6Z2W


Conserved Protein Domain Family
LCD1

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pfam09798: LCD1 (This model is not part of the current CDD release)
DNA damage checkpoint protein
This is a family of proteins which regulate checkpoint kinases. In Schizosaccharomyces pombe this protein is called Rad26 and in Saccharomyces cerevisiae it is called LCD1.
Statistics
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PSSM-Id: 519071
Aligned: 27 rows
Threshold Bit Score: 248.779
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6Z2W_D        77 MLRDKINFLNIEREKEKNIQAVKVNELQVKHLQELAKLKQELQKLEDEKKFLQMEARGKSKRevitnvkppsttlstntn 156 Saccharomyces c...
XP_001483927  63 ILRAQLEQLQNSSRDELAKLRETLALEKHNKDGQVELLRAAVQLLEDERKFLNNELRATSVA------------------ 124
Q6BPF5        66 ILRAQLQQLQNQKQEDLNKLKESHNISKVQNDEQLKALKFTVQKLEDERKFLNNELRGATA------------------- 126 Debaryomyces ha...
XP_006685101  58 ILKSQLESVKSRGYEEIKHLKEDNEETKRSMEEQIKMLKFSVQKLEDEKKFLDNQVKSTF-------------------- 117
XP_007372538  80 ILRMQLQQLQQQKQQEVIKLNDSYTALKRNNEEQIVALKQAVSKLEDEKKFLHNELVIASA------------------- 140
EMG49723      74 tLRAQLLQLQNQKQQEITELKQTYDTLKQTSEEQMLNLKNTVQRLEDEKKFLNNELISTTA------------------- 134
XP_002549810  70 tLRAQLLQLQNQKQKEVADLKDTFNTFKQSTEDQVASLKNTVQRLEDEKRFLSNELITTND------------------- 130
EDK42726     127 tLQAQLLQLQNQKRDELNDLRQAYEALKKSKDAETEALKEAVHKLEDDRKFLKNELITSNA------------------- 187
XP_036666318  86 tLKAQLISLQNAKRDELNTLRQSYDAFKKSKEEEAAALRDVVLKLEDDRKFLKNELVTTNA------------------- 146
XP_001382376  36 ILRAQLEQLQKQNQKEIHQLRDQKDQLYRQNEDQVNVLKHAVQKLEDEKKFLNNELKTTTH------------------- 96 
6Z2W_D       157 titpdsssvaieakpqspqSKKRKI--SDNL------------------------------------------------- 185 Saccharomyces c...
XP_001483927 125 -------------------LKRRKV--GESQtanitfsgtmgattlatpstqlkspaiskqknssnsgqyrvpesdtrpl 183
Q6BPF5       127 -------------------LKRRKL---PSRaddsmmdidvmpildtqqang--------tryqheraesiepetelrpi 176 Debaryomyces ha...
XP_006685101 118 -------------------SKKRKL--ANPSeetipvtqaq-----------------------------rvapttvpva 147
XP_007372538 141 -------------------SKKRKV--NNQFdvttsivpattnesvkaas-----------lvsapapatatvpapapst 188
EMG49723     135 -------------------VKRRKV--TTTdtpntttfveshstppppapvpaqappqpqqpptpnqteptqlttqydyk 193
XP_002549810 131 -------------------LKRRKIvqnkvtppvvsnsphnedsiiee---------pvisvqpnneisivssepeitvk 182
EDK42726     188 -------------------LKKRKIvlTQEDgllatmgttngnttvnasg-----------maetpptsvatdvevirek 237
XP_036666318 147 -------------------LKKRKI--NGNDntnssqqtrpqvstemdq--------------svfeaslesegtsipsq 191
XP_001382376  97 -------------------NKRRKL--TPPVierqppshstplspsq-----------------lsmegsassvelphkh 138
6Z2W_D       186 LKKNMVPLNPnriipdETSLFLESILLHQIIGADLSTIEILNRLKLdyITEFKF--KNF---VIAKGAPIGKSIVSLLLR 260 Saccharomyces c...
XP_001483927 184 VPQKVIKIDN------DASLLEDHLWNHCINGTKRTTVSYLSKIYL--DRDVRI--RDF---VLHKKQPISTAVTEFLMV 250
Q6BPF5       177 LPQKIIKIQN------DASLFTDHIWNHCINGSKRSTLNYLSKIYV--DIDILV--HDF---KTHAKMPLSTAITEYLML 243 Debaryomyces ha...
XP_006685101 148 TGQRIIRTQN------DTTLLTDYIWKLSINGSDRTIMEYLGKVTL--KDSLEI--QGY---RFQEKIPISSIILEYLIS 214
XP_007372538 189 PKPRIIKPSN------DAALFSDQIWNYCILGSTRTSLSYLSKICT--DFDLELtqHNF---KLLRRTPISSSIMELLMS 257
EMG49723     194 PVQKIIKLQN------DSSLLIDQLWNNSIIGSSRTSFEYLSKICL--DFDLELn-SGL---VILKQTSISSSIVEFLMI 261
XP_002549810 183 PIQKIIKLQN------DSSLLIDQLWNHSIIGSKRTSFEYLSKICI--DMDLTLs-SGL---KIVKRTSLSSGIVEFLMI 250
EDK42726     238 VVQKIVRVEN------DTVVFIDHLRKYIMLGTNRSSFSFLNKICF--DSDLDFnfETMsktQIKKQQAISPVLLDAIMN 309
XP_036666318 192 TIQKVIRVQH------ETSALIDQIWRYCIPGSKRSTIEYLSKICF--NFDI----DTLygyKLEKKTAIASFISNVLMS 259
XP_001382376 139 LAQQIFQQQQ------TSALYTDHIWNHCIVGSNRTSLSYLGKISI--HFDVVV--GDL---SLVKREPLSRSIVDYMML 205
6Z2W_D       261 CKKTlTLDRFIDTLLEDIAVLIKEIS-VHPNESKLAVPFLVALMYQIVQFRPSATHNLALKDCFLFICDLIRIYHHVLKV 339 Saccharomyces c...
XP_001483927 251 KKAL-RLDSLIHEFSLTMCELVEDII---AHQILTSVPFLLSLVYASLIFRSSALNKETIQLLVPKICLIAVDFAFLLDS 326
Q6BPF5       244 KKNL-RLDELVAEFTQTLSDLVDILL---EKKLILSIPFLLALIHASLNFRSSAVSQTSIKSLLESICKLALNFTFLLDS 319 Debaryomyces ha...
XP_006685101 215 RKNL-RLDKLLEELFSIINELIVHLI---DTSLITSVPFMLSLLHGILGFKPSAVNENTIVISVSRIFEIIMLYKYTLSN 290
XP_007372538 258 RKSL-RLDQLIQEFVTVLLEIIDNLLnRQKSKSCLAVPFLLSLVHCSITFRPVAVSVELIGHIVIHVSNIAKDLSYLVSE 336
EMG49723     262 NKNN-RLDKLIEIFTLSLIQLVERLL---KQKSILSIPFLLSLIHCSISFRPAALTKALITQLLKRVSKITEGLSFLLNS 337
XP_002549810 251 NKNN-RLDKLVENFTLSLIQLIEKLL---KSKSILSVPFLISLIHCSINFRPAALTKSLISQLLKRVSKIAEGWAFLLDS 326
EDK42726     310 LREN-RLDDMIDKVNTLLMNIIEKSI---QNDLILPVPFLVSLMHCSLTFKSAAVTERLIKKLVVWLSDFAAKYVYLLSP 385
XP_036666318 260 MKAA-RLDELIEKLSLLVLDIIRQVV---AQKATLSVPFLLSLIYCTISFRPVAVTKPVIIKLIHDCCELAMSYTFLLNP 335
XP_001382376 206 KKSL-RLDELVEDFCLSIAEVVDILL---EKKAILAIPFLLSLVHCSIAFRPAAITPNLIVKLLQRFSRISNNLSFLLSS 281
6Z2W_D       340 PIH--E----SNMNLH-VEpqiFQYELIDYLIISYSFDLLEGILRVLQSHpkqtymeffDENILKSFE-F--VYKLALTI 409 Saccharomyces c...
XP_001483927 327 SQDq-----dDIINYHnVP---LQVMVLQKFSLICCFDILERILYVATVF---------DTEFSSGLW-Qe-PQMVQLFK 387
Q6BPF5       320 SQDe-----eDFINYHdVP---NQVMVLEKFALICCLDIIEKLMSLSSLF---------GAKFIETIW-KenYVRVELFR 381 Debaryomyces ha...
XP_006685101 291 e---dR----ELFNYNkTP----QMFLLEKFTLICSMDMLEKLMSLCNLHq--------EVKLGSRLF-He-VRILDLVN 349
XP_007372538 337 GSDlplgledEFMNYHdVP---NHVSILQKFIFVCCMDILEKAITLSSMY---------EAQYIRNTWn---LFPLELFN 401
EMG49723     338 NLDe-----dDLANYHdVP---YQIMVLEKFIFTSCLDLVERLVTLSTIFd--------EPQFVKKIW-QnhILSESLIT 400
XP_002549810 327 NLDe-----dDLANYHeVP---YQVMVLEKFIFTCCLDLIERLVTVSTIF---------EPDFIKAIW-QkqILSQTLVK 388
EDK42726     386 DLEeeS----RIGIHSeKP---LQVTALEKFLLIQLVDTLEKVVILASGF---------GAKFLTSVWk--iSLMVSLVN 447
XP_036666318 336 NLEeeA----DFGNYHdVP---DQVIAIERFILICCLELIEKLTVISSIY---------DADFIRQVWtDqtVIPKALVT 399
XP_001382376 282 NLNe-----eDYVNYHdVP---NQVMILEKFIFICCLDIIEKLTSVSSLH---------GSNFIKSVW-KddVLSIELLN 343
6Z2W_D       410 SYKPM----------VNVIFSAVEVvniitsiilnmdnssdlksLISGSW---WRDCITRLYALLEKEIKSgdvYneNVd 476 Saccharomyces c...
XP_001483927 388 FCLPEnserfmnttqSNLVYSVVEM-------------------LISSITelgFAFDNQPV---KNDAIVS---SllKV- 441
Q6BPF5       382 KCLPEnterfknlaqINLIYNFVEI-------------------LMSSISettFAYNDTPN-KILDESIIN---SllKV- 437 Debaryomyces ha...
XP_006685101 350 QLIPKndealmngaqINIIYNVVRI------------------------LdnfYDTNDTEE---TSSQTVH---SllNI- 398
XP_007372538 402 LCLPQnperfkntaqVNLVYNMVEM-------------------LLGSITddtFAFNNSEL----NGVIIS---SllKV- 454
EMG49723     401 SCLPEnserfkntaqINAVFNIVEM-------------------LIASVSettFGFNETKT----DESIIS---SllKI- 453
XP_002549810 389 SCLPEnserfkntvqINAVFNIVEM-------------------LGASITedtFAFNETKL----DESIIS---SllKV- 441
EDK42726     448 TLLPQnterfksiaqINTVTSIVGL-------------------TASSVAeegFTFNSVKT----ETSIVS---AliKV- 500
XP_036666318 400 SCLPQnverfkstaqINLVFNVVEI-------------------LLASITedtFGFNEAVS----DFNMIS---SlmRI- 452
XP_001382376 344 RCLPEnterfknsaqINVVYNIVEM-------------------LISSTTddtFAFSDVANAKVSDSSIFN---SllKI- 400
6Z2W_D       477 TTt-LHMSKYHDFFGLIRNIGDNELGGLISKLIYT-------DRLQSVPRVISKEDIGMds---------------dkFT 533 Saccharomyces c...
XP_001483927 442 FLidIPIKEDFKFYGLNRVLGNNSDLSKVEATVPElet-llqESMVLIPCPIPQTMQQE--------------------L 500
Q6BPF5       438 FLieLPVKDDFMFYGLNRIMGNNIDFNKIDSIIPTset-llnHSMISRPCPIPYEYLQErmvpikkesnltskdsqmnQL 516 Debaryomyces ha...
XP_006685101 399 NLvgVPIKEDFRFYGLNRCIGNNTDFQEIDKIIFSdnatvdpSSLIILPNPISERSKESr------------------NS 460
XP_007372538 455 CLieLPIRENFMVYGLNRIVGNNYDLKKIDSMVPIdhd-clnNYVVVAPQPIPYELLETp-----------------gEL 516
EMG49723     454 FLieIPLRQDFMFYGLNRILGNNHDFIKVDSVIPVqhd-ylnNYLVSIPQPIPYNITEP--------------------S 512
XP_002549810 442 FLidIPLRQDFMFYGLNRILGNNLDFLKINSMIPVdrd-hlnNYLVVLPQPIPFNMAIP--------------------S 500
EDK42726     501 LTfdLLVKNGFHFYGLNRILGNNSDMQKIELAVPRehd-rlnNYLVTIPPPIHLNLFSQd-----------------pQT 562
XP_036666318 453 FLidVPIKDGFRFYGLNRFNGNNYDLKVIDLTIPIkhd-nlhNYLVSIPQPVYKNLDSD-------------------LN 512
XP_001382376 401 FLieLPIKDDFMFYGLNRVIGNNIDFRKIDATIPQtad-ilnNFNILIPQPIPFNLIKEnqs--------------neSI 465
6Z2W_D       534 APIIGYKMEKWLLKLKDEVLNIFENLLMIYGDDATIVNGEMLIHSSKFLSREQALMIeryVGQDSPNLDLRCHLIEHTLT 613 Saccharomyces c...
XP_001483927 501 AVTVETNHELHLLYLRLRVATMIEGHIVTKGSTQLFQDKEYLKSIVRYIGLEQGLIM---NSPRAPTVHIRVRIISTLVR 577
Q6BPF5       517 AFEVQSNHEYHVLDLRLKVATLLESFIVTKSSTQIFELKEYIKSIVRTIGFEQVFIM---RSPRSKTIYLRIQIIAVLVR 593 Debaryomyces ha...
XP_006685101 461 NYSIEYNHEFHVLDLRLQISQSIENYIINRMDTSILKEIEVVKLMIRSINLQQNGIL---RSPRSKFVDLRIKIICSFVR 537
XP_007372538 517 QYELSANHQFHLLTLSVKVSELLHSLIVTQETIDFLYNREHFKSMIRIVAFEQDYIM---RSPRSKYIYLRIQLVSNFVK 593
EMG49723     513 QFEINMNHEYHLLTLRIKVAELLLSLIITKQTVDFLYSKDHFKSLIRVIGFEQNYIA---RSPRSKHIYLRLQIIAILVK 589
XP_002549810 501 KFGIDMNHEYHLFTLRIKVAQLLLGLIITKQTFDFLYKKEHFKSMIRVIGFEQNYIA---RNPRSKHVHLRLQLIAILVR 577
EDK42726     563 FGFSHEKYETHLLHLRIQVAHLFLTWIITKQSVSMLRDRDHFKSLFRVIGIHQSYVA---NNVRSKHVGLRIQLIALLVK 639
XP_036666318 513 QKEIQLHHEAHLLNLKIKVCELFQSLIISKQTIDFLIDKEHFKSFVRIIHFEQTYMA---NDPRSPTLHSRVHLIGQIVK 589
XP_001382376 466 RFELLSNHEFHLLNLRIKVADLLESYIVAKQSVEFLMSREHVKSIMRIINFEQMYIM---RSPRSKYIHLRIQIVSKLVK 542
6Z2W_D       614 IIYRLWKDHFKQLREEQIKQVESQLIMSLWRFLVCQTETvtanerEMRDHRHLVDSLHDLTIKDQASYYEDAFEDLPEYI 693 Saccharomyces c...
