Conserved Protein Domain Family
Guanylate_cyc_2

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pfam09778: Guanylate_cyc_2 (This model is not part of the current CDD release)
Guanylylate cyclase
Members of this family of proteins catalyze the conversion of guanosine triphosphate (GTP) to 3',5'-cyclic guanosine monophosphate (cGMP) and pyrophosphate.
Statistics
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PSSM-Id: 519055
Aligned: 28 rows
Threshold Bit Score: 240.62
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001639623   6 LPHIKQEFDWDCGLACVQMVLRRiRGNRLSKTEFEDVCKDLGFGNSVWTIDLASIFAYYGM-KCGFFTETLGvdIAYKSN 84 
XP_009023478  33 IHHVRQHSNWDCGLACVQMILKTyDKN---IDNFKSVCVRLNLKTSIWTIDLAYILQYYHI-AHKFMTITLGvdEAYSKK 108
EPB91549      28 IPHILQDTNWDCGLACVVMTLRGlGFNVS-LEDVARQCP----VNSVWTIDLAFLLRNYVH-DFTYYTSYLGsrKEYQDQ 101
XP_006680608   1 --------SWDCGLACTSMVLAGlGIPRSTLLDVSNMCS----TRSIWTVDLVYIFRHYGVqDFTMYTSYIGvnWQNASK 68 
EFJ14805       1 VPHVRQLRSWDCGLACVSMVLRAlGIESCNLKTLSQLCR----NTSIWTVDLAYLLRHFSV-DVAFLTITLGanPLLAVE 75 
ERN12004      76 VPHIQQLSTWDCGLACVLMVLKTlGIDCGDIPCLEKLCC----TTSVWTVDLAHLLHKFSV-KFFFLTVTLGanPNYAVE 150
XP_002277052  57 VPHMNQLSTWDCGLACVLMVLRTfGINNCNIQALEELCC----TTSIWTVDLAYLLQKFSV-SFSYFTVTLGanPNFSVE 131
KRH31061      55 VPHINQIYTWDCGLACVLMVLKTiGVNNCDIQTLAELCC----TTSIWTVDLAYLLQRFAV-AFSYFTVTFGanPNYSIE 129
Q8L870        59 VPHVHQLASWDCGLACVLMVLRAsGIASCTLEDLAEICS----TNSIWTVDLAYLLQKFCV-EFSYYTITFGanPNYSIE 133 thale cress
1_pfamImport   1 VPHVSQLHSWDCGLACVLMALNTiGINNCSIQALAELCS----TTSIWTVDLAYLLQKFSV-RFSYFTVTLGanPNYSAE 75 
XP_001639623  85 SFYCETFQMDSNRVNRLFRKAKKLGIDVEKRVVSLEEILEKLSSGY-VAIALTNSYMLH----------CDWCTPLdTYS 153
XP_009023478 109 SFYKDNYDEDSARVEAMFNNAGEAGVNITECSVGMDEIVKHLKSNR-PIIVLIDWNIVKwtsslplkcqC---------- 177
EPB91549     102 KFYQEDFDEDEKRVNKLFAIAKSCSVHVVRMMLPLDDFKRFLYCKKfAIITLVNARLLK----------CQLCRRHrGCL 171
XP_006680608  69 PFYRDSIAEDLKRVHSLFAKARACQVRIVPLVLAMDDICRFLASNRyAIIILVNFNLLK----------CTTCSKNkAKT 138
EFJ14805      76 SFYKDNMEADEKRVNKLFEKAPQAGIQIQWRSISGEELAMLILSGRyLAIALVDKHKLRyfl----fsnSEYLL------ 145
ERN12004     151 SFYQDNLPDDIRRVNGQFQVALENGINIQCRSIGGEEISVLILSGKfVAVALVDKHKLScrp-----wlEEICLP----- 220
XP_002277052 132 TFYKDQLATDLVRVDSLFKKAMEAGIDIQCRSISGDEISLLILSGKyIAIALIDQYKLsqs------wlENVHVS----- 200
KRH31061     130 SFYKEELPNDLVRVDLLFQKAVEAGIDIQCRSISEEEISILILSGKyIAIVLVDHNKLRfcfs--hvlqEDVPMP----- 202
Q8L870       134 EFYKEQLPEDLVRVDLLFRKAHESGIIIQCRSVSIHEISCLLLSGNyIAIALVDQDKLsks------wlEEVLVS----- 202 thale cress
1_pfamImport  76 TFYKEQLPTDLVRVDRLFQKAREKGINIQCRSINEKEISLFILSGKyIAVALVDQYKLsrs------wvEDVILS----- 144
XP_001639623 154 MIma---sYCSKCTGLdnYNGHFVIVCGYDLDSKCFYYKNPSKDENLCRMKFHAFESAWHCFGTDSDIVFI 221
XP_009023478 178 -F-------GNVMKKVtsYQGHYILLNGYNEKKKSIYYHNPEKSDVVHNIRLDVLEKARKAHGTDEDIIFI 240
EPB91549     172 GSvcgqldLLLEKFKGndYLGHFIVLIGYDPTEDLFIYRDPAANDEFCTISADDLDDARQSEGTDHDCIVV 242
XP_006680608 139 S---------TIYDQQneFEGHYIVLIGYDAARDVVYYRDPGVSDTLCSVKVDCLDKARMSCGTDCDLIVV 200
EFJ14805     146 ----------RASPGDvdFAGHYVVICGYDLETNEFEIKDPSSSSCSDKLPLEALDEARKSFGTDEDILLV 206
ERN12004     221 ----------EIYGGTsgYTGHFVVICGYDADTNEFEIRDPASSRKYERVSLECLEEARKSFGTDEDILLs 281
XP_002277052 201 ----------GFCGGYseYTGHYVVICGYDVDTDEFEIRDPASSRKHERISSNCLEEARKSFGTDEDLLLI 261
KRH31061     203 ----------GLFSNNpgYTGHYVLICGYDAGADMFEIRDPASSKKHKRISSKSLEEARNTFGTDEDLLLI 263
Q8L870       203 ----------GLHSSNscYTGHYVVICGYDAVRDEFEIRDPASSKIHERISSKCLENARKSFGTDEDLLLI 263 thale cress
1_pfamImport 145 ----------GLKDSKssYTGHYVVICGYDANADEFEIRDPASSRISERISSKCLEEARKSFGTDEDLLLI 205
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