Conserved Protein Domain Family
MIX23

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pfam09774: MIX23 
Intermembrane space protein MIX23
Intermembrane space protein MIX23 regulates or stabilises the mitochondrial protein import machinery and is specifically up-regulated under stress conditions. It is critical for the efficient import of proteins into the mitochondrial matrix, particularly if the function of the translocase of the inner membrane 23 is compromised. MIX23, also known as Caffeine-induced death protein 2 (Cid2), is evolutionarily conserved and a homologue of the human protein CCDC58.
Statistics
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PSSM-Id: 490620
Aligned: 73 rows
Threshold Bit Score: 83.9969
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ERT01037     434 DFLRASRAIDDTITQHLNALVTPAR-AGFDPSSTAHrassysaypp--ssaslsagpPPaACRAFRDALLFPAWQARDDL 510
XP_011387226  70 ELLRQYRQLDDGITTRLNRSFARSRaLGESTSPSLLsssktnsassidlgtstygtpAPgACAAFWRE-LVDVWIGREEV 148
KDE03458      47 ALLRSSRALDDSIALRLNRASALHRsfa---------------------------npDGdSCDSFWNE-LTTRWNERTRV 98 
XP_004996476  13 RLLLEMRDTDDKIIYKMNTIiptksn--------------------------vdhldATsNCAALYHE-LNSAHMQRRQS 65 
EKD05569      46 GVVRQYRKLDDQVVTRLNRAQAQLRdEVRQGKGDS----------------------PDgMCAKMWAE-MMTGWLNRQKL 102
XP_007406242  57 KYIGRYRKLDDSLTLHLNRISIPTQsNTNSNQAKE----------------------ATiECSQFW-GILTQTWLNRESV 113
XP_053026040  63 RQLQRFRKLDDSITVSLNRSFVLLGsSDYHHRMSQTq-------------------tSPsQCAEFW-KMLTASWLSREKL 122
XP_003327600  83 RLLQRYRKSDDSITLALNRSFLLLGsPSDHPPHQHNqs-----------------qpSTsQCAEFW-KILTASWASRENL 144
XP_013023479  17 NVLRKTRKMDDTIQLSLNSA------KWESP-GQAResq-------------------eqRCYRVKRE-LFQSWLNRDQF 69 
O74982        17 NVLRKARKIDDTIQLSLNSA------KWEYPEGKVHetq-------------------eeRCQNVKKK-LFEGWLSRDQF 70  Schizosaccharom...
ERT01037     511 IQYCSRVADDAVAKDA--EAAAQAAAQAAAAAAAsgtlvdgdyatpppplpppaeITERID------------PYIKRkq 576
XP_011387226 149 VRFCIKVADQH-----------ARPAPTPLLSTSds-------------------tDRLLDadyhp---tsasQSRPEnr 195
KDE03458      99 LAFCDQVHLDQ-----------ARTLPIPTADSTr--------------------IEKGLD----------------Rdr 131
XP_004996476  66 MERCLTQVQQEIRD-----------------------------------------LKTQLNvgdr-----dmrAEQGKgk 99 
EKD05569     103 LTYCQNTVAQNLKIAQaaQAEQAQVAAVPASHDTap-----------------------------------twGHAGKdg 147
XP_007406242 114 IRSCIDILERSLKVKS--DSIERPSLDTSEKGPNe--------------------------------------TLEKSqr 153
XP_053026040 123 IRSCIEVVDRSVLERN--QSIQRLSNPVDLSSQStqdtt------------------------------asnkQKISSke 170
XP_003327600 145 IRSCIDIVDQSVSERS--RAIQELSGAPTKSEQVg-----------------------RTSgafeddiarrhrPSTGEkk 199
XP_013023479  70 LKECISIAEEEIHKDT--PSLKSSTFSPEEp-----------------------lVSERLD------------PYAKT-- 110
O74982        71 LKECQTIVRSQLDQDR--NTSKSPLKSQQQLPSSst-----------------tqVSERLD------------PYAKE-- 117 Schizosaccharom...
ERT01037     577 YALVEPQ---ANLLASLMRNEKGVESIVRARSWDVLQARCGG 615
XP_011387226 196 WSRAENT---SETLARQLHNELSVESIIRARSLDAFKSRCKF 234
KDE03458     132 LTTQGRGeteVEVERRQLRTETNVEAIIRARSLDLFLSRCPY 173
XP_004996476 100 TSLEGQAlreKQALSRQIRRELVAEDILQEQTKKVFKDRCGR 141
EKD05569     148 AYPRGVSe--NQVLADQLANEATVEAIVRKRTLEVFKTRCPF 187
XP_007406242 154 KRAIESElynERLKLKMIYDELNVESLIRQQSMKKFKSRCSA 195
XP_053026040 171 KSQLEAEvytAELKRRMVHDELAVESAIRKQTLQKFRARCSE 212
XP_003327600 200 RAELEAEvytAELKRRMIHDELAVESAIRNQALQKFSARCSp 241
XP_013023479 111 ---QEIRtspPEEVRMALQSEQAVENIIRGQTWETLKNACPG 149
O74982       118 ---VQVQlspPEEVQIVLQSELSVEQIIRDQTWEVLTNACPG 156 Schizosaccharomyces pombe 972h-
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