8T9G


Conserved Protein Domain Family
VEFS-Box

?
pfam09733: VEFS-Box (This model is not part of the current CDD release)
VEFS-Box of polycomb protein
The VEFS-Box (VRN2-EMF2-FIS2-Su(z)12) box is the C-terminal region of these proteins, characterised by an acidic cluster and a tryptophan/methionine-rich sequence, the acidic-W/M domain. Some of these sequences are associated with a zinc-finger domain about 100 residues towards the N-terminus. This protein is one of the polycomb cluster of proteins which control HOX gene transcription as it functions in heterochromatin-mediated repression.
Statistics
?
PSSM-Id: 519017
Aligned: 25 rows
Threshold Bit Score: 138.597
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
8T9G_B       480 SEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEME--VDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMK 557 human
XP_032240044 504 lEPDDADENRPYHSGYTRTYFHSSTCVPISQSELGslSDSEGEENPLWMRMRTIQMIDDFTDVNDGEKELMKLWNLHLME 583
1_pfamImport   1 -EDGDQEQ--PIVSGHNRLYFHSDSCVPLRPQEME--VDSEDERDPDWLKEKTAMQIEDFTDVNEGEKEIMKLWNLHVMK 75 
Q6DC03       511 PEDGEQEQQRTYISGHNRLYFHSDSCTPLRPQEME--VDSEDERDPDWLREKTAMQIEEFTDVNEGEKEIMKLWNLLVMK 588 zebrafish
EFX88992     493 dgyevcETQRPFITGHNRLYHHTSTCLPIQAKELD--VDSENETDPEWLRAKTCMMIDEFTDVNEGEKELMKLWNLHVLK 570
Q9NJG9       510 LDEDEISNQRSYITGHNRLYHHTETCLPVHPKELD--IDSEGESDPLWLRQKTIQMIDEFSDVNEGEKELMKLWNLHVMR 587 fruit fly
EEC19851     479 QDEVDIDLPRPYISGHNRLYYHTETCLPIRPQEID--RDSESEDDPDWLRIKTQLMIDEFTDVNEGEKELMKMWNLHIMK 556
XP_015793128 456 ddpdgiiSIRPYIRGHNRQYYQSTDCFPIKPQEID--EDSEAEIDPEWMRIKTQLMIDEFTDVNEGEKEVMKLWNLHGMK 533
XP_002129124 554 keenetSPAAHYAAGHHRLYFHSETVVPIRPCEFD--VDSEEETDPEWLRAHTTKMLDEFTDVNDGEKPIMKLWNLYIMK 631 vase tunicate
XP_029692121 409 SEDGEQEQQRTYISGHNRLYFHSDSCVPLRPQEMD--VDSEDERDPDWLKEKTSKQIEEFTDVNEGEKEIMKLWNRHVMK 486 torafugu
8T9G_B       558 HGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTK 614 human
XP_032240044 584 KGYVADAQVYSACLTFIDVNAKKIMSQNLKRNFLIHLVSLHDFNLLNGGQIFQLMQK 640
1_pfamImport  76 HGFIADNQMNESCLRFADHHGVHIVRNDLCRNFLLHLISMHDFNLVTTQTIDQAMAR 132
Q6DC03       589 HGFIADNQMNQACMSFVEQHGTIMVEKNLCRNALLHLINMHDFGLITTATIDKAMTH 645 zebrafish
EFX88992     571 HNYVGDCQMGVALQMFLDNHGQELLKRNLYRNFILHLSNLYDFGIIAPATVLRTIns 627
Q9NJG9       588 HGFVGDCQLPIACEMFLDAKGTEIVRKNLYRNFILHMCSLFDYGLIAAETVYKTVQK 644 fruit fly
EEC19851     557 HGFVGDCQIALACNLFVEQQGEVLMQRNLYRNFVLHMCNLLDFGLVSTSVVYTTVRR 613
XP_015793128 534 HGYVGDCQIPAACEKFVDQYWQEIFNRGLYKNFILHLNNLFDFGILPATHMRSVIKr 590
XP_002129124 632 HSCIADAQMLSTCREFLNQYTTLIVKHSLRRNLLLHFVTLVDFGVLKASalcslmdh 688 vase tunicate
XP_029692121 487 RGFIADNQMNEACLLFAEHHGAHIVHNNLCRNFLLHLISMHDFNLINTLTIDRAMAR 543 torafugu
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap