Conserved Protein Domain Family
Use1

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pfam09753: Use1 
Membrane fusion protein Use1
This entry is of a family of proteins all approximately 300 residues in length. The proteins have a single C-terminal trans-membrane domain and a SNARE [soluble NSF (N-ethylmaleimide-sensitive fusion protein) attachment protein receptor] domain of approximately 60 residues. The SNARE domains are essential for membrane fusion and are conserved from yeasts to humans. Use1 is one of the three protein subunits that make up the SNARE complex and it is specifically required for Golgi-endoplasmic reticulum retrograde transport.
Statistics
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PSSM-Id: 401631
View PSSM: pfam09753
Aligned: 36 rows
Threshold Bit Score: 199.437
Threshold Setting Gi: 1009343972
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EEN65884       5 RLEINFRRLLGRCEEMAAERRTG-DWRLEKYIEALQGQLSELNNLPSPg---kPTSDILKEYNKKVEFLKKYIEA-EKLE 79  Florida lancelet
XP_015625914   5 KVEVNLIRLLEAAPRQQn------QTKLVHYVTTARELLEQLGSETTPegissVSKAKTSEYSEKIEALAARLAA-PEPE 77  Japanese rice
EEE69326     129 KTEVNLLRLLDSAPRQQn------QAKLIHYVTTSRELLEKLAAENTSegissIAKGRLNEYSERIEELAARLAS-LVPG 201 Japanese rice
XP_009411799  27 KTEINLRRLLDAAPRQKn------QTKLIHYVTTLREQLEQLGAETTPqgapsIPKAKLNEYSERIEALAAKLAA-PLAE 99  wild Malaysian ...
ERN07430       5 KTEVNLRRLLAAVPQQQn------QAKLMHYVATLREQLEQLMGESTLegfpsISKAKINDYSEKIEAIATKLASdPLPD 78  Amborella trich...
CBI17875       5 RTEVNLRRLLAAAPQQQn------QAKLIHYVATLREQLEQLTEERTLeglprVSKPKVNEYSEKIEAIASKIGS-PSSN 77  wine grape
XP_002324665   5 KTEINLRRLLSSAPQQQn------QAKLVHYIATLREQLEQLAEERTAdelprVSKAVLNDYSEKIEAIASKLVN-SLPE 77  black cottonwood
XP_006595567   5 KTEVNLRRLLAAAPQQQn------QAKLVHYVATLREQLEQLAEERTLeglprISKAMLNDYSEKIEAIASKLVN-HVID 77  soybean
XP_004233203   5 KTEVNLKRLLVTAPQQQn------QAKLIHYVATLRELLEQLADERNSdglprVSKAKVNEYAENIETVAAKLAV-PMSD 77  tomato
EGT54136       6 ENELKFLRLLERTKRLTKENLSAnVWKVTAATKILNNMIYVLQNAD-------KTNDILHEYRQEVLQLKLLAEA-ESKS 77  Caenorhabditis ...
EEN65884      80 SPSERVLATELMKPGqps----lehYSTPSSQLSNRKTRELHARARSRYQKDMREELLGKMHQMHQVQggagecpykesv 155 Florida lancelet
XP_015625914  78 nempvde-----------nrevessYEGDKPGSPISLSSGLRRRPIAHNVVGPSSHERKDRD-IGAPI------------ 133 Japanese rice
EEE69326     202 yenavea-----------irkeesyLEGEQIRSPIALSPGLRRRLTALQEIEQPTNA-KERN-VAEPL------------ 256 Japanese rice
XP_009411799 100 heeathe------------akeegpSSTEQTVNYTSSLPGLRRRPTAKMETKESSHDAKEKD-SAMPV------------ 154 wild Malaysian ...
ERN07430      79 tlnavhe-----------tpvegrpFKAEEVKMHASVSPGLRRRLVSHKEGEGRTQEISERE----PV------------ 131 Amborella trich...
