Conserved Protein Domain Family
Macoilin

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pfam09726: Macoilin (This model is not part of the current CDD release)
Macoilin family
The Macoilin proteins has an N-terminal portion that is composed of 5 trasnmembrane helices, followed by a C-terminal coiled-coil region. Macoilin is a highly conserved protein present in eukaryotes. Macoilin appears to be found in the ER and be involved in the function of neurons.
Statistics
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PSSM-Id: 519010
Aligned: 8 rows
Threshold Bit Score: 914.281
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q2TLY1         2 KRRnadc-sklrRPLKRNRIT-EGIYGSTFLYLKFLVVWALVLLADFVLEFRFEYLWPFWLFIRSVYDSFRYQGLAFSVF 79  zebrafish
XP_028936675  10 KLR---------RPLKRNRIA-DGIYGSTFLYLKFLVVWALVLLADFVLEFRFEYLWPFWLFIRSVYDSFRYQGLAFSVF 79 
Q2TLY2         2 KRRnadc-sklrRPLKRNRIT-EGIHSSTFLYLKFLVVWALVLLADFVLEFRFEYLWPFWLFIRSVYDSFRYQGLAFSVF 79  zebrafish
XP_015792346   2 RRRnadfcgkfrRPVKKSKLTsSGFYGSTFMYLKFLMVWSFVLFADFILEFRFEYLWPFWLLIRSVYDSFKYQGLAFSVF 81 
3_pfamImport   1 KRRnieagkpprRPVKRAGKFaEGVCGSSFVYIKFILIWFFILMADFILEFRFEYMWPFWLLIQSVHDTFKYQGLAYSVF 80 
NP_001071887   2 KRRnteagkpprRPVKRAGKFaEGVCGSSFVYIKFVTIWLFILLADFILEFRFEYMWPFWLLLQSVYDTFKYQGLAYSVF 81  vase tunicate
NP_001072062   2 KRRnadc-sklrRPLKRNRIT-EGIYSSTFLYLKFLVVWVLVLLADFVLEFRFEYLWPFWLFIRSVYDSFRYQGLAFSVF 79  torafugu
XP_011613926   2 KRRnaec-sklrRPIKRNRIT-EGIYGSTFLYLKFLVVWALVLLADFVLEFRFEYLWPFWLFLRSVYDSFKYQGLAFSVF 79  torafugu
Q2TLY1        80 FVCVAFTSDIICLLFIPVQWLFFAASTYVWVQYVWHTERGVCLPTVSLWILFVYIEAAIRFKDLKH--FHVDLCRPFAAH 157 zebrafish
XP_028936675  80 FVCVAFTSNIICLLFIPIQWLFFAASTYVWVQYVWHTERGVCLPTVSLWILFVYIEAAIRFKDLKN--FHVDLCRPFAAH 157
Q2TLY2        80 FVCVAFTSDIICLLFIPKQWLFFAASTYVWVQYVWHTERGVCLPTVSLWILFVYIEAAIRFKDLKH--FHVDLCRPFAAH 157 zebrafish
XP_015792346  82 FVFIALTSDMICFLLIPVHWLFFVASTYVWVQYVWHTEKGICLPTLSLWLLFVYIEASFRLKELKNlpFHLDLCRPFAAH 161
3_pfamImport  81 FVCIAITSDTVCLLFIPIQWLFFMASTYVWIHYVWHTDKGICIPTVSLWLFFMYIEATMRLRDLKNspFHIDLCRPFAAH 160
NP_001071887  82 FVCIAITSDTICLLFIPIQWLFFMASTYVWIHYVWHTDKGICLPTVSLWLLFMYIEATMRLRDLKSspFHIDLCRPFAAH 161 vase tunicate
NP_001072062  80 FVCVAFTSDIICLLFIPVQWLFFAASTYVWVQYVWHTERGVCLPTVSLWILFVYIEAAIRFKDLKN--FHVDLCRPFAAH 157 torafugu
