Conserved Protein Domain Family
HECT_2

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pfam09814: HECT_2 
HECT-like Ubiquitin-conjugating enzyme (E2)-binding
HECT_2 is a family of UbcH10-binding proteins.
Statistics
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PSSM-Id: 401681
View PSSM: pfam09814
Aligned: 98 rows
Threshold Bit Score: 148.693
Threshold Setting Gi: 0
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EEH04717             14 ELLPNIRQITLHVSLPASSrlaqssitsdtpgdlvrgnfslsllpsrdavslysshtvhtlplpacvsesahtilstklt 93  Histopla...
XP_001847825         12 ELRPRLQSANFFICFSRRFveikstkidlapdritistenndeqye---------------------irlgdffklhtqt 70  southern...
Q16XY0               12 ELRPRLQSANFFICFSRRFaeikttkidlgsdritistennderye---------------------irlgdyfklhtqt 70  yellow f...
WGS:AAPP:GF19245-PA   9 ELRPNLRSGVVFLQFDHDIgtcnqtrlvirehnvyisegpvktstprsdsdseee--yheedeenslvirhdcfgmdigc 86  Drosophi...
Q9VWP0                9 ELRPNLRSGVVFLRFDQQVsqsqktrvvvrdynvyisekpknqaidldsssesd-----sedsdklmlirhaqygmdivc 83  fruit fly
EDV95222              9 EFRPNLCCGQICLQFDEPIrnckntrliinngdmfflengnsefv-----------------------lrhdswdmditq 65  Drosophi...
XP_002010793          9 ELRPNLSSGHVFLQFDQEIrgrkktrliikehdvhivengqnsggsq-------------------lvlrhdtfgmdiqr 69  Drosophi...
XP_002054975          9 ELRPNLSSGHVFLQFDQEIrdrqktrliikehdvhivengtdstese-------------------lvlrhdsfgmdiqr 69  Drosophi...
Q29GF2                7 EIRPYLNCGQVYIQLHRNdasnmrvvileqriyiddadrgtgksid-------------------teimrvnefdmdlss 67  Drosophi...
WGS:AAQB:GK19715-PB   9 ELRPNLRCGNAYLQFNRQLredgrktriilkehnvhimedddennl---------------------viryncfgmdiqg 67  Drosophi...
EEH04717             94 pnppgaghgellfRLPVDVEAGLPGASQPANGQPGHGs--nEVQVPWTAKDMCA-----E-SRVRCQRCKNTLFTP-SDK 164 Histopla...
XP_001847825         71 lsslliknnyicfRI-----NTNENKFHSEVLEINEYnactDL-------KLECrlekgVnYTVTCSNCGNDLHEQpVAF 138 southern...
Q16XY0               71 lsslliknnyicfRI-----NTNENKFHSEVLEINEYnactDL-------KLECglqagKgYRLMCSNCGNPLKDEtVSF 138 yellow f...
WGS:AAPP:GF19245-PA  87 isvfvvtgshisfRF-----NYSQ--IDLDALDAGSVqv-aME-----PLLLSCre--dDpFALTCRNCSAELVEN-RGY 150 Drosophi...
Q9VWP0               84 lstflvsgrnisfRF-----NYNQ--IDLASVDGSAVdv-pLA-----PLLLSCqe--nEpITINCRDCRAELVAG-RSY 147 fruit fly
EDV95222             66 lslfnasgchitfRF-----NYTK--IDLIKLFKIGSgpkvSH---LMPLELSFve-kkDhLTLHCNKCLYELAPG-CNY 133 Drosophi...
XP_002010793         70 isvfiangchisfRF-----NYTT--LDVEALENSIAvpmkAQ-----PLVLGFeehseQlVALHCNNCRSELVPG-CSY 136 Drosophi...
XP_002054975         70 isvfivngchisfRF-----NYTT--IDLEALENCVGlpmaPQ-----PLLLSFae-rtQtVSLHCSNCHNQLVPG-CSY 135 Drosophi...
Q29GF2               68 lsgfllsgknmsfRFSFNR-------IAVAVLDKRTVrv-pMQ-----PLLLSCce--nEsLAIQCVGCQAEVAPR-RIY 131 Drosophi...
WGS:AAQB:GK19715-PB  68 isiftvsgnhltfRFNYTKIDMDALEQNTV-------------QVDMQPLVMACre-neE-FSLICHNCGNELAES-TVY 131 Drosophi...
EEH04717            165 GKvtWKDLPSTDWAEmmDLWHCHKPDTHADdhgdaavgtvlhthdeNETVKG--YGAsn--------qVVCTSGTVLIDV 234 Histopla...
XP_001847825        139 KR--ILELPSDHMDS--NEWYCHRHDt------------------pETHTEGecSSKsssaasphpnsFTPAETDLFYGP 196 southern...
