Conserved Protein Domain Family
Cas_Cmr3
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pfam09700: Cas_Cmr3 (This model is not part of the current CDD release)
CRISPR-associated protein (Cas_Cmr3)
CRISPR is a term for Clustered Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This highly divergent family, found in at least ten different archaeal and bacterial species, is represented by TM1793 from Thermotoga maritima.
Links
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Statistics
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PSSM-Id: 490558
Aligned: 13 rows
Threshold Bit Score: 231.178
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q8TVU0        10 FLVLPQDRAFFRRPEPFR-AAAES---VAESEGPKPWTVAGCVRNALLEVTDGDL---GEVLEYPRKLVrsa-----ppg 77  Methanopyrus ka...
WP_011813436   5 RYIEPQDVLFFRGNRLFG-EPGNA---GAALMPPWPSVFAGALRSAMLSAAGADP---AQLRSGELPAPldt------vl 71  Halorhodospira ...
O28413         3 LVMKPYDSLLFREPRPFD-VNNH----VARTILPLPQTLAGAVRSAIYVKYGSKV---KDLIGFGKE------------- 61  Archaeoglobus f...
Q7MTH3         6 IKLTPLDKFFFGQKKTFG-DDNANy-fVYSSLFPQQTTLLGLLRYQLLQIAGEEIfkdNKIQDEHKAGEligkqsfspfv 83  Porphyromonas g...
Q8R6Z6         4 FKITPYDVFFFGSGRPFN-VGD-----VVYSIFPHPHTLAGAICTKIHAHTKIDT---SRILK----------------- 57  Caldanaerobacte...
Q9KFY7         8 IRIRPLDPLMVRDGRPFK-DSPGAr--AYSMMDVVPGVIAGTVRTMLAEQAAKSS------------RV----------- 61  Bacillus halodu...
WP_011530100   6 LELQPLAPLLLRDGRPFAgGGEESr--AQSLPLPLPHTLAGFIRTQLGEGRGLKW---RNLSDDALRR------------ 68  Deinococcus geo...
BAF60108       4 WVIEPRDPLIARDGRPFG-PVPGAr--AFTLAFPFPSTIAGAVRTRDGLDASGRF------------QP----------- 57 
Q53W08         1 mLIEPRDPLIVRDGRPFT-NSPGAr--AKSLPFPLPQTLAGAYRTRRALLEGLPL---PERAEEVLR------------- 61  Thermus thermop...
Q2JN53         4 FTLSPLDVWMFRDAKPFA-PGERAw--ANSSFPPSGHTLAGAVQAYLGQPLT---------------------------- 52  Synechococcus s...
Q6ZEA9         4 YSLTPLDILLLRDAKPFT-PGDRAw--AGSIFPPNGHTLAGAVRSLLPQNQT---------------------------- 52  Synechocystis s...
A0B6W4         4 LRITPVDSWFFRDGRPFH-LGEATs-dVGGLFPPSAFTVVGAIRAHLARSMGWRE---GKWSEEICRVL----------- 67  Methanothrix th...
Q1AZD9         4 YGIEALDTLFFGDGSPFD-AGETGqieVTGVFPPSPTTVVGALRAAFARELGWRC---GDWPENVKAKL----------- 68  Rubrobacter xyl...

Q8TVU0        78 SIGEALGETALFlGTWVVEvrpgaPDRLERVWWPCPAHLARy-------ePESGGEAVDLLRVEEvgda----------- 139 Methanopyrus ka...
WP_011813436  72 GTPEEPGTFTLT-GVTLARr---qSSGTAEPLHPLPADLSVe--------RDEATGECAVHRLTP--------------- 124 Halorhodospira ...
O28413        62 -----EPEFEIL-GHFFYR-----YDGKFELLVESPHD------------VTQNLGLVKPHRIDK--------------- 103 Archaeoglobus f...
Q7MTH3        84 KDKLQFGIIQSL-SPVFIIdkkknDEGKEEYFLPVGRRFQ----------KENEKAPYNLLHLSC--------------- 137 Porphyromonas g...
Q8R6Z6        58 ---------NVY-GPFIER--------NGKLYFPKPSNILG---------ERKKEEIENIFHARHyelntklfkkentna 110 Caldanaerobacte...
Q9KFY7        62 VDYHTFSKVPVY-GPLYVW--------KGKPFFPLPSDIGF---------YEDENGALQMNYRQPqpl------------ 111 Bacillus halodu...
WP_011530100  69 -ELQALHNTPIR--ALLRR--------DETFMFPAPLNAV----------VDKNGQIFRALPAELregeg---------t 118 Deinococcus geo...
BAF60108      58 AEIPRLKKIEVL-GPLLVEld-agTGDIDRWLVPAPADALFfel---vpsDFTKAAIRQLTPLQLppgsht--------n 124
Q53W08        62 --------WGLR-GPLLAEe----GEGGWRLLAPRPLDAL-----------KLGEALYPLRPLELpqgag---------t 108 Thermus thermop...
Q2JN53        53 --------LRLR-GPFLCH--------DERLYFPAPLHLEDgfplvpvpwLDERDPYFHC-HWDP--------------- 99  Synechococcus s...
Q6ZEA9        53 --------ISLI-GPLLYH--------KETLYFPRPLGFVGktpllplpwHDATSPLRSQMLWDK--------------- 100 Synechocystis s...
A0B6W4        68 GDGYDLAGLRFR-GPLLCRe----GDRGPEMLYPAPLNLL----------GKRNDSGYEMRLLRPgee------------ 120 Methanothrix th...
Q1AZD9        69 GDGQRLGPLRFA-GPYVTR--------GGEPLFPAPLYLM-------------KSGERFTTRLRPrdtp----------- 115 Rubrobacter xyl...

Q8TVU0       140 aiafSGHDEALRRRYGFMtpk----pprPGSDVETPGRY-VDTGTISK-ILAGRTPARR---------TPDLEDNvag-- 202 Methanopyrus ka...
WP_011813436 125 ----QPLPAGVASSQPLErlp----vlrRSDRGKPAAGYwLTHSGWQR-YCQGEPPPAE---------ALVHRSA----- 181 Halorhodospira ...
O28413       104 -----LGITILMDS--------------EGIKFRPFNGF-LKFSGLID-YLQGRIAEDS---------VVERQK------ 147 Archaeoglobus f...
Q7MTH3       138 ----------------------------QAGCPPIFGEY-KPKKGLAScWLSSK---SH---------TLLNEED----- 171 Porphyromonas g...
Q8R6Z6       111 dsniKTFPLYM-----------------GKEDIGTFPAF-ISIEGLRK-WLKGEKIEIH---------EILQYKE----- 157 Caldanaerobacte...
Q9KFY7       112 --vnGQGYLGIGDKGDHEslwpakvipqMGKVSSIVPAY-LSLDWMSR-WLRGDLSPKSwtsplaewqQLVRDNKldstd 187 Bacillus halodu...
WP_011530100 119 dapeGLRPLLLTDRDGNA----------PGDAFKPQGDYrYWPQDAMQtWLLGGIPERL---------ERVE-------- 171 Deinococcus geo...
BAF60108     125 lpedSLAPVGMPDRD-------------PRKPFSKTPAY-WYWKLFEK-WLVDPFDGDV---------QLVEVGHn---- 176
Q53W08       109 nlpeGLSPVGLPSPA-------------LKEKPAPLPAF-WYWESFLE-WLLQDAPAGF---------APRGHE------ 158 Thermus thermop...
Q2JN53       100 -----TRPAPLVSLRPVEeep----ersQSSKKKKTGGY-LPFEVVQK-ALEGKGWDLS---------QAVKP------- 152 Synechococcus s...
Q6ZEA9       101 -----TQPAPLAPLETVSqt-------dIKRDEKQARTW-LPLDVMMG-YLQTGAIKPE---------DWARPEDed--- 154 Synechocystis s...
A0B6W4       121 -vecDLGRVRLPTAE-------------KIDGMKQLSGY-VNGDQLKQ-VLRGEVPEGR---------VIPREE------ 169 Methanothrix th...
Q1AZD9       116 -letDMGEVRLPEVVPVEdds----gkeAKGFKPLADAY-LTKSGTER-ALRWELPQEE---------EVVKVSD----- 174 Rubrobacter xyl...

Q8TVU0       203 ----pgeLLRPELHVGVKLVGLKTA---DEGYLYAAR-FLRPGrsp---------------vdGGSLVGFLTVLAVPEDA 259 Methanopyrus ka...
WP_011813436 182 -------IWSSDPRLGIALKPEQRTa--AESQLYTTE-GIRLC--------------------EGYGFLAAIAGSDPTSL 231 Halorhodospira ...
O28413       148 -------IFKKERRVGIALTKAKVT---KEEHFYQVE-MLRFS--------------------DDCGIAVWVEDGVDFDD 196 Archaeoglobus f...
Q7MTH3       172 -------FFTKDERIGIRKDYEGAT---NDDAFFCQR-YYRFKnfkevegektkvckqppvreHDFCFAVLLETHRDIKH 240 Porphyromonas g...
Q8R6Z6       158 -------IFTKEERLGIKMDSTVNAvggEEDALYRIE-FMRLK--------------------EDVNLIVWVEFDFEAEE 209 Caldanaerobacte...
Q9KFY7       188 kdvhflpPFALDERDHIAVEAGTRMa--KDQALFTTQ-SIVFP--------------------PDLDMHARVEIPQEAAW 244 Bacillus halodu...
WP_011530100 172 -------GPPTDERTHVAMNSETGTg--DEGKLFTVS-YRAFEerre-------------gtyHRWTLRVKTDLQGHI-- 226 Deinococcus geo...
BAF60108     177 -------GPVQEVRMHASIRPDTQTadeEKGALFQTR-GLEFAcpvedha-------dggilsRVRRLGLAAAADAPNLK 241
Q53W08       159 -------GPVPETRTHVALDPAAQTa--REGFLFQTS-GLEFVr-------------------GRRRLALVLWPEGPEP- 208 Thermus thermop...
Q2JN53       153 -------PLKYEVRPHNTLQVSKRQv--READGYFVEtCIRLQ--------------------PGWSLALSIEGWDPDRE 203 Synechococcus s...
Q6ZEA9       155 -----sqPWTMESRPHNSIEAGTRQv--KESDGYFVEnGIRLK--------------------ENWSLAIAVDPTTHQQL 207 Synechocystis s...
A0B6W4       170 -------LWGTEYAVGLERERDTRTa--KEAHLYSIN-RIRLV--------------------RGVHLIMGVEGIDEGLL 219 Methanothrix th...
Q1AZD9       175 -------LWEGEGRLGIRRDPEKRTt--QEDALYLAS-HVRPR--------------------RGVALAMGVAGYEGPA- 223 Rubrobacter xyl...

Q8TVU0       260 WDdgvl---------edlpSPGGRLGRGRHAWVIPLra------gDWSDDVFPEVEEP--EGDLPGL--YLETPTPFPEG 320 Methanopyrus ka...
WP_011813436 232 PK-----------------QATLRLGGDGRGAFMSA---------VAAPVETSPEPAAieAEGRLRI--VLTTPGIFPGG 283 Halorhodospira ...
O28413       197 -------------------EGILGVGGERRFVKFEKreep--eciTNLRSKWKKIRDKinETGRLKI--YLATPAILGAK 253 Archaeoglobus f...
Q7MTH3       241 EEl---------------nKRIVYLGGERQPFLMDLme-----vsEETFKLNIESSTLtsDEKHYTV--VLLSDAMIEPK 298 Porphyromonas g...
Q8R6Z6       210 IKkagfsdesklrgffnqpPRALKIGGEMKNAFYEVeeenfveflRENLGVSQMVEVK--CGDIVKV--LFLTPGVFPDF 285 Caldanaerobacte...
Q9KFY7       245 PMq---------------lSTLHSLGGKRRLAHFSEsq------dDQFWQCPEALEQSldESQYVRL--VLATPAYFAKG 301 Bacillus halodu...
WP_011530100 227 -------------------APLGHLGGERRPVALRDcgn---qgqWPNLSTFGELKAAlaDPNSTRLcfVLTSPALFAGG 284 Deinococcus geo...
BAF60108     242 -------------------PGIAPLGGERRLAFWRQs-------nQVLPSCPEALKEKiaALGHCRL--ILLTPAHFGAG 293
Q53W08       209 -------------------EGVFPLGGERRLAFWQKg-------gPGVPPLPEEVVAGllRHRAARL--VFLTPAFLGEA 260 Thermus thermop...
Q2JN53       204 AWdplp----------ltqEAVLRLGGEGHCALLAPcpk----lqEQWQQLQALSQAAfcQAGRALA--YLATPGVFIKK 267 Synechococcus s...
Q6ZEA9       208 QSlp--------------qPLSMRLGGEGHRVTLVHrpa----ldQQWQRLQTLSDQNyqQRQKAIA--YLMTPGIFERG 267 Synechocystis s...
A0B6W4       220 EKl---------------dGAVMPIGGEGRMGCVEMls------pGKGVSEIRQEIGPidGRVRFTL--VHITPAFLGRW 276 Methanothrix th...
Q1AZD9       224 -------------------PGLMTLGGESRMAYLEP---------CEISLPEAPELEPdgGRLRYTV--TLLTPMRPQDE 273 Rubrobacter xyl...

Q8TVU0       321 DvrsssPGDRLKaeavlvrpgsprdrVLQVELEVSEveseVLADRVieTR------RVS-TWSG-KRASPDHLA------ 386 Methanopyrus ka...
WP_011813436 284 W-----QLPGLDan-----------gLWHYPGGRAR----LVAAAV--PRg----qVIS-GWDL-AHHRPKPAQr----- 330 Halorhodospira ...
O28413       254 G-----YSSK-----------------LDYDLLGDIgierVRSVNFigGKp----vIFS-GWDF-VTRKPKPTRy----- 300 Archaeoglobus f...
Q7MTH3       299 Lle------------------------------------gVKFASTevKDfaclltHVG-TRRFyNKKKKREEQnieeve 341 Porphyromonas g...
Q8R6Z6       286 Kfsv----------------------------------egFEVFSLalDKy----tIVG-RYSP-KLKITKTVRa----- 320 Caldanaerobacte...
Q9KFY7       302 Wkp--rWLDDELct-----------nEIFAKEISREvklqLVWACI--SRw----qPVS-GWSY-SLKQPKAVRr----- 355 Bacillus halodu...
WP_011530100 285 Wkp--gWLSLTPeevqghsgaglpagVRELMAGGAR----LVGAAV--GRr----vPVS-GWNL-RENKPKPVRw----- 345 Deinococcus geo...
BAF60108     294 Wkp--sRLLEEW--------------EGVRPY--------LQAAAL--KRh----qTVS-GWDLeGKGRRKPTRr----- 337
Q53W08       261 Ylp--kGR----------------------AFQGAS----VVAAVV--GRp----lAVS-GWNL-KEGKPKPSRr----- 299 Thermus thermop...
Q2JN53       268 VegrslCRAWPWewr--------latPHPAHPLTGP----LVSVAT--GKp----vAISgRLRVdRPPEQRQMSlpap-- 327 Synechococcus s...
Q6ZEA9       268 RdgvstCRPYPWew----------klTHNQGS--------FISMAT--DRa----vAISpRIRD-RQRNPGHSipap--- 319 Synechocystis s...
A0B6W4       277 Prp--gES---------------------IPGVPGE----VVSACV--GRa----lRIG-GWDS-VNRRPVELKp----- 316 Methanothrix th...
Q1AZD9       274 GwqrpgGG---------------------LAGLPGE----VVSACV--GKp----vLIG-GWDT-ERKRPLDLEp----- 315 Rubrobacter xyl...

Q8TVU0       387 ---------AAEGTVlalgkldvdpgtpllLFPRMGDEDRELLASRLAfhls--------------gvgTAYALSL 439 Methanopyrus kandleri
WP_011813436 331 --------aAPAGTV---------------YWLEALEGGLKPLRKLAE---------------------SGLWGMT 362 Halorhodospira halo...
O28413       301 --------aVPAGSV---------------YFVEFEGEVKLDMPYLKLgkltk------------lgygLCFMGVW 341 Archaeoglobus fulgidus
Q7MTH3       342 talshqhelYARGSV---------------FYFDTKEQANQFCEDLEKvpnfh-----------tigynHAIIIEP 391 Porphyromonas gingi...
Q8R6Z6       321 ---------FPSGTV---------------MWFKAKEDMLLMNPAFIVpegnyhsfkipsgeqefigsnLILIGKE 372 Caldanaerobacter su...
Q9KFY7       356 --------mVPAGSV---------------YFFKVTEGNPRELARRGWlntvsdanrrkgafdkedgfgLALWGTW 408 Bacillus halodurans
WP_011530100 346 --------aVPAGSV---------------YFLEVPHAFNRQKLLEAWlkplsddq-----edqrdgfgCALWGVW 393 Deinococcus geother...
BAF60108     338 --------lAPAGTV---------------YFLKLNGDSAAIKRWVDSiwltcvsdg---eqdrrdgfgLAVTGVW 387
Q53W08       300 --------aVPAGSV---------------YFVRLPEAWGEGEVRDWAekvwfqnlse-eeqdrrdgfgLAALGLW 351 Thermus thermophilu...
Q2JN53       328 -----qvfaAPPGSI---------------YYLEQPAPLNQEEPELEDgrlnvfhr------wrllgysELLWLPW 377 Synechococcus sp. J...
Q6ZEA9       320 -----qvfaAPPGTV---------------YYLNQPQGLFADQDNAPKhlqqtr----------klgysHLLWVNL 365 Synechocystis sp. P...
A0B6W4       317 --------fIPPGSV---------------WFCEAEADELNDVMSVSRigeyt-----------gfgfgEIALGIW 358 Methanothrix thermo...
Q1AZD9       316 --------hLPAGST---------------WFMETEAGEVDRVLEMHAghigak---------tewgygQILIGRW 359 Rubrobacter xylanop...
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