Conserved Protein Domain Family
Dymeclin

?
pfam09742: Dymeclin (This model is not part of the current CDD release)
Dyggve-Melchior-Clausen syndrome protein
Dymeclin (Dyggve-Melchior-Clausen syndrome protein) contains a large number of leucine and isoleucine residues and a total of 17 repeated dileucine motifs. It is characteristically about 700 residues long and present in plants and animals. Mutations in the gene coding for this protein in humans give rise to the disorder Dyggve-Melchior-Clausen syndrome (DMC) which is an autosomal-recessive disorder characterised by the association of a spondylo-epi-metaphyseal dysplasia and mental retardation. DYM transcripts are widely expressed throughout human development and Dymeclin is not an integral membrane protein of the ER, but rather a peripheral membrane protein dynamically associated with the Golgi apparatus.
Statistics
?
PSSM-Id: 519026
Aligned: 49 rows
Threshold Bit Score: 221.445
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q54JJ6         1 MGTGSSREQ---HLNSFNTLQKETVP-------FSSDLWKtilSQN-LEDDSLYL--------ENLKKLKNERPENLATF 61  Dictyostelium d...
XP_002128944   1 MGIGCSSFAh-lEDNEYLKRLSSNVSise-ndpFWNQLFSftlSAP-RDRNEAILleeatetfCKMLVDHNQHTGNFTSL 77 
XP_009022474   1 MGANNSTLSkdlSNNEYLLKLSGPDYisp-nepFWNQLLSfafSVP-KTSADQRHleditsnlCKNFAINNCRTGNFGSL 78 
XP_002423085   1 MGASNSKd---lSSNEYLLKFSGKDHisc-sdqFWNVFLSfsfKPP-SSKSENEVindklskiFENLLKNNLESGNFVSL 75 
1_pfamImport   1 MGMNVSRQVd-lAENEYLKRFVGRDHvpaynddFWNSFLQyhiNLP-TNSQEQLSldsrleslCQSFIAHNLSSGNFGSL 78 
Q7KNA0         1 MGINVSRTAd-lGSNQWLQRFVGRQHiahddeaFWNGLLNyniVLP-ENSQDQLNldsrlealCQSFIGNNLKTGNFGSL 78  fruit fly
XP_015794563   1 MGITNSALNn-lKSNEHLNKFASNQHipv-gdsFWNEMLSfsfTKSiRTLEETRVledsvsplLNSLLSHNLNSNNLGSL 78 
EJW84912       1 MGAKISSETl-iEENAYLRRFVGLQPisd-ndpFWNHFLSfnfLIDsNNRKEVEQfdislsdsLQSLMYNTPTTCNFASF 78 
XP_046451730   1 MGAQCSSVAn-lNSNEHLFQLCGSTPmta-ndpTWNQLFSfnlQIP-LSSLENHEviegtaqlFQLLESNNQATRNTSAL 77  common water flea
XP_003965250   1 MGANTSHISd-lSNNQSLKTLVGTESise-ndpFWNQLISftfISP-TSSGDSKLleevvvplAKTLVHNNPRTGNFGAL 77  torafugu
Q54JJ6        62 IKKLVNQLVLVKG----LQREtntpgdfQLTSISLsyLSRILPIVfesgddfadkvfwlnegieplshpsakistppsit 137 Dictyostelium d...
