7KAI


Conserved Protein Domain Family
Sec66
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pfam09802: Sec66 (This model is not part of the current CDD release)
Preprotein translocase subunit Sec66
Members of this family of proteins are a component of the heterotetrameric Sec62/63 complex composed of SEC62, SEC63, SEC66 and SEC72. The Sec62/63 complex associates with the Sec61 complex to form the Sec complex. Sec 66 is involved in SRP-independent post-translational translocation across the endoplasmic reticulum and functions together with the Sec61 complex and KAR2 in a channel-forming translocon complex. Furthermore, Sec66 is also required for growth at elevated temperatures.
Links
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Statistics
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PSSM-Id: 519074
Aligned: 59 rows
Threshold Bit Score: 165.43
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7KAI_E        27 SISVYTPLIYVFILVVSLVMFASSYRKKQAKKISEQPSIFDENDAHDLYFQIKEM----SE--NeKIHEKVLKAALLNRG 100 Saccharomyces c...
XP_001387034  15 RISVFTPLIYVAILLGVFIVFSIRYRRNRLNKLVSIEPIFPDNQPAKIYESLKQSaadpNVakEnKPHDKVLKAALLRRG 94 
CCE87251      11 KISVFTPIIYVGVLLSSFIAFSIIYRKRRLEKLVSADTLFSENHAQNLYEFLKEQyndpNAssDtKPHLKVMKAALLRRG 90 
Q6BRF8        12 KISIYTPLIYVGVLLTCFIAFSIIYRRKKLNKLTKVEPIFSDNHTLNLYLFLKQQynnpEAtaEtKPHTKVMKAALLRRG 91  Debaryomyces ha...
Q5A647        14 KISVFTPLIYVGVVLSIFITFSIIYRKRRLQSLTKVEPLFKENYTAVLYQHLKDQytnkDLpkDqRPHEKVMKAALLRRA 93  Candida albicans
XP_007373032  14 KISVFTPLIYVGVVLSVFVAFSIIYRRRRLNTLRQTEPLFKENYNAILYQNLKEQyhnqNIpkDqRPHEKVLKAALLRRA 93 
XP_002616599  12 RISVYTPLIYVAVMATAFVAFSVFYRRHRLRKLIEVEPLFGRNYSLELYILLKDKfynkSLpkEgRPPEKVVKAALLRRA 91 
XP_001487247  40 KISVVTPLIYVGVLLGAFVMFSIFYRRNKIQKLAEIEPIFKENHPASLYAFLKLQyvdpEVpkDqKPHEKVMKAALLRRG 119
XP_006690199  11 NISVFTPIIYLCILLSCFIAFSVIYRRRRVNNLAKVVPIFEENHSANVYAFLNSQysdpELpkDqKPHEKVMKAALLRRG 90 
XP_011273055  16 KISVFTPIIYVTVVLTALVVFSINYRKNKINALYNRQPFFKRNLPKELHFELRDS--------DpKPNEKVLKAALLRRG 87 

7KAI_E       101 AESVRRSLKLKELAPQINLLYKNGSIGEDYWKRFETEVKLIELEFKDTLQEAERLQPGWVQLFVMVCKEICFNQALSRRY 180 Saccharomyces c...
XP_001387034  95 AEAIRRSMKLKENEPIFNKLYEDGLIGDDVYKQFQIQAKLQEIELKEIVQECETYKKGWVQTFFPTVQEICFNEALRRRL 174
CCE87251      91 AEAIRRSLKLKENEPIFNRLYQEGHIGDATFKSFTISTKLQEIEIRDIVIEVENMKKGWTQQFFATCQEICFNEALRRRL 170
Q6BRF8        92 VEAIRRSLKLKENEPIFNKLYQEGLIGDDVFKNFQIQAKFQEIELKEIVQECETYKKGWVQQFFPVAQEICFNEALRRRL 171 Debaryomyces ha...
Q5A647        94 VEAIRRSMKLKENEPVFNKLYQNGLIGDDIFKQYQIQIKFQELELKDIVTECETYKKGWVQTFFPLAQEICFNEALRRRL 173 Candida albicans
XP_007373032  94 VEAIRRSMKLKECESIFNKLYQNGLIGDEIFKQYEIQLKFQELELKEIVQECESYKKGWVQTFFPVAQEICFNEALRRRL 173
XP_002616599  92 VEAIRRSLKLKENEPVFNKLYQEGLIGDELFKQFGLQSKIQQLELKEIVEECQQFSKEWPATFFPVAQEICYNEALRRRL 171
XP_001487247 120 VEAIRRSLKLKENEPIFNRLYQEGLIGDDVFRQFEFQAKFQEIEIKQIVQECESYKKGWAQLFFPVAQEICFNEALRRRL 199
XP_006690199  91 VEAIRRSLRLKEAEPVYKTLYQDGLIGDDVFQQFNIQLKLQELEINEIVQQCESFKKNWAQSFFKVAQEICFNEALRRRL 170
XP_011273055  88 AESIRRTIKLKEVQPFITALYQKGSIGDDLYERYQTATKLEELEVQEIVAETEKYKAGWIPKFVPLLQEICFNEALRRRY 167

7KAI_E       181 QSILKRKEVCIKEWELK 197 Saccharomyces cerevisiae BY4741
XP_001387034 175 SAIDSRSEEYAKLWEYL 191
CCE87251     171 NALDERHSVLSELWEYT 187
Q6BRF8       172 NSMDERSKNLSDLWQYY 188 Debaryomyces hansenii
Q5A647       174 KASDDRAETFSKLWETY 190 Candida albicans
XP_007373032 174 KAMEGREEALAELWQCF 190
XP_002616599 172 HAMDDRSKSLSELWNYY 188
XP_001487247 200 NAMTERGNSLAEVWGYQ 216
XP_006690199 171 YSMSERKVDLSEVWEYY 187
XP_011273055 168 SAIEDRKLDLLDQWEIK 184
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