5YJC


Conserved Protein Domain Family
Cas_Csm6_HEPN
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pfam09659: Cas_Csm6_HEPN 
Cas_Csm6 HEPN domain
This entry represents the HEPN domain of Csm6 from bacteria (i.e Enterococcus italicus), a Cas (CRISPR-associated) protein from type III-A CRISPR-Cas system. It consists of a CARF domain at the N-terminal, a six-helix domain and a C-terminal HEPN domain at the C-terminal, which has RNase activity.
Links
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Statistics
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PSSM-Id: 490529
Aligned: 7 rows
Threshold Bit Score: 181.496
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5YJC_A       104 KKSLFHYLL-LNMRYNRLDVAETLIRVKSIAEFI------------LKTYIEIHWPTLII---------------EKDGK 155 Staphylococcus ...
Q5HK94       249 KKSLFHYLL-LNMRYNRLDVAETLIRVKSIAEFI------------LKTYIEIHWPTLII---------------EKDGK 300 Staphylococcus ...
WP_013120866 257 CLEICEYCNvVKLLQRTGQLADFLLRLNPLVTELqtkflkyclgfaVEAIIEErhcagrknt-----agkfterlVRRDK 331 Thermincola potens
P71635       244 ANKVAEYISaLALLAKREQWAEFARSATPAITIV------------LRAAVAKHLPedry-----------lddmGRVDR 300 Mycobacterium t...
CCX73451     258 KEKMFEYALgLKVKVLREEYADFVRGITPLVVDM------------FEMIVKKYCGITIKdycyy-----dkkniMKWDQ 320
CDD66306     258 DRKYFEYALnIDIRLRKKEYVDFIRSITPLVVDL------------FELILKEQCKIDINkycdtyk--angttaRKWSM 323
Q0AW60       217 AQELFEYLLlLDLQQNSGQLMDFVRGISPALSRL------------FECFLREKCQRQVKldycvnkrhepdhywLKRDK 284 Syntrophomonas ...

5YJC_A       156 PYL-NDEDNLSFVYKYNlllEKRKQNFDVSRILgLPAFIDILTI---LEPNSQLLKEVNAVNDI---NGLRNSIAHNLDT 228 Staphylococcus ...
Q5HK94       301 PYL-NDEDNLSFVYKYNlllEKRKQNFDVSRILgLPAFIDILTI---LEPNSQLLKEVNAVNDI---NGLRNSIAHNLDT 373 Staphylococcus ...
WP_013120866 332 IRA-LNPELLAYLDECH---NGEYRDGSHVNIRmQNCLINFFLR---KNPDSQTRSFAGFLDTMeilNRDRNLAAHNLYG 404 Thermincola potens
P71635       301 RKLeREPEIRCALKHPP---KSPNAEWYLYTKD-WLALLRQFA------PDR--VGALEVLGRFe--SRVRNTAAHEIVS 366 Mycobacterium t...
CCX73451     321 KKL-QGTVALKALEDEY----GEFKYGPVYSVH-LTIIIDTLS------SEYSIKEKTSMLRKIe--ENVRNIAAHDIVS 386
CDD66306     324 SKL-NDSAVLEKLNQYFgtnGESFKGKNIYSIH-LKVLIDSFS------QDNKLKKLIGDVRNVe--ESIRNLAAHEIVS 393
Q0AW60       285 LAE-KDPSLLCYYDLRF---PNGFRDSDLSCST-LLPMIEFDCRpggRFPNEKVLLKAQYMRSVe--EKIRNPAAHNIVA 357 Syntrophomonas ...

5YJC_A       229 LNLDKNKNYKKIMLS--VEAIKNMLHISFP---EIEEEDYNYFEEKNKEFK 274 Staphylococcus epidermidis RP62A
Q5HK94       374 LNLDKNKNYKKIMLS--VEAIKNMLHISFP---EIEEEDYNYFEEKNKEFK 419 Staphylococcus epidermidis RP62A
WP_013120866 405 VLEEDIKQRSGLTGGqiVDKLENLIKFIFKg--RCKPEIFTIFDTVNNVIn 453 Thermincola potens
P71635       367 ISEDRITKDGGLLPEqlLKILA-----------RETGADLTLYDRLNDEII 406 Mycobacterium tuberculosis H37Rv
CCX73451     387 VTEEWVKKQTNKTPEeiMSLIQNLCMMIGI---GTKKEQWDSYDAMNQEII 434
CDD66306     394 VTEASIKNITGFSPEsiMDMIKKLFDYTGM---QVKKAYWNSYDDMNKLIL 441
Q0AW60       358 VKEKQFMQLVGISSAslVKDMQWMFKITYPqyfNTLENVWNSYNRMNEYII 408 Syntrophomonas wolfei subsp. wolfei str. Goe...
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