XP_011613926  80 FVCVAFTSDIICLLFIPVQWLFFAASTYVWVQYVWHTERGVCLPTVSLWILFVYIEAAIRFKDLKN--FHVDLCRPFAAH 157 torafugu
Q2TLY1       158 CIGY-PVVTLGFGFKSYVSYKMRLRKQKEVQKENEFYMQLLQQALPPEQ-----QLIQRQEREAEEaaaAAAAAAsks-- 229 zebrafish
XP_028936675 158 CIGY-PVVTLGFGFKSYVSYKMRLRKQKEVQKENEFYMQLLQQALPPEQ-----QMLQRQEREAEE---AAKGLS----- 223
Q2TLY2       158 CIGY-PVVTLGFGFKSYVSYKMRLRKQKEVQKENEFYMQLLQQALPPEQ-----QMLQRQERETEEa--TSKGMS----- 224 zebrafish
XP_015792346 162 CIGY-SVVTLGFGFKSHVSYKMRLRKQSEVAKENEFYFELLQKALPQET--------------------CATNLTdntsv 220
3_pfamImport 161 CIGH-PVVTLGIGFKSYVSYRFKLRMQREVQKENVFFYELLRQALPKEQpnhtlSVTDKEKSETST---TSNGVL----- 231
NP_001071887 162 CIGHpS-CDYGIGFKSYVSYRFKLRMQREVQKENTFYYELLRQALPKEQlnhtlSVTDKDKSEVSTpsnTSNGVL----- 235 vase tunicate
NP_001072062 158 CIGY-PVVTLGFGFKSYVSYKMRLRKQKEVQKENEFYMQLLQQALPPEQ-----QMLQRQEKEAEE---VAKGIS----- 223 torafugu
XP_011613926 158 CIGY-PVVTLGFGFKSYVSYKMRLRKQKEVQKENEFYMQLLQQALPPEQ-----QMLQRQEREAEE---ALKGIS----- 223 torafugu
Q2TLY1       230 -ihDVD-SPAVAQNGSAGGKK-----PSSNTLPELEYREK---ERGK-NE--SKKQHNhnQnhhsstsssiLPS-VDNKA 295 zebrafish
XP_028936675 224 ---DVDpSLILHHNGGIPSGK-----KLSPTLPELEYRDKgreRDKEaKK--HNLGINnnI----------LQP-VDSKI 282
Q2TLY2       225 ---EAD-SVLVAQNGTAINKK------LPISLPELEYKEK---GKDS-AK--DKKQQQhsIgin----nniLQT-VDAKL 283 zebrafish
XP_015792346 221 isnCVPlPLALNHNHHSLNNKkaisgSSNEKTPTVSHNSSnisKLNNeYD--SKKSYAngI----------D-------K 281
3_pfamImport 232 -------PNHLNKKPHDRSKIpa-iqDSTLQIAEINSSNHkssGAASgTP--T--------------------------V 275
NP_001071887 236 -------PHV--KKSHDRSKSspishDNTLQIAEVTPSPTkttVSSSgSS--STPS-----------------------L 281 vase tunicate
NP_001072062 224 ---EVE-PSVTSQNGAPPGKK-----SSTLPLPELEYREK---TKDSiGKerEGKK----Vgin----nnsIIHpLDSKL 283 torafugu
XP_011613926 224 ---EVE-APPVTQNGAPANKK------TSATLPELEFREKgkdGKGG-GE--AKKQHN--Si--------lPSA-VDSKL 279 torafugu
Q2TLY1       296 QEMEYMENHVNSKRLSSSdLLGSTENLLKDEHSSSSSssts----snsnKNYKNASGggggGGSSSPRGHGTANGSVPSS 371 zebrafish
XP_028936675 283 QEIEYMENHINSKRLNND-LVGSTENLLKEDSCSASS------------KNYKNASG----AVNSSPRGHNAANGSIPSS 345
Q2TLY2       284 QDIEYMENHLNAKRLNNE-LGGSAENLFLKEEVGAGGgsa-------psKHYK----------NSSPRSHNSTNGSVPSS 345 zebrafish
XP_015792346 282 QELQFMENPINKKPLSEYeNDSNISDCNHEESFKNLTssl------spnKSTEKLTNsmasISLSSSNKLNHSSNHVTSS 355
