Conserved Protein Domain Family
Mitofilin

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pfam09731: Mitofilin (This model is not part of the current CDD release)
Mitochondrial inner membrane protein
Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.
Statistics
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PSSM-Id: 519015
Aligned: 16 rows
Threshold Bit Score: 357.531
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6PFS4        39 GSSAGKiva---aslLTVGGGLGGTILYAKWDPKFRSSIEKS-VPYSDQLFDMVLGAPPsppvpi----------qkkpe 104 zebrafish
Q55BP9        65 PFGFKP---------LIALVLVGGISAYLYKAWDNQDFMFSSkLPYQREEVEKFKKIMK--------------------- 114 Dictyostelium d...
Q7SFD8       120 KGFFRRlrnfflsltILGAIAFGGGVYYSRINDAFHDFFTEY-IPYGEQAVLYLEELD---------------------- 176 Neurospora cras...
Q2HCU4       115 KGFFRRlrnffltltLLSALGFGGGVWYSRINDNFHDFFTEY-IPYGEQAVLYLEEMD---------------------- 171 Chaetomium glob...
Q5K8K8        77 PRRFRRvfv---ytaLGVAGFYALSGYVGTKSDAYRDLFTQY-VPGGEAVADYADDNDWd-------------------- 132 Cryptococcus ne...
XP_011386449  40 RSGLGRlfv---ystVGATVFYGISTVAALNNDRYNHFFVES-IPGGERIIDYLDTHDVgqeiksinlhgygdkaidvtk 115
P91928        68 EAGFGKvv-----lfVSPLAAVGGVITYAKYDDDFRKLVEKN-VPGAGSVIKVALQEEPpfkgitknvndqidkvksgie 141 fruit fly
2_pfamImport   1 EAGFGKvl-----vvLSPILIGGGVVTYAKYDNEFRKTLITN-VPALEPVLKTLLQETNpldev-----------skkmd 63 
Q9XXN2        20 SSGGLKfvg---atvGAVTAGAAGVAGYASYDNEFRKKLEGV-IPGSRTILNYTIGEEEppap--------------rlk 81  Caenorhabditis ...
Q22505        37 KSGGGKgla----lvGATVVGAGGVVGYAYVDPEFRHKVEST-VPPVKQVFDAVLGESslqk---------------tkq 96  Caenorhabditis ...
Q6PFS4       105 TVKPLQISSLSEATKDSKQPKAKAKKSDpapppsveeapapa---palqsleeasaeaAHI-ISAISEVPSVPAPGTSDE 180 zebrafish
Q55BP9       115 EIHQDSQRENLNIEKESKESKESDQQQQh-----------------------------QQQ-QQQQHHQQEEEKEEEKVG 164 Dictyostelium d...
Q7SFD8       177 -FKKRFPDVVSRVTG---RPRDSGEQVKv-----------------------------PAQ-SGASWRVASGGEPAGRQS 222 Neurospora cras...
Q2HCU4       172 -FKKRSLTWLAGWETAG------------------------------------------RQ-SSAVQKVAAAKEPSKKAE 207 Chaetomium glob...
Q5K8K8       133 NVSGKAVRAWQSITGARPETRTEKVERKi---------------------------------GEVRQEAAKVPAQVKDKA 179 Cryptococcus ne...
XP_011386449 116 TAYDSVSGAVSRVFSGDAGASESAGDERd------------------------------AR-LRVSEARATAKAEADKLA 164
P91928       142 TVTSTVDSVTSKVTGLFGGGSGDDKSKKskvepv------------------katpaeEKR-PSKPSEVSKTEAKPVSKP 202 fruit fly
2_pfamImport  64 DISKTIGEYTSTITGFFGGGDEEKKQEKkpdlppitraksvhvpvpspplpkpepinlSDKvPEQPKKKPEAAAPKVTTA 143
Q9XXN2        82 DLRPLQYSADPKVPPKPFEPKPVKKELIg-----------------------------VKEnLKETTEPKKIEKKPENPY 132 Caenorhabditis ...
Q22505        97 QIGDLKDAVVNAVPKKKEVLPPLELAPLppv-------------------------lpR---EPTHVDPVDVRKDVTPMI 148 Caenorhabditis ...
Q6PFS4       181 SPSGHsaaaeecckectepepavkerpaeevtarlaQQDKAELDALAALTAGLEETLGSSAKVTLQAIGAQEAALTAIAA 260 zebrafish
Q55BP9       165 VENTT-------------------------------LEDNIIESIKNHEEEMKNELVSLIESVQDKYAHSNDDEINADER 213 Dictyostelium d...
Q7SFD8       223 SSIK--------------------------------------KAGAAAQDAVPKSEPAVVAAAKEDTAELP--KTEATTT 262 Neurospora cras...
Q2HCU4       208 PVVV---------------------------------APPKEEAPKVPAPEVKAEEPKKPAPAPAAE------KKRPSKK 248 Chaetomium glob...
Q5K8K8       180 DEAKDhv----------------------------vGKHTASQKIHERAEELRKAVEQKTHEAEARLKELTGEAKHKVQE 231 Cryptococcus ne...
XP_011386449 165 QRAKV-------------------------------AAEKAEHQAESALQAVQDKTSELVNRAKAAAERAEAKVRGQTTE 213
P91928       203 AAAAApapaa---------------------kpkdnPLPRDVVELEKAIELSAQLAVKEYNVAIGVLKGFNDDVRKVVDK 261 fruit fly
2_pfamImport 144 TATKAaaaataaapaksap---aapskpaplasggeTVPKSISDLEQQVEVAATIAIKEYGHAVDVLKSYTNEVRKVVDE 220
Q9XXN2       133 IGAK---------------------------------TPLNPQERNEKLTESLKNHLTQAEKATKVATSAKLETIRAIEH 179 Caenorhabditis ...
Q22505       149 PKPS----------------------------------PDVVFAKNQQLEEKLKIAIHSAEGKVRLATEAKLKTINAINE 194 Caenorhabditis ...
Q6PFS4       261 HTDKLREAMDSETPPDEKSTQalnealneraravddagea--------lfkakgeleklrsvidkaKQSKIDSARPQILA 332 zebrafish
Q55BP9       214 EMDSETGVSISDEISKLIEEH---------------------------------------------KQNEEESLPDLLDV 248 Dictyostelium d...
Q7SFD8       263 ATPA-EPAPAPAATDASGTP------------------------------------------------VKKPFKAPEVDE 293 Neurospora cras...
Q2HCU4       249 VTEKKAVENKPVEKQPEPETSlvpa-------------------------------------ttalTPAQKAFKAPEVDE 291 Chaetomium glob...
Q5K8K8       232 ATKDAPFNFSEGVEGIVRAAEsalhktehkaaeaadkvkpaearpsspfpdtqrprelkpetvtpqVPSYEGKKLYTGPP 311 Cryptococcus ne...
XP_011386449 214 ASKDGRNIIQRAVDSVQVMTDigantkaapsksaap---------------gngpkeevketyigeLPVNHEAPVGYAAP 278
P91928       262 AVENGENSLWTTLKNRASARDtavataeraa-------------------------reaqekivacEIALSAAATAQNAK 316 fruit fly
2_pfamImport 221 SVDKLDSSSWTTLRNRTSARDtalqaaedaadk---------------------argnieklhallNSREIKCSDELKDK 279
Q9XXN2       180 HVQTIREAIEAGKDGDWDSVTvahlkakrlaekdekae-----------klarnavadlvteanlgGQGETTQLNPLVPI 248 Caenorhabditis ...
Q22505       195 HASILKQTVDDAKHANWENVTsalqraeaearvdsgqe-----------vdgrnyidnlrkivndgKRDSTTATNPLLLN 263 Caenorhabditis ...
Q6PFS4       333 AEEN----------LHSMIVDLDKVVTKVQTAqseakivsqYSELVNEAKAQFQQELANITPEIQANWKGLSGkLSADDL 402 zebrafish
Q55BP9       249 NYGV----------LSIIPEAVKSAEETVENA---------LKKFTHSNDDDDDTTTTSIIINTSDELKNHNInIENGNE 309 Dictyostelium d...
Q7SFD8       294 PSRW----------PPASPid-------------------pLTVNGATDPIV--QDLVKMLNDVITVINHDNA---NEKY 339 Neurospora cras...
Q2HCU4       292 PSRW----------PPASPid-------------------pLAVPNAADPVV--QDLVRMLNDIITVINHDGA---NDRY 337 Chaetomium glob...
Q5K8K8       312 LPLGhepppgyylpPPPSTKKEKVEEKVEEIKerlpllvpkVKEFASEEPII--SQLASTIDSLTSSLSTPSK-ALSSDA 388 Cryptococcus ne...
XP_011386449 279 RRDR----------GLQAPDHPTARLRPDPEApklpllapsIKSLSASEPMI--AQLAGTIDELTVFLKETPS--SGAKA 344
P91928       317 KVEAvr------dkIKKLVDHIGNVKDELYRHkdtasvsdkYWRNVEKARNYFIDEIESIFPGLSLADKKLNL--SKEDL 388 fruit fly
2_pfamImport 280 ARQN----------IAAYLDHLKKAKEEVYAArdlaslgekYWKRVESARNYFVEEMESLFPGI--NLAERKLnLSKDEL 347
Q9XXN2       249 SKAT----------AEKLSNELDEMISNVKHVdserifvhdYSDRVAESRRKFQMELKAVHPNLN---YEDGMkIKKADL 315 Caenorhabditis ...
Q22505       264 AQET----------ANKLSHQLDEINALVNKSrqesavlnqYKDLIEKSRQQFALEMKSILPNVDIHAKDKNL--NEDEL 331 Caenorhabditis ...
Q6PFS4       403 NSLIAHAHRRIDQLNReLAEQRVREQIHIEVALEQQKLEdQKAQERAVISALEHSRE------DMRLEQEKKVQEVREVM 476 zebrafish
Q55BP9       310 ESLVDSLDVNYNVLSI-IPEKVKSAEEKVENVLKKFEEQyLEKVEKLISENMKLKVDfdklinGKDDELKRVEEEIREKY 388 Dictyostelium d...
Q7SFD8       340 APTICKAKNELSKVADkINEMKAKVEADAAKQVKARVDG-FDKAANELVSRVESAMAaq--eaAWRREFEEEITRLKKSY 416 Neurospora cras...
Q2HCU4       338 GATIGKAKNEISKVGQkILDIKTAVEKDAAQQVRQRVDG-FDQAANDLVARLEAAMTvq--eqQFRREFEAEMERLRKSY 414 Chaetomium glob...
Q5K8K8       389 TGILNKAQDDLTALNArLQEVKKAEKAKLEQSISEKKKE-----FEALLKSMEAEKAks--eeGLKQTWQHERQTMVEDW 461 Cryptococcus ne...
XP_011386449 345 KGVLESAQIDLEQLSQrLETIKRQEAKRVEDSLAAQAKR-YETQISKQSQEAADKLSsr--esDWQKSFEEEHAKQTQQF 421
P91928       389 DLFILHAYTHVLAYQKeLQRLQTDGELRLKRAIDSVR---GDNDSEALRAQLEYHLEae--rrKLAVENQKKIFHIHAES 463 fruit fly
2_pfamImport 348 DLFILHAYTQVIAHQKeLQKLQIEGDQNLRRALEAVR---GSDQSEEVKARLEYEIAke--krQLNLLNQKKLLLTRAEL 422
Q9XXN2       316 HTILAHAHLRIDQLSQkLIDSKLNEEKRIQSIIAKKKEDlLEKLRLETNAKQAAVIPefd-kkKLDAELARATAEIQKKY 394 Caenorhabditis ...
Q22505       332 NALIAHAHLKVDQLRCqLSDQQVREELHISKALEEQRLAdERIASEKLSIEMSrv------grQNELEIERALVESRSSW 405 Caenorhabditis ...
