Conserved Protein Domain Family
E3_UFM1_ligase

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pfam09743: E3_UFM1_ligase 
E3 UFM1-protein ligase 1
The ubiquitin fold modifier 1 (Ufm1) is the most recently discovered ubiquitin-like modifier whose conjugation (ufmylation) system is conserved in multicellular organisms. Ufm1 is known to covalently attach with cellular protein(s) via a specific E1-activating enzyme (Uba5), an E2-conjugating enzyme (Ufc1), and a E3-ligating enzyme.
Statistics
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PSSM-Id: 401622
View PSSM: pfam09743
Aligned: 53 rows
Threshold Bit Score: 230.123
Threshold Setting Gi: 284085872
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EEH60340       3 EILALQAQLASAQDAKS---SFRLNERNVIELVGKLKKLGYLd-dTLMHTLDGKEFVTVEQLRKEIAEEVRASGGRVPVF 78  Micromonas pusi...
XP_002903570   3 EIALLQQQLAAVQQQEA---ALKLSDHNVIDLLLKLQQLGKL---QVIHTRTGKQFLTPLQIQREIADYVALHGGRLSLT 76  Phytophthora in...
Q4E139         5 DLSELVKKFQAIQRQTF---PDQIGERNVVEIINVLREKQLV---DLLYTLDGKEYLTWDQLRREVVDEIVFNGGRMNVV 78  Trypanosoma cruzi
Q38AF6         5 ELSELIRKFQAIQRQDI---PNQITERNVVEIVNVLQRKKFV---DLLFTVDGKEYLTWDQLRREVIDEVHANGGRMNVT 78  Trypanosoma brucei
EFC39553      10 SIEQLQQQFEQVQQESLsggSYKLNEHNIIELIQYIKKQDPNfaeQLCFTSDGKEYITRDQIEYELQILLEKYGGRINKN 89  Naegleria gruberi
ESS30027       3 sLEELQRQFMAVQEAAP---TQMLSERACVDIVVKLMEKKKI---QLVTTTNGKEFVTLETLAQEIRTHLANHKGRVNVI 76  Toxoplasma gond...
Q4MZ62         3 SISELRSRLASAQSTKS---KLRLSNLQCIDLLLKICKKKGV---DLITSTDGMLFYTLEEVQAEVENELLSRGGRIPIF 76  Theileria parva
A0E4Z0         3 ELFALQQQLAEIQETST---KYRLSDRIIIDLIEKLVKEYDL---KVYHSTDGQSLVTPNQLSKEIHQLILSN-KRVAVN 75  Paramecium tetr...
Q22YA0         3 EILELQRLLAEVQEQTC---TNKFSDRVIVELVNKIINDYGL---HLIYSQDGQEYMTPEHLDEQLAQLISER-GRIQVL 75  Tetrahymena the...
XP_004024371   5 EILELQRQLAQIQEQTT---QNKFSDRVIVDLINKLIQEYNL---TLIYSSDGQEYMTPEHLDNQIQQLTQEKG----VQ 74  Ichthyophthiriu...
EEH60340      79 DLQSALNIDVHHCEREAKFL----AADAtAg-LSLVEG--ELMTPAYFDGVAAEVEEELRELGVVAV------------- 138 Micromonas pusi...
XP_002903570  77 ELEKLIDVDRTRVEKQATALcrgsRSKD-S--YHLVNNgeELLTSWYLDGIMEDTDVLLQESGTTSI------------- 140 Phytophthora in...
Q4E139        79 DLPGSLNVHFTHIERVLQDV-----LED-Pt-IRIESG--ELLTDEYLDSTIQAAADVLKENGFLSI------------- 136 Trypanosoma cruzi
Q38AF6        79 DLPGLLTVHMIHIERVLPEV-----LEE-Pn-IRLEAA--ELMTDEYLDSTVSAAQDVLKEKGFVAV------------- 136 Trypanosoma brucei
EFC39553      90 ELPKLLRVDFTYLEQPIHNL----IQKQ-IvlPDLINGc-EILTPSYLESVVMEINELLKLSGYIYI------------- 150 Naegleria gruberi
ESS30027      77 EMATALGVSPDIVEAKTEEM----TRRS-Rh-LMLLDG--DLISTLYLNMIAGEIENLLEEKGQLTI------------- 135 Toxoplasma gond...
Q4MZ62        77 ELNSVLNFQPDHIDRAVSNI----VKPG-Ge-YLNSHG--VIISKQYLERLMHSIDDRIQECGTVAI------------- 135 Theileria parva
A0E4Z0        76 QLPEILGIGFDKIEGQIEKD---------SngWDVVRMqdEMMSHDYILNVCEEINEDLQQKSIISL------------- 133 Paramecium tetr...
Q22YA0        76 EIPPILNVTEDVVENRVPKI----IKKN-KkdFIRVGN--EVITSNYLNQICEEINEDLQQQSQIFL------------- 135 Tetrahymena the...
XP_004024371  75 TLQTIHNYQMLILKQS------------------------KVVYLKYQRKTNENSQDQKTKQQQVHIqtkyvkiqmkiys 130 Ichthyophthiriu...
EEH60340     139 -------ADLARAHGLSADLMSR-ALR---ERVgdGGIVSGRMEGGLLYTPQYVARITAQLRGAMRAALTPTTRdALVTN 207 Micromonas pusi...
XP_002903570 141 -------GDLAQQFDFAVDYMRD-VVR---TRL--GSILKARERDNVLYTDSYVTAQKARLRGVFAAVTRPVFV-PDVLR 206 Phytophthora in...
Q4E139       137 -------AEFAKTHRFSSVFAQD-LLM---KAVesQR-LRAVAERSAMYTTQFVHSQKAILRAGLMAATRPVNL-TTFFE 203 Trypanosoma cruzi
Q38AF6       137 -------SEFARIHRFTSLFAQN-LLT---GAVesGR-LRAVLQGGALHTKQFVGAQKVVLRAGLLAATEPVNL-TTFFE 203 Trypanosoma brucei
EFC39553     151 -------GTLTKQLFLPSDFIKEhIITkymHLLlnGTIFS----NNSLYTEKYINNLKSITIGICNSITSRSMEcNDLLK 219 Naegleria gruberi
ESS30027     136 -------AELSQKYSLPAEFLRQ-EIH---ARL--GTVIHGELKNQYLTTAHFSRRVESIVRGVLTAACRPVAV-SAIAT 201 Toxoplasma gond...
Q4MZ62       136 -------SDLSKEYDLPLEMMRT-YVS---ANL--GSIIKGNINGNLIESLTFEQRKINNFLASVLAITMPIST-NDLSR 201 Theileria parva
A0E4Z0       134 -------QEIMQKYALPMQFVTKyILKq------vGAVIQGVCnEDKLTTVTYQEIMTAKLCGILRATLSPVSF-LKLNK 199 Paramecium tetr...
Q22YA0       136 -------FELTSKYSLTLQFLKEqLQYridNNIidGNII-----GDKLCTLTYQELTKSKFRGLFRGATKPILL-SSLAK 202 Tetrahymena the...
XP_004024371 131 kdrkyclQKQAKIYNLTMQFIKDqLQSridQRIidGNIVG----GEKICTSTFQLLMKAKLRGSLRAATKPIVL-GNLSK 205 Ichthyophthiriu...
EEH60340     208 AlrgcdgdgdggdgggggvgdgrgtgAELTGSIVG--ELGKN-VDA--SGLDGVfQRGa--WQPAAYSRAQTAAVGDLYA 280 Micromonas pusi...
XP_002903570 207 S-------------------------FSFDEAVAN--EALTElIQS--KVLMGT-LRGr-eYVPYVFMAAQRESVYSFFQ 255 Phytophthora in...
Q4E139       204 R-----------------------------HNLFV--PLMDPvIDAvrAELPGKfVGGv--YVPTYFEVTRAEQVENVYL 250 Trypanosoma cruzi
Q38AF6       204 R-----------------------------HNLFA--PLVDVlIEAvrNDLPGK-IEGr-vYIPTYFEQDRANEVENVYL 250 Trypanosoma brucei
EFC39553     220 Vtkkfylmne-------sngneyaddIEIELELYQ--NIVKDlIKN--KQINGTlQVNstlYVPNIYEKMATDQVCKFIH 288 Naegleria gruberi
ESS30027     202 E-------------------------FNLPNDSVT--NAAVQlIRL--AQLQGRlQSGi--FTPARFSTGQSDKVTSFYK 250 Toxoplasma gond...
Q4MZ62       202 I---------------------------IKQNINTvnDTLGNlIKQ--GNVNGf-IKGn-eFVPQCYINSVDTFLTHYYA 250 Theileria parva
A0E4Z0       200 D-------------------------LEIQNSQ----KICEQlLIT--KQIDGKiFSGq--YVSSRFLQNQEAQVKSFFD 246 Paramecium tetr...
Q22YA0       203 D-------------------------YQIEQRQLQ--EIIEDlISS--EAIEGKiISGq--FVPTRFQRNQENTIRDFLK 251 Tetrahymena the...
XP_004024371 206 E-------------------------FGIENKVLQ--EIIEElINQ--EYIEGKiHTGs--FIPQKFQKNQENIIRNFLK 254 Ichthyophthiriu...
EEH60340     281 TAGIVTIDQATR-MGVERPREYF 302 Micromonas pusilla CCMP1545
XP_002903570 256 QNGYLEHARAKE-LQVARPYDFL 277 Phytophthora infestans T30-4
Q4E139       251 SNGFIEYASLHQ-HGISQAKEFL 272 Trypanosoma cruzi
Q38AF6       251 SNGFIEYALLHR-KGITQAREFL 272 Trypanosoma brucei
EFC39553     289 SNGYVSVERVESmLGYK----AF 307 Naegleria gruberi
ESS30027     251 ANAFVPFSLAKD-CGFSDAHGFL 272 Toxoplasma gondii VEG
Q4MZ62       251 RNGYIEVSLINS-FHyfttntin 272 Theileria parva
A0E4Z0       247 QNSYVEYDKLHQqFFIQKPKEYL 269 Paramecium tetraurelia
Q22YA0       252 QNKYIEYSMLQK-LFIQKPEETL 273 Tetrahymena thermophila SB210
XP_004024371 255 QNNYIEYSMLQKqLYVQKPQDTL 277 Ichthyophthirius multifiliis
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