XP_002128944  78 LKVFLSRFSELKSs---AECDdqlfiwqSRNAMFV--IQHLCKFL----------------------------------- 117
XP_009022474  79 IRVFLMRANELSTs---ALCKddlftwqTCNALFI--IRIVCKYF----------------------------------- 118
XP_002423085  76 IRVFINKSTDVLSa---SSTGneilvwqTYNALFI--IRCFTRYL----------------------------------- 115
1_pfamImport  79 FNVFLVKVSELLAl---SDAEstvhiwqAFNALFI--IRCLVKYM----------------------------------- 118
Q7KNA0        79 VTVFLEKTSELLSl---SDQEsnmhvwqTFNALFI--IRSLVKYI----------------------------------- 118 fruit fly
XP_015794563  79 VKIFISKSAALKDelnkEASQnii-icqTFNSMFV--IRCCAKHL----------------------------------- 120
EJW84912      79 IHVLLRRTAELKAs---EIYNntiflwqTGNALIV--LRYICKFL----------------------------------- 118
XP_046451730  78 LRVFLSRATELKAs---AQCDkif-iwqTCNALFI--VRVIFSHW----------------------------------- 116 common water flea
XP_003965250  78 VKIFLARTKELKIs---TECQdqlfiwqAHNALFL--IRCLLKVF----------------------------------- 117 torafugu
Q54JJ6       138 ttktteiieEQEKKDQenkqveenkeneekkdeekkdeekkdeekkdedkkenkttttttttnttnntnnNnnsdessfd 217 Dictyostelium d...
XP_002128944 118 ---------AENTTEMkmmeqfgar-------------------------------------slverqkdLtsgsvfegt 151
XP_009022474 119 ---------IENLTEEvvvqqfe-----------------------------------------tinyteGtnq----le 144
XP_002423085 116 ---------VETVKEAeyirhfnvkp-----------------------------------mmvsqtvaeQqldnlsnkk 151
1_pfamImport 119 ---------IETGSEYqllqhfealpvqqdd------------------------adveqgseavtvavtGetrtalakl 165
Q7KNA0       119 ---------NETGSEFqllqhfeampnaellqaal----------------eqqqqtpaesatiameateQsaaaavpvi 173 fruit fly
XP_015794563 121 ---------VQTLTEEnvlkhfl-----------------------------------------arkdgkEgn------e 144
EJW84912     119 ---------VQRLSETefikvfhmdk-----------------------------------tylekkdayDsdfeeefdg 154
XP_046451730 117 ---------IRLEKEAvlikkfs-----------------------------------------fqeensC--------- 137 common water flea
XP_003965250 118 ---------IREMSEEelqqqfs-----------------------------------------yqerapGsca----et 143 torafugu
Q54JJ6       218 TTP-LAVKLMDSLLDLLFfpgfTVTeslglkspkeaspdaipvlfswaggfgvdsvptvhnKq-FWINRLSVLQCLITCL 295 Dictyostelium d...
XP_002128944 152 ENVnYAHELLSALMDIII----HVPi-----------------------------------LdfTYSLHIEALNTILVLL 192
XP_009022474 145 ARDaLMEEFLNRLVYILI----DVPq-----------------------------------TdvTYSIHIECINIILSLL 185
XP_002423085 152 IHEnPLESLLESLLEILI----DVPl-----------------------------------DfqTYSLHLEVVNCLLVFL 192
1_pfamImport 166 IDGtKFETFLEALVNIIV----VIPv-----------------------------------KefTYHLHLEAVNCLIVLL 206
Q7KNA0       174 VDGsKFETFIDALVNLIV----VIPv-----------------------------------KefTYHLHLEAVNMLITLL 214 fruit fly
XP_015794563 145 TGVeVMESLINNLVSVLV----DIPl-----------------------------------SdsTYALHCECINLLLVLL 185
EJW84912     155 LCEnKAEELLDTLVDILV----DLPs-----------------------------------NdsTETIHIEAVKCLMVLL 195
XP_046451730 138 --EsLLENLAVQLVEILV----DVPl-----------------------------------KeeTALLHRESVQTLMLLL 176 common water flea
XP_003965250 144 DKQdLLEELLSNLIHLIV----EVPl-----------------------------------LdiTYSILFEAVTTLLVLF 184 torafugu
Q54JJ6       296 --SEQLYVPQDSVSTF-K-SKWLDWITHTQEYyteALLFSLINTFATFDPI------------GWGIpynhLMY--SDDH 357 Dictyostelium d...
