Conserved Protein Domain Family
HECT_2

?
pfam09814: HECT_2 (This model is not part of the current CDD release)
HECT-like Ubiquitin-conjugating enzyme (E2)-binding
HECT_2 is a family of UbcH10-binding proteins.
Statistics
?
PSSM-Id: 519080
Aligned: 88 rows
Threshold Bit Score: 168.41
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_045285198         14 ELLPNIRQITLHVSLPASSrlaqssitsdtpgdlvrgnfslsllpsrdaVSLYSSH-----------TVHTLPLPA-CVS 81 
XP_011067566          7 ELRPRLQSCNVFISMRKDLcl--------------------------knVRIKLLEstiv-------------------- 40 
XP_011150266          7 ELRPRLQSCNAFIAMRKDLdl--------------------------kdVQVKLSEsnia-------------------- 40 
XP_001847825         12 ELRPRLQSANFFICFSRRFvei-------------------------ksTKIDLAPdriti------------------- 47 
WGS:AAQB:GK19715-PB   9 ELRPNLRCGNAYLQFNRQLred------------------------grkTRIILKEhnvhimedddeNNLVIRYNCfGMD 64 
XP_001995570          9 EFRPNLCCGQICLQFDEPIrnc-------------------------knTRLIINNgdmf-------------------- 43 
XP_002010793          9 ELRPNLSSGHVFLQFDQEIrgr-------------------------kkTRLIIKEhdvhiv------------------ 45 
XP_002054975          9 ELRPNLSSGHVFLQFDQEIrdr-------------------------qkTRLIIKEhdvhiv------------------ 45 
XP_001966859          9 ELRPNLRSGVVFLQFDHDIgtc-------------------------nqTRLVIREhnvyi-segpvKTSTPRSDS-DSE 61 
Q9VWP0                9 ELRPNLRSGVVFLRFDQQVsqs-------------------------qkTRVVVRDynvy----iseKPKNQAIDL-DSS 58  fruit fly
XP_045285198         82 ES-----AHTIlstkltpn--------ppgaghgELLFRLPVDVEAGLPGASQPANgqpgHgs--neVQVPWTAKDMCA- 145
XP_011067566         41 ----livEDCStsfslpsvkviptslsmlnimnnWICFRLQTVPLESTFGSFSTEVmtnlNklvqsnT----HSQSIVNd 112
XP_011150266         41 ----lvlKDHNmdfslpfikivptslsmlsirnnWICFRLQMMPLNSVFGSFSVEVltdsNksaqltC-----SQPILEd 111
XP_001847825         48 --stennDEQYeirlgdffklhtqtlsslliknnYICFRI-----NTNENKFHSEVleinEynactdL-------KLECr 113
WGS:AAQB:GK19715-PB  65 IQ-----GISIftv-----------------sgnHLTFRFNYTKIDMDALEQNTV-------------QVDMQPLVMACr 109
XP_001995570         44 ---flenGNSEfvlrhdswdmditqlslfnasgcHITFRF-----NYTK--IDLIKlfkiGsgpkvsH---LMPLELSFv 110
XP_002010793         46 -engqnsGGSQlvlrhdtfgmdiqrisvfiangcHISFRF-----NYTT--LDVEAlensIavpmkaQ-----PLVLGFe 112
XP_002054975         46 -engtdsTESElvlrhdsfgmdiqrisvfivngcHISFRF-----NYTT--IDLEAlencVglpmapQ-----PLLLSFa 112
XP_001966859         62 EEyheedEENSlvirhdcfgmdigcisvfvvtgsHISFRF-----NYSQ--IDLDAldagSvqv-amE-----PLLLSCr 128
Q9VWP0               59 SEsdsedSDKLmlirhaqygmdivclstflvsgrNISFRF-----NYNQ--IDLASvdgsAvdv-plA-----PLLLSCq 125 fruit fly
XP_045285198        146 -------E-SRVRCQRCKNTLFTP-SDKGKvtWKDLPSTDWAEmmDLWHCHKPDTHADdhgdaavgtvlhthdenETVKG 216
XP_011067566        113 ikllfetSkCTILCTCCKNVISKL-ISFKR--FLPLPDAEYDP--DEWFCCKHScnsv---------------------- 165
XP_011150266        112 ikllfkaSeCIVLCACCKNVISKP-TTFKR--ALPLPDIQCSP--DEWFCCKHSsnd----------------------- 163
XP_001847825        114 le---kgVnYTVTCSNCGNDLHEQpVAFKR--ILELPSDHMDS--NEWYCHRHDtp------------------eTHTEG 168
WGS:AAQB:GK19715-PB 110 e----neE-FSLICHNCGNELAES-TVYKR--LREFPSCIVDP--SDFFCHNHGSAAE---------------------- 157
XP_001995570        111 e----kkDhLTLHCNKCLYELAPG-CNYNR--LRELPSGLFDA--SEFFCHSHGtsgqeq-------------------- 161
XP_002010793        113 eh---seQlVALHCNNCRSELVPG-CSYNR--LRECPSGLIDP--SEFFCHNHGpadk---------------------- 162
XP_002054975        113 e----rtQtVSLHCSNCHNQLVPG-CSYSR--LREFPSGIIDP--SEFFCHNHGtvtk---------------------- 161
XP_001966859        129 e-----dDpFALTCRNCSAELVEN-RGYRR--LREFPSCVVDP--GEFFCHNHGsgcds--------------------- 177
Q9VWP0              126 e-----nEpITINCRDCRAELVAG-RSYRR--LREFPSLLVDP--TEFFCHNHGpagkt--------------------- 174 fruit fly
XP_045285198        217 --YGAsn--------qVVCTSGTVLIDVLSFVMAEGDCQGlqkskiagnprkgfrasdylvlsptaaqsimmkearkwen 286
XP_011067566        166 -------------lnsVQPQESDYLYGSCFSVLHKSIFASnv-------------------------------------- 194
XP_011150266        164 -------------ivnIETQKSDYLYGSYFALLHKNIFINnl-------------------------------------- 192
XP_001847825        169 ecSSKsssaasphpnsFTPAETDLFYGPFYAVLNRQHLQRvh-------------------------------------- 210
WGS:AAQB:GK19715-PB 158 ---SHqd--------vLVPPERDLFYGLNFIVVNIFKIKGvm-------------------------------------- 188
XP_001995570        162 -----------ptssvLVPRATQIYYGLNYIVLNMCVVQNri-------------------------------------- 192
XP_002010793        163 ------------paatLVPGPKDLYYGLNYIVLNMSVLQDri-------------------------------------- 192
XP_002054975        162 -------------patLVPRRDDLYYGLNHVVLNMTAVEAqv-------------------------------------- 190
XP_001966859        178 ------------kppsLVPAETDLFYGLNYVVVSLSQTNPni-------------------------------------- 207
Q9VWP0              175 ------------qpisLVPAETDLFYGLNYVVINFNEESScm-------------------------------------- 204 fruit fly
XP_045285198        287 rgpnqmsgssirseilplsstsrhigngnqpanetkfqPVVDLSCSRCSAVVGEEHK--AfsgLRLYKANVSLLRKPKdg 364
XP_011067566        195 ------------------------------------ctDNKTLSCNKCLLHIGTFHAynL---FKIWNCCIDYKPENStl 235
XP_011150266        193 ------------------------------------riDNKTLTCDKCFLHIGALYScnL---LKLWNCCVDYKPQDDtl 233
XP_001847825        211 ------------------------------------lrADRFLYCKCCLQFLGVAKRngS---VKLWYENLQFLKPDEhe 251
WGS:AAQB:GK19715-PB 189 -------------------------------------nrGGQLYCQRCLGLVGNTVL--NdkaAKLWADAVRYLPTSLdi 229
XP_001995570        193 ------------------------------------snISGNLYCKRCMRMLGSSIEsgAa--AKLWADALRWLPLSSln 234
XP_002010793        193 ------------------------------------mnRADHLYCKRCMWMLGLSTQagAa--AKLWADALRWLPQPTda 234
XP_002054975        191 ------------------------------------inRSEHLYCKRCMWMLGLTIEsgSa--AKLWADALRWLPSAVkt 232
XP_001966859        208 ------------------------------------liREDHLYCRRCMRFLGLAIFngAa--ARLWADAVSWLPSGGgs 249
Q9VWP0              205 ------------------------------------lnRDDHLYCQRCMRYLGLTMFdgAa--ARIWADAVRWRPAGAat 246 fruit fly
