Conserved Protein Domain Family
ApoO
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pfam09769: ApoO (This model is not part of the current CDD release)
Apolipoprotein O
Members of this family promote cholesterol efflux from macrophage cells. They are present in various lipoprotein complexes, including HDL, LDL and VLDL. The apoprotein is secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL.
Links
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Statistics
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PSSM-Id: 519049
Aligned: 97 rows
Threshold Bit Score: 81.8317
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_003718574   76 QQQQVvaRG---------------PTPTDQLAAQIRRARLFLHRQAAVAEDGVNAAMDRAFDLEQSFTSTLASLAPSRes 140
XP_002073224   41 PIYGSlrESspkser----rtlrdSALHQNLEGGVRYVRQELQTGYKAVADQASVVGDYVDTAKAHTQRTIDILNEP--- 113
XP_001955614   37 PIYGSlrKTqpkvdrh--rsetqdSALHRNLESGVRYVREELQSGYNSVAGHAGVVGQYWETAKEHTRHTIDTLNEP--- 111
Q9VEY5         42 PIYGSlrKTepkper----hppqdSVLHKNLEAGVRYVREEVQSGYKAVADQAGIVGHYVETAKAHTQSTIDMLNEP--- 114 fruit fly
XP_002053352   84 PIYGSlrKPvpekrs---ehkpkdSALQKSLENSVRYVRLEMQNGYKAVGERTAVVSEYYNTAKNHTQRSIDFLNEP--- 157
XP_001989503   35 PIYGSlrTPapqrvq---ehtrreSSLHKSVEEGVRTVRTEIQNGYKVVGDRTAIVSDYYNTAREHTQRSIDFLNEP--- 108
15_pfamImport   1 PVYAPlhSLtkkepkcphphqpkqAAPIQALECGIRTVRVEVFNVCNALSEQKKNFDDVLETGRAHTQTTIDYLNEP--- 77 
Q7QCS7         43 PLYRPlnQKiacech---qrrnesTGPASMLEEGFRTIRVQVQEASKLVDDQKKQIVDLFEEGKKQTKFINDYLHQE--- 116 Anopheles gamb...
9_pfamImport    1 NIYTPlpDSaqa---------tfvPESPGVIERGVSVTRQSIVPLVQAVKDACVYVKKGSVNIYHGGEDVYYYLIEPP-- 69 
10_pfamImport   1 NIYTPlpQS--------------------AQAQVVPERSGIIQSGITTSQDSLYTKDPCDFVIYKVIKFALCEMDH---- 56 

XP_003718574  141 gERLMPGLVYVLVASMAGSIVSRRRNVVFRAAAPIAFGVAAGWAVLPVT----MRNVGDLAWRYEQ-RFPVVA 208
XP_002073224  114 -QNSLHRSGAIVVGGLAGFIFAARGGFIKKVVYTGIGAGAVASLCYPRQaeenARVVL-----YEGrKIFAVA 180
XP_001955614  112 -QNSLHRSGAIVVGGLAGFIFAARGGFIKKVIYTGIGAGAVASLCYPRQaeenCRVVL-----YEGrKIFAVA 178
Q9VEY5        115 -QNSLHRSGAIVVGGLAGFIFAARGGFIKKVLYSGIGAGAVASMCYPRQaeenCRVVL-----YEGrKIFAVA 181 fruit fly
XP_002053352  158 -QNSMHRSGAIVMGGLAGFIFAARGGFFKKVVYTTIGAGTVASLCYPRQ----AEENV-RIVLYEGrKIFAVA 224
XP_001989503  109 -QNSIHRSGAIVVGGLAGFIFAARGGFFKKILYTTIGAGTVASLCYPHQaednVRIVL-----YEGrKIFAVA 175
15_pfamImport  78 -ANTMPRVGAIAIGGLAGMIFAVRGGFIKKVLYTGVGAGGIASLCYPKEaehyGQIAL-----QEAkKNFAIG 144
Q7QCS7        117 -DNTMPRVGAIAIGGLAGLIFGLRGGFFKRVIYTSFGAGGLASICYPQEaemyAQHGL-----VEAkKFATIG 183 Anopheles gambiae str...
9_pfamImport   70 -PEFLPRFGTITMAGLLGMFLARKGSRFKRLAVPLGLMSAAASVCYPAQ----AVAAL----KVTGkKVYAAG 133
10_pfamImport  57 ------GSLIISID------LALLGSRFKRTVVPLGLMSAAASVCYPAQavavVKVTGKKVYAAGQwSSAAVA 117
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