Q16XY0              139 RR--ILELPSDHMDS--NEWYCHQHPhgeg-------------ktdDTHAHAecSSSstkap--hpnkFSPTEVDLFYGP 199 yellow f...
WGS:AAPP:GF19245-PA 151 RR--LREFPSCVVDP--GEFFCHNHGsgcds---------------------------------kppsLVPAETDLFYGL 193 Drosophi...
Q9VWP0              148 RR--LREFPSLLVDP--TEFFCHNHGpagkt---------------------------------qpisLVPAETDLFYGL 190 fruit fly
EDV95222            134 NR--LRELPSGLFDA--SEFFCHSHGtsgqeq-------------------------------ptssvLVPRATQIYYGL 178 Drosophi...
XP_002010793        137 NR--LRECPSGLIDP--SEFFCHNHGpadk----------------------------------paatLVPGPKDLYYGL 178 Drosophi...
XP_002054975        136 SR--LREFPSGIIDP--SEFFCHNHGtvtk-----------------------------------patLVPRRDDLYYGL 176 Drosophi...
Q29GF2              132 TR--LREFPNCIVDP--NEFFCHGHG----------------------------HDHghghgqdrpqsLLPGEKDLFYGL 179 Drosophi...
WGS:AAQB:GK19715-PB 132 KR--LREFPSCIVDP--SDFFCHNHGSAAE-------------------------SHqd--------vLVPPERDLFYGL 174 Drosophi...
EEH04717            235 LSFVMAEGDCQGlqkskiagnprkgfrasdylvlsptaaqsimmkearkwenrgpnqmsgssirseilplsstsrhigng 314 Histopla...
XP_001847825        197 FYAVLNCQHLQRvh------------------------------------------------------------------ 210 southern...
Q16XY0              200 FYALLDRKHLERvh------------------------------------------------------------------ 213 yellow f...
WGS:AAPP:GF19245-PA 194 NYVVVSLSQTNPni------------------------------------------------------------------ 207 Drosophi...
Q9VWP0              191 NYVVINFNEESScm------------------------------------------------------------------ 204 fruit fly
EDV95222            179 NYIVLNMCVVQNri------------------------------------------------------------------ 192 Drosophi...
XP_002010793        179 NYIVLNMSVLQDri------------------------------------------------------------------ 192 Drosophi...
XP_002054975        177 NHVVLNMTAVEAqv------------------------------------------------------------------ 190 Drosophi...
Q29GF2              180 NNVIIRMVNLAKiv------------------------------------------------------------------ 193 Drosophi...
WGS:AAQB:GK19715-PB 175 NFIVVNIFKIKGvm------------------------------------------------------------------ 188 Drosophi...
EEH04717            315 nqpanetkfqPVVDLSCSRCSAVVGEEHK--AfsgLRLYKANVSLLRKPKdginsd---hdvwetYPVDMIVGTQLLDLV 389 Histopla...
XP_001847825        211 --------lrADRFLYCKCCLQFLGVAKRngS---VKLWYENLKFLKPDEheqeh-----vnpasLFRTDDALLNFQYLV 274 southern...
Q16XY0              214 --------lrAERFLYCKRCLQFLGTMKRngS---AKLWYENVRFKSVGEdqsdel---nptgqsLFCVDQSLPNFQYLV 279 yellow f...
WGS:AAPP:GF19245-PA 208 --------liREDHLYCRRCMRFLGLAIFngAa--ARLWADAVSWLPSGGgsts-------lprhFFKSSSLTQLVKRLL 270 Drosophi...
Q9VWP0              205 --------lnRDDHLYCQRCMRYLGLTMFdgAa--ARIWADAVRWRPAGAatna-------pdrhFFQNSTLTQLFKRLL 267 fruit fly
EDV95222            193 --------snISGNLYCKRCMRMLGSSIEsgAa--AKLWADALRWLPLSSlnangndrasaltrlLFKHATVTHLMIRLL 262 Drosophi...
XP_002010793        193 --------mnRADHLYCKRCMWMLGLSTQagAa--AKLWADALRWLPQPTdatapk----lqprqLFKHSTVTQLMLRLL 258 Drosophi...
XP_002054975        191 --------inRSEHLYCKRCMWMLGLTIEsgSa--AKLWADALRWLPSAVktedat---qqeprqLFKYSTVTQLLLRLL 257 Drosophi...
Q29GF2              194 ---------rRGEHLHCQRCMRFLGMAIFngEa--ARLWADTVRWLPSAQksdglp----pairhFFQFSTMTELVLRLL 258 Drosophi...
WGS:AAQB:GK19715-PB 189 ---------nrGGQLYCQRCLGLVGNTVL--NdkaAKLWADAVRYLPTSLditq--------krhLFQHPSVTQVMKRLL 249 Drosophi...
EEH04717            390 ERV-------------GARRFAVHSAEYtdtssrdnKIGLLLWVFNPDLRYSsllld----------------------- 433 Histopla...
XP_001847825        275 RKTvndynfishlglpPIFKIIFEMRRPgqd---geLFYLLMQIMDANLNVFkirkgvdaedsssasddpse-skeaatd 350 southern...
Q16XY0              280 RKTvndfnfishlglpPIFKLIFEMRRPgld---gdVFYLLMQIMDANLNVFkirkdldadssasddqteerqakegvde 356 yellow f...
WGS:AAPP:GF19245-PA 271 HSLwpqplp--qlclsTSRAALVTSMPNr------cHRYMLIHVVESQLRVLrrv------------------------- 317 Drosophi...
Q9VWP0              268 HSLwpqplp--qlclnTSRAVLVTSLPNr------nQQYMFLHVVESQLRVLrri------------------------- 314 fruit fly
EDV95222            263 SSLwplagt--qfsphGKRAILTTTMPDg------hDHYMLIQVRETQLAILrri------------------------- 309 Drosophi...
XP_002010793        259 STLwptllp-plfspaNSRAVLVASMPDr------qQHHMLIQVLEPQLTVLrrt------------------------- 306 Drosophi...
XP_002054975        258 NDLwptf------cpgNSRALLVANMPDr------hQHYMLIQVLDPQLSVLrrt------------------------- 300 Drosophi...
Q29GF2              259 NSLwphvlp--sinltGSRAVLYASPTSq------qKQYMLIRVVEPQLRVLrri------------------------- 305 Drosophi...
WGS:AAQB:GK19715-PB 250 HTLwpqsls--plcptKNRALLFTTLPNr------qQQSILIHIVDSQLRVLrri------------------------- 296 Drosophi...
EEH04717            434 --------sttdKV------ASITSQRAMKILYQ---EVQDVQSMlnpa----qgvPSPAALEEVSLPPNIYDGVKQTLE 492 Histopla...
XP_001847825        351 eddddddvftpsPKrpikrnIHVDRHRTMKVMYRydqFDQQPIFNf---------wLQDSNVVSVEISEQMFRAAVRYLD 421 southern...
Q16XY0              357 eddeddevfvptQKth--rnIHLDRHRVMKVMYRyekFEQQPIINf---------wLQDYNVVSVEISEQMFKTAIRYLD 425 yellow f...
WGS:AAPP:GF19245-PA 318 ----------qpHS------NKLRCYRACKLYFGlfgSSSSQEQPelm-----qqwQTEQTLPQMEISPDMFQALQERLE 376 Drosophi...
Q9VWP0              315 ----------rpNS------NRLRCFRACKLYYGvfgAN-----Ppll-----ekwQAQQTLPQMDVSPNMFLKIQKRLE 368 fruit fly
EDV95222            310 ----------pnDEy----lDKGCFHRACKLYFRdygSCHFD--RqwleqwmqqqeQQQQYVPKLSISPYLYAELLKRFD 373 Drosophi...
XP_002010793        307 ----------vsET------EQLQHYRACKLYFRvfgSCPPD--Apvl-----tqwQQQIEVPKMHISPHMFLELQARFD 363 Drosophi...
XP_002054975        301 ----------gsETpkctdpQQLQHSRACKLYFRvfgSCQQD--Pttl-----iqwQEQMQVPKMTISPYMFLELQARLN 363 Drosophi...
Q29GF2              306 ----------sgKA------PVLRGYYAIKLSYGiyeDCHEEP-Pdil-----qrwQAHQDVSQFEISPKMFMELRQRLD 363 Drosophi...
WGS:AAQB:GK19715-PB 297 ----------qpNN------PDLQCFFACKMYFGinrHDQQIPESvpk------pwQSDHSLPQMEISPRMFQELHTQLT 354 Drosophi...
EEH04717            493 RTSEALPISAR 503 Histoplasma capsulatum G186AR
XP_001847825        422 DNSDYVPECYR 432 southern house mosquito
Q16XY0              426 SNSDYVPECYR 436 yellow fever mosquito
WGS:AAPP:GF19245-PA 377 ANSQLIPLAWR 387 Drosophila ananassae
Q9VWP0              369 TNGHLIPDALS 379 fruit fly
EDV95222            374 DNMSLIPKRLR 384 Drosophila grimshawi
XP_002010793        364 YNSALIPHAWR 374 Drosophila mojavensis
XP_002054975        364 CNSMLIPHAWR 374 Drosophila virilis
Q29GF2              364 RNAEYQPMEWR 374 Drosophila pseudoobscura
WGS:AAQB:GK19715-PB 355 TNSQLVPYAWR 365 Drosophila willistoni
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