Q6PFS4       477 EAEMRTQLRRQAAAHTDHLRDVlkvqeqelreeaQEILNSKMMEQEthyrrltqeqlDTFTLDMNAAYAR-LKGIEEAID 555 zebrafish
Q55BP9       389 RSSLDAAIEELNKDLDEKLKDM------------DQFIKSKVFDNQ-----------AVLQETLEKQKSNlINIFKQQAE 445 Dictyostelium d...
Q7SFD8       417 DEKVHLIQDREHQIAEEKLNNRlleqaiqlqrqfTENIKKHVEQER-----------DGRLGKLNELHKA-VAELERLTS 484 Neurospora cras...
Q2HCU4       415 DNKVHLIQERERQLAEEKLNNQlleqavqlqrafTQDIKKHVEQER-----------DGRLGKLNELKAA-VEGLEKLTA 482 Chaetomium glob...
Q5K8K8       462 RKELEGELEQQRQSIEQRLREEvvsqgielqrrwLRSIKTQVETER-----------GGRLAKLDSLTTS-LKQLERITL 529 Cryptococcus ne...
XP_011386449 422 KEKLEKELATQSQIINERLKEEviaqgielqrrwMKDIKAKVEEER-----------GGRLSKLDELATD-LKSLEKVSL 489
P91928       464 DKLLRLQLKKQAEAHADHIKDIvaqretdltrsfKRELEDKLATEK-----------ANYKLQLAGMLGK-LRGMDAALA 531 fruit fly
2_pfamImport 423 EQQMREQLKRQTEAHVDHLKDAltqkelemkrkfQRELDEKITTEQ-----------ASYKLQLAAMLGK-LKGIHNALV 490
Q9XXN2       395 DEKLK---------------EVvrtqkqlydiehAKDVDEAVLKER-----------NLHSSAVGKALAQ-LAGIEKALS 447 Caenorhabditis ...
Q22505       406 EGELENQLKRTASAHSEHLEQVirtqrqlfeieqNQKVEEAVLQER-----------NLHSKQVGAALSR-LEGIEEALG 473 Caenorhabditis ...
Q6PFS4       556 SHVIAEEEARKAHQLWLSVEALNYTLKSAGADS-----PTEPLEGAVRAIKES-----CAENEFAQALAIAIPEESLNR- 624 zebrafish
Q55BP9       446 SIKQSELEKRAITQLTQCIVDLQKLLHDKSAIDga--nGKGLLVRSFKNLTDL-----SNYDQLIKELLSTLPEGFEKK- 517 Dictyostelium d...
Q7SFD8       485 GLNEVVDTNLRTQQLHVAVDAVRASLEDAHH--------PRPFIKELVALKEI-----AADDPVVDAAIASINPTAYQR- 550 Neurospora cras...
Q2HCU4       483 GWNEVIDANLRTQQLHVAVEAVRASLEDAHH--------PRPFIKELVALKEI-----AAQDPVVDAAIASVHPSAYQR- 548 Chaetomium glob...
Q5K8K8       530 DNSATLDDNVRLHKIWSALRAVQSKVDSGD----------LAFDDELRALKSLstptaSSGEGVVRSALEQIEKSGIPQt 599 Cryptococcus ne...
XP_011386449 490 DNSSVLDENLSVHTLWTAVRAVQHALDDASATK-------RPFAEQLRVLKGTs---kARDDPVLSAAIEALDASGAADt 559
P91928       532 ERADAERTANQAQALWAACQALWASVRAATPGVhy-kdRLRPLKNEINAIAKV-----AKGDDLVAAVLESVPKEAQER- 604 fruit fly
2_pfamImport 491 EHADAEKSAHQAQALWGACQSLWSSIRSGQPGKsw-rdQLRPLKDEIAAVARS-----AEGDELVTVVLKGLPETAVKR- 563
Q9XXN2       448 GHLQMDIENRKSKQMWLATQNLKGTVIFGNRASccmegRRAPLGDQMKTLLSCcg--gGNSDEFVKTINTAMSKTSKVR- 524 Caenorhabditis ...
Q22505       474 SRVALDNENRRAKQFWIACHNLIDTLKHGNKAGnnideRRLPLNESLNLLKEV-----NPEDEFVNAIIDSFPKQATTV- 547 Caenorhabditis ...
Q6PFS4       625 GIYSEASLRARF-YDIRRLARRVALI-DETRNSLYQYFLSYLQSVLLFERDQeapp-----aklAPEDLDTFKLLAYATY 697 zebrafish
Q55BP9       518 PVIPLDTLNNQF-QDIAKKLRKSQLI-DPNDNSLLGKAVSELASLFIIPEKG------------MVQGNDYDAILARAED 583 Dictyostelium d...
Q7SFD8       551 GIPTTAELIDRF-RRVATEVRKASLL--PEDAGVASHASSYVLSKLMFK-KEgl-----------aAGDDVESILTRTQT 615 Neurospora cras...
Q2HCU4       549 GISTPAELIDRF-RRVAAEVRKASLL--PDDAGVASHASSYVLSKVMFK-KQgl-----------aAGDDVESILTRTQT 613 Chaetomium glob...
Q5K8K8       600 GVKSFAALSSWFtNTVAPRIQSSSLVpAPEEATVISHLASAGLSKIMFRPQAgr-----------vPGDSVGAVLARAEW 668 Cryptococcus ne...
XP_011386449 560 GVETFTTLKQWFdDKVGPRVRQVSLVpSPETSGVLSHLASAALSPILFH-KKgl-----------vPGQDVPSVLARAEY 627
P91928       605 GVYPEDALRERF-LNVERVARRLALV-PEEGAGLPIYFLSYLQSLFILRPDNpiskdelenkpfDYSKLDTYDILNRARY 682 fruit fly
2_pfamImport 564 GVYPEDALRERF-LKVEEVSRRLALV-PAEGARLPMYVLSYLQAALIARPDKpisqdelenkpfDFSKLDTYDILNRARY 641
Q9XXN2       525 GEYTEQDLNTRF-NKVCRIGRRVAYV---NEGGALAHLYSWLKSSLTIELVPkkga----neslTPAVENNFTLLTRAEQ 596 Caenorhabditis ...
Q22505       548 GTYTEQDLKNRF-EQLYKIGRKTASI-DENGGTLGAYFWSYVKSLFLVDMPQqygn----ldaiDVNNTDNYEILSRAKQ 621 Caenorhabditis ...
Q6PFS4       698 SIERGDLELAAKFVNQLRG-ESQ-----------RVAQDWLKEARLTLETKQVISLLsaYAN 747 zebrafish
Q55BP9       584 HLRKNNLSSAIKEMESIQQqSSKsstnidnhhlsKLTSNWIKQAKERDQLENISKLL--ELK 643 Dictyostelium discoideum AX4
Q7SFD8       616 YLEEGDLDNAAREMNGLKG-WAK-----------TLSRDWLGEVRKVLEVQQALDVIqaEAR 665 Neurospora crassa OR74A
Q2HCU4       614 FLEEGDLDNAAREMNGLTG-WSK-----------TLSRDWLGEVRKVLEVRQALEVIqtEAR 663 Chaetomium globosum CBS 148.51
Q5K8K8       669 CLAEKDLDGAAREINSLTG-WPA-----------KLANDWLQQARRKLEVQQALEVVatEAT 718 Cryptococcus neoformans
XP_011386449 628 YLDRKDLDSATRELNQLKG-WPK-----------LLASDWLAASRKRLEVQQALDVVqtEAS 677
P91928       683 HVDRSDFLQALKYMNLLQG-ASR-----------KIAGEWMKEARLMLETQQAANTLmaHAA 732 fruit fly
2_pfamImport 642 WLDRGDLVKTVQYVNLLQG-APR-----------KAALDWLNEARLLLETQQAASTLmaHAA 691
Q9XXN2       597 LWKSGKKSDAIRVLQLTDG-ATR-----------RVAADFIADARRQHEALLLSRLLlaHAA 646 Caenorhabditis elegans
Q22505       622 YVHNGDLDKAIRVVQLLKG-QPA-----------HLARDWIVDTRSYLESRLLAQLLvaHAA 671 Caenorhabditis elegans
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