Conserved Protein Domain Family
Use1

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pfam09753: Use1 (This model is not part of the current CDD release)
Membrane fusion protein Use1
This entry is of a family of proteins all approximately 300 residues in length. The proteins have a single C-terminal trans-membrane domain and a SNARE [soluble NSF (N-ethylmaleimide-sensitive fusion protein) attachment protein receptor] domain of approximately 60 residues. The SNARE domains are essential for membrane fusion and are conserved from yeasts to humans. Use1 is one of the three protein subunits that make up the SNARE complex and it is specifically required for Golgi-endoplasmic reticulum retrograde transport.
Statistics
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PSSM-Id: 519037
Aligned: 29 rows
Threshold Bit Score: 209.102
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EDO37586       5 RMEINLQRLLVRCEAMAGDYQEKkec-lnWRLEK--YVCALQNNANELSKSASK-PSQDAMSDYTK--RVEFLKGLVETE 78 
1_pfamImport   1 RLETNVKRLLTRCELIAKDDPHQd-----WKLEK--YILSLDDMMNKLQTSPNK-PSKDTMMGYIK--RINFLKGVINAM 70 
EEC15053       6 RLEINFGRLLQRCEVLADDRNPTn-----WRFKKvgHVGVTYTSITIMNSCSQ--PSKDTLVQYSN--KVEFLKRLIAQD 76 
2_pfamImport   1 KTEINLIRLLARCEVKAADNVKDd-----WRLEQ--YVECLETYLEELKKDTQKkPSEEALKEYAK--KIAFLKDFLNTR 71 
NP_001244850   5 RLELNLVRLLSRCEAMAAEKRDPd----eWRLEK--YVGALEDMLQALKVHASK-PASEVINEYSW--KVDFLKGMLQAE 75 
EHB05358       5 RLELNLVRLLCRCEAMAAEKRDPe----eWRLEK--YVGALEDMLQALKAQASR-PAAEVLHEYARspRPHAAPRGPRSP 77 
XP_015220720   5 RLEINFIRLLSRCESIAAEKRGDt----eWRLEK--YVGALEEMLTALKKSTSK-PVPEVMTDYSR--KVDFLKGLLEAE 75 
5_pfamImport   1 RLEINFVRLLAESESRAGEKRDRdrgqesWRLEQ--YVAALEEMLVALKKSPSK-PSAEMLTDYTR--KVDFLKGLIEAE 75 
Q7ZTY7         5 RLEINFVRLLSRCESLASEKRAEt----eWRLEK--YVGALEEMFVALKKSPSK-PTPETLTDYNR--KVDFLKGLLEAE 75  zebrafish
XP_011613167  12 RLEINFTRLLSRCESIASEKRGEt----eWRLEK--YVGSLEEMLAALRKSHSK-PTAEVLTEYTR--KVDFLKGLLEAE 82  torafugu
EDO37586      79 KAKs-------TSDKAVTSHHLSRssahasllsDRPPADRV----------QELHLKTKSRLDKEMRDELLRTGKTSVTI 141
1_pfamImport  71 KLSn-------PVERVVAAQLLSKnsv---stnNSASTNIT----------TQIHQKTVAKYNRELRAELFHSNREANKD 130
EEC15053      77 KQG--------TTERTLRNEQLATl--------SPAPDQKA----------KEILLKRQSKVVQDVRDELFDSRTSNRPA 130
2_pfamImport  72 NLPt-------AAEKALANQLLIPs------------DKQTipglvgsptgKQIKQNAAFKYQSQMKKELFAKSDGATSD 132
NP_001244850  76 KLTs-------SSEKALANQFLAPgrv---pttARERVPAT----------KTVHLQSRARYTSEMRSELLGTDSAEPEM 135
