Conserved Protein Domain Family
Membralin

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pfam09746: Membralin (This model is not part of the current CDD release)
Tumour-associated protein
Membralin is evolutionarily highly conserved; though it seems to represent a unique protein family. The protein appears to contain several transmembrane regions. In humans it is expressed in certain cancers, particularly ovarian cancers. Membralin-like gene homologues have been identified in plants including grape, cotton and tomato.
Statistics
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PSSM-Id: 519030
Aligned: 9 rows
Threshold Bit Score: 398.751
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003373324  11 GALGTPRdrLFQALYYRAAYIYHITVAVSVRRFIEFIVLLMAILLFGLVTYVHIVFTRQQPSCLESVRHLWPRNGILNVH 90  
3_pfamImport   1 NHLNAAR--LFHAMLVRVALKYSSKVPLKWRKVIEGAVLFLALILFFSLTFIHFNFTKTPIKCMDIMKPDWIRQGIVRIE 78  
XP_003137694  46 NQFGAVRdrLFHAMLVRVAISYNRHVPMLGKRFIEFSSLITAIILLSIMVYVHHFFDETDSNCLAPFMDQWPRNGVLRVE 125 
EFP12979      54 NSLNAARdrLFHAMLVRIALKYSGRVSLRWRKAIEGSILFVALLLFASLIFIHFNFTRSPATCLDSMQADWIRKGIVRIE 133 
Q7K4L9        44 NNMMNMRdrLFHAIYFRAAATYAELVPRKVQLTIEFLLLAKALLFFFTLIYVHNSFIKNPCTCLQDVKN-WPREGVIRVE 122  fruit fly
XP_009024019  21 HPFFNVRerLFHALFHRIAVAYCRAVPSSFRIALEIFALLKALVLFFVLCYIHVVLARGPKHCLQHIKQNWPRDGVLRVE 100 
XP_002125973 109 prngilraqvsyneslpnyklyfssqhlddskmsvqstgynmeyeytvpiqnnqlsnlkqwqadlfqkypfaiqnldhqs 188  vase tunicate
XP_056650081  43 DPLLTARdrLFHVLFFNMALIYSRLFPPTFRRVFEFFVLLKALFVLFILAYVHTAFSPEPINCSQYRWSDNPGTGLLQVE 122  gray short-tai...
XP_046446957  46 NQLATVRdrMFHAIFHRMAIAYARTFPKPIRRLLEWLFLLKALAAFLMLLYIHIIFSRSPITCLDHIKADWPREGIVRID 125  common water flea
XP_003373324  91 ITSGls------kvLLVNYNPDTYQSPDesmlhnnsstFSYEFSNSPSLSVFRPSLYWSKEHPADVSTKPPEEvELYMPV 164 
3_pfamImport  79 IVQN----------LDVLEEKEHFINQYisersarvchFNPADVFRFGPSVIPTAMRNEQRSDEVTKSKISEP-RPQAFI 147 
XP_003137694 126 VVRNlkrfnayqdrLLEKSYGKQ-SESNttvydlkrvlMKGPSALPKELQSRPKHYFRKRSDHWSSFLTAEDSlLSFFIR 204 
EFP12979     134 VVRN----------LEVLEEKENFISSYisdnshrtchFNPIDVFRFGPSVIPYSMK-ERQAAKARQMKIASPfRPMTYY 202 
Q7K4L9       123 IIPHlae----kraIWQGIKRDQEIVRS----------LKDSYYYGIGPQTR--QNHETLKRYESILGKLGLPvRPTFAY 186  fruit fly
XP_009024019 101 VLRNapp----gysLAHSYRKEDDDNGG----------VNDSNVTSHDDQRAAVAATAAEDENRSVGW------------ 154 
XP_002125973 189 kdktpntakleamrifglfdrkcpvlvdeyvedfklsilkklasvmphmtmvqtrdqdggsfiddefivgdnfetVFSPF 268  vase tunicate
XP_056650081 123 IEQNagpag-vpshLVIEAKEE-------------------------------VKVELSEENSGKLELDVQLKvILKTPG 170  gray short-tai...
XP_046446957 126 ITRSgngpdiqgysLHHSYAKEQRIHQR----------EQFEYQAMFGFWSGPYSSSADSEETESSALKETTElLSDEIY 195  common water flea
XP_003373324 165 S--------------------------------SSEVN-----------------NNNHHNygdds-------iseeFWL 188 
3_pfamImport 148 T--------------------------------YLLSVirphllsdeepsnyqieRTIDEQeeieftd---pleaeaHLA 192 
XP_003137694 205 S--------------------------------DSNLKkklfledl-dddeldfeSQDLI------------------DD 233 
EFP12979     203 S--------------------------------SVLSFlrpnlf-----fdeeeeETVKHYdsveeleyqdpleaeaHIA 245 
Q7K4L9       187 S--------------------------------NESLYyyfdainildtydhpnaIQLK--------------------N 214  fruit fly
XP_009024019 155 ----------------------------------SRMLsnllalhdlsissltslIFNNVGnndgg-------dddnGKV 193 
XP_002125973 269 E--------------------------------PSPIRs----------------------------------------- 275  vase tunicate
XP_056650081 171 KagpegltqmtqnksqklsfpkakptgmqplvkTVPLLevm--------------------------------------- 211  gray short-tai...
XP_046446957 196 F--------------------------------NDTLTnnitnld---deridslLPTEVS----------------ELD 224  common water flea
XP_003373324 189 YPQEVEKNEEEP-----SAIEYAVEYGFLRLSSA-TRDRLKIPIMYVALNpYQEVCFGESFNRFLLDHFFGYDFLLISSV 262 
3_pfamImport 193 YTEAMQDHDYADyk-yvYRVEYAVLFGLLRLPPD-YRELHNIPTTWVRID-AKSQCFGDKLSRLMMTFFVGYDEAVTSAL 269 
XP_003137694 234 SDASF------E-----YVVEYSLYYGLLKLPHS-YRLEHNIPFLLVRLDpEVDSCFGDWVSRTLMKNFIGYEDVLMSSV 301 
EFP12979     246 FYETMKDRPEPReyeylYRVEYAMLYGVLRLPPD-FREEHGIPTTWIRID-SKSRCFGDQMSRLMMRLFVGYEDTIIAAL 323 
Q7K4L9       215 EEDD-----EEQ-----YIVEYSLEYGHLRLSSS-TRKRLRIPVLTVQLDpNTDKCFGDSLTRYLLKRLLGYDDLLMASV 283  fruit fly
XP_009024019 194 ASDVGTIWPEDK-----YIVEYSLEYGFLRLTPN-TRQQLNISVKLVVLDpMKDECFGDQLSRFLLDEFLGYDDVLMSSV 267 
XP_002125973 276 ----------------yYAIEYSSEFGYLRLSSE-ARSVLAIPTLVVNLNpDKDQCFGSGLKKFMLETFLGYDDYLMTSI 338  vase tunicate
XP_056650081 212 ---arEAWPQGK-----YRVQYSLRYGLLLPSSQkTPQGRSLPAMVVKLNpKRHLCFAEQVRSLVLGKFLNYVNVHMSHM 283  gray short-tai...
XP_046446957 225 KIIRATVWPPEE-----YIVEFSLEYGFLRLSPT-TRRKLNITILLVTLDpVNNTCFGDSFGRFLLDEFLGYNDFIMGAV 298  common water flea
XP_003373324 263 KSLASN-------ESEKGYMRNLVTGEQYRFVTMW-MSRSSYISAFLTMLTFTFSISALLRFSHQQFFVFIINVFQLFEL 334 
3_pfamImport 270 RHQYSNmswnypdSYSMGYMHNILSHEHYSVVTTI-LGKSSYFIAALLMVIFTFAISMLLRFSHHQIFVFIIDLLHMFEL 348 
XP_003137694 302 KALAEN-------ETDKGYLRDMITGEHYRFVTMG-NPRASYFTALIVMLIFTFAISMLLRFSHHQIFLFIVDLLQMFEL 373 
EFP12979     324 RGQAYNlslvhpeTHSMGYLHNLQTHDHYHFVANS-LGKWSYITAAVLMIIFTFAISMLLRFSHHQIFVFIIDLLHMFEL 402 
Q7K4L9       284 RTIAEQ-------EENKGYLRNVITGEHYRFVSMWwAAWSSYPAAFCVMLLFTFSVSMLLRYSHHQIFVFIVDLLQMLEY 356  fruit fly
XP_009024019 268 KQLAED-------ETNKGYLRNVVNGEHYRFVSIW-MAKSSYLAAAFIMVVFTLAVSMLLRYSHHQIFVFIVDLLQMLEM 339 
XP_002125973 339 KKLAEK-------DNSQGYLRNLVTGEYFRFVTLW-VNHASVIIAFSAMIVFTLIVTMLLRYSYHQIFMFMVEVLRLLDT 410  vase tunicate
XP_056650081 284 KTLGEN-------EESKSFLSSVFSEEFYPFVSIW-LARTCYLTAFVIMLIFTLSVSVLLRYSHYQIFIFIVDLLQMLEM 355  gray short-tai...
XP_046446957 299 KALAEA-------EDSQGYLRNVVTGEHYRFVNMW-MARTSYIASAFAMVIFTLSISMLLRYSRNQIFIFIVDLLQMLEF 370  common water flea
XP_003373324 335 NAAF-VQVAPLISVILGLVGMEAVMSEFFNDTNIAFCVILMIWFADQYDFICCTSPLSRR 393 
3_pfamImport 349 QQPLnPPVAPLVTVVLALVGMEAIMAEVFNDTSIAFYVILIVWVADQYDAICCHSAISKK 408 
XP_003137694 374 NQALvFPAAPLLTVILALVGMEAIMSEVFNDTSTAFYVILLVWIADQYDAICCHSPISKR 433 
EFP12979     403 QQPLnPPVAPLITVVLALVGMEAIMAEVFNDTSIAFYVILIVWVADQYDAICCHSPTSKK 462 
Q7K4L9       357 NVSArFPIAPLLTVILALVGMEAIMSEFFNDTTTAFYIILIVWIADQYDAICCHTSITKR 416  fruit fly
XP_009024019 340 NRSLaFPAAPLLTVILALVGMEAIMSEFFSDTTTAFYIILIVWIADQYDAICCHTAVTKK 399 
XP_002125973 411 DTRLaFPAAPMLTIILALVGMEEIMTEFFHDSTVAFYVILIIWAADQFDVICLHTMVGRR 470  vase tunicate
XP_056650081 356 NMTIaFPAAPLLTVILALVSMEAVMSEFFNDTTTAFYIILIVWLADQYDAICCHTNTSKR 415  gray short-tailed opossum
XP_046446957 371 NINVtFPVASFFTVILALVGMEAIMAEFFNDSSTAFYVIIFVWVADQYDAVCCHTSVTKR 430  common water flea
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