Conserved Protein Domain Family
Exo5

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pfam09810: Exo5 (490651 is an unknown moldel)
Exonuclease V - a 5' deoxyribonuclease
Exonuclease V is a monomeric 5' deoxyribonuclease that is localized in the nucleus. It degrades single-stranded, but not double-stranded, DNA from the 5'-end, and the products are dinucleotides, except the 3'-terminal tri- and tetranucleotides, which are not degraded. The initial hydrolytic cut of exonuclease V on the dephosphorylated substrate produces a mixture of dinucleoside monophosphates and trinucleoside diphosphates. The enzyme is processive in action. Exo5 is specific for single-stranded DNA and does not hydrolyze RNA. However, Exo5 has the capacity to slide across 5' double-stranded DNA or 5' RNA sequences and resume cutting two nucleotides downstream of the double-stranded-to-single-stranded junction or RNA-to-DNA junction, respectively.
Statistics
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PSSM-Id: 490651
Aligned: 61 rows
Threshold Bit Score: 237.174
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q5BFF0        187 SPVERF-RRPPNKAFSVTDLISPAWCEVQYWYTLTKh----GRKQRTAAMKKGSTIHKTLEDEI---Y----------TT 248  Aspergillus n...
XP_011127614  281 SPLDRWrKRGSNTKLSVSDLLCNMWCEQQYHYTLLR-----GFKRRTAEMQAGTKIHREMEEEV---H----------TI 342 
EPS42027      263 SPLDRWrSKAGLSKLSVSDLLSNMWCEQQHHYTLLR-----GFKRRTAEMQAGTKIHREIEEEI---H----------TV 324 
XP_002173998   79 nlyeMF-RSD-RGYLKVTDMVAPLWCGVQHSYALLD-----RVERKTPAMEKGTIIHLKLELETtppK----------ER 141 
XP_013021104   63 tlydlF-RKR-RGYLNVTDLVSPLWCEVQQDYYLTK-----KIKKTSPQMIKGSSVHQHLEYETtppT----------DR 125 
Q9Y7L4         63 SLFQLF-RKH-KGYLNVTDLVLPLWCEVQHEYYLLR-----RIKKKTPKMERGIKLHQILEYETsppS----------ER 125  Schizosacchar...
Q6CHE7         71 lQLKAL-KNPGSNRVSVTAASAP-FCEVRTLYELAEva--vEEEKPTNAMERGAQVHNMAEYSL---Y----------EA 133  Yarrowia lipo...
XP_002141959   49 vPIQKY-RD--KSQIGVTTLSRQIWCEKSLELSLEY-----DVIASSKAIDEGVRHHEILELQD---H----------DI 107 
XP_003674688  106 spfidthKSQGINRLSVTKLLTKSWCELRFTYDMYAqaglqIQPPPDKFLTSGTSIHGSLETAL---Hpgl--------- 173 
A7TMJ6        113 nsdgngeneKVRNRLSVTKLLTKRWCELREAYDIYSe----TPLFEHKQIIEGKLVHQKLEEDI---HpvtedlesfvED 185  Vanderwaltozy...
Q5BFF0        249 VPVEV-----TTKEDALALRIWNVIQGLRTLRE-------------FGITRELEIWGL-------V-DG-----E----L 293  Aspergillus n...
XP_011127614  343 VPVTV-----KTSHDKWGLRIWNMIQGLESLRA-------------TGLTRELEVWGW-------I-DG-----V----F 387 
EPS42027      325 VPVTV-----KSRHDKWGLRIWNMIQGMESLRT-------------VGLTRELEVWGW-------I-DG-----V----F 369 
XP_002173998  142 VRTDE-----TLAEEPWALHILLQLDGLLLLTK-------------NGITREFPIWGF-------YkDS----------L 186 
XP_013021104  126 ILLNK-----TSKEEPWALKILKQIEGLQQLYL-------------NGITREFPIWGL-------YkDS----------F 170 
Q9Y7L4        126 RVLDR-----TSKEEPWALRLLRQLEGIMLLQK-------------NGITREFPIWGY-------YkES----------S 170  Schizosacchar...
Q6CHE7        134 TEVSLpvppaTTPTEEWYQKLMNMYLKLSMLRTdsapavnelemspTFMAREIPVFGN-------Y-KN-----T----R 196  Yarrowia lipo...
XP_002141959  108 IDVIV-----ETSIEKLGLELLSIANLLEALYE-------------RGYVRELPIIGF-------H-KD-----I----M 152 
XP_003674688  174 --------ldWNLEHDLFDVWFDSLLKMANLFQ-------------GGQCREIIAHGYvnsndltLlDGdmdvtDeddvL 232 
A7TMJ6        186 FEVPIp----TDNFHNHVDDLFSCSMRLLSLFR-------------CGEAREVRCHAFldsrtgtFiDGlp--kDgkdvL 246  Vanderwaltozy...
Q5BFF0        294 VNGVIDQL---CYECPDM----ELEASAAS-----------------------------------------------YYA 319  Aspergillus n...
