7ZNL


Conserved Protein Domain Family
FmiP_Thoc5

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pfam09766: FmiP_Thoc5 (This model is not part of the current CDD release)
Fms-interacting protein/Thoc5
This entry carries part of the crucial 144 N-terminal residues of the FmiP (Fms interacting protein). A member of the THO (suppressors of the transcriptional defects of hpr1delta by overexpression) complex which is a subcomplex of the transcription/export (TREX) complex. It is essential for the binding of the protein to the cytoplasmic domain of activated Fms-molecules in M-CSF induced haematopoietic differentiation of macrophages. Fmip is also known as THOC5 (THO complex subunit 5) a 683 amino acids long protein which contains a nuclear localisation sequence (NLS), a leucine zipper and a PEST like sequence (aa. 303-319) that carries three ataxia-telangiectasia mutated (ATM) kinase specific phosphorylation sites. The C-terminus contains a THOC1 binding site. The level of FMIP/Thoc5 expression might form a threshold that determines whether cells differentiate into macrophages or into granulocytes.
Statistics
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PSSM-Id: 519046
Aligned: 53 rows
Threshold Bit Score: 193.303
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7ZNL_E       103 RLAHIRLKKGRDQTHEAKQKVDAYHLQLQNLLYEVMHLQKEITKCLEFK-------SKHEEidl---vslEEFYK-EAPP 171 human
XP_052145585  84 REILMEEDRVKAETEAAKAPVDSTTLQLHNLLYEKNHYVKAIRACLDFQ-------TKYPGiel---vptEEFHR-AAPA 152
F4K4J0        87 RAILTEEDKVKAETERAKAPVDFTTLQLHNLMYEKSHYVKAIKACRDFK-------SKYPDidl---vpeQDFFR-HAPE 155 thale cress
XP_002891320  67 RAILIEEEKTKTETELAKSPVDFTTLELHNLMYEKSHYLKANKASRDFK-------SKYPNidl---iseQDFFS-DAPE 135
XP_003545313  92 RSILMEEERARTETERAKAPLELATHQLQNLTYEKSQFVKAIKACNDSK-------SKYPDiev---vseEEFFR-DAPQ 160
XP_002504681  52 RAALEGVEATRATTAKAKLDLDHKRLELQNVLYEKGHIQKEIRACQDFR-------SAYDDetig-lcsvAEFKR-QAPG 122
Q010M5        91 CAALSGLEHLRDKTGERNVEVNRARTRAGTIAYETATLERELR---DFEre----dGASGSvkgvdlmdrGEYEA-DARA 162 Ostreococcus tauri
XP_001420073 101 RRALMGLEYLKAGTRRRDKETDPARVRAATVAYETAWRESALKRHADAEg-----sGGGVSaggielmelKEYEA-DAKR 174
CBN79838      75 RKIHSAIETIRNKVATAKQTMDVNHLQLENLLYERDYLSRETQLCRDFTmtelnkmEEDEE---------QGFLEdvdt- 144
XP_002899690  59 RDTFLEADARRTRVQEQKDVAEAHQLQLQNLLYEKDHLLREIRRCRGFS-------TKEMDk--------IEFADgPLPI 123
7ZNL_E       172 DIskaevtmgDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKEIEVKKEYL-SSLQPRLNSIMQASLPVQEYLFMP 250 human
XP_052145585 153 DIrdktlaadASHDLMLKRLNFELVQRKELCKLHEKLEQRKSSLLDTIANQKKFL-SSLPTHLKSLKKASLPVQQQLGMQ 231
F4K4J0       156 AIkdqslssdSSHVLMPKRLNFELHQRKELCKHRARLEQQKKSLLETIAERKKFL-SSLPLHLKSLKKASLPVQNHLGIQ 234 thale cress
XP_002891320 136 AIksqtlsndSSHDLMLKRLNFELHQRKELCKLRVRLEQQKKCLLETNAERNKFL-SSLLVHLKSLKKASLPVQSQLSLQ 214
