7ABI


Conserved Protein Domain Family
Bud13
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pfam09736: Bud13 (This model is not part of the current CDD release)
Pre-mRNA-splicing factor of RES complex
This entry is characterised by proteins with alternating conserved and low-complexity regions. Bud13 together with Snu17p and a newly identified factor, Pml1p/Ylr016c, form a novel trimeric complex. called The RES complex, pre-mRNA retention and splicing complex. Subunits of this complex are not essential for viability of yeasts but they are required for efficient splicing in vitro and in vivo. Furthermore, inactivation of this complex causes pre-mRNA leakage from the nucleus. Bud13 contains a unique, phylogenetically conserved C-terminal region of unknown function.
Links
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Statistics
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PSSM-Id: 519020
Aligned: 123 rows
Threshold Bit Score: 108.063
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7ABI_3       460 ETVFRD-K-SGRKRNLKL-ER-LEQRRk-----------------------aEKDS--ERDELYAQWGKGLAQSRQQQQN 510 human
XP_003059284 321 ATQFRD-KaTGQLIDLEEqKKrMELANa-----------------------rRKEP------ERPVWTQGIAQGRAASDA 370
Q6BGC8       108 EVIHRDvK-TGQRITQSQrVEqEKQLNpklk-----------------akedKQTVlqANKQQIEMWSKGLVQIQEKQKK 169 Paramecium tetr...
XP_012656229 195 QTIHRD-E-FGRKIDIDKiIQeKLSKKe-----------------------qIEELkkKNQERIDQWGKGMKQKEQKLQQ 249
XP_004040201  84 ETVYRD-A-LGRKVSARElLNqQKTKKd-----------------------kIEELkiQNQERIDQWGKGLKQKEDKQNQ 138
XP_002141196   6 VAIYRD-N-EGKRIDEEIwLNeRIKKKk-----------------------qKLKEskVTIQKDLPWSTGIIQQKRLEKV 60 
Q8I4W6       223 KTIYRD-K-SGKIISREKwIEeQKKEMkykhgk--------------ykdkkKKQE--EEKKRKLEWDGGLVQKDIRQKN 284 Plasmodium falc...
XP_001613991 330 STIYRD-K-GGKIISREEwVSkQKIEMnatnrrrgktggegeedqeggekkkKKRS---KDSKELEWGSGLVQKEMRKKN 404
XP_002953812 389 QTVYRD-KaTGRVMTAEEaRQaKEDERa-----------------------aRRKPsiYDEDQTLEWRAGLAQKRQAEER 444
XP_002262539 274 STVYRD-K-GGKIISREEwISiQKMDMntkyrrggkkg---veeedpdvdksKKKN---KDAKEIEWGSGLIQKEMRKKI 345 Plasmodium know...

7ABI_3       511 VEDAMKEMQ---KP-LARYIDDEDLDRMLREQEREGDPMANFIKKNK-----------------AKEN---KNK--KVRP 564 human
XP_003059284 371 AEALRREAD---AP-FARADIAPEAEDAQRAAVRFGDPMAHLARKKQqnaeismp--svvagisEEQLkksGFRipQEVP 444
Q6BGC8       170 QEDAQQALA---TK---NEEQIKQIDMQLMGQQKFDDPMRKMIQ--------------------EEDDkqiTL-----KQ 218 Paramecium tetr...
XP_012656229 250 KQNEINAAKetyNG---DYTISKQADIELMKQEKFNDPMRLLIQ--------------------KEDQkiaSAQlnLQNK 306
XP_004040201 139 KEAIKNAKNelyVG---EYAISKQTEIELMKQTRFNDPMQNLID--------------------KEDQkitQAKl-NLGK 194
XP_002141196  61 LNSKEVPHEq-----FIRFDGNKSIDEELRNKVYWDDPLFLINSkl----------------vnLNSDkkmISPnnAIKR 119
Q8I4W6       285 IEENEKLIK---KKnIINYEFDSDYDIELKMKKRKDDPMNIYLE--------------------AKEEnqeN------KK 335 Plasmodium falc...
XP_001613991 405 LEQNDKLAK---KKnIINYEYDSDYDAQLRKMKRKEDPMNEYLD----------------------VTteqP------AK 453
XP_002953812 445 MRDMQEEAS---KP-FARGDVDSSHDAALRNQVRFGDPFAHLARRKQsaaaaaaadaplterydLDKLnksGFKipQEVP 520
XP_002262539 346 LEENDKLVK---KKnIVNYEFDSDYDVELRKAKRKEDPMNKYLD----------------------HTkeqP------QK 394 Plasmodium know...

7ABI_3       565 R---YSG--PaPPPNRFNIWPGYRWDGVDRSNGFEQKRFARLA 602 human
XP_003059284 445 EhswIRRgvG-PPLNRYGIKPGRHWDGVDRSTGFEQEMFKAKN 486
Q6BGC8       219 SdflLKCkfP-PPINRFNILPGFRWDGVDRSNGYEMKLLNSIN 260 Paramecium tetraurelia
XP_012656229 307 QfcrLKCrfP-GVTNRFDIPPGHMWDGVDRGNGAEKRYFNMVN 348
XP_004040201 195 NfcrLQCkfP-PVSNRFNILPGHMWDGVDRGNQFEARYFDMLN 236
XP_002141196 120 LkcrF----L-SPQNRFGIEAGYRWDGVIRGNGYEEKLLLRLN 157
Q8I4W6       336 LtcrY----Q-SPYNRFNIQAGYRWDGVIRGNGFEERRLEAQK 373 Plasmodium falciparum 3D7
XP_001613991 454 AtcrY----Q-SPYNRFNILAGYRWDGVVRGNGFEKRRFEALK 491
XP_002953812 521 VhswLKRgvA-APANRYNIRPGRHWDGVNRSNGFEAELFKHQN 562
XP_002262539 395 AmcrY----Q-SPYNRFNILAGYRWDGVVRGNGFEKRRFEALK 432 Plasmodium knowlesi strain H
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