Conserved Protein Domain Family
ETRAMP

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pfam09716: ETRAMP (This model is not part of the current CDD release)
Malarial early transcribed membrane protein (ETRAMP)
These sequences represent a family of proteins from the malaria parasite Plasmodium falciparum, several of which have been shown to be expressed specifically in the ring stage as well as the rodent parasite Plasmodium yoelii. A homologue from Plasmodium chabaudi was localized to the parasitophorous vacuole membrane. Members have an initial hydrophobic, Phe/Tyr-rich, stretch long enough to span the membrane, a highly charged region rich in Lys, a second putative transmembrane region and a second highly charged, low complexity sequence region. Some members have up to 100 residues of additional C-terminal sequence. These genes have been shown to be found in the sub-telomeric regions of both Plasmodium falciparum and P. yoelii chromosomes.
Statistics
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PSSM-Id: 490566
Aligned: 35 rows
Threshold Bit Score: 38.4383
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001612771   1 MKFTRVCSVFAFLLAVNLLapechcdhvnnKPHVHNNHshgsgncgghhgnssansgnsgcphaasgnssnsvnapgaga 80 
2_pfamImport   1 MRIYNAFFLFQLLLVSCCF-----------IPCLSHKPh----------------------------------------- 28 
6_pfamImport   1 MNTLNVFFVFYVLYITTFFf----------NPCFCEDTd----------------------------------------- 29 
XP_001613359   1 MNAKNLMASFSLILLLCVLlnl------aiVQVNANENnkikggkvpppsvptgn------------------------- 49 
XP_002808889   1 MKVFIFFAFVNFLFVLNLF-----------SPCTCKKD------------------------------------------ 27 
1_pfamImport   1 MRISCIFLLLNFLFIINLL-----------APCMCSEN------------------------------------------ 27 
XP_001614867   1 MKIFCIFILINFLFIINLL-----------APCMCSEN------------------------------------------ 27 
3_pfamImport   1 MKITKVLVTLAILVALNLL-----------TPCTCKN------------------------------------------- 26 
Q8I2F9         1 MRILKVLTLLVFLLCINVF-----------SPCYTKN------------------------------------------- 26  Plasmodium falc...
XP_001608327   1 MKVTKVLVTLAVLVALNLL-----------TPCTCKN------------------------------------------- 26 
XP_001612771  81 spssaklsgpgtpppaptpspatpSSKDDAGKAIDQIDqqiekkKKNKKICLISAAATALTLLLGGALGFGIYKNRKA 158
2_pfamImport  29 ------------------------qPTVGSLHALKSMEnkmqmrRSRRKKIILYSIGSILALATVIATGVGIGMYMKK 82 
6_pfamImport  30 ------------------------YYSETNDNSLKNIDtaigkkKGKKSVAI-ALLSSGLVASII---GVLYYMYKSH 79 
XP_001613359  50 -------nsdnnvpkkdggennppPDAENALQELKNFTknlekkTTTNRNIIISTTVINMVLLVLLSGLIGYNTKKGF 120
XP_002808889  28 ------------------------YGKEWVKDKLSLVNlklekyDKKKKFALISGAAIGALALITLIG--GIYMTKGR 79 
1_pfamImport  28 ------------------------VVKKKVLNAFNTVSeklngsDKTKKNVALAGAATTAIALISTLIG-GAYLLKPK 80 
XP_001614867  28 ------------------------VVKKKVLDMFNTVNdrlnsyDKKKKNAIMAGAATTAIALISTLIG-GVYLFKPK 80 
3_pfamImport  27 ------------------------VHLEKMKAELDVVDknvrkkHFKKKFII-SSVVIGVAILVNVLAAIGYYNYKKK 79 
Q8I2F9        27 ------------------------GFLSRIKDRFTKFEkkmkdkENKKKLLI-SASIVGLSLLTNLIVGFAYYNYRKN 79  Plasmodium falcip...
XP_001608327  27 ------------------------LFLEKVKAKLDAFDknmkkkDFKKKVLI-SSAILGAAILANVLAGIGYYSYKKK 79 
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