XP_003545313 161 DMkdsvlsnhSEHNVVLKRLNFELFQRKELCKLGDKLEQKRKTLLETIASRKKFL-SSLPSLLKSLKKASLPVQNQLGVQ 239
XP_002504681 123 EWkea---gdDPHAVMLKRLSHELAERKKLCELEKELEARKRTLQDGIKSRRKFL-DGLGNQLKGLKRSTAPLQEHLALP 198
Q010M5       163 RGldt--eaaDEYDEMKKRLAHELIVRKELVERQKALTLELAEVKAAIEERKKTL-SGDPGAIKAMKRHAEELRRKFDLP 239 Ostreococcus tauri
XP_001420073 175 RGlptk-kprDEYELMTRRLAHELIVRREMVEEQNALKAELAALQQQVAEKKKLLgGSLEATMTNVRKSAEPLRRMFDLA 253
CBN79838     145 ------lqtaEEHAGNLAILKDQKEQRINAQLALKATQIRVKAASSTVKESRDYL-DRLPENLKDVERALAPLKKNMpwr 217
XP_002899690 124 KVd------pDVHRQHLDQLTQELHARKSLQTELKELKLKITKVEDATETKQAFL-NALPDHLAGIEAATTGLQKYMGEP 196
7ZNL_E       251 FDq-AHKQYETARHLPPPLYVLFVQATAYGQACD--KT-LSVAIEGSV--------------------DEAKALfkpped 306 human
XP_052145585 232 HTk-KLKQHHAAELLPTPLYIVYTQLLGQKEAFG--EN-IEVEITGST--------------------KDAQMFaqqqak 287
F4K4J0       235 HTk-KLKQHNLAELLPPPLYVLYSQLLAQKEAFE--ES-IELEVVGSL--------------------KDAQAYarqqsr 290 thale cress
XP_002891320 215 NQk-KLKYHNLAELLPPPLYVIYSQFMAQKEAFE--EN-IDIEVSGSL--------------------NDAQSYarqqae 270
XP_003545313 240 HTk-KLKQHHSAELLPPPLYVIYSQLLAQKEAFG--ES-IDVEIIGSV--------------------KDAQAFahhqah 295
XP_002504681 199 ITv-EEKRKGAARLLPPPLYVTYTQLAAAREAFD--DD-FEVHIEGSV--------------------ADAEALqrk--- 251
Q010M5       240 YTt-TETLDKQVAVLPGPLYILYAQLKHAQQM----GEdIRVQILGRE--------------------ADAEAYeeame- 293 Ostreococcus tauri
XP_001420073 254 YAs-TEDLDARIGLLPVPLHVLYAQLKHLQQN----EEeIKVELVGRI--------------------DDAQNFkq---- 304
CBN79838     218 -pgsRRGRHERSSELPGPLFTLYCQLEAYCDSV--------LAATGGM--------------------DESGAFsplatf 268
XP_002899690 197 VTaqRNRHHAAGTELSTPLYALYCELEAYQTASGdaGKrLQLEIVDSIgvkhtgayrkrgfptalerqEHASTKrlkaps 276
7ZNL_E       307 sq------------------------------------------ddesdsdaEEEQT----------------------- 321 human
XP_052145585 288 qenagtl---------------------------------sngdnrvdddaiDDEEDaq--------------------- 313
F4K4J0       291 kdsgmss---------------------------------ntessrleddgpDDDDDgq--------------------- 316 thale cress
XP_002891320 271 qns-----------------------------------------enlrmeidDEDNDgk--------------------- 288
XP_003545313 296 ketgifi---------------------------------tvespklendepNEE-Dgq--------------------- 320
XP_002504681 252 -------------------------------------------------aaaAEEEEarrreegaaaetvaeaehkaaga 282
Q010M5       294 ------------------------------------------------nptaTDDGNvrd-------------------- 305 Ostreococcus tauri
XP_001420073 305 --------------------------------------------------kkASEEEgelvdeg---------------- 318
CBN79838     269 ggdggdvggdrhppglaasvtiepakacvsasakaaaagpkdasdsaeapaaSTDSTsgssepd---------------- 332
XP_002899690 277 rspsaslngatpp---------------------hsrapsrspsvkrvadssSQEPEsgeivaah--------------- 320
7ZNL_E       322 ---------TKRRRPt-------LGVQLDDKRKEMLKR-----------HPLSVMLDLKCK----------------DDS 358 human
XP_052145585 314 --------rRRSRSRk-------SVVKEASNSVVAYQL-----------HPLKVILHVY------------------DTE 349
F4K4J0       317 --------rRRKRPKk-------LTSKEGSDKAGLYQV-----------HPLKIVLHIY------------------DDE 352 thale cress
XP_002891320 289 --------rQRKRPK-----------KEGFDEGGLYEV-----------HPLNVVLHVY------------------DDE 320
XP_003545313 321 --------rQSKRPRr-------FQGKESLDQEGIFQI-----------HPLTVNLHVY------------------DDE 356
XP_002504681 283 fagdeeetrKSKRARv-------SENERAVDESDPYAA-----------HPLRVELRLDGA------------------- 325
Q010M5       306 -------erDGHKRQrggrggrgRGGRGMKLSSSTYAE-----------HPLRIELDGVGG------------------- 348 Ostreococcus tauri
XP_001420073 319 ---aennrrSKKRKAr-------GGRQAASASSSLYEE-----------HPLRVEVGFGAT------------------- 358
CBN79838     333 ---skrprlDREQEDgeggvaggGEGRARLKRTISRREagkatlealrpSPLEVQLTINFGdrksdagaaaappkasGST 409
XP_002899690 321 -taekllqlRPHEEEtkeetkdqDENSEAATSQKLWNP-----------HARALQLTISVTvpm-----------dtDKN 377
7ZNL_E       359 v---------LHLTFYYLMNLNIMTVKAKVTtamel------itpiSAGDLLSPDSV--LSCLYPGDHGKKTPNPANQYQ 421 human
XP_052145585 350 esgak-rrklMVLRFDYLAKLNVVCVGI------------------EDSK-GLDHDI--LCNLFPDDTGLELPHQMAKLY 407
F4K4J0       353 ipdtk-slklVILKFEYLLKLNVVCVGA------------------EGSQDGPEKNI--FCNLFPDDAGLEPPHQSTKLI 411 thale cress
XP_002891320 321 vpdpk-shdlIMLKFEYLLKLNVVCVGI------------------EESQDGLEKNI--LCNIFPDDSGLEPPHQSAKLI 379
XP_003545313 357 isdle-saklTTLKFEYLMQLNIICVGN------------------KASNDGPENDI--LSNLFPDDTGLELPHQSAKLF 415
XP_002504681 326 -----------SFTFAYLHNLHVVTADVKPRevgapgankgnrrgkGGGDETVDDDL--LVNLFPGDTGADTPNIANKLR 392
Q010M5       349 ----------RKVIFNYLTKLHMVIARANPGkd------------------------daLKDLFPGDDGSATPNHAIEIV 394 Ostreococcus tauri
XP_001420073 359 -----------KVFFTYLTKLHVVVVSSKPE----------------------DEKF--LGELFPDDDGSEMPNHAVAVV 403
CBN79838     410 sta-----etFKVRFSFFPSLGVVAVRPAAHdgg-----------------------alLANLFPADTGKDTPNPANHHN 461
XP_002899690 378 gtttktvsgsFTVMFQYFPVAKMVTAEVVKT---------------APAGFYPGSQRcmLTNLFPGDDGLTVPQVAVNYT 442
7ZNL_E       422 FDkvgiltlsDYvleLG----------HPYLWVQKLGGLHF 452 human
XP_052145585 408 AGevp---nfSEk--dS----------RPYKWAQHLAGIDF 433
F4K4J0       412 LGdgq---tfDEnr-tS----------RPYKWVQHLAGIDI 438 thale cress
XP_002891320 380 LGndh---afDEsr-tS----------RPYKWAQHLAGIEI 406
XP_003545313 416 VGdai---mfNGdr-tS----------RPYKWAQHLAGIDF 442
XP_002504681 393 VAgfeyd---------------rsrrdRPYRWAQHLAGLDF 418
Q010M5       395 ESdftfdes------------ctgyggKPYKWAQDLAGMSF 423 Ostreococcus tauri
XP_001420073 404 APnftfdas------------capsnaKPYKWAQNLAGLSF 432
CBN79838     462 KA--------AQaspLGvfeypadvpcRPYRWAQRLAGLRF 494
XP_002899690 443 FQ--------EDsdeRTevefpasaacRPYYWTQWICGLNP 475
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