XP_001483927 578 VLHHIA-TEAKTITNVVYPETMYEVFVILLRIAFGSD-S------LSVDAYQLSSHARQMNYT--GTIYNYWCEQRARQL 647
Q6BPF5       594 ILNYIS-SEVRGLNNLIYPETLYEIFVILLRIAFGSN-S------LSAEAHSLLLEIRSKHKY-DKLVFNDDCERKAREI 664 Debaryomyces ha...
XP_006685101 538 NLNYVF-KTSKQLNEIINSETLNELSIVLSQIAFTSSSD------LSGSSAKLYKLLRTQNYR--LKILNEESEAKAREL 608
XP_007372538 594 IINYLTQQEGKDMTELIFPETMHELFVVLSRIAFGSDSS------TTAEGQQLLFKVREKGYY-NQVVFNETCESRAREL 666
EMG49723     590 IVDYLT-QDLREISELMYGELMYEIFVIFSRIAFGSD-S------LSIDAHKLLVKIRAGGLT---PVFNKWCESRAREL 658
XP_002549810 578 IIDYLT-QDLRDASELIYGEQMYEIFVVFSRIAFGAD-S------LSIEAHNLLIKIRSQPKFVDFPVFNKWCENRALEL 649
EDK42726     640 VINYIT-QDLHEASDLIYSETMYEMFVVLLRIAFGAD-S------LSSDAFKLLVKIRSRGLS-KLTVFNEWCEMRAREV 710
XP_036666318 590 IMNYLT-QDLHEASDLIYSETMYEMFVALSRIAFGAD-S------LSLDAHKLLVKIRTQGHF-DITIFNKSCEVRARQL 660
XP_001382376 543 ILNYLI-QNAVEYGAFIYPETMYELYVALSRIAFSSD-S------LSDHAHKLLIQVRNKGLK--EPIFNAWCENKAREL 612
6Z2W_D       694 EE------------ELKMQLNKRTGRIMQVKYDEKFQEMARTILESksfdLTTLEEADSLYISM 745 Saccharomyces cerevisiae S288C
XP_001483927 648 GHsd--------gvEEMADVESEFANGLEFPYEPEIIELAREILEP----CVTHEEADNLYFNM 699
Q6BPF5       665 NHitfsn--lhtdgKLVADIESELANGLEFPYETDTIEVAREILDL----CVTHEEADNLYFNM 722 Debaryomyces hansenii
XP_006685101 609 SNvnfs----nknkEYLAEVENEHANGLETLYDHETVELAREILGF----CIDNEVADNLYINi 664
XP_007372538 667 NHltdi----ipngKYLADLQTDFANGLEFPYESDAIECAREILNK----FVTHEEADNLYFNM 722
EMG49723     659 NHivpsn--nhergSEIADIESDFANGLEFPYESETVELARDILNR----FVDHDEAENLYFSM 716
XP_002549810 650 NHitpq----tsngETIANIESDFANGLEFPYESDTVELARDILNR----FVDHDEADNLYFNM 705
EDK42726     711 NHvgllq--kdisgRSLATIESDYANGLEFPYEAETVELARDILNR----FVNHEEADNLYFNM 768
XP_036666318 661 NHltakdfisknggKLVANVESDYANGLEFPYEAETVELSREILNR----FVNHEEADNLYFNM 720
XP_001382376 613 NHltse----dlqgKFLADIESDFANGLEVAYEADTVEIAREILNT----FVTHDDADNLYFTM 668
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