7NAD


Conserved Protein Domain Family
Nop25

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pfam09805: Nop25 (490648 is an unknown moldel)
Nucleolar protein 12 (25kDa)
Members of this family of proteins are part of the yeast nuclear pore complex-associated pre-60S ribosomal subunit. The family functions as a highly conserved exonuclease that is required for the 5'-end maturation of 5.8S and 25S rRNAs, demonstrating that 5'-end processing also has a redundant pathway. Nop25 binds late pre-60S ribosomes, accompanying them from the nucleolus to the nuclear periphery; and there is evidence for both physical and functional links between late 60S subunit processing and export.
Statistics
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PSSM-Id: 490648
Aligned: 89 rows
Threshold Bit Score: 40.6946
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7NAD_5        18 TKQSKkFGTDEVTFDKDSRLDYLTGFHKRKLQRQKKAQEFIKEQERLRKIEERQKIRQERKEVM--EEQLKTFKESLNLe 95  Saccharomyces c...
XP_004997258  19 NRKTK----LVVQFDEDDRHDYLTGFSRRKKERQRKAQEAAELQAKESKREEKQHKREALRKRL--SK-LTSIPEILSKp 91 
XP_001864753  10 rPGAGaKRKTELVFDPLKRTEFLSGFHKRKLHRKKVAQGQLERKLKEETRRIRTEAK-ENKKKL--YHSYKPIPELTAE- 85 
6_pfamImport   1 --KTRkKQKVELVFDEQKRKDFLTGFRKRKNERRKKAKEQVEAMIKEERKRIKSELK-AGMKNM--KKSFQPLQELTEE- 74 
XP_002008206   1 -maARkKKKVEIVFDPQKRKEFLTGFRKRKNERRTRAKAELDRNLKEEHKRIRKEVK-DSFKHL--KKSFEPLRELTEEd 76 
XP_001957512   2 tKKKApKKKLEIVFDEKNRREFLTGFRKRKNERRSRAKAQLEKDLKEERKRIRLEVK-DGFKHL--KKSYEPLRELTEEd 78 
Q8SWS7         2 tRKKApKKKTEVVFDNKKRIEFLSGFRKRKNERRSRAKADLERNLKNERKRIRQEVK-DGFNHL--KKSFEPLRELTEEd 78  fruit fly
Q2LZB2         2 aRKKTpKKKVEVVFDTEKRKEFLTGFRKRKNERRTRAKAELTKNLKDERIRIRQEVK-EGFKHL--KKSYEPLKELTEAd 78  Drosophila pseu...
XP_011251984  16 pgqpKrRKKITLVFDEEKRREFLGGFRKRKLERKRKAQEQLQKQLKEERKKIKQEAR-ERYKKFvaHRNVPELEELLSK- 93 
XP_002316654  22 kKRVLkNKGVSVSFNEKDLRDYVTGFHKRKKKRRKEAIKQQEVKLRHKRIAARKQRKLEKELALnggap----------- 90 
7NAD_5        96 a--eIEDAKNDKTedlq-------------vesDESWHGFDSD----------------------KDDGDNDNNESSvkp 138 Saccharomyces c...
XP_004997258  92 e--wVATNTDTHRfdteekkvsvnvatmeltegPPSIDALTDDdgrpqrkrsktgsdaaaktsksSAGDNDDDEEddtr- 168
XP_001864753  86 -------DREEQEydtenvtvkvvelstkelakQNNWIGENHGmvrgdqe--------aedesddEGEQQSSEEEdd--- 147
6_pfamImport  75 --------DKKQEyeddevevkivelsandfaaQRNMIGANTGqes-----------------eeEEEPEEDEEEEV--- 126
XP_002008206  77 kiddSE---QTEAyeddevqvkivelttndlaaQRNMLGANTAees-----------------eeEEAPQ-NSEDdd--- 132
XP_001957512  79 kaedGQQKAQEESyedeevqvkivelttndlaaQRNMLGANTAeds-----------------eeEEEKESESEEde--- 138
Q8SWS7        79 kaeeAEQQ-QEETyeddevqvkivelttndlaaKRNMLGANTAees-----------------epEEQAD-QSEEde--- 136 fruit fly
Q2LZB2        79 kageE----KQETyeddevqvkivelstndlaaHGNMIGANTGees-----------------eeEEKQS-ESEVed--- 133 Drosophila pseu...
XP_011251984  94 -----------QEydleghtvsilelnvtdlagDR-WIGENKIae------------------kkEEEQDDQSEHsn--- 140
XP_002316654  91 -----------------------------paadESDNYGEDDEeiepiasisgttkydngdmqvtVTTSEISREded--- 138
7NAD_5       139 ilkkgaiteiydDSTTVELETLE 161 Saccharomyces cerevisiae BY4741
XP_004997258 169 --------hlprDDTTTTIEfkk 183
XP_001864753 148 ----------enEVDTIPGMELd 160
6_pfamImport 127 ------------DENTIPGMDI- 136
XP_002008206 133 ----------eqQTNVIPGMDfd 145
XP_001957512 139 ----------asQANRIPGMDFD 151
Q8SWS7       137 ----------adQANRIPGMDFD 149 fruit fly
Q2LZB2       134 ----------tsRPDRIPGMDYd 146 Drosophila pseudoobscura
XP_011251984 141 -----------nDNNEIVGMSLk 152
XP_002316654 139 ---------ghsEKTQVTVPRln 152
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