8CLK


Conserved Protein Domain Family
Tau95
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pfam09734: Tau95 (This model is not part of the current CDD release)
RNA polymerase III transcription factor (TF)IIIC subunit HTH domain
TFIIIC1 is a multisubunit DNA binding factor that serves as a dynamic platform for assembly of pre-initiation complexes on class III genes. This entry represents the tau 95 subunit which holds a key position in TFIIIC, exerting both upstream and downstream influence on the TFIIIC-DNA complex by rendering the complex more stable. Once bound to tDNA-intragenic promoter elements, TFIIIC directs the assembly of TFIIIB on the DNA, which in turn recruits the RNA polymerase III (pol III) and activates multiple rounds of transcription.
Links
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Statistics
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PSSM-Id: 519018
Aligned: 56 rows
Threshold Bit Score: 100.03
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8CLK_E       181 YIPPPIFSRLDAPVDyfYRPETQHREgynNPp---iSGEnligl-----srarRPHNAIFVNfed--------------e 238 human
XP_001884384 199 LFPPPLFSRQTIPQGynFKGNPASMV---SIsvdeqTGEekkrli---nkmrwKGYGPAAIMfsd--------------p 258
XP_003331701 198 LFPPPLFSRYLVPQLyhYRQNIPTVV---Tqt---sDGSqrlin-----rtryVPMGPQTITydq--------------p 252
CCA66550     200 SFPSPLFTRYDMPMNynFKPNPSSIQ---QTvvdkeTGEtstrlv---nssrlRMQTPVSIKwge--------------- 258
EGU13262     208 FIPPPAFSRHRLPQNfdMRPAFGTTI---Qtt---eSGVtrlvh-----aarsKTRTIRSIMsfe--------------e 262
KDE09825     184 FLPPPIFARHTVPLKyeYKPAARTVP---TTsi-rpSGQevlrla---sstryKTKPHTTIPhss--------------p 242
NP_190510    171 MLLPQFFAPKDIPDNvalkpp---------------------------atsgpKKKDDAATQnfyeidvgpvfaidfsvk 223
XP_003537671 172 IIVPPIFAPKDVPENlvlrpa---------------------------tmsssKKKPEEVVQphfemdmepvlaidfdik 224
XP_004360005 199 NTIPSIFSRIDKPQNyqFKINPLATF---DPdvlytqvivvqtrqftlkssfaTAFRTKVVQfpa--------------g 261
Q54GS8       240 NLIPPLFSRIDFPQNylFKANPNAQF---DKtskqfvfak----qttrkatghAKFNNVI-------------------- 292 Dictyostelium d...

8CLK_E       239 evP-KQPLEAAAQTWrrvctnPVDRKVEE-ELRKLFDIRPIWSRNAVKANISVHPDk-----LKVLLPFIAYYMITGPWR 311 human
XP_001884384 259 hvP-LKPPDAVEKGRd-----QISEVILA-KLQAVFVDRPIWTRMSLFNQFAPLETrei-lnSKLLLPLVCYVFQDGPWR 330
XP_003331701 253 dvP-QSALARDLEQKk-----PENQALFQ-KLASLFEQRPIWSRMAFQHHLTPVDLryi-rqNKVILAHYCYLFSDGPFR 324
CCA66550     259 ptP-TTCGPERESLRp-----WANSDLLQ-KLNELLEKRPVWTRQGLLNQMTLLEArrm-hnNKAPWALATYVFHEGPWR 330
EGU13262     263 qvP-TGPEEVLLKELg-----REEPNAIEaRLMQLLEERPVWTRPAMMNHLTPAEVkmvhanKSQCWARVGYTFSDGPFR 336
KDE09825     243 tvP-SEPTPELLQVVg-----RRTHDALEiKLLAYLERRPVWTRQSLLNQLSEQELrti-qnRKTAIPMVSYSFQDGPFK 315
NP_190510    224 eiPkKLKWEDFVSRSsn---hWQWQVAVS----ALFEERPIWTRDSVVQRLLDKGLkcthhmLNRFLLRAAYYFSSGPFL 296
XP_003537671 225 eiPkKVNWEEYIPQGsd---qWELQMVVS----RMFDERPIWSKNSLTELLLDKGLsfshsmLRRLLSRISYYFSSGPFL 297
XP_004360005 262 itP-QEPLQKFVSKSp----nSTLQRTYN-VLKEMFEERPIWLVEPLKDYLQKRGGfl--kdIRATQPYLSYSFKKGPWR 333
Q54GS8       293 --P-VAP-QELPKVFgv---nELMKKTRD-ILVALFEKRPIWLYISLLDKVQKEGGlv--ahTKRVLPSLAFNFVDGPWR 362 Dictyostelium d...

8CLK_E       312 SLWIRFGYDPRKNPDAKIYQVLDFR 336 human
XP_001884384 331 DTLVRFGYDPRSDPSARFYQRLYFR 355
XP_003331701 325 ELLIRFGYDPRLIPEARFFQRMSLR 349
CCA66550     331 DSVIKLGYDPRQDPESVKYQIVSIR 355
EGU13262     337 DLIVRFGYDPRQHPEARFLQHITLR 361
KDE09825     316 ELVIRFSYDPRQHVEARLYQHIVLR 340
NP_190510    297 RFWIKRGYDPRNDPESRVYQRMEFR 321
XP_003537671 298 RFWIKKGYDPRKDPNSRIYQRIDYR 322
XP_004360005 334 NCYIRFGYDPRIRNESRIYQVVDFR 358
Q54GS8       363 KCWVKLGFDPRIHPETSQYQTIDFR 387 Dictyostelium discoideum
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