CBI17875      78 vqvsqepfs--------gtsgkegtSKTEE-EDHMPLSPGLRRRFVPASKFEDRSHDTIKAD-ASGPV------------ 135 wine grape
XP_002324665  78 ieapqetfa--------gdsgkespKA--DGGDQIAPSPGLRRRFAPVSNFEDKTRDSIKAD-ASAPV------------ 134 black cottonwood
XP_006595567  78 tqvpgkdfe--------rnfvkekhSEIEE-KKQILLSSGLRRRPVPASSTEDRAHEPAETD-HTSPI------------ 135 soybean
XP_004233203  78 vhtpeepva--------essssgtpKAEESVN---SASEGLRRRFGVHSNNEERSRDTIDSDQSSAAV------------ 134 tomato
EGT54136      78 STEESLKVIEKIPRVfadvqvdvsdGKSANDSFEKESAAGLRAIQRSIYRSDLRKQLLSTTKHK---------------- 141 Caenorhabditis ...
EEN65884     156 rggeEPEEDLDTVLQRHQDMQAKIAEEMLTLARSLKHNQLAAQNIIREDTKVLDKSSKLAEGNYDRLKVETERLEQ-H-V 233 Florida lancelet
XP_015625914 134 ----KLDEEAQAHIEKHRKLQEDLTDEMVELARQLKESSLTMHQSVQETEKILDSTERAVEHSLASTGRATTRAAEvYsL 209 Japanese rice
EEE69326     257 ----RLDEAAQANIEKYRNLQEDLTDEIVELARQLKDSSLMMNQSVQATEKILDSTERAVAYSLAGTDRANAQAVEvSsL 332 Japanese rice
XP_009411799 155 ----KLDASALDHIEKHRKLQEDLTDDLVALARQLKEGSLLINRSVQDTEKILDSTENAVEHSLASTSRASKRAIEvYsE 230 wild Malaysian ...
ERN07430     132 ----KLDASAQEHVEKHRKLQEDLTDEMVGLARQLKESSLMMSQSLHDTEKILDSTERAVEQSLASTGQANAKAMQvYsE 207 Amborella trich...
CBI17875     136 ----KLDAAAQAHIEKHRKLQEDLTDEMVGLAKQLKQSSLLMSQSIQNTEKILDSTEKAVEHSLASTGHVNTRAMDiYsN 211 wine grape
XP_002324665 135 ----KLDAAAQAHIEKHRKLQDDLTDEMVGLAQQLKESSLLMSQSLQNTEKILDSTEQAVEQSLASTGHANVRTMDiYsK 210 black cottonwood
XP_006595567 136 ----KLDATAHAHIEKHRKLQEDLTDEMVVLAKQLKESSLTMSQSLQNTEKILDSTEKAIEHSLASTGRANVRATAiYsE 211 soybean
XP_004233203 135 ----KLDDAARTHIEKHRKLQEDLTDEMVVLARQLKESSLMMNQSIKNTEKILDSTEKAVEHSLASTGHATSRAMDvYsR 210 tomato
EGT54136     142 ----IADTSADETFMKNERLEEDLANDLLSMTRSLKTVMSAAGEVIKDDNQRLTKMQKQIEDNKAALETESTRLEH-HaY 216 Caenorhabditis ...
EEN65884     234 KRSCNWTMWTMLAIVCIIFLFMILFIRLF 262 Florida lancelet
XP_015625914 210 ASKTTCFQWLLIFMMTCMFIMVVLLIRVT 238 Japanese rice
EEE69326     333 TSKTTCFQWFLLFVMTCMFIMVVLLIRVT 361 Japanese rice
XP_009411799 231 SFKTTCFTWLVIFIMICVFIMVVLLIRIT 259 wild Malaysian banana
ERN07430     208 SFKTSCFTWLLMFGMACIFFFVVLLIRVT 236 Amborella trichopoda
CBI17875     212 SFKTTCFTWIMIFVMTCIFIMVVLLIRVT 240 wine grape
XP_002324665 211 TSKTTCFTWLLMFLMTCIFIMVVLLIRVT 239 black cottonwood
XP_006595567 212 SSKTSCLTWLVMFVMTCVFVMVILLIRVT 240 soybean
XP_004233203 211 SFKTTCVQWLLIFVMTLIFVMVVLLIRVT 239 tomato
EGT54136     217 KCGFDCMRLFLVVLLFWSFIAMVVIMKVF 245 Caenorhabditis brenneri
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