XP_011127614  388 INGVIDEV---NFKKFERdr-dDKENGAVGrvgdrgeakevslpenvteamitgaapmeekagdiletpkkkrgrprKTP 463 
EPS42027      370 INGVIDEV---NFTKFRNeardEKENQKVEdiddkaeelevalakndpdtii---tvvgesskeipetpkkkrgrpkKNP 443 
XP_002173998  187 LFGIIDELtvlKTEKDDN-------------------------------------------------------------- 204 
XP_013021104  171 VVGIIDEI---SLAQQGT-------------------------------------------------------------- 185 
Q9Y7L4        171 IFGIIDEI---SLNNPSK-------------------------------------------------------------- 185  Schizosacchar...
Q6CHE7        197 LFGIMDLI---YWRNK---------------------------------------------------------------- 209  Yarrowia lipo...
XP_002141959  153 LRGIIDSL---KLIHNNNl--eMLDSLNFNnynsk--------------------------------------------- 182 
XP_003674688  233 ISGVIDHL---TLRGKDVrl-------------------------------------------------------fpDVN 254 
A7TMJ6        247 VSGIIDHL---SLRRKIRvftssgftef----------------------------------------nglndevfeNGN 283  Vanderwaltozy...
Q5BFF0        320 EAAASRAVLPEYQMSLTDYLLSPAqggkrladmsrhevepqaaedpvssqstaeLQQLPRIYLTDIKTRGsnS--TPTvk 397  Aspergillus n...
XP_011127614  464 EPTSPAPKTPKQQKTILDFITPSPkk---------------------------tRSKGQPAYVLDLKTRA--SarIPEpg 514 
EPS42027      444 DPVSPEPATPKQQSSILDFITPSPkk---------------------------sRSKGKPAYVLDLKTRF--SsrIPEsg 494 
XP_002173998  205 -----------------------------------------------------------LLSMKDNKTRG--TitIPS-- 221 
XP_013021104  186 --------STKEHSDIRDFWLP----------------------------------GTRNIYFTDNKTRF--SnaKPS-- 219 
Q9Y7L4        186 ---------SNFNSDIRNYFNF----------------------------------KMYDLSFVDNKTRF--SsrKPG-- 218  Schizosacchar...
Q6CHE7        210 -----------------------------------------------------------KLNICDMKTTY--RrsVPE-- 226  Yarrowia lipo...
XP_002141959  183 ------------------------------------------------------miqkyEVLITDTKTRR--KpsTPS-- 204 
XP_003674688  255 DIGALLMELDKHRELIKGDT---------------------------------------NILVSDVKTRS--InrLPTq- 292 
A7TMJ6        284 NFQSIIEWLNANIDFLKSEY---------------------------------------QINVSDVKTRM--FrsVVSq- 321  Vanderwaltozy...
Q5BFF0        398 SSSFRPTLLQLQLYYHMLNRLVLtd---------dVT-----------------------IELLASRY-------GLDPE 438  Aspergillus n...
XP_011127614  515 SSQSLSVHIQLMLYRQLLNDMIR------------AT-----------------------PKSMVKKLck---hhDLPAD 556 
EPS42027      495 SSQSKSVHIQLMLYRQLLNYMIK------------AT-----------------------PKSMVRRLcl---qqDIPAD 536 
XP_002173998  222 QSQILGSELQLMYYYHLFQEYFQnad--------------------------------swWDSFLKQQ-------DLDGK 262 
XP_013021104  220 ISQVFQSKIQVMYYAHLFLHYFPs-----------LNikstqplyatqkddnqmklekpwMDSFLNSL-------NLDGS 281 
Q9Y7L4        219 ASQILSSKVQLMYYVHLFLNYFPslgekqqsifrdISptysnrl----------hsqshwWNMFLSQL-------SLDGT 281  Schizosacchar...
Q6CHE7        227 EPQMTSHIHQTMLYHYLFSDMCR-------------D-----------------------IDATMGEYlrddiciDTDVR 270  Yarrowia lipo...
XP_002141959  205 IPQQKTTVFQLGLYKLLLNRMRLaglewknkhscnINfsesydln-------eccegckfLYKLFEFN-------KVDYM 270 
XP_003674688  293 GTVLKATKLQLMYYKFFLKSFG-------------LN-----------------------QESTYKKLlvnaqrrGIDVD 336 
A7TMJ6        322 KSVLKYSKYQVMYYRYFLELLG-------------LH-----------------------PDVTYGQLlnsslsrGFNID 365  Vanderwaltozy...
Q5BFF0        439 KTF-----------TDAFICE-VGSLN---DQFFDALsslefdpdyiptpedaitrqqmsq------------------- 484  Aspergillus n...
XP_011127614  557 EPF-----------SDDLIAG-LAGNGnetQPGSDEL------------------------------------------- 581 
EPS42027      537 EPF-----------SDDMIAE-LAGLDngtEPGSDDL------------------------------------------- 561 
XP_002173998  263 KNL-----------GQNFLKQaIETLPsidP------------------------------------------------- 282 
XP_013021104  282 KDL-----------GTEFLEQsIRTIPtipE------------------------------------------------- 301 
Q9Y7L4        282 KDL-----------GPKFLEQsILSIPdipE------------------------------------------------- 301  Schizosacchar...
