Conserved Protein Domain Family
LRRFIP

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pfam09738: LRRFIP (This model is not part of the current CDD release)
LRRFIP family
LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin.
Statistics
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PSSM-Id: 519022
Aligned: 15 rows
Threshold Bit Score: 270.02
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WGS:AANI:GJ18437-PA  29 AEARLAARRLARAEAREIRMRELERQQKELEQNADRAFDMQSTSgsviidtLSSHPTRHGY-SGLVNLVRATT------- 100
3_pfamImport          1 AEARLAAKRAARAEAREIRMKELERQQKELSDDDERMSVGSRGS-------VRGSRAASALtAATLTSVGGTS------- 66 
EEC04563             21 AEARLAQRRQARAEARAIRLRELEKQAREVIRPVRTSREVSSASallpesdARPGLPPQGRtSSFVSSSSFSS------- 93 
B2GUE2               31 AEARLAAKRAARAEARDIRMRELERQQKELDEKIDKQFTENYSR-------PSSRNATSGI-PGTFTPLSGSS------- 95  tropical...
NP_001033159         31 AEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAENYTR-------PSSRNSASAT-----TPLSGNS------- 91 
1_pfamImport          1 AEARLATRRAERAEAREIRMKELERQQKEVEEKPDRDFV------------DKGSRTASTLsAATLASLGGAS------- 61 
XP_971050            28 AEARLWAKRQARAEAREIRMRELERQQKEQEENADRQFDMLAEP-------------MARTaRTVTAGSRYLS------- 87 
XP_002430218         31 AEARLTARRQARVEAREIRLRELERQQKEQEENADRVYDMSHSGd------NTMRPGRVSNaAMVSGKDRQNSfinnyyg 104
NP_001104782         33 AEARLAAKRAARAEAREIRMKELERQQKEVEERPDKDFA------------EKGSRNMPSLsAATLASLGGTS------- 93  house mouse
XP_011601212         31 aearlaakraaraearDIRMRELERQQKELDEKCDKQYS-DYSR-------PSSRCATPGLsAATLASLGGTS------- 95  torafugu
WGS:AANI:GJ18437-PA 101 SRRSSEDS---LEDEGrSFRDI------------------------KHELKEVEERFRKAMITNAQLDNDRSSQTYEVKL 153
3_pfamImport         67 SRRGSGETaiaIDAET-SIREI------------------------KDALGEVEEKYRKAMVSNAQLDNEKNNLMYQVDT 121
EEC04563             94 SRRSSEDSteaLDG-----RDF------------------------RHQLQEVEESFRKAMISNAQLDNERTALAYHVDT 144
B2GUE2               96 SRRGSGDAnssLDPDA-SLSEL------------------------RESLAEVEEKYKKAMVSNAQLDNEKSNLVYQVDT 150 tropical...
NP_001033159         92 SRRVSGDTsslIDPDT-SLSEL------------------------RESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDT 146
1_pfamImport         62 SRRGSCDTsfsVETEA-SIRDM------------------------KDSLAESEDKYRKAMVSNAQLHNDKSTLMYQVEN 116
XP_971050            88 SRRSSEDS---LEDGG-SLRDL------------------------RNELKEYEEKFRKAMIANAQLDNDKTSLTYQLEL 139
XP_002430218        105 SRRSSDDS---NEDGSyCLRDV------------------------KHELKEVDEKFRKAMIANAQLDNEKSELVYQVEL 157
NP_001104782         94 SRRGSGDTsisMDTEA-SIREIkelnelkdqiqdvegkymqglkemKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDT 172 house mouse
XP_011601212         96 SRRGSTDTgsiYDPDT-SLNEL------------------------RESLAEVEEKYKKAMVSNAQLDNDKANLIYQVDT 150 torafugu
WGS:AANI:GJ18437-PA 154 LKDKSETMEESFAQLQREFKNKLRDCNTLKRNLERTTLELSLVQGQLCERDALIEEHGLIIVSIENSDGS---------- 223
3_pfamImport        122 LKDSLMELEELLSESRRGYEDKVKEYEREKHSHTVLQFQFTEMKETLKQSEELLNKHGIVLGPDLNINGElgea-----e 196
EEC04563            145 LKDDMEEMAENYLQVQRDFREKARALDQLIRDFRKLKEENAFLEESLKQRDELIEDHGLVLKLVLVPKAQ---------- 214
B2GUE2              151 LKDVVEEMEEQMAEYHRENEEKSKELERQKHNCSILQHKLDELKEGIQQRDEFIEKHGLVIIPDGTPNGDinh------- 223 tropical...
NP_001033159        147 LKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMDELKEGLRQRDELIEKHGLVIIPDGTPNGDvhq------- 219
1_pfamImport        117 LKAELSDMEELLWESRRHCDDRTKEFERELQAHRVLQFQFKEAEEALRRTEELLTKHGVVVPPENSTNGDrg-------- 188
XP_971050           140 LKDRLEELEEEHSQLKREHREKCRDFDQLKRLCAKLKDDLAVTRAELEERDQLISEKGLVIVGEDSINEEeqrngdvsls 219
XP_002430218        158 LKDKLEELEESHIQLQKENRDKCREHEQLKRVALKLKDDLVSYKSQLEERDRLIANYGLMIVGGEDEEGP---------- 227
NP_001104782        173 LKDMLLELEEQLAESQRQYEEKNKEFEREKHAHSILQFQFAEVKEALRQREEMLEKHGIILNSEIATNGEtsdtv----n 248 house mouse
XP_011601212        151 LKDVIEEMEEQMAEMKRELEEKSKELERQKHTCTVLQHKQEELKEGIRQRDELIEKHGLVIIPDGTPNGDvnh------- 223 torafugu
WGS:AANI:GJ18437-PA 224 ---DAKRALVSVENANILSTV----QGSLDVRLKKFAEENQRLLNEIQKLHEQLGAFKSeGRVGRGSSLCGSLRYDDD-- 294
3_pfamImport        197 vveTPGADHVTQPAADAQGAPte-gNSMLEIRLRKLVDEREKMIEQVKKLKSQLDLKTQ-RNGTDSSVSPDGEILENGnd 274
EEC04563            215 ---AAKAALVSQEAAQLLDQAg---DGSLDVRLKRFAQEKQELQDEVGVLMEVQSECRPqARSTSARRLSLTFFVFS--- 285
B2GUE2              224 epvVGAITVVSQEAAHVLESAg---EGPLDVRLRKLAEEKEELVAQIRKLKLQLDDERQ-RSAKNNSTTTDSTGLENGsd 299 tropical...
NP_001033159        220 epaVGAITVVSQEAAQVLESAg---EGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQ-KCSGRDGTAGDLAELQNGsd 295
1_pfamImport        189 --qGEGVDEVTADSASPEEPPpggrESALELRLKKLFEERESLRDQVRQLKSQLDRRQ--KNGTDEVQNPEGDHLE-Dsh 263
XP_971050           220 sigTPKKALVSVENAQLLQSAg---EGSLDVRLAKLMKEKGELQDQISHLKLELEEERSkRKKSSAGGTLNGPSSDPDld 296
XP_002430218        228 ----SERALVTVETADLLQKVg---EGSLDVRLKKIVEERNELFDEVRHLKLELEEEKSkRRIDGKSGYSAANG------ 294
NP_001104782        249 dvgYQAPTKITKEELNALKSAg---EGTLDVRLKKLIDERECLLEQIKKLKGQLEGRQ--KNNKLDLLRAEDGILENGtd 323 house mouse
XP_011601212        224 eppSSGITVVSQEAAQLLESVg---EGPLDVRLRKLAEEKDELLAQIRKLKNQLEEERQ-KHSKMDSLYTDGERMENGtd 299 torafugu
WGS:AANI:GJ18437-PA 295 ---YEVQRESNKIISDYKYKLQKAEQEIAS 321
3_pfamImport        275 pnlIELQRDSSRQISDFKFKLVKTEQEVTA 304
EEC04563            286 ----LVPGEANKQVDDYKYKLRKAEQENMT 311
B2GUE2              300 lqlIEMQRDANRQISEYKFKISKAEQDMTT 329 tropical clawed frog
NP_001033159        296 lqlIEMQRDANRQISEYKFKLSKAEQDITT 325
1_pfamImport        264 --lLDLQRDANRQISDLKFKLVKSEQEVTT 291
XP_971050           297 --eIDIQREASKQLGDYKFRAQKAEQDVAT 324
XP_002430218        295 ----LIDEETSKIMSDYRFKLQKAEQDVST 320
NP_001104782        324 ahvMDLQRDANRQISDLKFKLAKSEQEITA 353 house mouse
XP_011601212        300 lhfIEMQRDANRQISEYKFKLSKAEQEIGt 329 torafugu
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