8OHD


Conserved Protein Domain Family
E3_UFM1_ligase
?
pfam09743: E3_UFM1_ligase (This model is not part of the current CDD release)
E3 UFM1-protein ligase 1
The ubiquitin fold modifier 1 (Ufm1) is the most recently discovered ubiquitin-like modifier whose conjugation (ufmylation) system is conserved in multicellular organisms. Ufm1 is known to covalently attach with cellular protein(s) via a specific E1-activating enzyme (Uba5), an E2-conjugating enzyme (Ufc1), and a E3-ligating enzyme.
Links
?
Statistics
?
PSSM-Id: 519027
Aligned: 50 rows
Threshold Bit Score: 228.586
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
8OHD_A         7 EIRRLAADFQRAQFAEATQRLSERNCIEIVNKLIAQKQL--EVVHTLDGKEYITPAQISKEMRDELHVRgGRVNIVDLQQ 84  human
A0E4Z0         3 ELFALQQQLAEIQETSTKYRLSDRIIIDLIEKLVKEYDL--KVYHSTDGQSLVTPNQLSKEIHQLILSN-KRVAVNQLPE 79  Paramecium tetr...
Q22YA0         3 EILELQRLLAEVQEQTCTNKFSDRVIVELVNKIINDYGL--HLIYSQDGQEYMTPEHLDEQLAQLISER-GRIQVLEIPP 79  Tetrahymena the...
XP_004024371   5 EILELQRQLAQIQEQTTQNKFSDRVIVDLINKLIQEYNL--TLIYSSDGQEYMTPEHLDNQIQQLTQEKg----VQTLQT 78 
Q4MZ62         3 SISELRSRLASAQSTKSKLRLSNLQCIDLLLKICKKKGV--DLITSTDGMLFYTLEEVQAEVENELLSRgGRIPIFELNS 80  Theileria parva
XP_002903570   3 EIALLQQQLAAVQQQEAALKLSDHNVIDLLLKLQQLGKL--QVIHTRTGKQFLTPLQIQREIADYVALHgGRLSLTELEK 80 
Q4E139         5 DLSELVKKFQAIQRQTFPDQIGERNVVEIINVLREKQLV--DLLYTLDGKEYLTWDQLRREVVDEIVFNgGRMNVVDLPG 82  Trypanosoma cruzi
Q38AF6         5 ELSELIRKFQAIQRQDIPNQITERNVVEIVNVLQRKKFV--DLLFTVDGKEYLTWDQLRREVIDEVHANgGRMNVTDLPG 82  Trypanosoma brucei
XP_003055088   3 EILALQAQLASAQDAKSSFRLNERNVIELVGKLKKLGYLddTLMHTLDGKEFVTVEQLRKEIAEEVRASgGRVPVFDLQS 82 
XP_001569327   5 ELSELVKRFQSLQRVQVSNQITERNAVEIVNALIQKKLI--DLLFTTDAKEYLTWDELKREIMDEVLANgGRLNVVDLPG 82  Leishmania braz...

8OHD_A        85 VINVDLIHIENRIGDIik----seKH-VQLVLG--QLIDENYLDRLAEEVNDKLQESGQVTI------------------ 139 human
A0E4Z0        80 ILGIGFDKIEGQIEKD--------SNgWDVVRMqdEMMSHDYILNVCEEINEDLQQKSIISL------------------ 133 Paramecium tetr...
Q22YA0        80 ILNVTEDVVENRVPKIik----knKKdFIRVGN--EVITSNYLNQICEEINEDLQQQSQIFL------------------ 135 Tetrahymena the...
XP_004024371  79 IHNYQMLILKQS-----------------------KVVYLKYQRKTNENSQDQKTKQQQVHIqtkyvkiqmkiyskdrky 135
Q4MZ62        81 VLNFQPDHIDRAVSNIvk----pgGE-YLNSHG--VIISKQYLERLMHSIDDRIQECGTVAI------------------ 135 Theileria parva
XP_002903570  81 LIDVDRTRVEKQATALcrgsrskdS--YHLVNNgeELLTSWYLDGIMEDTDVLLQESGTTSI------------------ 140
Q4E139        83 SLNVHFTHIERVLQDVle-----dPT-IRIESG--ELLTDEYLDSTIQAAADVLKENGFLSI------------------ 136 Trypanosoma cruzi
Q38AF6        83 LLTVHMIHIERVLPEVle-----ePN-IRLEAA--ELMTDEYLDSTVSAAQDVLKEKGFVAV------------------ 136 Trypanosoma brucei
XP_003055088  83 ALNIDVHHCEREAKFLaad---atAG-LSLVEG--ELMTPAYFDGVAAEVEEELRELGVVAV------------------ 138
XP_001569327  83 LLNVHTFQVERVLPSVla----enPA-LTLEGG--ELMTDGYLDSVVLAAGDLLKEQGSLAI------------------ 137 Leishmania braz...

8OHD_A       140 --SELCKTYDLPGNFLTQ-ALTqr-----lGRIISGHIdldnRGVIFTEAFVARHKARIRGLFSAITRPTAV-NSLISK- 209 human
A0E4Z0       134 --QEIMQKYALPMQFVTKyILKq------vGAVIQGVCn---EDKLTTVTYQEIMTAKLCGILRATLSPVSF-LKLNKD- 200 Paramecium tetr...
Q22YA0       136 --FELTSKYSLTLQFLKEqLQYridnniidGNII--------GDKLCTLTYQELTKSKFRGLFRGATKPILL-SSLAKD- 203 Tetrahymena the...
XP_004024371 136 clQKQAKIYNLTMQFIKDqLQSridqriidGNIVG-------GEKICTSTFQLLMKAKLRGSLRAATKPIVL-GNLSKE- 206
Q4MZ62       136 --SDLSKEYDLPLEMMRT-YVSan-----lGSIIKGNIn---GNLIESLTFEQRKINNFLASVLAITMPIST-NDLSRI- 202 Theileria parva
XP_002903570 141 --GDLAQQFDFAVDYMRD-VVRtr-----lGSILKAREr---DNVLYTDSYVTAQKARLRGVFAAVTRPVFV-PDVLRS- 207
Q4E139       137 --AEFAKTHRFSSVFAQD-LLMkav---esQR-LRAVAe---RSAMYTTQFVHSQKAILRAGLMAATRPVNL-TTFFER- 204 Trypanosoma cruzi
Q38AF6       137 --SEFARIHRFTSLFAQN-LLTgav---esGR-LRAVLq---GGALHTKQFVGAQKVVLRAGLLAATEPVNL-TTFFER- 204 Trypanosoma brucei
XP_003055088 139 --ADLARAHGLSADLMSR-ALRerv---gdGGIVSGRMe---GGLLYTPQYVARITAQLRGAMRAALTPTTRdALVTNAl 209
XP_001569327 138 --SKFASVNQLSSLFAKS-LLSkam---drGR-IDALMq---DGSLYTKQFVNRQRMIVRAGLLAAEEPVRL-DAFYRR- 205 Leishmania braz...

8OHD_A       210 ------------------------YGFQEQLl--ySVLEElVNS--GRLRGTVVGGrqdkavFVPDIYSRTQSTWVDSFF 261 human
A0E4Z0       201 ------------------------LEIQNSQ----KICEQlLIT--KQIDGKIFSGq-----YVSSRFLQNQEAQVKSFF 245 Paramecium tetr...
Q22YA0       204 ------------------------YQIEQRQl--qEIIEDlISS--EAIEGKIISGq-----FVPTRFQRNQENTIRDFL 250 Tetrahymena the...
XP_004024371 207 ------------------------FGIENKVl--qEIIEElINQ--EYIEGKIHTGs-----FIPQKFQKNQENIIRNFL 253
Q4MZ62       203 --------------------------IKQNIntvnDTLGNlIKQ--GNVNG-FIKGn----eFVPQCYINSVDTFLTHYY 249 Theileria parva
XP_002903570 208 ------------------------FSFDEAVa--nEALTElIQS--KVLMGT-LRGr----eYVPYVFMAAQRESVYSFF 254
Q4E139       205 ----------------------------HNLf--vPLMDPvIDAvrAELPGKFVGGv-----YVPTYFEVTRAEQVENVY 249 Trypanosoma cruzi
Q38AF6       205 ----------------------------HNLf--aPLVDVlIEAvrNDLPGK-IEGr----vYIPTYFEQDRANEVENVY 249 Trypanosoma brucei
XP_003055088 210 rgcdgdgdggdgggggvgdgrgtgAELTGSIv--gELGKN-VDA--SGLDGVFQRGa-----WQPAAYSRAQTAAVGDLY 279
XP_001569327 206 ----------------------------NKLf--aPLLSHvVTEvrQELPGSFDGFs----tYIPLVYEAKRTAEVENLY 251 Leishmania braz...

8OHD_A       262 RQNGYLEFDALSR-LGIPDAVSYI 284 human
A0E4Z0       246 DQNSYVEYDKLHQqFFIQKPKEYL 269 Paramecium tetraurelia
Q22YA0       251 KQNKYIEYSMLQK-LFIQKPEETL 273 Tetrahymena thermophila SB210
XP_004024371 254 KQNNYIEYSMLQKqLYVQKPQDTL 277
Q4MZ62       250 ARNGYIEVSLINS-FHYFTTNTIN 272 Theileria parva
XP_002903570 255 QQNGYLEHARAKE-LQVARPYDFL 277
Q4E139       250 LSNGFIEYASLHQ-HGISQAKEFL 272 Trypanosoma cruzi
Q38AF6       250 LSNGFIEYALLHR-KGITQAREFL 272 Trypanosoma brucei
XP_003055088 280 ATAGIVTIDQATR-MGVERPREYF 302
XP_001569327 252 ASNGYVEYAQLQR-QGISNPRQYL 274 Leishmania braziliensis MHOM/BR/75/M2904
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap