8IA0,7NAC


Conserved Protein Domain Family
Nop25

?
pfam09805: Nop25 (This model is not part of the current CDD release)
Nucleolar protein 12 (25kDa)
Members of this family of proteins are part of the yeast nuclear pore complex-associated pre-60S ribosomal subunit. The family functions as a highly conserved exonuclease that is required for the 5'-end maturation of 5.8S and 25S rRNAs, demonstrating that 5'-end processing also has a redundant pathway. Nop25 binds late pre-60S ribosomes, accompanying them from the nucleolus to the nuclear periphery; and there is evidence for both physical and functional links between late 60S subunit processing and export.
Statistics
?
PSSM-Id: 519076
Aligned: 91 rows
Threshold Bit Score: 43.0007
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
8IA0_Ca        15 KKRKTePAVEEITFDKEARIEYLTGFRKRKQARIKQAKEIAERKAREERLAIRKQLREQRKQAV--EEHIKAINKILRE- 91  Thermochaetoid...
XP_004997258   19 NRKTK----LVVQFDEDDRHDYLTGFSRRKKERQRKAQEAAELQAKESKREEKQHKREALRKRL--SK-LTSIPEILSKp 91 
XP_001864753   10 rPGAGaKRKTELVFDPLKRTEFLSGFHKRKLHRKKVAQGQLERKLKEETRRIRTEAK-ENKKKL--YHSYKPIPELTAE- 85 
10_pfamImport   1 --KTRkKQKVELVFDEQKRKDFLTGFRKRKNERRKKAKEQVEAMIKEERKRIKSELK-AGMKNM--KKSFQPLQELTEE- 74 
XP_002008206    1 -maARkKKKVEIVFDPQKRKEFLTGFRKRKNERRTRAKAELDRNLKEEHKRIRKEVK-DSFKHL--KKSFEPLRELTEEd 76 
XP_001957512    2 tKKKApKKKLEIVFDEKNRREFLTGFRKRKNERRSRAKAQLEKDLKEERKRIRLEVK-DGFKHL--KKSYEPLRELTEEd 78 
Q8SWS7          2 tRKKApKKKTEVVFDNKKRIEFLSGFRKRKNERRSRAKADLERNLKNERKRIRQEVK-DGFNHL--KKSFEPLRELTEEd 78  fruit fly
Q2LZB2          2 aRKKTpKKKVEVVFDTEKRKEFLTGFRKRKNERRTRAKAELTKNLKDERIRIRQEVK-EGFKHL--KKSYEPLKELTEAd 78  Drosophila pse...
XP_011251984   16 pgqpKrRKKITLVFDEEKRREFLGGFRKRKLERKRKAQEQLQKQLKEERKKIKQEAR-ERYKKFvaHRNVPELEELLSKq 94 
XP_002316654   22 kKRVLkNKGVSVSFNEKDLRDYVTGFHKRKKKRRKEAIKQQEVKLRHKRIAARKQRKLEKELALnggap----------- 90 
8IA0_Ca        92 ----AESAGTGdise---------------sgsEGEWGGFSDAEdtg----------------vpEPPPLDLEEEYIDED 136 Thermochaetoid...
XP_004997258   92 e--wVATNTDThrfdteekkvsvnvatmeltegPPSIDALTDDDgrpqrkrsktgsdaaaktsksSAGDNDDDEE--DDT 167
XP_001864753   86 -------DREEqeydtenvtvkvvelstkelakQNNWIGENHGMvrgdqea--------edesddEGEQQSSEEE--DDE 148
10_pfamImport  75 --------DKKqeyeddevevkivelsandfaaQRNMIGANTGQes-----------------eeEEEPEEDEEEEV--- 126
XP_002008206   77 kiddSE---QTeayeddevqvkivelttndlaaQRNMLGANTAEes-----------------eeEEAPQ-NSED--DDE 133
XP_001957512   79 kaedGQQKAQEesyedeevqvkivelttndlaaQRNMLGANTAEds-----------------eeEEEKESESEE--DEA 139
Q8SWS7         79 kaeeAEQQ-QEetyeddevqvkivelttndlaaKRNMLGANTAEes-----------------epEEQAD-QSEE--DEA 137 fruit fly
Q2LZB2         79 kageE----KQetyeddevqvkivelstndlaaHGNMIGANTGEes-----------------eeEEKQS-ESEV--EDT 134 Drosophila pse...
XP_011251984   95 eydleghtvs------------ilelnvtdlagDR-WIGENKIAek------------------kEEEQDDQSEH--SNN 141
XP_002316654   91 -----------------------------paadESDNYGEDDEEiepiasisgttkydngdmqvtVTTSEISRE---DED 138
8IA0_Ca       137 -----KYTTVKVEAVS 147 Thermochaetoides thermophila DSM 1495
XP_004997258  168 rhlprDDTTTTIEfkk 183
XP_001864753  149 n----EVDTIPGMELd 160
10_pfamImport 127 -----DENTIPGMDI- 136
XP_002008206  134 q----QTNVIPGMDfd 145
XP_001957512  140 s----QANRIPGMDFD 151
Q8SWS7        138 d----QANRIPGMDFD 149 fruit fly
Q2LZB2        135 s----RPDRIPGMDYd 146 Drosophila pseudoobscura
XP_011251984  142 -----DNNEIVGMSLk 152
XP_002316654  139 gh--sEKTQVTVPRln 152
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap