Conserved Protein Domain Family
SNAPC1
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pfam09808: SNAPC1 (This model is not part of the current CDD release)
Small nuclear RNA activating complex (SNAPc), subunit SNAP43
Members of this family are part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. They bind to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Furthermore, they also recruit TBP and BRF2 to the U6 snRNA TATA box.
Links
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Statistics
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PSSM-Id: 490650
Aligned: 59 rows
Threshold Bit Score: 114.281
Created: 21-Aug-2024
Updated: 4-Feb-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_001994197   5 VYGDCWKLLQRFSSavaataGQDAKFELFCEMWH---TLRMQHIYSAQTNHiEVIETTMAALHVAKRVAC--GRrtngda 79 
XP_020437913 275 LLEAIRNVIFKFQQ------STEFTFSTFKEIWKq--EACLLEFFEIQPHQpELIHI---LYYGVIGYTLmn-------- 335
XP_003286403  98 LLKIIKEIIYQYQQ------KNVVSFSEFKELWKy-kMDTLGPFFESQHIYpDVIHI---LYYGVLGFTLld-------- 159
Q54B89       138 LLKLIKTIIFEYQI------KSEISFTQLKEVWKqfgSETFKIFFEAQTINhEVIHI---LYYGVLGYTLld-------- 200 Dictyostelium d...
Q8LNT0         6 FKLDIDELLADYTE------ANCTAFADFKRLWM---AKKFSYIYEGRPKT-NSGAFMQSLFLHCIGHMTs-QS------ 68  Japanese rice
XP_010237075   6 FKLDISELIADYAK------ENYTAFTDFKRVWT---AKKFSYIYEGRPKT-NSGVFMQSLFLHCIGHMTs-QS------ 68 
XP_004963061  44 FKLDIDELVADYGK------ENSTTLADFKRVWK---EKKFSYIYEGRPNA-NSCLFMQSLFLHCIGHLTs-ES------ 106
XP_006836204   6 FKRDVDDLLGEFIE------IGAVTLAEMKKVWV---SRKFTYIYEAMPSShNLAFFMQALYAHAIGYMVt-EG------ 69 
A0E5H2        19 FKQDIINFIGNVLAymreknIEILSYQHFNKCWM---ENDIQFIHQCQLEWeSQDDYYNLLYGIILNKLIesPL------ 89  Paramecium tetr...
EPB85743      34 IEDDVEYLLYHFIS------HPTRTFHDFDRLWH---ELHFNHVHFACVKReFRANYMNAFYKSFLDYFSs--------- 95 

XP_001994197  80 faaTRAERIGAIYLLYAIYNKQPTm-rFIKIEVSPSTWQCLtgyvEQLRRVEAERRDTqQVSYVFWRLVQDQAFRYTALd 158
XP_020437913 336 --qPVNSKSAIVYLLYVLYTCQIIq-pPIPIDITLNIWDGL----MLYFNCFKLYRLA-EPYHVFKILMDRGAFHFSASl 407
XP_003286403 160 --lPINGKVSIIYSLYCLYNCQITn-pRVPIIITLNYWETL----LQYFEDIKNQTLY-EGYQAFRFLRKMGAFVFSATl 231
Q54B89       201 --qPINGKACIIFLLYILYNSQICs-pKQQIVLTINMWEKL----LGYFNEFKEQEIV-EAYQAFRSLRTSGAFVFSATl 272 Dictyostelium d...
Q8LNT0        69 ---CMPQRLAGLYCLYCLYESQPYk-pHFKIYLSLEELKKL----KDFVVEAKQNGMA-VVPSLVKRMLDKGMILFGFIn 139 Japanese rice
XP_010237075  69 ---SLSQKLAGLYCLYCLYECQPYk-pHFKIYLSLEESKKL----KDFVVEAKQNGVG-FVPALVKRMLDKGMFLFGFVn 139
XP_004963061 107 ---SLPRRLAGLYCLYCLYECQPYk-pQFKIYLSLEECRQL----KDFISMAKQNGVH-LVPALVKRMLDKGMFLFGYMn 177
XP_006836204  70 ---SLSKRLGGLYCLYCLYETQPFv-pPFKIYLSLVELQKL----KILVADAKRNGIE-IALAVVKRMLSKNMFLFGHVn 140
A0E5H2        90 ----YFEQLSLFYLIYTIYVTLDq---KILISLDQETMNQL----YFFFQECKEKGNH-DVFLLFLELNKQNAFLLSSRv 157 Paramecium tetr...
EPB85743      96 --eVTSMKSGVIFSLYFMYISQPAiwgKNRIRVTRDIYRSL----FEFYVESIDMDTDvEAALIFDKLRELEAFLFVEE- 168

XP_001994197 159 yc----qaLDALAAYDSLESFAESKk-TKNKTAllkhQLTQSeanIREe------LHSLAQLAHAAQSAC 217
XP_020437913 408 h------pVASLPIFKTNSTTVGATviPVDLVG-------------VNllnglinLDHLKDIHEQYNQAK 458
XP_003286403 232 h------pISTMNYFKTNSMQTNQPiiPHEIIN-------------NDpikplrnIKELKQITEQYNLAK 282
Q54B89       273 h------pVSTMNIFKTNSIALKSSviPPDLVG-------------QDttkslkeLSELERIHNAYNSAK 323 Dictyostelium discoideum AX4
Q8LNT0       140 ll----gdSGVKQVNELTASQNKRVkfACDKLF----MNTQIdsyMHMdlgseleLDKIKKSSLDYAKAK 201 Japanese rice
XP_010237075 140 ll----gvHGAKQVDELNESQNKRVkyACDKLF----ANTQIesyMRTdlgeefeVDNIKKLSMDYAKAK 201
XP_004963061 178 ll----gdNGEKQVEELTAMQNKRIkfACDKLF----ANTQAesyMHLdlgaefeLDSIKKLSKEYAEAK 239
XP_006836204 141 an----edSVTAVISGITKQQNTQIraAHDMLL----SNSKIeehVNMdlsskldLEGLKNLSADYAKTK 202
A0E5H2       158 gckrlsihPCGLPYIITKRNKAQLKqiTEERED------------EQEkvertdlTKQLLNASEKYHKAK 215 Paramecium tetraurelia
EPB85743     169 --------QEPDGYFTEEKIEFKKAieMNQKLNd--fKKTKMqndPLKlcs-nslLDEYKQLAMEYQQAK 227
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