Conserved Protein Domain Family
DRY_EERY
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pfam09750: DRY_EERY (This model is not part of the current CDD release)
Alternative splicing regulator
This entry represents the conserved N-terminal region of SWAP (suppressor-of-white-apricot protein) proteins. This region contains two highly conserved motifs, viz: DRY and EERY, which appear to be the sites for alternative splicing of exons 2 and 3 of the SWAP mRNA. These proteins are thus thought to be involved in auto-regulation of pre-mRNA splicing. Most family members are associated with two Surp domains pfam01805 and an Arginine- serine-rich binding region towards the C-terminus.
Links
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Statistics
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PSSM-Id: 519034
Aligned: 59 rows
Threshold Bit Score: 85.4417
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_005848655   30 LSIFGVPAEIFCDAAAAAELEEGSHLVPCW--GDPDDLTDRWDARLLL-DPLSLAA-----SARQRRqppssaaaEEAaa 101 
XP_009412426    3 LAVEGRHALLFDDDATAAFVNARDALVPWS--GDPALLIDRYDVRHLL-DRIPPRPpv--rAASRLCevpavdgvTSS-- 75  
2_pfamImport    2 LVVVGRHALFFDDDSLAAFVNSGDALVDWN-----SLQIDRYDVRHLL-SAPPPSRr----RSNSSSssnlvdasIQL-- 69  
CBI26667        3 LEVLGRHALLFDDDANSAFVNSNDALVEWN-----SLLIDRYDVRHLLpTPLPPLKr----RRHHSSalpaeisqLEL-- 71  
XP_002529444    3 LEVIGRHALLFDDDALAAFVNSPEALVDWN-----SLSIDRYDVRHLL-SSPPPPRnrhhrRNQHRSpshnlddsLES-- 74  
NP_851194       3 LEIVGRHALFFDDDSMATFVNSPTALVDWN-----SLFIDRYDVRHLL-SSPPP-------PRIKRRrpnsndadLES-- 67  
9_pfamImport    2 LEIVGRHALFFDDDSMATFVNSPTALVDWN-----SLFIDRYDVRHLL-SSLPP-------PRPKRRrpvsddpnLDA-- 66  
XP_006847574   29 LEVAGRHAFLFDDDSTSQFVDSSDALVPWN--GDSHLSIDRYDVRHLL-SDLSSLR-----KKQKLPsskspdavSES-- 98  
XP_004969650    3 LEIVGRHALLFDDDATAEVVNSGGSLVPWAaiGAADLLLDRHDVRHLL-DCVPPRPrr--aYSAAILyvpssdgvSEA-- 77  
XP_015619942    3 LEIVGRHALLFDDDPTAEVVNSGGSLVPWAavGADDLLLDRHDVRHLL-DRVPPRPrr--sYSAALLsapsldgvSEA-- 77  

XP_005848655  102 laaagasweELERERYRDL--------DPSREHElqRHGRLLPPAGRMYfsGAregddqaeegyqgalpppglPPPAASr 173 
XP_009412426   76 ---------QLDRERYLDLp------lSGPDA--------------------------------------------DPGg 96  
2_pfamImport   70 ---------ELDKERYLDLp------lPSD----------------------------------------------EPDl 88  
CBI26667       72 ---------ELDQERFLDLp------pPSD----------------------------------------------EQEl 90  
XP_002529444   75 ---------DLDHERYLDLp------sTSDD---------------------------------------------EQDl 94  
NP_851194      68 ---------ELDHERYLDLpsespspsDDD----------------------------------------------EHDm 92  
9_pfamImport   67 ---------DLDHERYLDLpadsqspsHDESGKDceLRRNLSVLSIVDLvqTLg------------------sYV-RDDa 118 
XP_006847574   99 ---------DLDFERFRDL--------------------------------R---------------------KSDDPEg 116 
XP_004969650   78 ---------ELDRERYLDLp------dADGDG--------------------------------------------EDEg 98  
XP_015619942   78 ---------ELDRERFLDLt------aDDFGG----------------------------------------------Eg 96  

XP_005848655  174 faavahDYSGArdgggtgqYAAVGFSYGD 202 
XP_009412426   97 dddargSLSGTtkds-dgtYQAVPFSYGN 124 
2_pfamImport   89 eegdesADAGA--------YRAVGFSYGN 109 
CBI26667       91 dnglekADAAG--------YHTVAFSYGN 111 
XP_002529444   95 eteaeaKNAGG--------YNAVAFSYGA 115 
NP_851194      93 nedsanTNADG--------YRAVSFSYGS 113 
9_pfamImport  119 ndgsasTNAAG--------FRAVPYSYGS 139 
XP_006847574  117 ggrgaeMASGS--------YQAVPFSYGN 137 
XP_004969650   99 sgdaapSGNGTdtr--qsdCSSVPFSYGS 125 
XP_015619942   97 sqdavsSGNGTdtg--wadYNSVPFSYGS 123
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