Conserved Protein Domain Family
OSTMP1

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pfam09777: OSTMP1 (This model is not part of the current CDD release)
Osteopetrosis-associated transmembrane protein 1 precursor
Members of this family of proteins are required for osteoclast and melanocyte maturation and function. Mutations give rise to autosomal recessive osteopetrosis; also called autosomal recessive Albers-Schonberg disease.
Statistics
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PSSM-Id: 490623
Aligned: 11 rows
Threshold Bit Score: 270.848
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_045091722  37 CQKYVEKFAYYQAEMVACATNWSIPP-KVCTNCYQNYINFKTYEFE--TKNlnNVFs---lDNrtCSQVIYDNYLLSYSS 110
XP_006626098  82 CRELLHIFAQRCISYVDCLLQFARPV-RICQNCYSEIESLNNTYTNisKEN--TGN-----VS--CRNVLLRSDRLQLVS 151
XP_002112561  64 CLQRLHQYSVHHSQFIQCALDSGSILfRMCRNCAIYYSRLSQSYTQimEENttINQhfgllNGlkCSQDLKYSFHVQVLL 143
XP_001807287  25 CTELKEQFASATAEFSSCAIQNSRPV-TFCENCVNAYIQIVDSYNG--MKEvpD-------NGtyCIDRFVNLDRLGIVQ 94 
Q09322        42 CQKYVEKLAVVQSEMVACATNWSIPP-VVCTKCFQNYINFKQFEYE--TKNlnNVYs---lDNrtCSQVIYDNYLLSYST 115 Caenorhabditis ...
Q5ZMW4        57 CRRLLTAFAEGSATLSGCLARRARPV-RLCQACGGLYRSLLTQYGDi-ARAvgNSS-----EShnCAKSILTSDRLQVVV 129 chicken
XP_001511508  78 CRALLVLFARSSARLTDCLGRGARPV-RVCQTCYPLFREVVGSMENi-SRAagPGNa---sEShnCARSLLMSDRMQIVV 152
Q4QQU9        88 CRELLMDFANSSAELTACMVRSARPV-RLCQTCYPLFQQVAIKMDNi-SRNvgNAS-----ESqrCAGSLLMADRMQIVV 160 Norway rat
XP_003449914  76 CSDLLHIFGQRYVAYVNCLVPAARPV-KVCQSCYSTYGNLVEIYNNisSDQmgPGN-----VT--CRDSLLRSDRLMLVY 147
XP_003971934 100 CRNLLGIFGQRYVASIDCFVPAARPV-KVCQNCFSAYGSLGDIYVNi-SDKtgPGN-----ES--CKEILLHSDRLMLLD 170
XP_005802669  83 CTELLRLFGQRYVAFVNCLVPAARPV-RVCQNCSPGYSSLSEVFLNisSDKlgPAN-----ES--CRDSILRSDRLMLVF 154
XP_045091722 111 DISTALTsKIWEKSRCDSCVtitwslhdNKSAPTFTDRTIQFQQRLYEWRNCVVNYTSgdvldpkmvpndpiltpedLKN 190
XP_006626098 152 VLHRDMN-VIWDTADCEKCL--------TFPLGSFSNDSLYFMASLNQTLSCFDKYEQ-------------------QGN 203
XP_002112561 144 QTHKHAV-GLWKSCSCNECFlqr---hhQSDEWHLHENVTEFFLVLIETRKCFLHFFNktghvnvn---tseqllskAQS 216
XP_001807287  95 TSYINSY-NLWNNAKCYECFqv----vdGKLTPNKSLETIAFNKYYDNFMQCINGt---------------------DIN 148
Q09322       116 DISKALTsEIWEKSRCDSCItikwnfpqNKSEVSFSERTMQFQNRMYEWRNCVVNYTSggvl------------ddnLTN 183 Caenorhabditis ...
Q5ZMW4       130 TLSSFFN-DTWEAANCANCI--------KNNSEGLSNSTQEFMDLFNKSLACFEHNLQgqam------------dlsPNN 188 chicken
XP_001511508 153 ILSEFFN-TTWQEANCANCL--------MNNSEGLSNSTIHFLDLFNITMTCFEQNLQgges------------slqLRN 211
Q4QQU9       161 MVSEFFN-STWKEANCANCL--------TKNSEDLSNNTQDFLSLFNKTLACFEHNLQgrty-----------slppPKN 220 Norway rat
XP_003449914 148 QLYSNLE-SLWEDSNCAKCV--------TEHLESLTNDTLYFMATLNQTLTCFEKYQQ--------------------GN 198
XP_003971934 171 LLYNSLS-DIWTQSNCDRCI--------TTGYRSLTNDTLVFLATLNQTLTCFEKNQQ--------------------DN 221
XP_005802669 155 LLYGSLD-TIWKKSNCKQCV--------TTDLTGPNNDTLYYLTLLNQTITCFEKYKE--------------------GN 205
XP_045091722 191 SSKICNECKSEFDELYKFYWKIYTt--------pDVDFCVDVETTMNDTIHL-DDVWQCAERQdrNRDLFGIMVTFAtLM 261
XP_006626098 204 QSVVCKECKTTYRGLNDLYNRMEK----------NQTVCFDIEDAMNITRRLwSKNFNCSFPR--EEIVPVIAVSSF-ML 270
XP_002112561 217 NNSICVQCREAYNHLTATYAMLTP----------RVALCGDIVYMINITRTKwINEWKCNAKS--DDLTWLVIISTL-AF 283
XP_001807287 149 DTTLCPTCIDDYLDLNSYYHSISNen-------eKIGGCMDMVDLINNTRQFwSQ--KCCKYR--RHDEHIFLASAItVL 217
Q09322       184 GSKICNLCKTTFDELFGYYWKIYTt--------pDVDFCVDVETTMNDTIHLwDDVWKCAEKQdrNRDLFGIMITFGtLL 255 Caenorhabditis ...
Q5ZMW4       189 YTEVCKNCNGTYKKLNDLYNKLQRlnrhgdesghSAHLCIDVEDAMNITRKLwSRTFNCSVPC--SDTVPVIAVSSF-IL 265 chicken
XP_001511508 212 YTDVCKNCRESYKSLSALYAEMQKrndhenkaehGTHLCIDVEDAMNVTRKLwSRTFNCSVPC--SDTVPVIAVSVF-VL 288
Q4QQU9       221 YSEVCKNCKEAYRTLSLLYSEMQKmngleskaepGTHLCIDVEDAMNITRKLwSRTFNCSVTC--SDTVSVVAVSVF-IL 297 Norway rat
XP_003449914 199 HTELCKNCKSAYGTLNVLYSQMEK----------NSTLCIDIEDAMNMTRRLwSKNFNCSFPR--EENVPVIAVSSF-ML 265
XP_003971934 222 QTELCKSCKGIYGELNKLYNRLDK----------SQAVCIDMEDSMNTTHRLwSTSFNCSVPR--AETVPVIAVSSF-ML 288
XP_005802669 206 HTELCKNCKNAYKGLNDLYSGMEK----------NSTLCIDLEDSMNMTRKLwSKNFACSLPR--EETIPVIAVSSF-ML 272
XP_045091722 262 LLTALFYAASYIQGGGQQRNLVRYSRLSDPRGQRS 296
XP_006626098 271 FLPIIFYLSSFLHSEQKKRRLILPKRAKSSTSVMN 305
XP_002112561 284 LSPVIFYGYTTINGRKKDKAETLNTTCASNHNPGE 318
XP_001807287 218 IVTLLFYVIAQFSSVKKTPTIMQQTRFAESLSHNS 252
Q09322       256 LLTALFYAASYIQGGGETRRLIQYARLSDPHGQRS 290 Caenorhabditis elegans
Q5ZMW4       266 FLPVVFYLSSFLHSKQKKRILILPKRIQSNASLVN 300 chicken
XP_001511508 289 FLPVVFYLSSFLHSEQKKRKLILPKRIKSSTSFAN 323
Q4QQU9       298 FLPVVFYLSSFLHSEQKKRKLILPKRLKSSTSFAN 332 Norway rat
XP_003449914 266 FLPIIFYLSSFLHSEQKKRKLIHPRRAKSNTSLMN 300
XP_003971934 289 FLPVIFYLSSFLHSEQKKRKLIHPKRAKSYNTLMN 323
XP_005802669 273 FLPIIFYLSSFLHSEQKKRKLIHPKRAKSHTSLMN 307
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