Conserved Protein Domain Family
Es2

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pfam09751: Es2 (This model is not part of the current CDD release)
Nuclear protein Es2
This entry is of a family of proteins of approximately 500 residues with alternating regions of low complexity and conservation where the domain similarities are strong. Apart from a predicted coiled-coil domain, no other known functional domains have been characterised. The protein appears to be expressed in the nucleus and particularly highly in the pons sub-region of the brain. The protein is clearly necessary for normal development of the nervous system.
Statistics
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PSSM-Id: 519035
Aligned: 55 rows
Threshold Bit Score: 197.271
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_011386494  47 KQAILTEEEYTCALSSIIKRDFFPDLDRITAENEYLAAVEAEEPARIRIALDRLLRLDgrtNASpapQRA------SKRS 120
XP_002954839  37 QPIVLDEDTYTQQLEAIIERDYFPELPKMVNQLEWLRAVNSGDIREMQRAQRNIARRRaaaAAAvaaAAGatpapgSIGG 116
Q656K0        54 RPEVLDEDTYVAAVERIIERDFFPDLPRLRDRLDWLQALRSRDPLVLRDAQLKILERRrraQRQrqgGPVp--------- 124 Japanese rice
3_pfamImport   1 EVTVLDEDTYVAAIEKIVERDFFPDIPKLRDRLEWLEAVRSGDPLRIRDVQLKIRDRRgrkALNcaeTERn--------- 71 
XP_002301584  44 HPTVLDEDTYVATIEKIIERDFFPDISKLRDRLDWLEAMKSGDPIQIRDAQLKIMERRgk-kVNnpsSDGsfrsrnR--- 119
XP_002533868  45 RARVLDEDTYVAAIEKIIERDFFPDISKLRDRLDWLEAVKTGDPIQIRDAQLKIIERRgk-rVNssnSDGstqtrnRSQ- 122
Q9S7V6        44 RMRVLDEDAYVEAIEKIIERDYFPDITKLRDRLDWIQAVKTRDPIQIRDAQLKIIERRgk-kANhhvGDTeg-------- 114 thale cress
XP_003544200  38 HPAVLDEDTYVEALEKIIERDYFPDISKLRDRLDWLEAIKTGDPVVIREAQLKILERRagtAKVtnhNDTsr-------- 109
XP_024377067  52 SQIPLDEDTYVAAIEQIIERDFFPDIPKLRNRLEWLEAVRSGDPVIIRDAQMNIIRRRrekAREdgeRDGtps------- 124
NP_187436     44 RMRVLDEDAYVEAIEKIIERDYFPDITKLRDRLDWIQAVKTRDPIQIRDAQLKIIERRgk-kANhhvGDTeg-------- 114 thale cress
XP_011386494 121 r-----nHlsrasaaarndsgewDNTPIA-----F---GSssevfdptfTP-AESTiwldhqgEPQHEAEAEAApa---- 182
XP_002954839 117 dtpgllpP---------------FHTPGNgagwaTatpgt-----allrTPaMTPAvggggtgTEAAAAAAAANvaavag 176
Q656K0       125 -----------------------TPTPATstalrSpsf---------laTPsVAPSvagdegaDV--------------- 157 Japanese rice
3_pfamImport  72 ----------------------rSRTPGStf-trTftpFEld------kTPdVSNRessvageSAD-------------- 108
XP_002301584 120 -----------------------TQTPGStf-mrSltpFDefds--riqTPgVVMDrglssnaESNEN------------ 161
XP_002533868 123 -----------------------TQTPGStf-mrNlnpFDefdiinsnkTPrMDMFgdkeksdNNDEA------------ 166
Q9S7V6       115 ----------------------kTQTPGStf-lrNftpLDefd----gkTPrTPGVsgrefhgVEVDAGDG--------- 158 thale cress
XP_003544200 110 ---------------------ttSHTPGStf-vrNftpLDefdg-kpsqTPrAPAPeakegenN---------------- 150
XP_024377067 125 --------------------tniPDTPASmis--------------glaSPaVSLRsaaspsvSGLFPPTGSARdv---- 166
NP_187436    115 ----------------------kTQTPGStf-lrNftpLDefd----gkTPrTPGVsgrefh-----------------g 150 thale cress
XP_011386494 183 ---sGIHPD----LDLSLAHFQSRYTSEDNASFSQLLDRDNELRK-RKHAHLFAHE-AASGKRrqqlidaerRDAErgkr 253
