2P90,3E35,3VR0,2WAM,5Y9N,3GAA


Conserved Protein Domain Family
PAC2

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pfam09754: PAC2 (This model is not part of the current CDD release)
PAC2 family
This PAC2 (Proteasome assembly chaperone) family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 247 and 307 amino acids in length. These proteins function as a chaperone for the 26S proteasome. The 26S proteasome mediates ubiquitin-dependent proteolysis in eukaryotic cells. A number of studies including very recent ones have revealed that assembly of its 20S catalytic core particle is an ordered process that involves several conserved proteasome assembly chaperones (PACs). Two heterodimeric chaperones, PAC1-PAC2 and PAC3-PAC4, promote the assembly of rings composed of seven alpha subunits.
Statistics
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PSSM-Id: 519038
Aligned: 307 rows
Threshold Bit Score: 56.4461
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2P90_A        31 ALQGYADAGHAVESSSSHLMDAL--DHRLIASFNNDElIDyrs------rrPVvviehnevtsmdelnlglhvvrDnd-- 100 Corynebacterium...
P36040         4 LVLPLVSVGNIPQLSIDWLLNSQanEWEYLEALDSKYlVEfvgpldrpedgSDsly-----------------kdAdmky 66  Saccharomyces c...
XP_003959746   8 LLLPLVSTGNVPQLSVDLILHSLsdEFEFVKSIDSTFlHPfvgpldygidqTEpvlytqs---------sfletpSvkkf 78 
XP_003674170  19 LLLPLVSTGNVPQLTIDLMLHSLasEFQFIRALDGVFlHPflgpldhsldqDKpilyk-------------skldSgskf 85 
Q6FNF0         5 LIIPLIGTGNVPQLSIDLLLHSTn-SFNYVKRIDSKFcYPfsgpldhaageDpkl-----------------yngKtlfs 66  [Candida] glabrata
XP_003682061   5 LIVPLVSTGNVPQLALDLLVHSLssEFDFVKSLDSTFvHPfvgpldyvldqHVpvlf--------------sktaPqkiy 70 
XP_001647499   4 LVIPLVSTGNVPQLSTDLILHTLsnEFQFVQAVDSTFvHPfvgpldyvfgqDDpely---------------knvPhkqy 68 
XP_003688426   4 LILPLVSTGNVPQLCVDLLLHSVsdEFEFLANVDSTYlHPfvgpldhlagqDSpvly---------------aktPskky 68 
Q753Q7        26 LVLPLVSAGNVPQLCADVLLHSTpgEFRFVRELDGQWlHPfvgpldyvegqEslly----------------rdaPgkrv 89  Eremothecium go...
Q6CV80         4 LLLPLVSTGNVSQLCVDLVLHSEsdEFTFVKELDSIWlHSfigpldfvegsSKplyh--------------dckgSkkqf 69  Kluyveromyces l...
2P90_A       101 ----------nkPFLMLsGPEPDLRWGd---FSNA-VVDLVEKFGVENTICLyaapmtvphtrptvvtahgnstdrlkdq 166 Corynebacterium...
P36040        67 ssalevfynkkrGLFAIqQRTPLVSVNylnnFIVEiILPFLSKYNISEICIW---------------------------- 118 Saccharomyces c...
XP_003959746  79 stalelfynkskRVYVLqQRTPTIQGYln-nFIKDtLIPLIKELQITNISVL---------------------------- 129
XP_003674170  86 stalelfyneekNFYIIqQRTPIIQGYmn-nFIKEtILPLIMEFKIENVIVL---------------------------- 136
Q6FNF0        67 saie-lfkqkdeQIYVIqQRTPIIPGYln-nFIVEtLIPVLHEYQITELIVL---------------------------- 116 [Candida] glabrata
XP_003682061  71 stalelfyneskDIYVLqQRTPVIQGYln-nLIKEtILPLIDEFKIEDVVIL---------------------------- 121
XP_001647499  69 stglelfhneskDLYVLqQRSPVIQGYln-nFIKRsIVPLLNKYGIDEVVIV---------------------------- 119
XP_003688426  69 ttpmelfatrdkEVYVLqQRTPVIEGYln-nFVKTvLVPLVMKLEIDEIVIL---------------------------- 119
Q753Q7        90 ttplelfyceqrQLYLVqQRSPVVQGYen-eFCKEvLLPLLEELAPQRVVVL---------------------------- 140 Eremothecium go...
Q6CV80        70 ttplelfynrrlDLYVIqQRSPVIAGYen-qFFKEvIIPLIKSYGIESVIVL---------------------------- 120 Kluyveromyces l...
2P90_A       167 vsldtrmtvpGSA------------------------------------------------------------------- 179 Corynebacterium...
P36040       119 ----------DSLyamedengvivrpqevyslgefyfddeaellsnl-----------------hlndqesmvnnwlhft 171 Saccharomyces c...
XP_003959746 130 ----------DSFgpldekiikrklqsnnhnhknidpffsmgvcelqsignlvsnfdstlrlqmdpdtslhytnsifkft 199
XP_003674170 137 ----------DSFgvldelnlegrnfnsnksngfcslgscninsineltrnfnt---slnvntnngnnhsnnevdwfkft 203
Q6FNF0       117 ----------DSFgaldgvveslngsgsffnvgtcnlssvndliqqfddh------------lnlrnngqvnrvkafnfd 174 [Candida] glabrata
XP_003682061 122 ----------DSFgpldddvleattvparrgtnlisdgtcevgsvtdvirsfe------qslnlnqgselhlpsslfkft 185
XP_001647499 120 ----------DSYgaldedvlvpssiatrngnpfslgvidlnsigdmsrvfdt-----slnlgensnqtsniastlftft 184
XP_003688426 120 ----------DSFgsldedlavpssistrcgnplsvgtinvssisdmsnife-------snlhldtdtmqhvskslynfa 182
Q753Q7       141 ----------DSVgefetevpvhtetmesrfsvatcnvtsisdvakefaeg----------lqldeqndlsvnstlfsfr 200 Eremothecium go...
Q6CV80       121 ----------DSAgaldpsvpfsnanyqhqyatakcqlesldnitlqfqt-----------rlsiqddehsivnqvfhfd 179 Kluyveromyces l...
2P90_A       180 ------------------SLmLEKLL-KDKGknvsgytvhvphyvsaspypaAT-LKLLQSIadsadlnlpLL-ALERDA 238 Corynebacterium...
P36040       172 ptsfqdkisvdqpifkilFQ-ILNASqRPKA---------------------------LRSIkycs--claNEgDNSLDS 221 Saccharomyces c...
XP_003959746 200 psslideistdqpifkltYH-LLNDQn----------------------------LTNLKEVkyct--lfvHEgDNSIDA 248
XP_003674170 204 gdsvqqeispkqdifkfaYH-LINSN--------------------------LTtGSTLNEIkylt--cfvHEgDNSMDA 254
Q6FNF0       175 dkgiqqditteqdifkvvYH-LTNTS-----------------------------NLQLNKIkyys--tfvHEgDNSEDA 222 [Candida] glabrata
XP_003682061 186 pdslqqeisskqqifhfaYH-LLNGK-----------------------------SPYLKEIkycs--afvHEgDNSEDA 233
XP_001647499 185 eqslqqeistrqevfkfvYH-LLNSQ-----------------------------LNSLKTIkycs--lfvHEgDNSYDA 232
XP_003688426 183 edslqrevstsqqifkytYH-LLNSQ-----------------------------ITSLKEIkycs--lfvHEgDNSYDA 230
Q753Q7       201 qgsfqrgisteqfifkfsYH-LLHSP--------------------------LArSADFAELsyvs--ifiHEgDNNEDA 251 Eremothecium go...
Q6CV80       180 tasfqqnfsadqpvfklfHH-LLYQS-----------------------------DLNLKSItyls--kvvHEgDNSWDA 227 Kluyveromyces l...
2P90_A       239 EKVHRQLMEQ 248 Corynebacterium glutamicum ATCC 13032
P36040       222 QQFLQWIISQ 231 Saccharomyces cerevisiae S288C
XP_003959746 249 KLFCEHLPDL 258
XP_003674170 255 KMFTEWILRL 264
Q6FNF0       223 YTFYNNLMLA 232 [Candida] glabrata
XP_003682061 234 HLLCDHLPVV 243
XP_001647499 233 SVLCEYLPQA 242
XP_003688426 231 QTLCQKLPEI 240
Q753Q7       252 LLLCTELPTF 261 Eremothecium gossypii
Q6CV80       228 FQICEKLAEL 237 Kluyveromyces lactis
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