3_pfamImport 276 TRKSGHTNKSEPTPV-ITtSPTPETDLKRRSSARDKKttdl-----shsPTQKTTKTn---SGNSSPKSLKHNSSSRSSS 346
NP_001071887 282 SRKS--ANKSVPEHIPIWtPPVQEIEVIFRKSNKSKKssne----sassPTQQQQKSkssnSGNNSPKSLKQNSSSRSSS 355 vase tunicate
NP_001072062 284 QETEYIENYAGAKRLNND---------LAGENTDSNThptskeemagtgKNYKNNTGgggtISNSSPRNHSSSNGSVPPG 354 torafugu
XP_011613926 280 QEMEYMENHMNsKRLTTE--LGSTENLLLKEDNSSCssss-----ssssKNYKNASSns-sTLNSSPRGHSATNGSVPTA 351 torafugu
Q2TLY1       372 SgpsssasssSKGDRKQKYgGGKNSA--SHRDPVENCIPNNQL----------------------------SKPEALV-R 420 zebrafish
XP_028936675 346 A---------GKNEKKQKC-AGKTPA--AHKDLMENCIPNNQL----------------------------GKPDALV-R 384
Q2TLY2       346 Ss--------NRSDKKQKC-TGKNLA--PHRDLMENCIPNNQL----------------------------SKPDALV-R 385 zebrafish
XP_015792346 356 Ns--------NAN----SLpFGNVQSlnISNKKTKNNLANNLT----------------------------SQKDELViR 395
3_pfamImport 347 Th--------SNDSEKPKLp----------------SLPNGHAvmkepimlpltnghavqekgnetkieliCTPSAIE-R 401
NP_001071887 356 Vh--------SNDSEKQKAp----------------ILPNGHLgvkeviplpltngh-vipektenkieliSTPSAIE-R 409 vase tunicate
NP_001072062 355 Ss--------AKNEKKQKG-AGK-----AQKDPVENCIPNNQL----------------------------GKPDALV-R 391 torafugu
XP_011613926 352 Apsss--sstGRNEKK-KLaAGKGTSggSHKDPTDNCIPNNQL----------------------------SKPEALV-R 399 torafugu
Q2TLY1       421 LEQDVKKLKADLQASRQTEQDLRSQLGSLGTSERSIRSELGQLRQENELLQNKLHNAVQAKQKDKQTLGQLEKRLKAEQE 500 zebrafish
XP_028936675 385 LEQDIKKLKADLQASRQVEQELRSQISSLTGTERAIRTEIGQLRQENELLQNKLHNAVQMKQKDKQTVSQLEKKLKAEQE 464
Q2TLY2       386 LEQDIKKLKADLQASRQVEQDLRSQISSLSSAERSMRSELGQLRQENELLQNKLHNAVQAKQKDKQTIVQLEKRLKAEQE 465 zebrafish
XP_015792346 396 LEADIKRLKAYLQASRQTELELKSQINSLLSEERSLKSELSTLQQDNDSLQTRLHNLLSARQQDKQTVSQLEKRLQEEKK 475
3_pfamImport 402 LETTIAKLQAELAQARKNDSELNNRINLLTNLERAAKNDIIQLKKENDMMQTKMNGMMSSKQKEKQSMQSMEKRLKSEAD 481
NP_001071887 410 LEATIAKLQSELNQARKNDQEMKNQISLLTNLERSAKNDVNQLKKENDMLQTKVNSMVSGKQKDKQSMQSMEKKLKSEAD 489 vase tunicate
NP_001072062 392 LEQDVKRLKADLQANRQLESELRSQLSSLSSQDRSLRSELGQLRQDNELLQNKLHSAVQAKQKDKQTISQLEKRLKVEQD 471 torafugu
XP_011613926 400 LEQDVKKLKADLQASRQVEQDLRSQIGSLGSSERSVRSELGQLRQENELLQNKLHNAVQAKQKDKQAAGQLEKRLKAEQE 479 torafugu
Q2TLY1       501 ARAAAEKLLAEEKKRKKLEEATAARAVALAAATR-GECTESLRRRISELEAECKKLTLDIKVKEDQIRELELKVQELHKY 579 zebrafish
XP_028936675 465 ARAFVEKQLVEEKKRKKLEEATAARAVAFAAATR-GECTETLRSRIRELEAECKKLTLDMKLKEDQIRELEIKVQELRKY 543
Q2TLY2       466 ARAAVEKQLAEEKKRKKMEEATAARAVALAAASR-GECTDSLKSRIRELESECKKLTHDMKLKEEQIRELELKAQELHKY 544 zebrafish
XP_015792346 476 SRASYESQLASERKAKKDE----ANARAAAAAAR-IECTEICKNKRRELESELKLLRKEIKVREDQVKQIDCEAQSLRQY 550
3_pfamImport 482 SRVNAEKLLQEEKRRKREEEDTAKQAAAQAITSReRERAEVLKQAKQDLELEIQRLETKLRIKEEECAALK---KEIVDY 558
NP_001071887 490 SRVNVEKQLHEEKRRRKEEEETAKHAAAQAQNNReKEKAEALKQAKHDLENEILKLEGQLKAKQEECDVMK---KEISEF 566 vase tunicate
NP_001072062 472 ARTVAEKQLAEERKRKKMEEATAARAVALAAATR-VESTDTLRSRIRDLETECKKLTMDMKLKEEQIRDLEGKCQELRKY 550 torafugu
XP_011613926 480 ARATAEKQLAEEKKRKK---LEEARAVALAAASR-GECTDTLRRRITELETECKKLTMDIKLKEEQIRELELKVQELHKY 555 torafugu
Q2TLY1       580 ---KENEKDTEVLMSALSAMQDKTQHLENSLSAETRIKLDLFSALGDAKRQLEIAQGQILQKDQEIKD-------LKQKI 649 zebrafish
XP_028936675 544 ---KENEKDTEVLMSALSAMQDKTQHLENSLSAETRIKLDLFSALGDAKRQLEIAQGQIIQKDQEIKD-------LKQKI 613
Q2TLY2       545 ---KENEKDTEVLMSALSAMQDKTQHLENSLSAETRIKLDLFSALGDAKRQLEIAQGQILQKEQEIKE-------LKQKI 614 zebrafish
XP_015792346 551 ---KESHGDTEILLSALSAMQDKNAHLENSLSAETRLKLDLFSALGEAKRQLEINQALLQQKERQIEElestvdqLKARF 627
3_pfamImport 559 qvqEKSVKESETLMSALQAMQDKNLMLENSLSAETRLKLDLFSALGDVKRQLELAHGAIYKRDAEIVD-------LKSRL 631
NP_001071887 567 qlqEKSAKESETLMSALQAMQDKNLMLENSLSAETRLKLDLFSALGDVKRQLELAHGAIYKRDAEIVD-------LKSRL 639 vase tunicate
NP_001072062 551 ---KENEKDTEVLMSALSAMQEKTQHLENSLSAETRIKLDLFSALGDAKRQLEIAQGQIHQREQEIAE-------LKQKI 620 torafugu
XP_011613926 556 ---KENEKDTEVLMSALSAMQDKTQHLENSLSAETRIKLDLFSALGDAKRQLEISQGQILQKDQEIKD-------LKQKI 625 torafugu
Q2TLY1       650 AEVMAVMPSVVYSADTGSMTPVTPHYSSKFMDTSPSGLDPNASVYQPL 697 zebrafish
XP_028936675 614 AEVMAVMPSITYTAATSTLSPVSPHYSSKFVETSPSGLDPNASVYQPL 661
Q2TLY2       615 AEVMAVMPSITYSAETNNMTPVTPHYSSKFMDTSPSSLDPNASVYQPL 662 zebrafish
XP_015792346 628 TELLAVMPA------TNAYTGIDSDIVSSLMLNSKFMPDPNDS--HES 667
3_pfamImport 632 ADILSILPE-------SRIRSPTPHYSANFLEKPPLVRLSPTQEYPNN 672
NP_001071887 640 ADILSILPE-------SRIRSSTPHYSANFLEKPPLVRLSPTQEYPNN 680 vase tunicate
NP_001072062 621 AEVMAVMPSLSYSSDGSNLSPVTPHYSSKFMDNSPSSLDPNASVYQPL 668 torafugu
XP_011613926 626 AEVMAVMPSISYTADTSSMTPVAPHYSSKFMDTNSSGLDPNASVYQPL 673 torafugu
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