XP_045285198        365 insd---hdvwetYPVDMIVGTQLLDLVERV-------------GARRFAVHSAEYtdtssrdnkiGLLLWVFNPDLRYS 428
XP_011067566        236 ------------sITNATNPLSDFLILIKSSls---------eiLNEEVILQTSVGkq------thRLLIKPMDYKLNLI 288
XP_011150266        234 ------------sIVNATNPLDDFLIFIKDSlt---------niLGEEIILQTSIGkq------thYLLIKPMDRELNLI 286
XP_001847825        252 qeh-----vnpasLFRTDDALLNFQYLVRKTvndynfishlglpPIFKIIFEMRRPghdg---elfYLLMQIMDANLNVF 323
WGS:AAQB:GK19715-PB 230 tq--------krhLFQHPSVTQVMKRLLHTLwpqsls--plcptKNRALLFTTLPNrq------qqSILIHIVDSQLRVL 293
XP_001995570        235 angndrasaltrlLFKHATVTHLMIRLLSSLwplagt--qfsphGKRAILTTTMPDgh------dhYMLIQVRETQLAIL 306
XP_002010793        235 tapk----lqprqLFKHSTVTQLMLRLLSTLwptllp-plfspaNSRAVLVASMPDrq------qhHMLIQVLEPQLTVL 303
XP_002054975        233 edat---qqeprqLFKYSTVTQLLLRLLNDLwptf------cpgNSRALLVANMPDrh------qhYMLIQVLDPQLSVL 297
XP_001966859        250 ts-------lprhFFKSSSLTQLVKRLLHSLwpqplp--qlclsTSRAALVTSMPNrc------hrYMLIHVVESQLRVL 314
Q9VWP0              247 na-------pdrhFFQNSTLTQLFKRLLHSLwpqplp--qlclnTSRAVLVTSLPNrn------qqYMFLHVVESQLRVL 311 fruit fly
XP_045285198        429 sllld------------------------------sttdKV------ASITSQRAMKILYQ---EVQDvqsmln--paqg 467
XP_011067566        289 tep----------------------------------dhVTicdtdtISLQQKYAAKVLYKyekNKEIti---------- 324
XP_011150266        287 tep----------------------------------yhQIintdapISLQQKCVAKVLYKydtSKIAn----------- 321
XP_001847825        324 kirkgvdaedsssasddpseskeaatdeddddddvftpsPKrpikrnIHVYRHRTMKVMYRydqFDQQpif-------nf 396
WGS:AAQB:GK19715-PB 294 rri----------------------------------qpNN------PDLQCFFACKMYFGinrHDQQipesv----pkp 329
XP_001995570        307 rri----------------------------------pnDEy----lDKGCFHRACKLYFRdygSCHFdrqwleqwmqqq 348
XP_002010793        304 rrt----------------------------------vsET------EQLQHYRACKLYFRvfgSCPPdapv-----ltq 338
XP_002054975        298 rrt----------------------------------gsETpkctdpQQLQHSRACKLYFRvfgSCQQdptt-----liq 338
XP_001966859        315 rrv----------------------------------qpHS------NKLRCYRACKLYFGlfgSSSSqeqpe---lmqq 351
Q9VWP0              312 rri----------------------------------rpNS------NRLRCFRACKLYYGvfgANppll--------ek 343 fruit fly
XP_045285198        468 vPSPAALEEVSLPPNIYDGVKQTLERTSEALPISARLVLrPGPI 511
XP_011067566        325 iTNYLNVKYHDVGLPLIEAGLNYLLSSTKRLPHVYRTAAiDYFL 368
XP_011150266        322 tNNHWNVEYHEVSLPMIEAGLKHLLSSTERLPHNNRNIA-DYFL 364
XP_001847825        397 wLQDSNVVSVEISEQMFRAAVRYLDDNSDYVPECYRNNL-GFSL 439
WGS:AAQB:GK19715-PB 330 wQSDHSLPQMEISPRMFQELHTQLTTNSQLVPYAWRFNTaEEKL 373
XP_001995570        349 eQQQQYVPKLSISPYLYAELLKRFDDNMSLIPKRLRYNNfEEKL 392
XP_002010793        339 wQQQIEVPKMHISPHMFLELQARFDYNSALIPHAWRYNSeEEKL 382
XP_002054975        339 wQEQMQVPKMTISPYMFLELQARLNCNSMLIPHAWRYNTaEEKL 382
XP_001966859        352 wQTEQTLPQMEISPDMFQALQERLEANSQLIPLAWRFNApDQQL 395
Q9VWP0              344 wQAQQTLPQMDVSPNMFLKIQKRLETNGHLIPDALSTNCaEEHL 387 fruit fly
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap