8GUG,8QNL


Conserved Protein Domain Family
Xre_MbcA_ParS_C
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pfam09722: Xre_MbcA_ParS_C 
Antitoxin Xre/MbcA/ParS C-terminal toxin-binding domain
This entry represents the C-terminal domain of antitoxin components of a type II toxin-antitoxin (TA) system, including Xre from Pseudomonas putida, MbcA from Mycobacterium sp. and ParS from Sphingobium sp.. This domain interacts with the toxin component and sterically blocks its active site, neutralising its effect. These antitoxins also have a HTH domain at the N-terminal.
Links
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Statistics
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PSSM-Id: 490572
Aligned: 143 rows
Threshold Bit Score: 38.2544
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8GUG_B         97 LATELFDDEERALE-WMKENVYG--LGGKRPLDMVST--TVDFEIVKDLIGRLEHG 147 Vibrio parahaemolyticus RIMD 2210633
WP_014704102   78 SLQILLPDQVL-ADqWLATPNDNplFNGTAPLDRILAgqVVDLAVVRDFLDAERGG 132 Methylophaga frappieri
Q21PX8         94 ALHIIYGDKL--ADeWVSLPNKNaiFAGRTPLQYMLSggLIGMQTVRKLLDARRGG 147 Rhodoferax ferrireducens T118
WP_013615891   91 ALRILFVGEA--SKaWLTRPNGRrtLNGQRPLDYMLSggIPAMLTVRQLLDADRSG 144 Deinococcus proteolyticus
Q0VPE5         78 ALRTLFGNKEN-VYgFIRMANHNpfFNGLTPMDIMSNgrVASLYEVHRQLDTLRGG 132 Alcanivorax borkumensis SK2
WP_345995760   78 ALRTIFDNPEN-VYgFMSMDNHNpfFSGRSPLRIIGTgsFGALYEVHKRIDALRGG 132 Sodalis praecaptivus
WP_022561371   82 VLRTVFNNPEL-VYgFMTSQNHNtfFEGRAPIDVIEGgnFGSLYDVYHRVNALRGG 136 Vibrio
Q6LHR7        108 ALRIVFSNPAN-VSgFMSMKNNNdyFAGHTPLEIIESgkFGDLYEVARRVDALRGG 162 Photobacterium profundum
WP_012528500   82 ALRLLYPQNPEIRYsWVNRRNEA--FGNLRPLDVMKEqgIIGLARVSRYLDYYRgl 135 Citrifermentans bemidjiense
tigr:AFE_1071 126 NLRLLFPHDRDLAYrWMTARNRA--FGNQTPVEVICEwgFTGLLMVRSYLDRalgs 179
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