XP_002128944 193 --SVQMFVP-SPGDNGpIyRILMTGQCAAKAN---NFMRALLQNFIEQRPSpeags--renggGSFV-----IGiaSAVA 259
XP_009022474 186 --SIQLFQM-SPASESmLhRCFMQGKCSRNSC---KLVKNLLETFTSQCRTnnn-------tpHGAL-----YGvaCRFI 247
XP_002423085 193 --SAQMYTR-KPAAKLiIfKTLMQGRPSIHSP---LLIKTLLGHFIKQEKPyer-------ggGSIV-----IG----LA 250
1_pfamImport 207 --SVSQFTQQGTEKSN-IfRTIYKC---QHAN---TLMSALLHFLSRMTQVpatmf--gfgsgGSFV-----FG----IA 266
Q7KNA0       215 --SVHLFAQ-QPTDKSiVfRTVFKC---QHAN---VLMSALLHFVARIVEVphtmf--gsssaGSFV-----FG----IA 274 fruit fly
XP_015794563 186 --SVQMYSV-KPASKSvIyRCIMK-KCAIHSL---LLTKCLINNFIRQDLPpre-------dgGSVI---------LDLA 242
EJW84912     196 --SSQLYDD-DVMRPNiFyRYLMQGKCSTRSL---ELSRALISNYLQRYTPcvvkh---dkepESIV-----LG----LA 257
XP_046451730 177 fvAASSYLI---NNKSiIfKCLMHGPGALHAG---LLTRTLLQHYCQQQSVpvrwlr-kpeqgGSIV-----LGlaTglw 244 common water flea
XP_003965250 185 --SYQLFHKEILRNGI-IyQHIMKGRCLSLTS---RLVKTLLYNFIRQEKCpppsshvfepkdDGGL----LYGlaSGVA 254 torafugu
Q54JJ6       358 ----------------------------------EICSKLSIQILNVLLTYDPIENNDQQpqqQhhhhqqqhhqqqqqqq 403 Dictyostelium d...
XP_002128944 260 sglwsalklggkkd-------sgvskeltselgpPTIGRQSALLILALINHQSYVDPTGQp--F---------------- 314
XP_009022474 248 sslwsvvtlgla----------nqktehvvnesrAMLANQSLLLLLVLCNQFCSNGSFI--------------------- 296
XP_002423085 251 sniwhilslay------------knstnleppkgITLANQSLLLILVLVSHCTAEKNLL--------------------- 297
1_pfamImport 267 eslwsiltfarkqpd-----vltahdlpaafkdhYPLANQSLLLILILTNHYTTKD------------------------ 317
Q7KNA0       275 esllsiftfrkqpdilkagqaagggelsqrfrthYPLANQSLLLILILTNHCTAQD------------------------ 330 fruit fly
XP_015794563 243 sglwsaltlgy-------------gknnndetlkPVLSKLSLFLLLVLTYHCTTDS------------------------ 285
EJW84912     258 asvwsavqivtgmd------dsnslssdseitppVSLGSLSVLLLLNLACHQDPEAKL---------------------- 309
XP_046451730 245 slisrns------------------staesvdavSDFASQSLLLLLVLTNHCSTEKNWS--------------------- 285 common water flea
XP_003965250 255 sglwsvftlgga----------gskagideehnpLPLSNQSLLLLLVLANLTDGPDWP---------------------- 302 torafugu
Q54JJ6       404 qStiecrNKFIQYIKTLKRVR-------------------DFKFFFNAFERIMNVplIASHTklpnstkkielhqdlTYT 464 Dictyostelium d...
XP_002128944 315 -V-----NPYKAALCCFRHVQgqlqgpsn---gkqkgslpSFHINLSRLYGTACSvqVYESS---------------TLL 370
XP_009022474 297 -------NPYQTAFLSLHDDIpnaiet--------patrdHISVKFLDLYTTICStiKTDTC---------------TLL 346
XP_002423085 298 -------NPYRDFLFTFIHNSpghlslgsnpeeipvssvsALQINFDHLYVALCNtaANECS---------------TLM 355
1_pfamImport 318 -------NPYRVSLFGCADSQgaadssgs---skepeqavTFKIDFSSLYNTLCRivTIDQT---------------TLL 372
Q7KNA0       331 -------NAYRTSLFSCADSKdspk-----------qgavSFQIDFSAVYETLCTivTIDQA---------------TLL 377 fruit fly
XP_015794563 286 -------NPYREALFNCCDLQvdsigv--------aglvsGFKMNFNQLFSTLCAtqNEDQS---------------TLI 335
EJW84912     310 -------NPYKESLSKFQNSQevssln--------nsetdTFKLDYSLLYERLCAtvNQQSP---------------MLF 359
XP_046451730 286 -------NPYRQALLSFTDSQdpvqvs-------pvhpsaCFRLDYSVLYSTLCDrlGDERT---------------TLL 336 common water flea
XP_003965250 303 -------NPYRQAITCFRNTQdtsss---------aeqphSFQINFNSLYTALCErqRSDQA---------------TLL 351 torafugu
Q54JJ6       465 MWLFLSYNHDFLRSIVN-YENSPEFLIPLLQYMDEGR-------KSQTThgIVQIGTFILLLLSGERDFSISLNKP---- 532 Dictyostelium d...
XP_002128944 371 LYSLLHGNPDVKAFVLS-KTDIDSLVTPILQILYFAP-------SQNSH--HIYMALIILLMFTEDDHFNKYVHDIrlpt 440
XP_009022474 347 VYMLLHRVEPFKTYCLS-RTNIEQLVLPILEMLYNSH-------EGNSQ--HLYMALIIILILSEDANFSLAVHDIpisk 416
XP_002423085 356 LYLLLHRNENVKNFILA-RADLEYLVVPILKTLYNIT-------ESNSH--HIYMSLIILLILSEDGGFGQTVHQItikn 425
1_pfamImport 373 LYLLLHRNQRFYKYVMA-QQNLQQLVIPILQTLYNAP-------DSTSH--HIYMSLIVLLILSEDDNFNKSVHEIilkn 442
Q7KNA0       378 LYLLLHRNERFYRFVMQ-QQDLEQLVIPILQTLYNAP-------DSNSH--HIYMSLIVLLILSEDEGFNKNVHTImlkn 447 fruit fly
XP_015794563 336 LYLLLYKNPSFRAFLISrTSQLDDLTIPILKILYHSG-------EKTSH--HIYMAVIILLILSEDALFNESIHDItlkn 406
EJW84912     360 LYILLHRNVGFRNYILS-RINLEKLVLPVLIVLSDGAqsssminSYNAH--HVYLALIVILILSEDDFFCKVAHETmikd 436
XP_046451730 337 LYMLLHQHQQFRNYVYT-HADIQRMVIALLQELFNGD-------DQGSH--HLYMSLIILLLLSEDEGFNSNIHNVvvrn 406 common water flea
XP_003965250 352 LYTLLHQNANMKTYMLS-RTDMDNLVLPILEILYHVE-------DRNSH--HVYMALIILLILTEDDTFNRSIHEVvlkn 421 torafugu
Q54JJ6       533 ----F-VGRIHIDIQqpqvysDFVITVMYRLLVDTPDRLE--SIYECVLTILSNLSPYMKNLSMVTCVKLMKLFEYLSTP 605 Dictyostelium d...
XP_002128944 441 -vpwY-TDRILSDISl----gDLIILVVIRTIQFNMSRMRdrYLHTNCLAALANMSAHFRSLHPYAAQRIFSLVTLLTKK 514
XP_009022474 417 qipwF-NERQLGEISl----gGLMVLVLVRTIQYNMTRMRdqYLHTNCLGALANMSSHFMNLHPYVAQRLVSLFALLLKK 491
XP_002423085 426 -vtwY-HEKVLTEISl----gGLLLLVVIRTIHYNMLKMRdkYLHTNCLAALANMSNNFCNLNSYVSQRLLSLFETLAKK 499
1_pfamImport 443 -itwY-TERSISEISl----gGLLILVVIRTIQYNMLKMRdkYLHTNCLAALANMSGQFRSLHPYVAQRLVSLFETLAKK 516
Q7KNA0       448 -itwY-TERTISEISl----gGILILIVIRTIQYNMLKMRdkYLHTNCLAALANMSGHFRALHPYVAQRLVSLFETLARK 521 fruit fly
XP_015794563 407 -itwY-SERTLPEISl----gGLIILMIIRTVQYNISRTRdkFLHTNLLATLANMSNHFRRLSPYVCQRLVTLFEKISKK 480
EJW84912     437 -ttwFnSERPLGEISl----gGLIILVFVRIIQLNTLKTKdrYLHTNCLAALANMSSYFKNLSSIVCQKLIGLLEVFTRR 511
XP_046451730 407 -plwY-TDRVLNEISl----gGLAVLVIARTIQRNIVKASdkYLHTNCLATLANMAAHFRRLHPYTCQRLVSLLCTLNKR 480 common water flea
XP_003965250 422 -itwY-SERSLTEISl----gSLLILVVIRTIQFNMTRTRdkYLHTNCLAALANMSAQFRSLHQYAAQRIISLFALLSKK 495 torafugu
Q54JJ6       606 RFLF---ATNH--------------------------------------------------------------------- 613 Dictyostelium d...
XP_002128944 515 YRKL---TEKVlaimatsdtpgtvsdasats------------------------------------------------- 542
XP_009022474 492 HKKAadrLKEIaeiartnenki---------------------------------------------------------- 513
XP_002423085 500 YHRLeitLKTNmvkinsetrenddgekensfvemgknsttsqskpneensvketiingthesdkedmaiqiksstdldvk 579
1_pfamImport 517 HARLdqqLRQPaavaangdaaavvavp----------------------------------------------------- 543
Q7KNA0       522 HTRLdaqLKEPadsavfvnvst---------------------------------------------------------- 543 fruit fly
XP_015794563 481 LHKIlnsQNAIngnggdsgeklsdkdtd---------------------------------------------------- 508
EJW84912     512 HAKL---IENMrvraeydiiqek--------------------------------------------------------- 531
XP_046451730 481 RIRV---VQQIksdvkgdsatga--------------------------------------------------------- 500 common water flea
XP_003965250 496 HNKV---LEQAtqslrgrqgdnt--------------------------------------------------------- 515 torafugu
Q54JJ6       614 -------------------------NYRYVGFLLESLNNLLQ-HQYESNTRLIYAILRCQNQFSKLAYLKIsPVTpskpm 667 Dictyostelium d...
XP_002128944 543 -----seqaeidmeperdyasnlkvLEEVLRMLLEIVNSCLTgGALRHNANLVYALLQRREAFDQLRLHTV-YQD----- 611
XP_009022474 514 ---------------fipllqelavIEEVIRMTLEILNSCLC-HSLNYNPNLVYTMLYQKEIFVQLSSHPS-FQD----- 571
XP_002423085 580 nlsgdeavinvddnassdivqdlnvLEEVLRMILEIINSCLS-NQIQHNPNLVYALLYKKDIFDPFRTHQN-FND----- 652
1_pfamImport 544 ---------ivagsnpddmlqdlsvLEEVLRMVLEILNSCLS-HQLVYCPNLVYTLLYKRNVFEAFRSHSA-FQD----- 607
Q7KNA0       544 --------------tpedmlqdlsvLEEVLRMVLEILNSCLT-NQLVYCPNLVYTLLYKRSVFEGFRSHHA-FQD----- 602 fruit fly
XP_015794563 509 ---------vastvgpldptqdtsiYEEVLRMLLEIMNSTLS-SQLIHNPNLVYTLLYNRHVFEPFQSHPS-FQD----- 572
EJW84912     532 --------------eshnyhkditaLEEGIRTLLEICNSCLS-SNLRSNPHFIYTILYKRDLFDAFQNHPM-FQD----- 590
XP_046451730 501 --------------sreeleqdlsiLEEVLRMLLEILNAAFT-HQLGCNQNLIYSVLHKREVLDVLRRQPA-FQD----- 559 common water flea
XP_003965250 516 --------------alpdyaqdlnvIEEVIRMMLEIINSCLC-NSLHHNPNLVYALLYKRELFEQFRTHPS-FQD----- 574 torafugu
Q54JJ6       668 eqitqpspistseeafgklnklsiseepstlsneksdkttdggdhqdesiskskvqskpttehpnstgatpsstnsgtpt 747 Dictyostelium d...
XP_002128944     --------------------------------------------------------------------------------    
XP_009022474     --------------------------------------------------------------------------------    
XP_002423085     --------------------------------------------------------------------------------    
1_pfamImport     --------------------------------------------------------------------------------    
Q7KNA0           --------------------------------------------------------------------------------     fruit fly
XP_015794563     --------------------------------------------------------------------------------    
EJW84912         --------------------------------------------------------------------------------    
XP_046451730     --------------------------------------------------------------------------------     common water flea
XP_003965250     --------------------------------------------------------------------------------     torafugu
Q54JJ6       748 ikafssttpnqespklggdgidsqsstpnkqqlpppppqqtkktqmvshfmptdewlqdikkqlPLDNILKVITHLSPQI 827 Dictyostelium d...
XP_002128944 612 ----------------------------------------------------------------VLQNIDTVINFFTGRL 627
XP_009022474 572 ----------------------------------------------------------------IVFNIEMILNYFASCL 587
XP_002423085 653 ----------------------------------------------------------------VIQNLDSVINYFSDKL 668
1_pfamImport 608 ----------------------------------------------------------------IIQNIDMVVGFFSSRL 623
Q7KNA0       603 ----------------------------------------------------------------VIQNIDMVVGFFSSRL 618 fruit fly
XP_015794563 573 ----------------------------------------------------------------IIMNFDTVLTYFSNRI 588
EJW84912     591 ----------------------------------------------------------------LIWNICAVISHFASRV 606
XP_046451730 560 ----------------------------------------------------------------IVANLDTVSNYFNNRI 575 common water flea
XP_003965250 575 ----------------------------------------------------------------IMQNLDTVIGFFGQRL 590 torafugu
Q54JJ6       828 QGLCTGSG-SDEQKIMDYLKMSTIVGifh--npgPIMTRRYHSNAITKSWFIAYMWCI 882 Dictyostelium discoideum
XP_002128944 628 DQLNQQT--MTTDEVHSVIKDATVQLpshrlhkfPDLKFRYVEEDSPEEFFVPYVWSL 683
XP_009022474 588 EKQGGS---LSVTEVHALIKQAGLQFkkdrlkkfPELKFRYVEEERPEEFFVPYVWSL 642
XP_002423085 669 KQVQTD---LSVNEVLSTITQGTLVWpshklkkfPELKFKYVEEDQPENFFIPYVWNL 723
1_pfamImport 624 VRVQDQRGeLGVNEVLEVISKGASQWssdrlrkfPDLKFKYVEEDAPEEFFIPYVWTL 681
Q7KNA0       619 QRVQEQRGeLGVNEVLEVISKGASQWssdrlrkfPDLKFKYVEEDAPEEFFIPYVWTL 676 fruit fly
XP_015794563 589 AAAEDSN--TSVAQVYEIIQNCSLQWpadkmkkfPELKFRYVEDDQPEEFFIPYVWSI 644
EJW84912     607 QLLEKG---SSVSAILATIQKGVLHWptdrlkkfPELKFKYVEDDNTVEFFVPYVWRL 661
XP_046451730 576 SQLNE----PGVNEILQSIQLGCVDFpkdqlkkfPELKFRYVEEDQPEEFFIPYVWSM 629 common water flea
XP_003965250 591 EQAGSD---LSVERVQEVIMKGAQALptdrlkkfPELKFKYVEEDQPEDFFIPYVWSL 645 torafugu
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap