Conserved Protein Domain Family
Hyccin

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pfam09790: Hyccin (This model is not part of the current CDD release)
Hyccin
Members of this family of proteins may have a role in the beta-catenin-Tcf/Lef signaling pathway, as well as in the process of myelination of the central and peripheral nervous system. Defects in Hyccin are the cause of hypomyelination with congenital cataracts. This disorder is characterised by congenital cataracts, progressive neurologic impairment, and diffuse myelin deficiency. Affected individuals experience progressive pyramidal and cerebellar dysfunction, muscle weakness and wasting prevailing in the lower limbs.
Statistics
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PSSM-Id: 519066
Aligned: 23 rows
Threshold Bit Score: 177.225
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_009014294  58 TCYESYGESVRNDKELMDELYCLLnhtsfhkydQLLDPVCHQLFN-FYRSSVhsLHCFAIEFIPTIVGSYL--SASMSSS 134
1_pfamImport   1 KFLNKVAPSSLFAANYISTNYTDV---------DLIQPIIGQILAiYYKSGV--LRLYALQFVPGFVSLYL--LALSKKQ 67 
XP_001897193  34 IQLTRETCKTQYLINYLSCNYTDV---------DLVQPVVAQLLAcYYRGGI--LRYFVLQCIPSLIHIYL--LALAKRQ 100
2_pfamImport   1 DDWATFAITTSQNKTLIESIYAVLddih--kysKLVDRICGALFN-CYRTEEtdLHLFVLLFIPHLTYSYL--NSIAHVD 75 
Q9FMI8        92 ADSDRPALSLLSSRAAYSLISNSLcnp---asgSGSDPLCQWLYE-TYLSSDppLRLVVLSFFPLLVGMYL--SRIHSSD 165 thale cress
XP_009112116  69 ADSDRPALSLLSSRPAYSLISASLrdp---ssgSGSDPLCQWLYE-TYLSSDqpLRLVVLSFLPLLAGTYL--SRIHSSD 142
XP_004966258  60 ADSDRPARALLRSPAAYSALSDALra-----ggGADDPACHWLYD-TLLSADpdLRLAALAFLPLLAALYL--RRLPPEL 131
XP_006838380  55 SHSDRPAQALLEDSSLSSSLSSALsls---ssgSGSDPLCHWLYD-TFLTSDldLILVVLSFVPLISGLYL--SR-SSSL 127
XP_009014774  16 EKLLDFAEDIKKDHTLKKEIFFFIenk---nksEELDPVVHQLFN-FYRLDNdqLKKFSLEFIPAMLLKYY---SAINGQ 88 
XP_015788203  23 DEIHAYAIGVFNYPDLINAILNALeddk--qyeKFLAPICTQLFN-YHRLKDdrLRLFVIAFLPSLIGVHLlySVKPLEV 99 
XP_009014294 135 HLH------SGCLAAFLLGVYNL-----------GNSEMTTINafpiVPSLS-----QPSVYHD-PSSVSl--ITRLTEA 189
1_pfamImport  68 QKS------VSLFETFLTAIYNEeivkd-sergtNEKKTEDIR----IPSIR-----HHSVYHD-PAKIQiqtELPITRN 130
XP_001897193 101 KKS------VSIFETFFLAMFNEeilaggilsesVTKKVEEVR----IPSIR-----FPSVYHD-PKKLSlasDIALKSG 164
2_pfamImport  76 KQS------CRSIEALLIGIYNLeav-----denNTPRFISFR----LPSLA-----QPSIYHE-PSSLA---PTSLTET 131
Q9FMI8       166 STSlp---sLSGFEAVLLAIYAAevk-----araGKPILVH------IPDLS-----QPSLYHT-PRN-GvdkSRD-SNP 223 thale cress
XP_009112116 143 SSSlp---sLSGFEAVLLAIYAAevk-----sraGKGVLVH------IPDLS-----QPSLYHT-PRNGGvdrSRDSSNH 202
XP_004966258 132 PSS------LSGFEAVLLAVYSSeak-----nrqGKPVLVQ------VPDLS-----VPSLYHT-PASSPsskSPRRPQP 188
XP_006838380 128 SSSssprpnLAGFEAVLLALYSSevk-----irqGKPIKVN------IPDLG-----LPSLYHA-PRQAPa-gSPRVPEQ 189
XP_009014774  89 QVV------ISSLEAFLLGMYNLd---------sTRLKLNCQTdfllQPNSAlifntTSSIYHDiPMGVT---TSMLTRS 150
XP_015788203 100 RRK------YRCVDTVLLGIYNVeit-----nedGLGSNRTFR----IPTTS-----KPSIYHE-PPTTS---ASTFSQP 155
XP_009014294 190 ALSVRln--sEHVPVKRPTH-KKY---------DGITPQNRSAILSFVISVYNMNITLMSFR--SRKSLCHLSS-KL--- 251
1_pfamImport 131 ASVTP-----VLHTVHFGPF-PSV---------SKMNGENRFTVLNRILFSVNESLFEVASEi-AARYVCLGTL-SV--- 190
XP_001897193 165 APAFVq----ATKTVRIGPY-KSV---------DRIFPQNRQTVLTRLLKSVNGCLCRLSRDv-ICQGICLSTI-AL--- 225
2_pfamImport 132 AIRRLeq--rDTHPVRRGPF-NQI---------ERLSASNRMEVLSNLYFIYYKNLNLLPEVynPFDRFYRVTS-KM--- 195
Q9FMI8       224 t---------ASVGVLSPQLePQI----------AVKSTKRASIVGVGLQCYFKEISQMPAW--SKLEFCKFSAswa--- 279 thale cress
XP_009112116 203 v---------ASVGVLSPQLePQV----------AVKSTKRAGIVGVGMQCYFKEISQMPAW--SKLELCSFAGawa--- 258
XP_004966258 189 PPIPPpq-atPVVGVLSPPLePQA----------AVKSTKRAGIIGVAFEAYYSKISQMPAA--SKVDACNAVAawa--- 252
XP_006838380 190 -------------GVVSPPLePQT----------AVKSTKRASIVGVALDLFYRKIAVMPMR--SKLDLCNFAAswa--- 241
XP_009014774 151 ALDRWhvhnsHQSKIKNVTYlKAT---------DSVTNKNKLTIMIHALQRYNEHISDFSDL--SHLTLCKFCM------ 213
XP_015788203 156 TSTSNdn--sTKADSSSLPY-INVpvygnykssDYINASNRVSVLTALLHLFHDQMSSLPKQ--SHAALCRMTVsVLeke 230
XP_009014294 252 -------------------------SRTGFEDYveclsp--------ianqhCSTSGDNGSWQKDPESMHQ--------- 289
1_pfamImport 191 -------------------------CRSGFSFPetg-------------frsKVLESESPREVIEDFSRKP--------- 223
XP_001897193 226 -------------------------CQSGFSFReta-------------lvsRVFGSSFHHKEFDDFSKKP--------- 258
2_pfamImport 196 -------------------------VTQGYFH---------------------KRSTSFTNSDISTSTTLP--------- 220
Q9FMI8       280 ----------------------gqdCDCKEKIDededk----------vlalTNGFGD-SSSFNGSSG-RSleieedfdr 325 thale cress
XP_009112116 259 ----------------------gqdCDCKEKIDgegdk----------vlalTNGFVDSSSSLNGSSEIEAeeveeeeee 306
XP_004966258 253 ----------------------gqyCKCRFELD-------------------DKELEEEEGDSLGSVSPMSleaengkel 291
XP_006838380 242 ----------------------gqnCPCCHQLDdlnvgslqiamenldlqnhNNSEPSPSSPRSSSSSLSSrsvvqeeed 299
XP_009014774 214 ----------------------------MFTK---------------------TKKDNPNVESQADNNIMP--------- 235
XP_015788203 231 trppadwkqilnqhpnsignlhnsaLIPDFPR------------------------------------------------ 262
XP_009014294 290 ---------------------------------------------KIPFDESLIIEILVGIYYLMFNGLSKLCMQAVDDI 324
1_pfamImport 224 ---------------------------------------------RQKVTAEFLNHLLRGCYLALFNGAADLALRAIDSI 258
XP_001897193 259 ---------------------------------------------RLRISSQYLLESLNGLYFALFNGTPELAVQAVDAV 293
2_pfamImport 221 ---------------------------------------------RIPLSPKFLIHLLYCLYISIFNCGKAEAFQALEDI 255
Q9FMI8       326 lairene----------------------eqlssngggggvgrgvRIPLPWELFQPTLRILGHCLL-------------- 369 thale cress
XP_009112116 307 qvis-----------------------------sngvgvgvgggvRIPLPWELLQPILRILGHCLL-------------- 343
XP_004966258 292 eeelarmhi-------------------ngtssgrncgekddkegRVPLPWELLQPVMRVLGHCLL-------------- 338
XP_006838380 300 gpsakirvsleendhgqypeirappsreegeeirireearvssegRIPLPWELLQPVLRILGHCLL-------------- 365
XP_009014774 236 ---------------------------------------------KH-------------------NGQSEAGLMAVSSL 251
XP_015788203 263 ---------------------------------------------KIPVASQLLVRLSSCIYFCIYNGVGDVAIQALDHI 297
XP_009014294 325 HLRASYDLNYPVLLVTNAFLNSLHLNNTSPdlsqedskSLSVTASPIQT--------------------------HRHsk 378
1_pfamImport 259 HMRAQYEMLPETLLVVNSLRNSLLDNMWSK--------EKRGELMWTRP--------------------------QHKdm 304
XP_001897193 294 HQRALYEFYADVILVTNSISETLLESNFHK--------NEELTAQWVRP--------------------------GKLdn 339
2_pfamImport 256 YYRACYSCYCEVILLANAIKNSCQGSFEGgqt----pnVSSVGTPVSSN--------------------------TCStp 305
Q9FMI8           --------------------------------------------------------------------------------     thale cress
XP_009112116     --------------------------------------------------------------------------------    
XP_004966258     --------------------------------------------------------------------------------    
XP_006838380     --------------------------------------------------------------------------------    
XP_009014774 252 YKRAHYDLLPASIMSIGALMSFISNAQNDEdddnngdnAATTTTTTTTSqlkkllprhlqqhdaqqkflsqqqsqQQQqq 331
XP_015788203 298 HARGLSELYPDVLLMTNAIKHQLSTNPPTQsgd--cpaEIPVTFTPTST--------------------------VTStt 349
XP_009014294 379 FP---KDAITNASFRTRKLPDD 397
1_pfamImport 305 IRr--KDLVTNASLKMKRMPED 324
XP_001897193 340 HKr--NEVVTNASLRLKKMPED 359
2_pfamImport 306 VS---KSMITNASFRTKKLPDD 324
Q9FMI8       370 -----------SPLNTEDVKDA 380 thale cress
XP_009112116 344 -----------SPLNSEDVKDA 354
XP_004966258 339 -----------APLNPVEVRDA 349
XP_006838380 366 -----------APLNPQEVRDA 376
XP_009014774 332 LT---REAITNATFRTQTMPED 350
XP_015788203 350 SSssnKTAITNASFKTRKLPED 371
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