XP_002954839 177 gatsATATP----DDLSLDAFLSRYTSEDNASFQAILQEDNRRKRaKVRHHLERPDpRDPETR---------QLLLegpk 243
Q656K0       158 ----DDDVE----AALSLDDFFRRFTSEDNESFSRILEKVNHRRR-ERYAHLLEPGeVAKA-----------PQLEdakr 217 Japanese rice
3_pfamImport 109 ----DDSEA----LPLSLDQFFRRYTSEDNESFSKILEKANRKRK-ERYEFLTEGEk-EDV-----------KLIEdvkr 167
XP_002301584 162 ----EVAVD----KNLSLDEFFRRYTSEDNDSFSKILEKVNRKRK-ERYEHLLEGEk-EDV-----------KFIGdakr 220
XP_002533868 167 ----DDAVD----EFLSLDEFFRRYTSEDNESFSKILEKVNRKRK-ETYGHLLEGEk-EDV-----------KLIEdvkr 225
Q9S7V6       159 ----DEDID----LNLSLDEFFRRYTSEDNESFSKILEKVNRKKK-EKYGFLLEGEk-EDG-----------KSIEdvkr 217 thale cress
XP_003544200 151 ----DGGVD----TSLGLDQFMRRYTSEDNHSFSKILEKVNKKRK-ERFGYLNE-----DV-----------QGIEdvkr 205
XP_024377067 167 --dnGPSVD----VNMKLDDFLRKYTSEDNASFSKILEKVNKQRK-QKYEFLNEKGlVD-------------PNLRiena 226
NP_187436    151 vevdAGDGDedidLNLSLDEFFRRYTSEDNESFSKILEKVNRKKK-EKYGFLLEge-kEDG-----------KSIEdvkr 217 thale cress
XP_011386494 254 lmleASPDDSNmseeatemlliegsdakveeksataaavtvtgqrpetssekdpmddlvlvceprqDDRRTASglHRWKY 333
XP_002954839 244 -drpSDEYGTS-------------------------------------------------------GQMPMTLlpAP--E 265
Q656K0       218 -driTDGYGTS-------------------------------------------------------GQPLSTL--EGAKF 239 Japanese rice
3_pfamImport 168 -driTDGYGTS-------------------------------------------------------DQPPSTL--DGWKY 189
XP_002301584 221 -driTDGFGTS-------------------------------------------------------DQPPSTL--EGWKY 242
XP_002533868 226 -driTDGYGTS-------------------------------------------------------DQPVSTL--EGWNY 247
Q9S7V6       218 -driTDGYGTS-------------------------------------------------------DQPPSTL--EGWKY 239 thale cress
XP_003544200 206 -driTDGYGTS-------------------------------------------------------YQPPSTL--EGWNY 227
XP_024377067 227 ndrvTDGFGTS-------------------------------------------------------NQPFATL--DTWKY 249
NP_187436    218 -driTDGYGTS-------------------------------------------------------DQPPSTL--EGWKY 239 thale cress
XP_011386494 334 TARNALMFGADANESYLHARPLGVTADHEAsRPQTNFTALRLgEQSNShtAVRHVDapQSEA---GWCASTSRLDAAIQr 410
XP_002954839 266 PVVNALFYDSSQRPEVPFSAKELADRALGP-PKEINRAGTRL----------KAPPeaPPLTvaaPVAAAAAAAAAALAn 334
Q656K0       240 TAKNLLMYYPADRGEAPLTDEERAERLKGM-TKEIDRSNTRF-HGKSSv-DDGAKEeeAAAIlyaPVAGSTP---GGMAy 313 Japanese rice
3_pfamImport 190 TAKNLLMYHPADRGEAPLTEEERAERLNGL-TKEVNLTNTRF-HGKLM--DSRPKDedTVAVlytPIPGATP-VPLSLSe 264
XP_002301584 243 TAKNLLMYHPADRGEAPLTEEEQAVRLKGL-TKEINRSSTRF-HGKML--DTRPRDdgVVEVlytPVAGATP-LP--MYd 315
XP_002533868 248 TAKNLLMYHPADRGEVALTEEEREVRLKGL-TKEINRSNTRF-HGKML--DSRPKDdgSVEVlytPVVGGTP-LP--VSg 320
Q9S7V6       240 TAKNLLMYHPADRGEAPLTEAERAVRLLGL-TKEIVKGNTRF-HGKTM--DSRPREdgSVEIlytPIAGSSP-MH--ISg 312 thale cress
XP_003544200 228 TAKNLLMYHPADRGEVPLTEEERAHRIKAA-TKEINRGNTRF-HGKMM--DSRPKDdgTVEVlytPVGGATP-AP--MSl 300
XP_024377067 250 RAKNLLMYDSAEREDVPLTQAEKEELVEGP-PKSIEMKNTRF-HGKMF--DSKVREedTVAIlytPVAGGTPQAWPFAQr 325