EHB05358      78 RLTpapplqasSSEKALPNQFLAPgrv---ptsARERVPAT----------KTLHLQTRARYAGEMRQELLGTVERQPea 144
XP_015220720  76 KLTs-------PTEKALANQFLAPgrn---pttANERTSAS----------KTVHLQTKARCTGEMRTELLGTVSPN-AG 134
5_pfamImport  76 KLSs-------ATEKALANQFLAPgrt---ptiATERMPAS----------KTVHMQSKARCTGEMRSELLGIVSSSDTE 135
Q7ZTY7        76 KLPs-------PAEKSLANQFLAPgrt---ptiSSERTPAS----------KTVHIQSKARCAGEMRKELMSSGVSN-SA 134 zebrafish
XP_011613167  83 KLPs-------PTDKALANQFLAPgrt---ptiANERMSAT----------KTVHMQTKGRCTAEMRDELLST-GSDKS- 140 torafugu
EDO37586     142 YTPIfdhcknl------------------pgntdneGKEESIDAVLQYHQNMQEKIAEEMVLMAQNMKHTSMMAQNIIHK 203
1_pfamImport 131 GVRQrls--------------------------ssnIKDEDLDAILKYNRNIQEKIAENMLSMTSTMKEHALAASAIIKK 184
EEC15053     131 GKENlpktvtfehfffshelladwiilysygypakgTAGEDFDAVLRYHNSMQEKIAEEMVSLAQNLKQNALLAGHIVKK 210
2_pfamImport 133 DTTLrh----------------------------rnIGTRNVDEEVKHQQNVHENIAEEIISLTRNLRHNITVSGNIIRD 184
NP_001244850 136 DVRKrtgvags-------------------qpvsekQSAAELDLVLQRHQNLQEKLAEEMLGLARSLKTNTLAAQSIIKK 196
EHB05358     145 rkrsgla---------------------gprptdkkQSAAELDLILRRQQDLQEKLAEEMLGLARSLKTNTLAAQSVIKK 203
XP_015220720 135 RTDAemrqrrg-------------------lpldekQSDAVLDAVLQHHHSLQEKLAEEMLSLARNLKNNSLATQNIIKQ 195
5_pfamImport 136 LRHRsvpv-------------------------degQSAAELDAVLQHHNNLQEKLAEDMLNLARNLKNNTLAAQNIIKQ 190
Q7ZTY7       135 LLENdlrhrks-------------------lpvderQSAAELDQILQHHHNLQEKLADDMLNLARNLKNNTLAAQNIIKQ 195 zebrafish
XP_011613167 141 ---Tdlrnrrg-------------------lplderQSAAELEAVLQHHHNLQEKLAEDMLNLARNLKNNTLAAQNIIKQ 198 torafugu
EDO37586     204 DKQVLEASTRLADCNLSKLKHEADRLEEiANRRCSLWMWIALSLVMAVFIMTILFIKMF 262
1_pfamImport 185 DIGMLEMSDKLTDVNSINLKKESLKLEEhTNSKWRCWVWLMIAFVLIVFFNMVLFMKVT 243
EEC15053     211 DTETVQKNVLATDQNYQRLQDEQNRLEEhIRRSCSCWIWLMLGIVCIVFLQMVVFMRIF 269
2_pfamImport 185 DTKVIQQSVKKADSNISQLEHESNRLEAhLRKGTNWWLWISLAVVCATFLTMIVFIRFF 243
NP_001244850 197 DNQTLSHSLKMADQNLEKLKTESERLEQhTQKSVNWFLWAMLIIVCFIFISMILFIRIM 255
EHB05358     204 DNQTLSHSLKMADQNLEKLKTESERLEQhTQKSVNWLLWAMLIVVCFLFISMILFIRIV 262
XP_015220720 196 DNQTLTQSMRMADLNFEKLKTESERLEQhTKKSVNWFLWLMLIVVCFTFISMILFIRIF 254
5_pfamImport 191 DNQTLTQSMRQADMNFEKLKLESERLEQhAKKSVNWFFWLMLILVSFTFISMILFIRLF 249
Q7ZTY7       196 DNQTLTQSMRQADVNFEKLKTESERLEQhAKKSVNWFLWLMLIVVSFTFISMILFIRLF 254 zebrafish
XP_011613167 199 DNQTLGQSMRQADVNLEKLKTESERLEQhTKKSINWLLWLMLILVSFIFISMILFIRIF 257 torafugu
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