQIRFDdYKLQL-RPCAYLCMIVWRGLEIATRVTALVLFS 264
13_pfamImport 150 LQLYASIQE--KYLlpARLAVMIITLISITYGALVCSTLaIQIRYDdYKVRM-RPMAYLCMIVWRGLEIATRITTLVLFS 226
Q5U3R0        192 LQLYATIQEK-YILlpSRLALMIISLISITYGALVCSVLaIQIKYDdYKVRM-KPTAYLCMILWRGLEIATRITTLVLFS 269 zebrafish
Q5GH21        180 LQLYVSVLE--RNVppARAVLMAMCLASTTYGALILNVLaIQIKYDdYKVRL-SVPAFLCIVMWRCLEIATRVTVLVLFC 256 tropical clawe...
XP_005992052  183 LQLYVSVME--ETIlpERVALMVISLLSVTYGALVCNVLaIQIKYDdYKIQL-KFTSYLCIILWRSLEIATRVTVLILFC 259
XP_002719876  154 LQLYISVLQ--QHVtvGRCFLMTLSLLSIVYGALRCNILaIKIKYDeYEVKV-KPLAYVCIFLWRSFEIATRVTVLVLFT 230
XP_001514150  154 LQLYISVLQ--QEVtiGRSIFMSICLLSIVYGALRCNILaIKIKYDdYDITV-KPAAYICIFFWRGFEIATRVVVLVLYS 230
XP_029702972  185 LQMYATIQE--KYImpARLVLMIINLVSITYGALVCSVLaIHIRYDdYKVRI-RPAAYLCMTAWRGLEIATRVTVLVLFS 261 torafugu
7P14_A        225 FVDVRTVLLLLLFLWTVGFI--WAFINHTQFc------------NSLSMEFLYRLVVGFILVFTFF----------N-IK 279 Norway rat
XP_004073149  266 TALTRWVILVGVLNFLFFFFlpWVKLWCKKIgptgdvekdfsklGTTIVLCLFTLLFACINVFCWSavqld-lahnDlIE 344
XP_003445258  265 TALTHWTILVGMVNLLFFFFlpWVEFWARKGsltenveknfsklDTVVVLCMFTLLYACINIFCWSavqldlthqeL-IE 343
13_pfamImport 227 TALTYWVILVGMVNLLFFFFlpWAEFWARKGsltqdveknfsklGTTVVLSMFTLLYACINVFCWSavqld-fshrElIE 305
Q5U3R0        270 TAFTVWVVLVGLINLFIFFFqpWVEFWARRAslpenvennfsklGTTVVLCMVTFLYACINIFCWSavqln-ladhDlVE 348 zebrafish
Q5GH21        257 SALKAWVAAVALANLLALFLlpWVKFWSSGDslpqnieknfswfGTVTVLGSVTLLYSAINMFCWSavqln-lsdrDlID 335 tropical clawe...
XP_005992052  260 TALKIWILPVVLVNMLTLFFlpWVRFWRSKAsfpenieknfskvGTTVVLSMVIFLYASINMFCYSavqln-lsdrDlID 338
XP_002719876  231 SVLKTWVVAVILLNFFSFFLypWILFWCSGSpfpeniekalsrvGTTIVLCFLTLLYTGINMFCWSavqlk-idnpElIS 309
XP_001514150  231 SVLQIWILPVVLLNFFGFFFypWILYWHSRSpfpenvekamsrvGTSVVLFLLTFLYAGINMFCWSavqlkindpdL-IN 309
XP_029702972  262 TALTHWVILVGMANLLFFFFlpWAEFWAKKGsltqgvernfsnfGTVVVLTLFTLLYACINVFCWSavqld-fthrElIQ 340 torafugu
7P14_A        280 GQNTKCPMSCYYTVRVLGTLGILTVfwiyplsifnsdyfipISATIVLSLLFGIIFLGVYYGTYHP 345 Norway rat
XP_004073149  345 KRQNWFQLAMYYSGRFVENLLLITLwyffksdfyeyvcaplLAVQLLICYSLAVLFMLLFYEFCHP 410
XP_003445258  344 KRQQWGRLAMYYCGRFVENFLLITLwyffksdfyeyvcaplLVVQLLVCYSLAVLFMLLFYQFFHP 409
13_pfamImport 306 RKQQWGRLAAYYAARFLENFLLIGLwylfksdfyeyvcaplLAVQLLILYGLALLFMLLFYQFCHP 371
Q5U3R0        349 KQPRWRSLAVYYTLRFVENVTLIVLwyyfksdfyeyvctplLVVQLIVCYTLAVLFMLLFHQFCHP 414 zebrafish
Q5GH21        336 QSQNWGRLSLHYTIRLLENAALILLwyfykedvfeyfcsplLVVQLLVGYATAIFFMLLFYQYLHP 401 tropical clawed frog
XP_005992052  339 KAQNWGRLALYYTVRLLENTGLILLwyffqtdvhenictplLVLQLLAAYCLAIFFMLIFYQYCHP 404
XP_002719876  310 KSQNWYRLLVYYMMRFIENATLLLLwyffktdiymyvcaplLVLQLLVGYCTAILFMLVFYQFFHP 375
XP_001514150  310 KSQNWHVMAVYYLLRFVENAFLLLMwyifrtdiymyvcapmLIVQLLVAYCLAILFMLGFYQFCHP 375
XP_029702972  341 RKQGWGRLALYYCGRFVENLVLITLwyfyksdfyekvctplLVVQLLICYSLSVLFMLLFYQFCHP 406 torafugu
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