Q6CHE7        271 SEF-----------SAAYEGQsgpa------------------------------------------------------- 284  Yarrowia lipo...
XP_002141959  271 IQF-----------NE------INKLEisrNKENKYEdsqnkniigdyqdkniigdyqdkniiednqdkniiednqdkni 333 
XP_003674688  337 APIdpmkllnfmisSNGFLNDdMRKMRdgfDIGFPLFdnenssnnnndaefn---------------------------- 388 
A7TMJ6        366 QRIdpakviyfmasDEVIVDD-MRKLRdgdDIGFPPFdsdftgsspteee------------------------------ 414  Vanderwaltozy...
Q5BFF0        485 ------nignsasrsddaklqnpsasqdstSVLVAHSNLSRLWKL---MK---DQLRLTFlpptlttasvapsipseiqp 552  Aspergillus n...
XP_011127614  582 ------------------------------SLLLENNSIEKLYTL---FQ---KKLKQTI-------------------- 605 
EPS42027      562 ------------------------------TVLLENNSIEKLYTL---YH---RRLKQTI-------------------- 585 
XP_002173998  283 ------------------------------KELEAHNTLSGLHALatrLT---KDFQLRS-------------------- 309 
XP_013021104  302 ------------------------------DDFKENNSLNGLYKIsskLA---RRLRLNI-------------------- 328 
Q9Y7L4        302 ------------------------------DVFAGHNSLNGLYALvfaSA---KKLHLRL-------------------- 328  Schizosacchar...
Q6CHE7        285 --------------------------------dtiPTSISGLIKL---IG---DELPKPR-------------------- 306  Yarrowia lipo...
XP_002141959  334 iednqdkniiednqdkniiednqdkstiliSEILS--NFQNLLHIgfkLM---NLLAIMP-------------------- 388 
XP_003674688  389 ---------------msnipsidsevgvnnNILEKYEEFMTSWTRpvnLKyfaARMSQFYyn------------------ 435 
A7TMJ6        415 -----------------ydmsilsdqitdpNVLERYGEFLVPWKRpvtLKyfaARLAQMYnc------------------ 459  Vanderwaltozy...
Q5BFF0        553 smlesypTILSPLLTARYISSApta-------------elHPRVLGSRSFLFDPTSLEAYVSDQMTWWRGQRTPRGVEVM 619  Aspergillus n...
XP_011127614  606 -------STVSPDLTVVYRWQQ------------------NGQFMDSADYMADDDMLKQHVDNIISWWKGERETVGVPIE 660 
EPS42027      586 -------STIAPELTVVYRWQR------------------NGEFLDSADYMADDTYLKEHVDNVIAWWKGERATVGVEIN 640 
XP_002173998  310 ---------LSPKLTVTYRHNI------------------SGDVIRNHIFDMNSTILNHYFHEMFAYWHNEAEPKGVPEN 362 
XP_013021104  329 ---------SDKNLGITYWNPQ------------------TQQPLHVEKFNYEPTTLDDCYNRVNSLWRTMREPVGVSPN 381 
Q9Y7L4        329 ---------TDDNLTIAYRNDK------------------TGEVVYKDKFSFSNKLLEASYTKAYQFWHNLREPEGVPAE 381  Schizosacchar...
Q6CHE7        307 --------SLAKTVSVEYVKRSedrvpeeyqdlyplsdytQRQSFAVVQAPVDYKELKRVMSETLPFWHGQRAAIGVDAD 378  Yarrowia lipo...
XP_002141959  389 --------PIHNNMKVEYDCE--------------------GCTFATKWHTCEELTIMTEVDYLLGWWLGLRDSEPVLNS 440 
XP_003674688  436 -----igQLISDELMVEYYHK--------------------NENFHNILFKYDNKMLKEHVTDSGKYWFGKRDIEPIKPN 490 
A7TMJ6        460 -----isPLLSKHLTLEYYYK--------------------GDNFKNINFDFNEDEIRNGAFDSSMFWFGKRDIEPIEPT 514  Vanderwaltozy...
Q5BFF0        620 EA-WK--CRICEFQDECEW 635  Aspergillus nidulans
XP_011127614  661 EA-WK--CKRCEFSDNCEW 676 
EPS42027      641 ET-WK--CNKCEFMEDCIW 656 
XP_002173998  363 ET-FK--CKYCEFSERCWW 378 
XP_013021104  382 EV-FK--CRSCEFREECWW 397 
Q9Y7L4        382 EV-YK--CRSCEFQKECWW 397  Schizosaccharomyces pombe 972h-
Q6CHE7        379 SM-NK--CRYCQFRPVCGW 394  Yarrowia lipolytica
XP_002141959  441 EM-WK--CKYCNVLEYCNf 456 
XP_003674688  491 LKnFKifCKNCDYSHVCSW 509 
A7TMJ6        515 SEnLItyCKYCDYVNVCSW 533  Vanderwaltozyma polyspora DSM 70294
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