Conserved Protein Domain Family
Sec3_C

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pfam09763: Sec3_C (490610 is an unknown moldel)
Exocyst complex component Sec3
This entry is the conserved middle and C-terminus of the Sec3 protein. Sec3 binds to the C-terminal cytoplasmic domain of GLYT1 (glycine transporter protein 1). Sec3 is the exocyst component that is closest to the plasma membrane docking site and it serves as a spatial landmark in the plasma membrane for incoming secretory vesicles. Sec3 is recruited to the sites of polarized membrane growth through its interaction with Rho1p, a small GTP-binding protein.
Statistics
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PSSM-Id: 490610
Aligned: 18 rows
Threshold Bit Score: 121.189
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q57ZX4        200 IRATEKLLSTHQKKAELLSVNDLVISACAWEEVREHI-SSIMEDVGEMEARIAQYSKCILSQKEQLQRIEHQHNTLQRKQ 278  Trypanosoma b...
Q54NV1        111 VDILTERLGKTLSTLETEMIVGVLDSGVGVNEVISQLgDKDGTHLTGVTAWIEYYNKQLQDMKKYIEHIEGKNNKMEIVS 190  Dictyostelium...
XP_001636490  167 IETFTDQLSKDLSVLDGANIYSIMASEDQVTSLMDLL-EAALVELDKLDTRLTHYDDKLRTVREHMEQMEDKDRHMETES 245 
XP_001524607  996 TEVLLKGLTKELNKAKRETVKRLVSVDL-TKTLAQDV-ETASGEIDNMLRVFQRMDYNLKTLTNDVNAIDEKSKGLQLKF 1073
XP_001487248  599 GDILIKKLSHELSALKYNNVKQLVTLDFGHNSISKDM-TDSLNELSNLSTVFKRAELGFKFLSHEINSIENDSKGLQVKS 677 
XP_001387033  642 SDSLIKKLTRELNNVKQQNVRELIGLNFGSSNVSKDV-GTSINEVENLSHIFKKMEIDFKFLSSEVDTIENNSQGLQVKS 720 
Q6CQX3        542 SSSLLEKLHSRLADVDYQLNKNLLFLPKSLGELNPYK-DLVFKECDKLDPTLSLFTMELSSVSNDIEFVESQQNGLQVRV 620  Kluyveromyces...
1_pfamImport    1 SDVVLERLLLKVAEAEYQFNKQLMSLPKKASDLKLYK-AKTVQECDRMDPTLSLFTMELSSISKDIEYVERQSNGLQVNC 79  
Q6FRC5        654 ADTLLEKVNTNLSKTEYMFNTSLLTLSKLSNNLQPYE-TNVNKACDNINPTFSLFLMEMSNCSEDIDYVESQNNGLQIES 732  [Candida] gla...
XP_001642508  778 ADKLVERLDYKLAETEYDFNNDLLLLENLQTTLSGYE-QNVSKECEKINPTFSLFLMEMNNLLDDIEYVERQNNGLQVES 856 
Q57ZX4        279 QNLHKLQEQLQVVRGQLNLPPQVTALLQRvGEARSEDLEEFLsnESNVRRLSDAVGL 335  Trypanosoma brucei
Q54NV1        191 RNQKLLYSELNNLIGLMTLSDNTISTLTA-PQFNDTKGLKMA--IEAAEDLKRALTT 244  Dictyostelium discoideum
XP_001636490  246 TNRQKLLKQVEFLVNTLDIPERHIIALQE-GDLSKGLAVKEC--TNAAMAVLEALQA 299 
XP_001524607 1074 VNEKLLYNDLHEILSKVSINTSHLQEIGSfKEFSNLNRIEDL--ENKLSSLYNAIVT 1128
XP_001487248  678 INKKLLYNDLKGVLSKISINADDLRDIESfTQFDRLNLLEPL--EEKLLDLHYALGA 732 
XP_001387033  721 INRKLLYNDLRGILSKVSVNSDDLRIIEGfTEFDRLNKLENL--ELALLDLFNALST 775 
Q6CQX3        621 ANRKLLWKELNEILNSVSIDEKSLHELLR-LPMSKTS-IERM--EVLLVELYAALKA 673  Kluyveromyces lactis
1_pfamImport   80 VNKKLLSKDLSGILDSVSLAESSLEELLN-LSLVEKN-LDKI--ESLLLGLHKAIGA 132 
Q6FRC5        733 ANKKQLWSTLDNLLKIVSLDEETLNKLLN-CPIREKN-LPWI--EEQLDAMCKAYNA 785  [Candida] glabrata
XP_001642508  857 ANKKLLWSLLTDLLNTVSLDENALNELLS-STISERS-LPRI--EIQLEGLFNAIKA 909 
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