4K0U


Conserved Protein Domain Family
T2SS_PulS_OutS

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pfam09691: T2SS_PulS_OutS 
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Type II secretion system pilotin lipoprotein (PulS_OutS)
This family comprises lipoproteins from four gamma proteobacterial species: PulS protein of Klebsiella pneumoniae (P20440), the OutS protein of Erwinia chrysanthemi (Q01567) and Pectobacterium chrysanthemi, and the functionally uncharacterized E. coli protein EtpO. PulS and OutS have been shown to interact with and facilitate insertion of secretins into the outer membrane, suggesting a chaperone-like, or piloting function for members of this family. In the pilotin from this four-helix protein from enterohemorrhagic Escherichia coli, the straight helix alpha2, the curved helix alpha3 and the bent helix alpha4 surround the central N-terminal helix alpha1. These helices create a prominent groove, mainly formed by side chains of helices 1,2 and 3 suggesting this groove is important as a binding site.
Statistics
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PSSM-Id: 401580
View PSSM: pfam09691
Aligned: 4 rows
Threshold Bit Score: 143.915
Threshold Setting Gi: 306528961
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4K0U_A            1 KNTAsrs----aaSVPANEQISQLASLVAASKYLRVQCERSDLPDDGTILKTAVNVAVQKGWDT----GRYQSLPQLSEN 72  Dickeya dada...
AHG18863         28 NKNN---------PVPLNDQVEQLASLVAGAKYLKYKCNRSDLPADAVTMKVAYKVAKQRGWNT----SNYASLPQRSET 94  Chania multi...
IEC:ABF-0020718  25 QKKHe--------NSHAPENIENMSSTIAGINYLKQQCGYQHLGTEENIINRVMILA-SRKWDTafdeDEKNTITRSSRR 95  Dickeya dada...
Q6D2I1           28 AHKGtvagqssavTVSSNDQLNQLSSLVAATRYLKSKCNRSDLPDDATIANVALTVAKQRGWNV----ANYQALPQRSES 103 Pectobacteri...
4K0U_A           73 LYQGLLKDGTPKATQCSSFNRTMTPFLD 100 Dickeya dadantii 3937
AHG18863         95 IYQSLTRDSTPEQTKCSSFNSLLVPFTE 122 Chania multitudinisentens RB-25
IEC:ABF-0020718  96 SYTILVEN-YRDGKGCAVLTKSLQDIIN 122 Dickeya dadantii 3937
Q6D2I1          104 LYQGLLKDSTPKEAQCSEFNRTLTPFID 131 Pectobacterium atrosepticum
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