NP_187436    240 TAKNLLMYHPADRGEAPLTEAERAVRLLGL-TKEIVKGNTRF-HGKTM--DSRPREdgSVEIlytPIAGSSP-MHi--Sg 312 thale cress
XP_011386494 411 --GRAGSFTS-------PVasASGDETPK--------VN--GYGFVTpysTPQsgnsqsvdgemhlRVYNaikrsrQHHV 471
XP_002954839 335 geDAAAAAAA-------AAaaAAAAGAPAgapmpgglIGtvGYAPMA---TPAle----------dVMASplmtwgDIES 394
Q656K0       314 hdPDKAKKYDledlrktPNpfYVESGKNA--------NN--GYSFVR---TPSpa---------pgVDESpfmtwgEIDG 371 Japanese rice
3_pfamImport 265 reGDKSKKYDledlrktPNpfYVESRKRA--------DN--GYSYVK---TPSpa---------pgVDESpfitwgEIEG 322
XP_002301584 316 rdGDKAKKYDledlrrtPDrfYVESGKKA--------DD--GYSFVR---TPSpa---------pgVDESpfitwgEIEG 373
XP_002533868 321 rhGDKAKKYDledlrrtPNnfYMESGKKA--------EN--GYAFVR---TPSpa---------pgVDESpfitwgEIEG 378
Q9S7V6       313 rdRDKSKRYDlddlrktPNpfYVESDKRA--------DN--GYSFVR---TPSpa---------pgLDESpfitwgEIDG 370 thale cress
XP_003544200 301 reGDKLKKYDledlrktPNpfYLESGKKA--------EN--GYSFVK---TPSpa---------pgVDESpfitwgEIEG 358
XP_024377067 326 daERARKRYDledlrktPQalDSQSKGVG--------HPgaGYSYVA---TPSpa---------pgVDESpfmtwgEIEG 385
NP_187436    313 rdRDKSKRYDlddlrktPNpfYVESDKRA--------DN--GYSFVR---TPSpa---------pgLDESpfitwgEIDG 370 thale cress
XP_011386494 472 TAstsidd--------iaaraCGFQLPRLDKREQLAEKLTSTPklkrAAE------------------------------ 513
XP_002954839 395 TPlrlgaddmpvdleamvgggPSFRVQGMSEREQAAHRLAAAKagsgTAAgraitargstplltalrraatgtgggagat 474
Q656K0       372 TPlrldpeetp--ggsggsdrAHFKIPPPPARDVKAHLLSRDA----ARKikertkmfhk-----------------ppl 428 Japanese rice
3_pfamImport 323 TPlrlepedtp-igiggsgdgPHFKIPCPPSRDLKAHSLSREA----ARKlrerskmfqk-----------------ppl 380
XP_002301584 374 TPmrlepedtp-idiggsgngPHFKIPNPPARDVKAHSLSREA----SRRlrekskmfqk-----------------ppl 431
XP_002533868 379 TPlrlesedtp-idiggsgdgPHFKILNPPARDVKAHTLSREA----ARKlrerskmfqk-----------------ppl 436
Q9S7V6       371 TPmrldledtp-idiggsadgPHYNIPSAPPRDVRAHSLSRDA----SRKlrersnsmfk----------------kppl 429 thale cress
XP_003544200 359 TPlrldledtp-ldiggsadgPHYKIPSAPARDSKAHSLSREA----ARKirerskmfhk-----------------ppl 416
XP_024377067 386 TPlrleiedtp-vgiggngdgPHFKIPAPPTRDARAHALSRDA----ARSlrekakfrss----------------rfsp 444
NP_187436    371 TPmrldledtp-idiggsadgPHYNIPSAPPRDVRAHSLSRDA----SRKlrersnsmfk----------------kppl 429 thale cress
XP_011386494 514 ------RaSTPygqarytgltrlrtsafgrspqkmrdKVGGLTPAAKAL 556
XP_002954839 475 aragatGgKTP--------------------------LAVPLSPAARQL 497
Q656K0       429 pspvrgGsASP----------------------------RTFSPAAQKF 449 Japanese rice
3_pfamImport 381 pspvrgGsASP--------------------------SVRTLSHAAQKF 403
XP_002301584 432 pspsrgGsASP--------------------------SVRTLSPAAQKF 454
XP_002533868 437 pspgrgGsASP--------------------------NVRTLSPAAQKF 459
Q9S7V6       430 psphrsGsASP--------------------------NVRTLSPAAQKF 452 thale cress
XP_003544200 417 aspvrgGsASP--------------------------SMRTLSPAAQKF 439
XP_024377067 445 spgrgpGqASP---------------------------APGFSAAAQKF 466
NP_187436    430 psphrsGsASP--------------------------NVRTLSPAAQKF 452 thale cress
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